Homo sapiens

182 known processes

TRIM28

tripartite motif containing 28

(Aliases: TIF1B,RNF96,TF1B,KAP1,FLJ29029)

TRIM28 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
covalent chromatin modification GO:0016569 254 0.998
chromatin organization GO:0006325 351 0.998
Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.997
Mouse
chromatin modification GO:0016568 298 0.993
histone modification GO:0016570 251 0.970
protein acetylation GO:0006473 116 0.866
macromolecule methylation GO:0043414 97 0.847
Mouse
regulation of cell cycle GO:0051726 393 0.752
cellular macromolecule catabolic process GO:0044265 380 0.743
protein catabolic process GO:0030163 325 0.687
Human
cellular protein catabolic process GO:0044257 261 0.685
negative regulation of cellular protein metabolic process GO:0032269 353 0.610
gene silencing GO:0016458 49 0.542
positive regulation of developmental process GO:0051094 314 0.538
regulation of multicellular organism growth GO:0040014 8 0.530
chromatin assembly or disassembly GO:0006333 78 0.529
growth GO:0040007 202 0.515
Mouse
protein acylation GO:0043543 138 0.511
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.511
nucleosome organization GO:0034728 66 0.503
post embryonic development GO:0009791 2 0.501
mitotic cell cycle GO:0000278 326 0.472
protein dna complex subunit organization GO:0071824 80 0.445
negative regulation of cell cycle GO:0045786 193 0.401
dna repair GO:0006281 198 0.357
methylation GO:0032259 106 0.350
Mouse
nervous system development GO:0007399 293 0.327
Fly
cell development GO:0048468 328 0.312
Mouse Fly
determination of adult lifespan GO:0008340 2 0.293
negative regulation of mitotic cell cycle GO:0045930 102 0.292
negative regulation of protein metabolic process GO:0051248 391 0.288
cell cycle checkpoint GO:0000075 117 0.275
strand invasion GO:0042148 2 0.274
methylation dependent chromatin silencing GO:0006346 3 0.273
cellular response to dna damage stimulus GO:0006974 379 0.235
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.230
regulation of growth GO:0040008 165 0.218
organelle fission GO:0048285 149 0.213
response to oxygen containing compound GO:1901700 369 0.208
rna processing GO:0006396 255 0.208
developmental process involved in reproduction GO:0003006 66 0.207
Mouse
cellular protein complex assembly GO:0043623 188 0.200
mitotic cell cycle process GO:1903047 286 0.188
regulation of cellular ketone metabolic process GO:0010565 50 0.187
protein alkylation GO:0008213 74 0.184
dna methylation or demethylation GO:0044728 19 0.181
Mouse
oogenesis GO:0048477 2 0.178
single organism reproductive process GO:0044702 98 0.176
Mouse
negative regulation of protein modification process GO:0031400 200 0.174
embryo development ending in birth or egg hatching GO:0009792 34 0.170
Mouse
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.163
negative regulation of chromosome organization GO:2001251 48 0.163
proteasomal protein catabolic process GO:0010498 176 0.160
regulation of cell cycle phase transition GO:1901987 126 0.159
multicellular organismal aging GO:0010259 3 0.155
protein ubiquitination GO:0016567 314 0.154
negative regulation of cell cycle process GO:0010948 121 0.148
positive regulation of multicellular organism growth GO:0040018 6 0.148
peptidyl lysine modification GO:0018205 144 0.144
negative regulation of intracellular signal transduction GO:1902532 183 0.137
positive regulation of growth GO:0045927 58 0.135
microtubule based process GO:0007017 210 0.135
positive regulation of cellular amine metabolic process GO:0033240 7 0.134
dephosphorylation GO:0016311 209 0.128
locomotory behavior GO:0007626 1 0.122
neuron projection development GO:0031175 106 0.121
Fly
purine nucleoside triphosphate catabolic process GO:0009146 392 0.120
cellular response to oxygen containing compound GO:1901701 276 0.117
regulation of cell development GO:0060284 161 0.112
chromatin assembly GO:0031497 61 0.107
response to other organism GO:0051707 261 0.106
chromatin silencing GO:0006342 12 0.105
reproductive process GO:0022414 106 0.102
Mouse
negative regulation of cell cycle phase transition GO:1901988 89 0.102
regulation of protein acetylation GO:1901983 25 0.101
regulation of chromosome organization GO:0033044 103 0.101
cellular response to growth factor stimulus GO:0071363 197 0.100
Human
cell aging GO:0007569 52 0.097
internal peptidyl lysine acetylation GO:0018393 97 0.097
spindle organization GO:0007051 53 0.097
reproductive system development GO:0061458 56 0.096
Mouse
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.096
ras protein signal transduction GO:0007265 73 0.091
protein modification by small protein conjugation GO:0032446 342 0.089
regulation of dna metabolic process GO:0051052 153 0.087
histone acetylation GO:0016573 93 0.086
nuclear division GO:0000280 128 0.085
chromatin remodeling GO:0006338 55 0.085
chromosome segregation GO:0007059 114 0.084
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.084
regulation of mitotic cell cycle GO:0007346 189 0.084
response to abiotic stimulus GO:0009628 336 0.083
peptidyl lysine acetylation GO:0018394 101 0.083
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.077
vesicle mediated transport GO:0016192 371 0.076
regulation of proteolysis GO:0030162 293 0.076
regulation of gene expression epigenetic GO:0040029 73 0.075
Mouse
lens development in camera type eye GO:0002088 2 0.074
generation of neurons GO:0048699 152 0.073
Fly
regulation of chromatin organization GO:1902275 56 0.073
cell cycle phase transition GO:0044770 173 0.073
dna conformation change GO:0071103 113 0.072
cytoplasmic transport GO:0016482 379 0.072
regulation of cell cycle process GO:0010564 266 0.071
protein methylation GO:0006479 74 0.068
regulation of cellular response to stress GO:0080135 244 0.067
neurogenesis GO:0022008 169 0.067
Fly
female gamete generation GO:0007292 2 0.067
dna packaging GO:0006323 77 0.066
multicellular organism growth GO:0035264 8 0.066
positive regulation of ubiquitin protein transferase activity GO:0051443 18 0.066
positive regulation of organelle organization GO:0010638 195 0.063
positive regulation of transferase activity GO:0051347 227 0.061
cellular component morphogenesis GO:0032989 314 0.061
Mouse Fly
peptidyl threonine dephosphorylation GO:0035970 7 0.060
behavior GO:0007610 112 0.060
dna integrity checkpoint GO:0031570 71 0.059
microtubule cytoskeleton organization GO:0000226 176 0.057
protein dephosphorylation GO:0006470 81 0.055
regulation of locomotion GO:0040012 329 0.054
positive regulation of developmental growth GO:0048639 16 0.054
cellular macromolecular complex assembly GO:0034622 324 0.053
response to biotic stimulus GO:0009607 276 0.053
mitotic nuclear division GO:0007067 119 0.053
anatomical structure formation involved in morphogenesis GO:0048646 284 0.052
positive regulation of programmed cell death GO:0043068 249 0.052
modification dependent protein catabolic process GO:0019941 209 0.051
striated muscle myosin thick filament assembly GO:0071688 2 0.050
dna replication GO:0006260 116 0.050
mitotic cell cycle phase transition GO:0044772 162 0.048
mitotic sister chromatid segregation GO:0000070 53 0.048
cell division GO:0051301 168 0.047
multicellular organismal reproductive process GO:0048609 40 0.047
positive regulation of hydrolase activity GO:0051345 331 0.047
regulation of histone modification GO:0031056 47 0.046
embryo development GO:0009790 123 0.046
Mouse
amine metabolic process GO:0009308 44 0.045
histone methylation GO:0016571 60 0.045
nucleotide catabolic process GO:0009166 408 0.045
oocyte differentiation GO:0009994 2 0.045
rna interference GO:0016246 4 0.044
mitotic cell cycle checkpoint GO:0007093 68 0.043
stress activated protein kinase signaling cascade GO:0031098 94 0.043
negative regulation of phosphate metabolic process GO:0045936 267 0.042
regulation of chromatin modification GO:1903308 51 0.042
circulatory system development GO:0072359 262 0.042
notch signaling pathway GO:0007219 31 0.042
regulation of ras protein signal transduction GO:0046578 155 0.042
cellular amino acid metabolic process GO:0006520 116 0.041
positive regulation of chromatin modification GO:1903310 30 0.041
regulation of developmental growth GO:0048638 30 0.040
maintenance of location GO:0051235 112 0.039
cellular response to organonitrogen compound GO:0071417 124 0.039
mrna metabolic process GO:0016071 175 0.039
dna hypermethylation GO:0044026 1 0.038
positive regulation of cellular catabolic process GO:0031331 284 0.037
negative regulation of phosphorus metabolic process GO:0010563 267 0.037
positive regulation of protein ubiquitination GO:0031398 53 0.037
negative regulation of gene expression epigenetic GO:0045814 19 0.037
dna templated transcription elongation GO:0006354 25 0.036
glycosyl compound catabolic process GO:1901658 413 0.036
response to external biotic stimulus GO:0043207 261 0.035
negative regulation of multicellular organismal process GO:0051241 317 0.035
positive regulation of chromosome organization GO:2001252 41 0.034
negative regulation of proteolysis GO:0045861 132 0.033
translation GO:0006412 132 0.033
cardiovascular system development GO:0072358 262 0.033
aging GO:0007568 66 0.032
positive regulation of peptidase activity GO:0010952 88 0.032
negative regulation of cellular component organization GO:0051129 235 0.032
regulation of small gtpase mediated signal transduction GO:0051056 156 0.032
reproduction GO:0000003 63 0.032
regulation of endopeptidase activity GO:0052548 170 0.031
negative regulation of programmed cell death GO:0043069 321 0.031
regulation of response to external stimulus GO:0032101 222 0.031
regulation of immune response GO:0050776 201 0.031
negative regulation of protein acetylation GO:1901984 11 0.031
cellular senescence GO:0090398 34 0.031
positive regulation of histone modification GO:0031058 29 0.031
nucleoside catabolic process GO:0009164 408 0.031
dna damage checkpoint GO:0000077 68 0.030
nucleotide excision repair GO:0006289 31 0.030
regulation of cellular protein catabolic process GO:1903362 96 0.029
regulation of cysteine type endopeptidase activity GO:2000116 127 0.029
purine ribonucleoside metabolic process GO:0046128 437 0.029
osteoblast differentiation GO:0001649 92 0.029
gonad development GO:0008406 34 0.028
ncrna processing GO:0034470 83 0.028
sex differentiation GO:0007548 45 0.028
negative regulation of chromatin modification GO:1903309 21 0.028
internal protein amino acid acetylation GO:0006475 101 0.028
cell cycle arrest GO:0007050 71 0.027
nucleoside phosphate catabolic process GO:1901292 412 0.027
response to organonitrogen compound GO:0010243 156 0.027
regulation of mitotic cell cycle phase transition GO:1901990 118 0.027
ribonucleoside triphosphate catabolic process GO:0009203 391 0.027
regulation of binding GO:0051098 111 0.027
organ morphogenesis GO:0009887 147 0.026
cellular amine metabolic process GO:0044106 41 0.026
regulation of protein ubiquitination GO:0031396 95 0.026
negative regulation of apoptotic process GO:0043066 316 0.026
regulation of response to dna damage stimulus GO:2001020 94 0.026
regulation of notch signaling pathway GO:0008593 18 0.026
macromolecule deacylation GO:0098732 41 0.026
dna methylation on cytosine GO:0032776 3 0.026
ubiquitin dependent protein catabolic process GO:0006511 206 0.025
system process GO:0003008 349 0.025
response to decreased oxygen levels GO:0036293 96 0.025
protein import into nucleus GO:0006606 104 0.024
ribonucleoside catabolic process GO:0042454 406 0.024
ncrna metabolic process GO:0034660 108 0.024
signal transduction by p53 class mediator GO:0072331 72 0.023
response to inorganic substance GO:0010035 127 0.023
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.023
response to radiation GO:0009314 151 0.023
myosin filament assembly GO:0031034 2 0.023
nuclear transport GO:0051169 179 0.022
cell type specific apoptotic process GO:0097285 125 0.022
regulation of proteasomal protein catabolic process GO:0061136 87 0.022
negative regulation of catabolic process GO:0009895 104 0.022
mitotic dna integrity checkpoint GO:0044774 30 0.022
positive regulation of ligase activity GO:0051351 19 0.022
purine nucleoside monophosphate catabolic process GO:0009128 158 0.022
posttranscriptional regulation of gene expression GO:0010608 213 0.022
Human
protein processing GO:0016485 226 0.022
regulation of immune effector process GO:0002697 91 0.021
protein dna complex assembly GO:0065004 64 0.021
positive regulation of dna metabolic process GO:0051054 73 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.020
cellular ketone metabolic process GO:0042180 80 0.020
definitive hemopoiesis GO:0060216 2 0.019
defense response GO:0006952 315 0.019
digestive tract development GO:0048565 75 0.019
developmental growth GO:0048589 48 0.019
Mouse
nucleoside triphosphate catabolic process GO:0009143 394 0.018
mapk cascade GO:0000165 288 0.018
nucleocytoplasmic transport GO:0006913 176 0.018
positive regulation of cell death GO:0010942 263 0.018
brain development GO:0007420 97 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.018
microtubule organizing center organization GO:0031023 62 0.017
regulation of multi organism process GO:0043900 157 0.017
posttranscriptional gene silencing GO:0016441 25 0.017
positive regulation of apoptotic process GO:0043065 246 0.017
regulation of cell activation GO:0050865 125 0.017
intrinsic apoptotic signaling pathway GO:0097193 127 0.017
negative regulation of cell death GO:0060548 345 0.017
dna modification GO:0006304 27 0.017
Mouse
regulation of meiosis GO:0040020 3 0.017
cellular response to nitrogen compound GO:1901699 144 0.016
viral life cycle GO:0019058 132 0.016
regulation of ligase activity GO:0051340 29 0.016
negative regulation of developmental process GO:0051093 247 0.016
sensory organ development GO:0007423 52 0.016
protein localization to organelle GO:0033365 280 0.016
regulation of jnk cascade GO:0046328 73 0.016
immune effector process GO:0002252 159 0.016
development of primary sexual characteristics GO:0045137 35 0.016
actin filament based process GO:0030029 224 0.016
protein localization to nucleus GO:0034504 136 0.016
positive regulation of proteolysis GO:0045862 142 0.016
cell projection organization GO:0030030 252 0.015
Fly
regulation of mrna metabolic process GO:1903311 53 0.015
organelle assembly GO:0070925 176 0.015
regulation of cell growth GO:0001558 135 0.015
spermatogenesis GO:0007283 22 0.015
negative regulation of organelle organization GO:0010639 126 0.015
mrna processing GO:0006397 133 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.015
sexual reproduction GO:0019953 37 0.015
regulation of cell division GO:0051302 116 0.015
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.015
tube morphogenesis GO:0035239 95 0.015
negative regulation of cellular catabolic process GO:0031330 83 0.014
small gtpase mediated signal transduction GO:0007264 78 0.014
purine containing compound catabolic process GO:0072523 411 0.014
tissue morphogenesis GO:0048729 96 0.014
Mouse
ribosome assembly GO:0042255 9 0.014
intracellular protein transport GO:0006886 270 0.014
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.014
response to ionizing radiation GO:0010212 65 0.014
regulation of neuron death GO:1901214 56 0.014
mrna splicing via spliceosome GO:0000398 89 0.014
cellular response to cytokine stimulus GO:0071345 181 0.014
regulation of immunoglobulin production GO:0002637 4 0.014
protein maturation GO:0051604 233 0.014
alcohol catabolic process GO:0046164 20 0.014
positive regulation of spindle checkpoint GO:0090232 7 0.014
negative regulation of stress activated mapk cascade GO:0032873 19 0.013
rna splicing GO:0008380 131 0.013
protein polyubiquitination GO:0000209 110 0.013
base excision repair GO:0006284 21 0.013
cellular response to organic cyclic compound GO:0071407 127 0.013
Human
myosin filament organization GO:0031033 2 0.013
defense response to other organism GO:0098542 129 0.013
negative regulation of rna splicing GO:0033119 15 0.013
negative regulation of dna metabolic process GO:0051053 57 0.013
Mouse
negative regulation of notch signaling pathway GO:0045746 10 0.013
multi organism reproductive process GO:0044703 54 0.013
Mouse
single organism carbohydrate metabolic process GO:0044723 193 0.013
response to nutrient levels GO:0031667 81 0.013
protein deacylation GO:0035601 39 0.012
segmentation GO:0035282 4 0.012
regulation of cellular amino acid metabolic process GO:0006521 6 0.012
embryonic morphogenesis GO:0048598 85 0.012
Mouse
regulation of cell differentiation GO:0045595 393 0.012
oocyte development GO:0048599 1 0.012
regulation of protein processing GO:0070613 150 0.012
regulation of gene silencing GO:0060968 24 0.012
metencephalon development GO:0022037 2 0.012
regulation of spindle checkpoint GO:0090231 12 0.012
mitotic dna damage checkpoint GO:0044773 28 0.012
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.011
immune response GO:0006955 307 0.011
pharyngeal system development GO:0060037 2 0.011
meiotic nuclear division GO:0007126 10 0.011
purine nucleoside catabolic process GO:0006152 398 0.011
histone deacetylation GO:0016575 32 0.011
lymphocyte activation GO:0046649 133 0.011
multicellular organism reproduction GO:0032504 42 0.011
blastocyst development GO:0001824 3 0.011
central nervous system development GO:0007417 123 0.011
response to temperature stimulus GO:0009266 22 0.011
cell part morphogenesis GO:0032990 137 0.010
Fly
regulation of cell migration GO:0030334 289 0.010
blastoderm segmentation GO:0007350 2 0.010
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.010
protein sumoylation GO:0016925 25 0.010
response to nitrogen compound GO:1901698 184 0.010
negative regulation of catalytic activity GO:0043086 335 0.010
neuron death GO:0070997 65 0.010
gamete generation GO:0007276 25 0.010
regulation of secretion by cell GO:1903530 177 0.010
cell activation GO:0001775 213 0.010
head development GO:0060322 108 0.010
cellular homeostasis GO:0019725 196 0.010

TRIM28 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.118
Human
disease of cellular proliferation DOID:14566 174 0.118
Human
central nervous system disease DOID:331 186 0.111
nervous system disease DOID:863 431 0.111
organ system cancer DOID:0050686 164 0.083
Human
neurodegenerative disease DOID:1289 102 0.047