Homo sapiens

7 known processes

UBA1

ubiquitin-like modifier activating enzyme 1

(Aliases: UBE1,UBE1X,POC20,UBA1A,GXP1,A1S9,A1S9T,SMAX2,AMCX1,MGC4781,A1ST)

UBA1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein ubiquitination GO:0016567 314 0.993
Yeast Mouse Worm Fly
protein polyubiquitination GO:0000209 110 0.942
ubiquitin dependent protein catabolic process GO:0006511 206 0.916
protein modification by small protein conjugation GO:0032446 342 0.903
Yeast Mouse Worm Fly
covalent chromatin modification GO:0016569 254 0.777
protein monoubiquitination GO:0006513 39 0.769
histone modification GO:0016570 251 0.761
mitotic cell cycle process GO:1903047 286 0.761
protein k48 linked ubiquitination GO:0070936 38 0.739
cell cycle phase transition GO:0044770 173 0.737
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.725
proteasomal protein catabolic process GO:0010498 176 0.721
mitotic cell cycle GO:0000278 326 0.700
chromatin modification GO:0016568 298 0.636
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.564
mitotic cell cycle phase transition GO:0044772 162 0.540
modification dependent macromolecule catabolic process GO:0043632 212 0.532
negative regulation of cell cycle GO:0045786 193 0.529
protein catabolic process GO:0030163 325 0.513
regulation of protein ubiquitination GO:0031396 95 0.497
cellular protein catabolic process GO:0044257 261 0.434
modification dependent protein catabolic process GO:0019941 209 0.405
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.403
regulation of cell cycle GO:0051726 393 0.403
negative regulation of apoptotic process GO:0043066 316 0.399
mitotic cell cycle checkpoint GO:0007093 68 0.387
cellular macromolecule catabolic process GO:0044265 380 0.342
regulation of mitotic cell cycle phase transition GO:1901990 118 0.342
protein sumoylation GO:0016925 25 0.333
compound eye development GO:0048749 1 0.333
negative regulation of cell cycle phase transition GO:1901988 89 0.315
negative regulation of mitotic cell cycle GO:0045930 102 0.282
histone ubiquitination GO:0016574 31 0.279
regulation of innate immune response GO:0045088 97 0.273
protein k11 linked ubiquitination GO:0070979 24 0.269
protein k63 linked ubiquitination GO:0070534 31 0.269
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.252
regulation of cell cycle phase transition GO:1901987 126 0.239
response to external biotic stimulus GO:0043207 261 0.223
dna damage checkpoint GO:0000077 68 0.210
regulation of mitotic cell cycle GO:0007346 189 0.209
dna integrity checkpoint GO:0031570 71 0.207
immune response GO:0006955 307 0.207
post embryonic development GO:0009791 2 0.207
Worm Fly
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.206
regulation of intracellular steroid hormone receptor signaling pathway GO:0033143 32 0.203
cellular macromolecular complex assembly GO:0034622 324 0.185
mitotic dna damage checkpoint GO:0044773 28 0.183
locomotory behavior GO:0007626 1 0.180
cell cycle checkpoint GO:0000075 117 0.178
negative regulation of programmed cell death GO:0043069 321 0.176
epithelium development GO:0060429 227 0.171
metal ion transport GO:0030001 272 0.168
response to hormone GO:0009725 175 0.167
cellular response to dna damage stimulus GO:0006974 379 0.164
posttranscriptional regulation of gene expression GO:0010608 213 0.162
intracellular receptor signaling pathway GO:0030522 104 0.158
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.157
chromatin organization GO:0006325 351 0.150
cation transport GO:0006812 331 0.146
response to other organism GO:0051707 261 0.145
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.144
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.135
skin development GO:0043588 76 0.132
g2 dna damage checkpoint GO:0031572 26 0.132
negative regulation of cellular protein metabolic process GO:0032269 353 0.125
regulation of proteasomal protein catabolic process GO:0061136 87 0.119
histone monoubiquitination GO:0010390 20 0.114
regulation of cellular ketone metabolic process GO:0010565 50 0.113
innate immune response GO:0045087 178 0.110
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.109
dna conformation change GO:0071103 113 0.106
adult locomotory behavior GO:0008344 1 0.104
regulation of camp mediated signaling GO:0043949 13 0.103
cellular protein complex assembly GO:0043623 188 0.102
regulation of protein catabolic process GO:0042176 155 0.101
positive regulation of innate immune response GO:0045089 79 0.097
regulation of cellular protein catabolic process GO:1903362 96 0.095
positive regulation of membrane potential GO:0045838 2 0.095
neurogenesis GO:0022008 169 0.095
Zebrafish Fly
regulation of defense response GO:0031347 154 0.093
cyclic nucleotide mediated signaling GO:0019935 26 0.093
nervous system development GO:0007399 293 0.092
Zebrafish Fly
mitotic dna integrity checkpoint GO:0044774 30 0.091
system process GO:0003008 349 0.091
Worm
oogenesis GO:0048477 2 0.087
Worm
maintenance of location GO:0051235 112 0.087
Fly
monovalent inorganic cation transport GO:0015672 128 0.087
regulation of androgen receptor signaling pathway GO:0060765 18 0.086
regulation of cell cycle process GO:0010564 266 0.085
positive regulation of immune system process GO:0002684 283 0.085
cytoplasmic transport GO:0016482 379 0.083
negative regulation of protein metabolic process GO:0051248 391 0.083
vesicle mediated transport GO:0016192 371 0.082
Worm
negative regulation of cell death GO:0060548 345 0.081
single organism cellular localization GO:1902580 332 0.080
rna processing GO:0006396 255 0.078
positive regulation of defense response GO:0031349 87 0.075
androgen receptor signaling pathway GO:0030521 34 0.075
dna packaging GO:0006323 77 0.073
regulation of protein sumoylation GO:0033233 13 0.071
camp mediated signaling GO:0019933 23 0.070
segmentation GO:0035282 4 0.069
protein localization to organelle GO:0033365 280 0.068
ncrna metabolic process GO:0034660 108 0.064
regulation of secretion by cell GO:1903530 177 0.063
sodium ion transport GO:0006814 61 0.063
organelle assembly GO:0070925 176 0.060
regulation of transmembrane transporter activity GO:0022898 74 0.060
cellular homeostasis GO:0019725 196 0.060
female gamete generation GO:0007292 2 0.059
Worm
negative regulation of cell cycle process GO:0010948 121 0.057
negative regulation of protein modification process GO:0031400 200 0.057
regulation of metal ion transport GO:0010959 120 0.057
ncrna processing GO:0034470 83 0.056
regulation of transferase activity GO:0051338 355 0.054
positive regulation of immune response GO:0050778 159 0.054
wnt signaling pathway GO:0016055 156 0.053
lipid metabolic process GO:0006629 381 0.053
lipid localization GO:0010876 106 0.051
Fly
chromosome segregation GO:0007059 114 0.050
cellular ketone metabolic process GO:0042180 80 0.049
defense response to bacterium GO:0042742 63 0.049
mitotic g2 m transition checkpoint GO:0044818 9 0.047
organelle fission GO:0048285 149 0.047
somitogenesis GO:0001756 2 0.046
cell development GO:0048468 328 0.045
Zebrafish Worm Fly
peptide transport GO:0015833 74 0.045
regulation of proteolysis GO:0030162 293 0.044
organ morphogenesis GO:0009887 147 0.044
blood coagulation GO:0007596 76 0.044
defense response to other organism GO:0098542 129 0.044
ribonucleoprotein complex biogenesis GO:0022613 116 0.044
canonical wnt signaling pathway GO:0060070 116 0.043
positive regulation of cellular catabolic process GO:0031331 284 0.043
chemical homeostasis GO:0048878 306 0.042
positive regulation of protein ubiquitination GO:0031398 53 0.041
nucleoside triphosphate catabolic process GO:0009143 394 0.041
cell projection organization GO:0030030 252 0.041
Zebrafish
hair cycle GO:0042633 28 0.041
response to biotic stimulus GO:0009607 276 0.041
single organism membrane organization GO:0044802 268 0.040
epithelial cell differentiation GO:0030855 141 0.039
regulation of ion transmembrane transport GO:0034765 132 0.039
potassium ion transmembrane transport GO:0071805 60 0.039
blastoderm segmentation GO:0007350 2 0.039
protein stabilization GO:0050821 64 0.039
defense response GO:0006952 315 0.039
positive regulation of organelle organization GO:0010638 195 0.038
glycosyl compound catabolic process GO:1901658 413 0.038
distal tubule development GO:0072017 4 0.038
regulation of secretion GO:0051046 194 0.037
tube development GO:0035295 125 0.037
determination of adult lifespan GO:0008340 2 0.037
cellular component morphogenesis GO:0032989 314 0.036
Zebrafish
negative regulation of camp mediated signaling GO:0043951 4 0.035
inorganic ion transmembrane transport GO:0098660 231 0.035
cellular response to endogenous stimulus GO:0071495 336 0.034
protein autoubiquitination GO:0051865 37 0.033
regulation of translation GO:0006417 89 0.033
protein acylation GO:0043543 138 0.033
negative regulation of intracellular steroid hormone receptor signaling pathway GO:0033144 18 0.032
actin filament based process GO:0030029 224 0.032
trna processing GO:0008033 23 0.031
positive regulation of transport GO:0051050 336 0.031
mitotic nuclear division GO:0007067 119 0.031
response to oxygen containing compound GO:1901700 369 0.031
ion homeostasis GO:0050801 230 0.030
tube morphogenesis GO:0035239 95 0.030
embryo development GO:0009790 123 0.029
Worm
cell activation GO:0001775 213 0.029
cell adhesion GO:0007155 325 0.029
second messenger mediated signaling GO:0019932 78 0.029
negative regulation of protein ubiquitination GO:0031397 35 0.029
neuron projection development GO:0031175 106 0.029
Zebrafish
cell cycle g1 s phase transition GO:0044843 80 0.028
oocyte differentiation GO:0009994 2 0.028
defense response to gram negative bacterium GO:0050829 14 0.027
response to decreased oxygen levels GO:0036293 96 0.027
regulation of transporter activity GO:0032409 82 0.027
cellular potassium ion transport GO:0071804 60 0.027
nuclear division GO:0000280 128 0.027
negative regulation of cellular component movement GO:0051271 106 0.026
oocyte development GO:0048599 1 0.026
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 22 0.026
peripheral nervous system development GO:0007422 2 0.026
regulation of locomotion GO:0040012 329 0.026
response to bacterium GO:0009617 144 0.026
microtubule based process GO:0007017 210 0.026
regulation of small gtpase mediated signal transduction GO:0051056 156 0.026
Fly
regulation of cytoplasmic transport GO:1903649 149 0.026
anterior posterior axis specification GO:0009948 2 0.026
protein deubiquitination GO:0016579 79 0.026
carbohydrate metabolic process GO:0005975 207 0.025
protein k33 linked ubiquitination GO:1990390 1 0.025
actin cytoskeleton organization GO:0030036 207 0.025
hemostasis GO:0007599 76 0.024
purine nucleotide catabolic process GO:0006195 405 0.024
gtp catabolic process GO:0006184 237 0.024
multicellular organismal aging GO:0010259 3 0.024
positive regulation of hydrolase activity GO:0051345 331 0.024
regulation of cytokinesis GO:0032465 45 0.024
internal protein amino acid acetylation GO:0006475 101 0.024
visual behavior GO:0007632 2 0.024
memory GO:0007613 3 0.023
secretion by cell GO:0032940 226 0.023
chromosome condensation GO:0030261 15 0.023
regulation of ion transmembrane transporter activity GO:0032412 72 0.023
mitotic g2 dna damage checkpoint GO:0007095 7 0.023
positive regulation of transferase activity GO:0051347 227 0.023
monocarboxylic acid metabolic process GO:0032787 185 0.023
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.023
endosomal transport GO:0016197 129 0.023
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.022
regulation of cellular amino acid metabolic process GO:0006521 6 0.022
regulation of transmembrane transport GO:0034762 139 0.022
regulation of protein stability GO:0031647 87 0.022
protein localization to membrane GO:0072657 160 0.022
response to abiotic stimulus GO:0009628 336 0.022
purine containing compound catabolic process GO:0072523 411 0.022
purine nucleoside triphosphate catabolic process GO:0009146 392 0.021
nitrogen compound transport GO:0071705 191 0.021
regulation of homeostatic process GO:0032844 121 0.021
spindle organization GO:0007051 53 0.021
renal sodium ion absorption GO:0070294 2 0.020
regulation of cellular response to stress GO:0080135 244 0.020
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 43 0.020
regulation of growth GO:0040008 165 0.020
Fly
multi organism reproductive process GO:0044703 54 0.020
Worm
tripartite regional subdivision GO:0007351 2 0.020
ribonucleoside triphosphate metabolic process GO:0009199 412 0.020
circulatory system development GO:0072359 262 0.019
regulation of ion transport GO:0043269 189 0.019
osteoblast differentiation GO:0001649 92 0.019
nucleoside triphosphate metabolic process GO:0009141 422 0.019
secretion GO:0046903 254 0.019
translation GO:0006412 132 0.019
cellular amine metabolic process GO:0044106 41 0.019
interspecies interaction between organisms GO:0044419 156 0.019
establishment of protein localization to organelle GO:0072594 172 0.019
enzyme linked receptor protein signaling pathway GO:0007167 303 0.019
chromosome passenger complex localization to spindle midzone GO:0035853 1 0.019
regulation of response to external stimulus GO:0032101 222 0.019
peptidyl lysine acetylation GO:0018394 101 0.018
positive regulation of cellular component movement GO:0051272 181 0.018
coenzyme metabolic process GO:0006732 65 0.018
circadian behavior GO:0048512 2 0.018
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.018
positive regulation of proteolysis GO:0045862 142 0.018
regulation of establishment of protein localization GO:0070201 242 0.018
protein acetylation GO:0006473 116 0.018
motor neuron axon guidance GO:0008045 2 0.018
nucleocytoplasmic transport GO:0006913 176 0.018
endomembrane system organization GO:0010256 196 0.018
membrane organization GO:0061024 292 0.018
negative regulation of protein catabolic process GO:0042177 59 0.018
purine ribonucleoside metabolic process GO:0046128 437 0.018
copii vesicle coating GO:0048208 2 0.018
ribonucleotide biosynthetic process GO:0009260 81 0.017
regulation of vesicle mediated transport GO:0060627 130 0.017
response to endoplasmic reticulum stress GO:0034976 49 0.017
homotypic cell cell adhesion GO:0034109 47 0.017
regulation of peptide transport GO:0090087 62 0.017
t cell differentiation in thymus GO:0033077 4 0.017
transmembrane transport GO:0055085 399 0.017
renal sodium ion transport GO:0003096 2 0.017
hematopoietic or lymphoid organ development GO:0048534 186 0.017
ribonucleoprotein complex subunit organization GO:0071826 81 0.017
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 3 0.017
cation transmembrane transport GO:0098655 238 0.017
membrane budding GO:0006900 28 0.017
immune system development GO:0002520 195 0.016
internal peptidyl lysine acetylation GO:0018393 97 0.016
organelle localization GO:0051640 84 0.016
single organismal cell cell adhesion GO:0016337 148 0.016
single organism carbohydrate metabolic process GO:0044723 193 0.016
negative regulation of ion transport GO:0043271 39 0.016
peptidyl lysine modification GO:0018205 144 0.016
neurological system process GO:0050877 163 0.016
Worm
negative regulation of phosphate metabolic process GO:0045936 267 0.016
neuron development GO:0048666 113 0.016
Zebrafish Fly
leukocyte activation GO:0045321 164 0.015
positive regulation of catabolic process GO:0009896 310 0.015
positive regulation of cell proliferation GO:0008284 301 0.015
growth hormone secretion GO:0030252 4 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.015
hormone secretion GO:0046879 65 0.015
central nervous system development GO:0007417 123 0.015
Fly
cell type specific apoptotic process GO:0097285 125 0.015
amide transport GO:0042886 76 0.015
negative regulation of ion transmembrane transport GO:0034766 26 0.015
platelet activation GO:0030168 44 0.015
regionalization GO:0003002 29 0.015
metencephalon development GO:0022037 2 0.015
head development GO:0060322 108 0.014
Fly
regulation of purine nucleotide catabolic process GO:0033121 205 0.014
cerebellum development GO:0021549 2 0.014
establishment of planar polarity GO:0001736 3 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
regulation of potassium ion transmembrane transport GO:1901379 20 0.014
regulation of jak stat cascade GO:0046425 44 0.014
regulation of nucleoside metabolic process GO:0009118 209 0.014
spermatid differentiation GO:0048515 4 0.014
regulation of wnt signaling pathway GO:0030111 123 0.014
cell fate determination GO:0001709 3 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
lymphocyte homeostasis GO:0002260 4 0.014
neuron differentiation GO:0030182 138 0.013
Zebrafish Fly
ribonucleoside catabolic process GO:0042454 406 0.013
growth GO:0040007 202 0.013
Worm Fly
regulation of ligase activity GO:0051340 29 0.013
rhythmic behavior GO:0007622 2 0.013
eye development GO:0001654 42 0.013
regulation of protein processing GO:0070613 150 0.013
negative regulation of multicellular organismal process GO:0051241 317 0.013
negative regulation of cellular catabolic process GO:0031330 83 0.013
positive regulation of gtpase activity GO:0043547 166 0.013
negative regulation of catabolic process GO:0009895 104 0.013
response to hypoxia GO:0001666 96 0.013
regulation of protein complex assembly GO:0043254 147 0.013
negative regulation of proteolysis GO:0045861 132 0.013
single organism cell adhesion GO:0098602 179 0.013
platelet aggregation GO:0070527 32 0.013
nucleoside phosphate biosynthetic process GO:1901293 109 0.013
regulation of nucleocytoplasmic transport GO:0046822 98 0.013
exocytosis GO:0006887 71 0.013
response to growth factor GO:0070848 205 0.013
guanosine containing compound catabolic process GO:1901069 239 0.013
negative regulation of voltage gated calcium channel activity GO:1901386 4 0.013
regulation of multi organism process GO:0043900 157 0.013
hindbrain development GO:0030902 3 0.013
regulation of response to dna damage stimulus GO:2001020 94 0.013
sensory perception of chemical stimulus GO:0007606 38 0.013
regulation of canonical wnt signaling pathway GO:0060828 88 0.013
cell projection morphogenesis GO:0048858 129 0.012
Zebrafish
response to cytokine GO:0034097 232 0.012
mitochondrion organization GO:0007005 156 0.012
g1 s transition of mitotic cell cycle GO:0000082 78 0.012
regulation of ras protein signal transduction GO:0046578 155 0.012
Fly
purine nucleoside triphosphate metabolic process GO:0009144 412 0.012
histone methylation GO:0016571 60 0.012
protein maturation GO:0051604 233 0.012
gene silencing GO:0016458 49 0.012
anatomical structure formation involved in morphogenesis GO:0048646 284 0.012
mitochondrial respiratory chain complex assembly GO:0033108 23 0.012
negative regulation of organelle organization GO:0010639 126 0.012
amine metabolic process GO:0009308 44 0.012
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.012
neural tube formation GO:0001841 3 0.012
positive regulation of protein sumoylation GO:0033235 7 0.012
regulation of immune effector process GO:0002697 91 0.012
response to nitrogen compound GO:1901698 184 0.012
cell junction assembly GO:0034329 67 0.012
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.012
regulation of immune response GO:0050776 201 0.012
apoptotic signaling pathway GO:0097190 268 0.012
lymphocyte activation GO:0046649 133 0.012
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.012
t cell activation GO:0042110 99 0.012
regulation of hormone levels GO:0010817 125 0.012
response to wounding GO:0009611 168 0.012
regulation of nervous system development GO:0051960 88 0.012
distal tubule morphogenesis GO:0072156 3 0.011
regulation of intracellular transport GO:0032386 195 0.011
positive regulation of ubiquitin protein transferase activity GO:0051443 18 0.011
regulation of dna metabolic process GO:0051052 153 0.011
negative regulation of locomotion GO:0040013 118 0.011
cell morphogenesis GO:0000902 296 0.011
Zebrafish
mrna metabolic process GO:0016071 175 0.011
dna repair GO:0006281 198 0.011
protein autophosphorylation GO:0046777 123 0.011
histone acetylation GO:0016573 93 0.011
response to drug GO:0042493 81 0.011
cellular response to lipid GO:0071396 127 0.011
ribonucleoprotein complex assembly GO:0022618 78 0.011
viral process GO:0016032 146 0.011
cell division GO:0051301 168 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
negative regulation of transmembrane transport GO:0034763 29 0.011
cell junction organization GO:0034330 79 0.011
regulation of protein localization GO:0032880 296 0.011
long term memory GO:0007616 2 0.011
cellular response to hypoxia GO:0071456 51 0.011
jak stat cascade GO:0007259 46 0.011
positive regulation of secretion by cell GO:1903532 108 0.011
reproduction GO:0000003 63 0.011
Worm
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.011
myosin filament assembly GO:0031034 2 0.011
neuron death GO:0070997 65 0.011
mitotic spindle organization GO:0007052 27 0.011
nuclear transport GO:0051169 179 0.011
immune effector process GO:0002252 159 0.010
toll signaling pathway GO:0008063 2 0.010
coagulation GO:0050817 78 0.010
spermatid development GO:0007286 4 0.010
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.010
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.010
nucleoside catabolic process GO:0009164 408 0.010
regulation of cellular response to growth factor stimulus GO:0090287 76 0.010
intracellular mrna localization GO:0008298 1 0.010
potassium ion transport GO:0006813 62 0.010
ribonucleoside monophosphate metabolic process GO:0009161 187 0.010
regulation of cellular component movement GO:0051270 334 0.010

UBA1 disease predictions

Disease DO term ID Size Probability Func Analog Org
urinary system disease DOID:18 40 0.035
kidney disease DOID:557 36 0.035
nervous system disease DOID:863 431 0.025
sensory system disease DOID:0050155 203 0.025
nonsyndromic deafness DOID:0050563 50 0.025
auditory system disease DOID:2742 53 0.025
central nervous system disease DOID:331 186 0.020
specific developmental disorder DOID:0060038 19 0.020
disease of mental health DOID:150 70 0.020
intellectual disability DOID:1059 13 0.020
developmental disorder of mental health DOID:0060037 29 0.020
disease of cellular proliferation DOID:14566 174 0.013
neuromuscular disease DOID:440 38 0.010
neuropathy DOID:870 52 0.010
charcot marie tooth disease DOID:10595 33 0.010
immune system disease DOID:2914 155 0.010