Homo sapiens

78 known processes

TRAF1

TNF receptor-associated factor 1

(Aliases: EBI6,MGC:10353)

TRAF1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 1.000
Human
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 1.000
Human
osteoclast differentiation GO:0030316 21 1.000
Human
cytokine mediated signaling pathway GO:0019221 109 1.000
Human
peptidyl serine autophosphorylation GO:0036289 2 1.000
positive regulation of osteoclast differentiation GO:0045672 9 1.000
Human
i kappab kinase nf kappab signaling GO:0007249 166 1.000
Human
regulation of i kappab kinase nf kappab signaling GO:0043122 162 1.000
Human
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 1.000
cellular response to tumor necrosis factor GO:0071356 63 0.999
Human
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 22 0.999
adaptive immune response GO:0002250 49 0.999
Human
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.999
positive regulation of cytokine production GO:0001819 167 0.999
Human
immune system development GO:0002520 195 0.999
Human
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.998
Human
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.998
positive regulation of mapk cascade GO:0043410 190 0.998
Human
response to nitric oxide GO:0071731 4 0.998
positive regulation of jnk cascade GO:0046330 52 0.998
Human
hemopoiesis GO:0030097 180 0.998
Human
cellular response to muramyl dipeptide GO:0071225 3 0.998
positive regulation of apoptotic signaling pathway GO:2001235 70 0.997
Human
immune response activating signal transduction GO:0002757 90 0.997
Human
lymphocyte apoptotic process GO:0070227 20 0.995
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.995
extrinsic apoptotic signaling pathway GO:0097191 119 0.995
cellular ketone metabolic process GO:0042180 80 0.995
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.994
regulation of transferase activity GO:0051338 355 0.994
Human
programmed necrotic cell death GO:0097300 18 0.994
regulation of cytokine production GO:0001817 232 0.992
Human
positive regulation of protein phosphorylation GO:0001934 313 0.992
Human
cellular response to biotic stimulus GO:0071216 71 0.991
Human
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.991
Human
positive regulation of jak stat cascade GO:0046427 35 0.991
toll like receptor 2 signaling pathway GO:0034134 4 0.991
cellular response to mechanical stimulus GO:0071260 39 0.990
cell type specific apoptotic process GO:0097285 125 0.989
regulation of cytokine production involved in immune response GO:0002718 22 0.989
Human
positive regulation of stress activated mapk cascade GO:0032874 60 0.988
Human
leukocyte differentiation GO:0002521 98 0.988
Human
response to tumor necrosis factor GO:0034612 76 0.986
Human
cellular amino acid metabolic process GO:0006520 116 0.985
positive regulation of defense response GO:0031349 87 0.984
myeloid cell differentiation GO:0030099 117 0.983
Human
positive regulation of interleukin 2 production GO:0032743 11 0.983
Human
regulation of lymphocyte activation GO:0051249 103 0.982
erk1 and erk2 cascade GO:0070371 104 0.980
regulation of leukocyte differentiation GO:1902105 61 0.980
Human
response to cytokine GO:0034097 232 0.980
Human
positive regulation of cellular amine metabolic process GO:0033240 7 0.978
regulation of mononuclear cell proliferation GO:0032944 65 0.977
protein catabolic process GO:0030163 325 0.977
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.976
regulation of jnk cascade GO:0046328 73 0.975
Human
cellular amine metabolic process GO:0044106 41 0.975
positive regulation of cdc42 gtpase activity GO:0043089 6 0.973
apoptotic signaling pathway GO:0097190 268 0.971
regulation of cellular amino acid metabolic process GO:0006521 6 0.971
positive regulation of immune system process GO:0002684 283 0.968
Human
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.967
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.966
negative regulation of apoptotic signaling pathway GO:2001234 97 0.966
interleukin 2 production GO:0032623 20 0.963
Human
cytokine production involved in immune response GO:0002367 27 0.960
Human
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.960
Human
myeloid leukocyte differentiation GO:0002573 60 0.959
Human
regulation of jun kinase activity GO:0043506 27 0.955
Human
jak stat cascade GO:0007259 46 0.954
activation of innate immune response GO:0002218 55 0.954
positive regulation of leukocyte proliferation GO:0070665 48 0.953
regulation of osteoclast differentiation GO:0045670 18 0.951
Human
negative regulation of neurological system process GO:0031645 2 0.949
positive regulation of cell activation GO:0050867 81 0.942
regulation of necroptotic process GO:0060544 7 0.941
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.936
leukocyte activation GO:0045321 164 0.936
regulation of myeloid cell differentiation GO:0045637 81 0.935
Human
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 28 0.929
positive regulation of programmed cell death GO:0043068 249 0.926
Human
t cell cytokine production GO:0002369 12 0.926
Human
negative regulation of apoptotic process GO:0043066 316 0.923
regulation of immune response GO:0050776 201 0.920
Human
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.918
positive regulation of myeloid cell differentiation GO:0045639 39 0.911
Human
hematopoietic or lymphoid organ development GO:0048534 186 0.910
Human
positive regulation of gtp catabolic process GO:0033126 166 0.910
positive regulation of protein kinase activity GO:0045860 190 0.908
Human
peptidyl tyrosine phosphorylation GO:0018108 170 0.906
mononuclear cell proliferation GO:0032943 71 0.899
positive regulation of cell differentiation GO:0045597 211 0.897
Human
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.894
Human
cytokine production GO:0001816 247 0.893
Human
response to interleukin 1 GO:0070555 47 0.889
Human
amine metabolic process GO:0009308 44 0.882
regulation of cellular amine metabolic process GO:0033238 11 0.878
regulation of kinase activity GO:0043549 314 0.878
Human
regulation of cell differentiation GO:0045595 393 0.877
Human
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.872
Human
regulation of cdc42 protein signal transduction GO:0032489 14 0.867
regulation of apoptotic signaling pathway GO:2001233 175 0.865
positive regulation of developmental process GO:0051094 314 0.864
Human
response to lipid GO:0033993 206 0.855
Human
regulation of lymphocyte proliferation GO:0050670 64 0.853
necroptotic process GO:0070266 16 0.852
activation of protein kinase activity GO:0032147 90 0.852
Human
jnk cascade GO:0007254 80 0.852
Human
cellular response to external stimulus GO:0071496 111 0.847
regulation of leukocyte proliferation GO:0070663 67 0.844
innate immune response activating signal transduction GO:0002758 48 0.842
regulation of map kinase activity GO:0043405 108 0.842
Human
regulation of cellular response to stress GO:0080135 244 0.841
Human
positive regulation of adaptive immune response GO:0002821 21 0.838
Human
regulation of peptidyl serine phosphorylation GO:0033135 50 0.837
regulation of ion transmembrane transport GO:0034765 132 0.836
cellular response to lipid GO:0071396 127 0.832
Human
cd8 positive alpha beta t cell activation GO:0036037 3 0.832
positive regulation of kinase activity GO:0033674 204 0.831
Human
activation of immune response GO:0002253 114 0.830
Human
immune effector process GO:0002252 159 0.826
Human
regulation of anion transport GO:0044070 25 0.824
regulation of necrotic cell death GO:0010939 9 0.823
regulation of leukocyte activation GO:0002694 115 0.821
protein secretion GO:0009306 98 0.818
response to biotic stimulus GO:0009607 276 0.812
Human
protein homooligomerization GO:0051260 100 0.796
Human
protein ubiquitination GO:0016567 314 0.786
Human
regulation of cytokine secretion GO:0050707 57 0.784
gtp metabolic process GO:0046039 239 0.784
interleukin 12 secretion GO:0072610 1 0.783
regulation of t cell mediated immunity GO:0002709 18 0.782
Human
positive regulation of cell death GO:0010942 263 0.781
Human
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.780
protein kinase c signaling GO:0070528 17 0.779
lipopolysaccharide mediated signaling pathway GO:0031663 26 0.778
signal transduction by phosphorylation GO:0023014 297 0.769
Human
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.768
positive regulation of apoptotic process GO:0043065 246 0.766
Human
trail activated apoptotic signaling pathway GO:0036462 4 0.765
mature natural killer cell chemotaxis GO:0035782 1 0.763
small gtpase mediated signal transduction GO:0007264 78 0.754
t cell differentiation GO:0030217 29 0.748
cdc42 protein signal transduction GO:0032488 4 0.746
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 11 0.739
positive regulation of necrotic cell death GO:0010940 4 0.739
positive regulation of tumor necrosis factor production GO:0032760 21 0.738
regulation of stress activated mapk cascade GO:0032872 84 0.737
Human
regulation of erk1 and erk2 cascade GO:0070372 99 0.732
positive regulation of cell proliferation GO:0008284 301 0.725
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.722
Human
negative regulation of cell death GO:0060548 345 0.721
regulation of proteolysis GO:0030162 293 0.719
Human
cellular response to nitrogen compound GO:1901699 144 0.719
regulation of ras gtpase activity GO:0032318 128 0.717
interferon gamma production GO:0032609 39 0.716
positive regulation of cytokine biosynthetic process GO:0042108 25 0.716
peptidyl serine modification GO:0018209 106 0.716
tumor necrosis factor production GO:0032640 43 0.715
lymphocyte activation GO:0046649 133 0.707
regulation of leukocyte apoptotic process GO:2000106 25 0.706
defense response GO:0006952 315 0.696
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.696
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.694
cd4 positive alpha beta t cell differentiation GO:0043367 4 0.693
response to mechanical stimulus GO:0009612 51 0.691
carbohydrate derivative transport GO:1901264 20 0.690
guanosine containing compound metabolic process GO:1901068 244 0.688
regulation of lymphocyte mediated immunity GO:0002706 33 0.685
Human
positive regulation of leukocyte differentiation GO:1902107 37 0.680
Human
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 4 0.678
ras protein signal transduction GO:0007265 73 0.677
regulation of protein secretion GO:0050708 86 0.677
regulation of t cell proliferation GO:0042129 42 0.673
response to external biotic stimulus GO:0043207 261 0.672
Human
positive regulation of phosphorylation GO:0042327 394 0.672
Human
positive regulation of cd8 positive alpha beta t cell proliferation GO:2000566 1 0.672
negative regulation of lymphocyte chemotaxis GO:1901624 2 0.667
lymphocyte proliferation GO:0046651 70 0.667
pattern recognition receptor signaling pathway GO:0002221 48 0.664
necroptotic signaling pathway GO:0097527 6 0.662
immune response GO:0006955 307 0.655
Human
regulation of rho gtpase activity GO:0032319 66 0.643
negative regulation of alpha beta t cell proliferation GO:0046642 1 0.634
regulation of atp adp antiporter activity GO:0070926 1 0.630
regulation of t cell activation GO:0050863 77 0.629
regulation of reactive oxygen species metabolic process GO:2000377 41 0.625
positive regulation of endothelial cell apoptotic process GO:2000353 8 0.622
positive regulation of transferase activity GO:0051347 227 0.610
Human
t cell proliferation GO:0042098 45 0.607
regulation of immunoglobulin secretion GO:0051023 1 0.600
establishment of protein localization to organelle GO:0072594 172 0.599
negative regulation of cytokine production GO:0001818 82 0.597
regulation of rho protein signal transduction GO:0035023 79 0.583
membrane protein proteolysis GO:0033619 38 0.578
positive regulation of interleukin 8 production GO:0032757 36 0.575
mapk cascade GO:0000165 288 0.574
Human
positive regulation of immune response GO:0050778 159 0.568
Human
positive regulation of hydrolase activity GO:0051345 331 0.564
regulation of cd8 positive alpha beta t cell proliferation GO:2000564 1 0.563
cellular divalent inorganic cation homeostasis GO:0072503 128 0.561
regulation of protein transport GO:0051223 213 0.558
nucleoside triphosphate metabolic process GO:0009141 422 0.557
stress activated protein kinase signaling cascade GO:0031098 94 0.554
Human
regulation of establishment of protein localization GO:0070201 242 0.539
negative regulation of alpha beta t cell activation GO:0046636 3 0.539
response to oxygen containing compound GO:1901700 369 0.530
Human
secretion GO:0046903 254 0.529
nucleoside transport GO:0015858 8 0.527
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.521
cytokine biosynthetic process GO:0042089 37 0.512
regulation of nucleoside transport GO:0032242 1 0.506
positive regulation of jun kinase activity GO:0043507 23 0.504
Human
regulation of secretion by cell GO:1903530 177 0.501
positive regulation of protein catabolic process GO:0045732 75 0.499
neuronal action potential GO:0019228 9 0.498
cd4 positive alpha beta t cell proliferation GO:0035739 2 0.497
t helper 1 type immune response GO:0042088 8 0.496
positive regulation of nucleotide metabolic process GO:0045981 230 0.494
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.493
Human
cellular response to oxygen containing compound GO:1901701 276 0.492
Human
regulation of alpha beta t cell activation GO:0046634 13 0.492
positive regulation of nf kappab import into nucleus GO:0042346 13 0.489
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 20 0.486
cd8 positive alpha beta t cell proliferation GO:0035740 1 0.480
response to abiotic stimulus GO:0009628 336 0.479
organophosphate catabolic process GO:0046434 430 0.475
natural killer cell apoptotic process GO:0070246 1 0.475
protein oligomerization GO:0051259 173 0.473
Human
cellular response to lipopolysaccharide GO:0071222 57 0.471
Human
regulation of adaptive immune response GO:0002819 33 0.470
Human
stress activated mapk cascade GO:0051403 93 0.465
Human
positive regulation of lymphocyte migration GO:2000403 16 0.463
cellular response to endogenous stimulus GO:0071495 336 0.459
regulation of myeloid leukocyte differentiation GO:0002761 39 0.453
Human
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.452
Human
regulation of secretion GO:0051046 194 0.451
negative regulation of myelination GO:0031642 1 0.450
regulation of protein binding GO:0043393 66 0.447
Human
regulation of cytokine biosynthetic process GO:0042035 35 0.447
amyloid fibril formation GO:1990000 3 0.439
system process GO:0003008 349 0.435
cellular response to cytokine stimulus GO:0071345 181 0.434
Human
skeletal muscle satellite cell proliferation GO:0014841 1 0.432
positive regulation of intracellular protein transport GO:0090316 76 0.431
nucleotide catabolic process GO:0009166 408 0.430
regulation of production of molecular mediator of immune response GO:0002700 25 0.429
Human
secretion by cell GO:0032940 226 0.427
regulation of protein localization GO:0032880 296 0.424
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.419
peptidyl tyrosine modification GO:0018212 170 0.419
membrane protein ectodomain proteolysis GO:0006509 33 0.417
regulation of transmembrane transporter activity GO:0022898 74 0.415
positive regulation of necroptotic process GO:0060545 2 0.411
regulation of immune effector process GO:0002697 91 0.409
Human
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.404
intrinsic apoptotic signaling pathway GO:0097193 127 0.404
regulation of nik nf kappab signaling GO:1901222 11 0.403
Human
interleukin 6 production GO:0032635 37 0.396
response to nitrogen compound GO:1901698 184 0.395
regulation of defense response GO:0031347 154 0.393
regulation of oxidoreductase activity GO:0051341 43 0.391
response to lipopolysaccharide GO:0032496 70 0.391
Human
regulation of protein serine threonine kinase activity GO:0071900 179 0.390
Human
transmission of nerve impulse GO:0019226 11 0.390
positive regulation of protein kinase c signaling GO:0090037 5 0.389
protein modification by small protein conjugation GO:0032446 342 0.386
Human
purine nucleotide catabolic process GO:0006195 405 0.385
neurological system process GO:0050877 163 0.384
regulation of interleukin 8 production GO:0032677 49 0.384
positive regulation of t cell migration GO:2000406 13 0.382
regulation of peptidase activity GO:0052547 180 0.379
guanosine containing compound catabolic process GO:1901069 239 0.377
negative regulation of programmed cell death GO:0043069 321 0.377
negative regulation of signal transduction in absence of ligand GO:1901099 16 0.373
lymphocyte migration GO:0072676 28 0.365
positive regulation of t helper cell differentiation GO:0045624 2 0.361
positive regulation of t cell cytokine production GO:0002726 4 0.359
Human
ubiquitin dependent protein catabolic process GO:0006511 206 0.357
regulation of lymphocyte apoptotic process GO:0070228 15 0.351
antigen receptor mediated signaling pathway GO:0050851 38 0.349
Human
response to virus GO:0009615 126 0.349
protein k63 linked ubiquitination GO:0070534 31 0.349
Human
negative regulation of cell proliferation GO:0008285 228 0.347
endothelial cell apoptotic process GO:0072577 26 0.347
negative regulation of developmental process GO:0051093 247 0.346
ripoptosome assembly GO:0097343 1 0.342
protein processing GO:0016485 226 0.337
regulation of macrophage differentiation GO:0045649 9 0.332
ribonucleoside triphosphate metabolic process GO:0009199 412 0.331
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.331
Human
regulation of protein kinase activity GO:0045859 289 0.327
Human
positive regulation of map kinase activity GO:0043406 80 0.323
Human
regulation of gtp catabolic process GO:0033124 180 0.322
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.319
regulation of t cell cytokine production GO:0002724 10 0.317
Human
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.315
positive regulation of ras gtpase activity GO:0032320 117 0.313
negative regulation of t cell apoptotic process GO:0070233 4 0.312
regulation of mapk cascade GO:0043408 262 0.306
Human
positive regulation of alpha beta t cell activation GO:0046635 10 0.303
tumor necrosis factor mediated signaling pathway GO:0033209 27 0.302
Human
regulation of cell activation GO:0050865 125 0.297
regulation of immunoglobulin production GO:0002637 4 0.295
action potential GO:0001508 34 0.295
positive regulation of t cell proliferation GO:0042102 33 0.294
leukocyte migration GO:0050900 107 0.293
alpha beta t cell proliferation GO:0046633 5 0.293
cellular response to molecule of bacterial origin GO:0071219 62 0.293
Human
positive regulation of interferon gamma production GO:0032729 26 0.292
inflammatory response GO:0006954 79 0.287
calcium ion homeostasis GO:0055074 122 0.284
negative regulation of multicellular organismal process GO:0051241 317 0.283
protein polyubiquitination GO:0000209 110 0.279
Human
regulation of purine nucleotide catabolic process GO:0033121 205 0.276
regulation of cysteine type endopeptidase activity GO:2000116 127 0.275
cytokine secretion GO:0050663 64 0.269
regulation of cellular ketone metabolic process GO:0010565 50 0.267
positive regulation of leukocyte migration GO:0002687 46 0.267
positive regulation of cellular catabolic process GO:0031331 284 0.264
negative regulation of natural killer cell chemotaxis GO:2000502 1 0.263
regulation of endothelial cell apoptotic process GO:2000351 24 0.263
gtp catabolic process GO:0006184 237 0.260
regulation of ion transport GO:0043269 189 0.260
regulation of neurological system process GO:0031644 6 0.259
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.258
purine nucleoside triphosphate catabolic process GO:0009146 392 0.257
cellular homeostasis GO:0019725 196 0.251
ion transmembrane transport GO:0034220 338 0.251
multicellular organismal signaling GO:0035637 34 0.250
cellular response to oxidative stress GO:0034599 85 0.248
positive regulation of proteolysis GO:0045862 142 0.247
negative regulation of necroptotic process GO:0060546 2 0.246
response to muramyl dipeptide GO:0032495 4 0.245
reactive oxygen species metabolic process GO:0072593 75 0.245
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.239
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.239
Human
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.235
positive regulation of t helper 1 type immune response GO:0002827 4 0.235
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.232
Human
regulation of alpha beta t cell proliferation GO:0046640 5 0.231
regulation of transporter activity GO:0032409 82 0.224
alpha beta t cell differentiation GO:0046632 7 0.224
positive regulation of lymphocyte activation GO:0051251 73 0.223
positive regulation of alpha beta t cell proliferation GO:0046641 5 0.223
necrotic cell death GO:0070265 21 0.222
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 42 0.219
regulation of innate immune response GO:0045088 97 0.219
nucleotide binding domain leucine rich repeat containing receptor signaling pathway GO:0035872 5 0.218
purine ribonucleoside metabolic process GO:0046128 437 0.218
response to oxidative stress GO:0006979 121 0.217
regulation of inflammatory response GO:0050727 46 0.215
t helper 1 cell activation GO:0035711 1 0.212
positive regulation of lymphocyte proliferation GO:0050671 46 0.211
negative regulation of immune response GO:0050777 40 0.209
purine ribonucleotide catabolic process GO:0009154 404 0.208
response to other organism GO:0051707 261 0.206
Human
leukocyte apoptotic process GO:0071887 31 0.204
protein heterooligomerization GO:0051291 16 0.202
positive regulation of membrane protein ectodomain proteolysis GO:0051044 13 0.198
negative regulation of interleukin 12 secretion GO:2001183 1 0.198
regulation of nucleotide catabolic process GO:0030811 205 0.198
positive regulation of cytokine secretion GO:0050715 42 0.197
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.197
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 22 0.197
cell activation involved in immune response GO:0002263 30 0.196
immune response regulating signaling pathway GO:0002764 97 0.192
Human
negative regulation of chemokine mediated signaling pathway GO:0070100 5 0.190
modification dependent protein catabolic process GO:0019941 209 0.190
nucleobase containing compound transport GO:0015931 51 0.189
regulation of ras protein signal transduction GO:0046578 155 0.186
nitrogen compound transport GO:0071705 191 0.184
peptidyl serine phosphorylation GO:0018105 101 0.183
regulation of protein ubiquitination GO:0031396 95 0.182
regulation of tumor necrosis factor production GO:0032680 43 0.180
innate immune response GO:0045087 178 0.179
regulation of interleukin 6 production GO:0032675 37 0.177
regulation of gtpase activity GO:0043087 180 0.177
alpha beta t cell activation GO:0046631 15 0.177
positive regulation of rho gtpase activity GO:0032321 56 0.177
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.175
regulation of interferon gamma production GO:0032649 36 0.175
positive regulation of protein import into nucleus GO:0042307 46 0.172
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 3 0.172
positive regulation of cytokine secretion involved in immune response GO:0002741 2 0.172
negative regulation of t cell proliferation GO:0042130 8 0.172
cell cell signaling GO:0007267 155 0.171
divalent inorganic cation homeostasis GO:0072507 136 0.171
negative regulation of c c chemokine binding GO:2001264 1 0.171
regulation of leukocyte mediated immunity GO:0002703 38 0.171
Human
positive regulation of protein polyubiquitination GO:1902916 3 0.168
defense response to gram positive bacterium GO:0050830 29 0.167
tnfsf11 mediated signaling pathway GO:0071847 2 0.167
purine ribonucleoside catabolic process GO:0046130 398 0.166
leukocyte proliferation GO:0070661 74 0.166
t helper 1 cell differentiation GO:0045063 1 0.166
positive regulation of protein transport GO:0051222 135 0.166
positive regulation of protein linear polyubiquitination GO:1902530 2 0.165
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.164
response to organonitrogen compound GO:0010243 156 0.161
negative regulation of nervous system development GO:0051961 28 0.161
regulation of protein kinase c signaling GO:0090036 8 0.160
positive regulation of binding GO:0051099 45 0.159
Human
lymphocyte mediated immunity GO:0002449 48 0.159
Human
regulation of protein linear polyubiquitination GO:1902528 2 0.158
negative regulation of leukocyte proliferation GO:0070664 16 0.157
negative regulation of cd4 positive alpha beta t cell proliferation GO:2000562 1 0.156
regulation of response to external stimulus GO:0032101 222 0.155
regulation of membrane potential GO:0042391 95 0.153
t cell apoptotic process GO:0070231 12 0.152
activation of nf kappab inducing kinase activity GO:0007250 9 0.151
Human
execution phase of apoptosis GO:0097194 32 0.150
negative regulation of i kappab kinase nf kappab signaling GO:0043124 32 0.149
nucleoside triphosphate catabolic process GO:0009143 394 0.149
regulation of small gtpase mediated signal transduction GO:0051056 156 0.148
negative regulation of secretion by cell GO:1903531 52 0.148
positive regulation of protein complex assembly GO:0031334 86 0.147
regulation of transcription factor import into nucleus GO:0042990 39 0.145
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.144
lipid metabolic process GO:0006629 381 0.144
regulation of protein homodimerization activity GO:0043496 9 0.143
Human
protein k48 linked ubiquitination GO:0070936 38 0.142
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.141
regulation of protein monoubiquitination GO:1902525 1 0.139
regulation of protein catabolic process GO:0042176 155 0.139
rho protein signal transduction GO:0007266 26 0.139
negative regulation of secretion GO:0051048 58 0.137
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.136
t cell receptor signaling pathway GO:0050852 21 0.136
Human
regulation of nucleoside metabolic process GO:0009118 209 0.135
peptidyl threonine modification GO:0018210 45 0.134
negative regulation of proteolysis GO:0045861 132 0.132
t cell mediated immunity GO:0002456 25 0.132
Human
positive regulation of mononuclear cell proliferation GO:0032946 47 0.131
positive regulation of t cell apoptotic process GO:0070234 4 0.130
cell activation GO:0001775 213 0.129
metal ion homeostasis GO:0055065 169 0.128
protein homotrimerization GO:0070207 9 0.126
Human
cytokine metabolic process GO:0042107 38 0.126
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.125
interleukin 10 production GO:0032613 17 0.124
response to molecule of bacterial origin GO:0002237 82 0.124
Human
regulation of protein localization to nucleus GO:1900180 85 0.122
epithelium development GO:0060429 227 0.121
regulation of wnt signaling pathway GO:0030111 123 0.121
chemokine biosynthetic process GO:0042033 4 0.121
purine nucleoside catabolic process GO:0006152 398 0.121
granzyme b production GO:0071613 1 0.121
t cell differentiation in thymus GO:0033077 4 0.120
cellular response to growth factor stimulus GO:0071363 197 0.120
chronic inflammatory response GO:0002544 2 0.118
regulation of endopeptidase activity GO:0052548 170 0.118
cellular ion homeostasis GO:0006873 168 0.116
cellular macromolecule catabolic process GO:0044265 380 0.116
regulation of jak stat cascade GO:0046425 44 0.113
immunoglobulin secretion GO:0048305 1 0.112
negative regulation of endopeptidase activity GO:0010951 84 0.111
regulation of anatomical structure morphogenesis GO:0022603 286 0.110
wnt signaling pathway GO:0016055 156 0.109
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 19 0.109
Human
cellular protein catabolic process GO:0044257 261 0.107
response to lipoteichoic acid GO:0070391 3 0.106
positive regulation of tyrosine phosphorylation of stat1 protein GO:0042511 8 0.106
myeloid dendritic cell chemotaxis GO:0002408 3 0.106
intracellular protein transport GO:0006886 270 0.105
interleukin 12 production GO:0032615 15 0.104
regulation of b cell proliferation GO:0030888 18 0.104
negative regulation of response to external stimulus GO:0032102 83 0.103
ribonucleoside triphosphate catabolic process GO:0009203 391 0.103
regulation of nucleotide metabolic process GO:0006140 269 0.102
positive regulation of transcription factor import into nucleus GO:0042993 25 0.100
positive regulation of cd8 positive alpha beta t cell activation GO:2001187 1 0.099
positive regulation of protein monoubiquitination GO:1902527 1 0.098
cellular response to dna damage stimulus GO:0006974 379 0.098
negative regulation of defense response GO:0031348 47 0.097
response to peptide GO:1901652 65 0.097
positive regulation of protein homodimerization activity GO:0090073 5 0.096
Human
response to reactive oxygen species GO:0000302 61 0.096
purine nucleoside triphosphate metabolic process GO:0009144 412 0.096
astrocyte cell migration GO:0043615 1 0.095
regulation of granzyme b production GO:0071661 1 0.095
positive regulation of innate immune response GO:0045089 79 0.094
anion transport GO:0006820 161 0.094
negative regulation of immune system process GO:0002683 136 0.093
regulation of canonical wnt signaling pathway GO:0060828 88 0.092
regulation of locomotion GO:0040012 329 0.092
positive regulation of peptidyl threonine phosphorylation GO:0010800 9 0.091
positive regulation of protein ubiquitination GO:0031398 53 0.091
regulation of cd4 positive alpha beta t cell proliferation GO:2000561 2 0.090
negative regulation of lymphocyte migration GO:2000402 4 0.090
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.090
cellular extravasation GO:0045123 21 0.089
positive regulation of lipid metabolic process GO:0045834 50 0.089
chemokine c c motif ligand 21 signaling pathway GO:0038116 1 0.087
regulation of alcohol biosynthetic process GO:1902930 22 0.086
negative regulation of protein maturation GO:1903318 142 0.085
regulation of dephosphorylation GO:0035303 96 0.085
modification dependent macromolecule catabolic process GO:0043632 212 0.083
canonical wnt signaling pathway GO:0060070 116 0.082
immature t cell proliferation GO:0033079 1 0.081

TRAF1 disease predictions

Disease DO term ID Size Probability Func Analog Org