Homo sapiens

18 known processes

UBE2D2

ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)

(Aliases: PUBC1,E2(17)KB2,UBC4,UBC4/5,UBCH5B)

UBE2D2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein polyubiquitination GO:0000209 110 1.000
protein k48 linked ubiquitination GO:0070936 38 1.000
protein k11 linked ubiquitination GO:0070979 24 1.000
Human
protein k63 linked ubiquitination GO:0070534 31 1.000
Human
protein modification by small protein conjugation GO:0032446 342 1.000
protein ubiquitination GO:0016567 314 1.000
protein monoubiquitination GO:0006513 39 1.000
Human Yeast
proteolysis involved in cellular protein catabolic process GO:0051603 244 1.000
Human Yeast
cellular protein catabolic process GO:0044257 261 1.000
Human Yeast
ubiquitin dependent protein catabolic process GO:0006511 206 1.000
Human Yeast
cellular macromolecule catabolic process GO:0044265 380 1.000
Human Yeast
protein autoubiquitination GO:0051865 37 1.000
isg15 protein conjugation GO:0032020 5 1.000
modification dependent protein catabolic process GO:0019941 209 1.000
Human Yeast
modification dependent macromolecule catabolic process GO:0043632 212 1.000
Human Yeast
protein catabolic process GO:0030163 325 0.998
Human Yeast
histone ubiquitination GO:0016574 31 0.998
proteasomal protein catabolic process GO:0010498 176 0.995
Human
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 10 0.982
Yeast
regulation of protein ubiquitination GO:0031396 95 0.940
Human
protein k29 linked ubiquitination GO:0035519 4 0.931
Human
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.918
protein k27 linked ubiquitination GO:0044314 4 0.917
Human
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.905
Human
histone monoubiquitination GO:0010390 20 0.893
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.875
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.803
Human
histone h2b ubiquitination GO:0033523 8 0.596
response to abiotic stimulus GO:0009628 336 0.589
Yeast
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.542
Human
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.538
chromatin organization GO:0006325 351 0.498
regulation of cell cycle GO:0051726 393 0.473
histone modification GO:0016570 251 0.394
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.371
positive regulation of protein catabolic process GO:0045732 75 0.337
lipid localization GO:0010876 106 0.306
chromatin modification GO:0016568 298 0.269
positive regulation of proteolysis GO:0045862 142 0.252
mitotic cell cycle GO:0000278 326 0.227
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.225
lipid storage GO:0019915 28 0.211
histone h2a ubiquitination GO:0033522 17 0.205
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.203
covalent chromatin modification GO:0016569 254 0.197
regulation of ubiquitin protein transferase activity GO:0051438 28 0.191
regulation of cell cycle process GO:0010564 266 0.179
response to radiation GO:0009314 151 0.175
positive regulation of cellular protein catabolic process GO:1903364 37 0.169
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.162
cellular response to heat GO:0034605 14 0.157
Yeast
double strand break repair GO:0006302 101 0.142
dolichol biosynthetic process GO:0019408 1 0.112
negative regulation of cell cycle process GO:0010948 121 0.108
regulation of proteasomal protein catabolic process GO:0061136 87 0.101
single organism cellular localization GO:1902580 332 0.096
positive regulation of cellular catabolic process GO:0031331 284 0.095
positive regulation of apoptotic signaling pathway GO:2001235 70 0.094
positive regulation of catabolic process GO:0009896 310 0.088
defense response to other organism GO:0098542 129 0.086
organelle assembly GO:0070925 176 0.082
response to biotic stimulus GO:0009607 276 0.081
maintenance of location GO:0051235 112 0.079
regulation of cellular protein catabolic process GO:1903362 96 0.078
hindbrain development GO:0030902 3 0.074
defense response GO:0006952 315 0.072
negative regulation of cell cycle phase transition GO:1901988 89 0.072
positive regulation of protein ubiquitination GO:0031398 53 0.072
Human
positive regulation of mitotic cell cycle GO:0045931 60 0.071
response to cytokine GO:0034097 232 0.069
regulation of mitotic cell cycle GO:0007346 189 0.069
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.068
negative regulation of protein polyubiquitination GO:1902915 4 0.066
negative regulation of protein metabolic process GO:0051248 391 0.065
negative regulation of catalytic activity GO:0043086 335 0.064
microtubule based process GO:0007017 210 0.061
vesicle mediated transport GO:0016192 371 0.061
regulation of mitotic cell cycle phase transition GO:1901990 118 0.058
regulation of transmembrane transport GO:0034762 139 0.058
nitrogen compound transport GO:0071705 191 0.057
regulation of proteolysis GO:0030162 293 0.057
positive regulation of protein kinase activity GO:0045860 190 0.055
positive regulation of transferase activity GO:0051347 227 0.054
cellular response to dna damage stimulus GO:0006974 379 0.051
regulation of organelle assembly GO:1902115 40 0.051
negative regulation of programmed cell death GO:0043069 321 0.050
cell cycle phase transition GO:0044770 173 0.048
regulation of dna metabolic process GO:0051052 153 0.047
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.047
dna repair GO:0006281 198 0.046
nuclear transport GO:0051169 179 0.046
cerebral cortex cell migration GO:0021795 3 0.046
mitotic cell cycle process GO:1903047 286 0.045
regulation of protein kinase activity GO:0045859 289 0.044
g1 dna damage checkpoint GO:0044783 18 0.044
carbohydrate metabolic process GO:0005975 207 0.044
dna templated transcription elongation GO:0006354 25 0.044
signal transduction by phosphorylation GO:0023014 297 0.043
negative regulation of cell death GO:0060548 345 0.043
microtubule cytoskeleton organization GO:0000226 176 0.043
intracellular receptor signaling pathway GO:0030522 104 0.042
apoptotic signaling pathway GO:0097190 268 0.042
response to oxidative stress GO:0006979 121 0.041
negative regulation of multi organism process GO:0043901 92 0.040
negative regulation of protein ubiquitination GO:0031397 35 0.039
regulation of cytoskeleton organization GO:0051493 177 0.038
response to uv GO:0009411 73 0.037
regulation of nuclear division GO:0051783 65 0.036
regulation of protein catabolic process GO:0042176 155 0.036
apoptotic mitochondrial changes GO:0008637 57 0.035
cellular potassium ion transport GO:0071804 60 0.032
autophagy GO:0006914 88 0.032
cellular response to uv GO:0034644 32 0.032
regulation of response to dna damage stimulus GO:2001020 94 0.032
dna damage checkpoint GO:0000077 68 0.031
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.031
signal transduction by p53 class mediator GO:0072331 72 0.031
protein maturation GO:0051604 233 0.029
nuclear migration GO:0007097 1 0.029
intrinsic apoptotic signaling pathway GO:0097193 127 0.026
negative regulation of transmembrane transport GO:0034763 29 0.026
negative regulation of protein transport GO:0051224 75 0.026
polyprenol biosynthetic process GO:0016094 1 0.026
positive regulation of mapk cascade GO:0043410 190 0.026
meiotic chromosome segregation GO:0045132 4 0.026
dolichol metabolic process GO:0019348 3 0.025
glycoprotein metabolic process GO:0009100 110 0.025
negative regulation of cell cycle GO:0045786 193 0.025
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.025
negative regulation of transport GO:0051051 176 0.025
regulation of meiotic cell cycle GO:0051445 4 0.025
response to drug GO:0042493 81 0.024
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.024
mitotic cell cycle checkpoint GO:0007093 68 0.024
posttranscriptional regulation of gene expression GO:0010608 213 0.024
cellular amino acid metabolic process GO:0006520 116 0.023
positive regulation of endopeptidase activity GO:0010950 84 0.023
cellular macromolecular complex assembly GO:0034622 324 0.023
response to inorganic substance GO:0010035 127 0.023
regulation of endopeptidase activity GO:0052548 170 0.023
cell division GO:0051301 168 0.023
stem cell development GO:0048864 69 0.022
negative regulation of protein catabolic process GO:0042177 59 0.022
response to transforming growth factor beta GO:0071559 94 0.022
microtubule organizing center organization GO:0031023 62 0.022
negative regulation of calcium ion import GO:0090281 1 0.022
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.022
regulation of protein stability GO:0031647 87 0.022
multicellular organismal aging GO:0010259 3 0.021
negative regulation of cellular protein metabolic process GO:0032269 353 0.020
negative regulation of protein phosphorylation GO:0001933 140 0.020
protein targeting GO:0006605 187 0.020
cellular ketone metabolic process GO:0042180 80 0.019
regulation of intracellular transport GO:0032386 195 0.019
system process GO:0003008 349 0.019
regulation of kinase activity GO:0043549 314 0.019
meiosis i GO:0007127 4 0.019
regulation of mrna export from nucleus GO:0010793 3 0.018
enzyme linked receptor protein signaling pathway GO:0007167 303 0.018
nucleic acid transport GO:0050657 39 0.018
negative regulation of mitotic cell cycle GO:0045930 102 0.017
protein n linked glycosylation via asparagine GO:0018279 10 0.017
establishment of organelle localization GO:0051656 59 0.017
mitotic sister chromatid segregation GO:0000070 53 0.017
response to light stimulus GO:0009416 87 0.017
multi organism cellular process GO:0044764 156 0.016
response to ionizing radiation GO:0010212 65 0.016
cerebral cortex radially oriented cell migration GO:0021799 1 0.016
cell growth GO:0016049 160 0.016
positive regulation of cell cycle GO:0045787 140 0.016
regulation of response to external stimulus GO:0032101 222 0.016
negative regulation of transcription elongation from rna polymerase ii promoter GO:0034244 4 0.016
positive regulation of dna repair GO:0045739 25 0.016
cell development GO:0048468 328 0.015
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.015
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.015
regulation of protein localization to cell surface GO:2000008 15 0.015
cell cycle checkpoint GO:0000075 117 0.015
neuromuscular junction development GO:0007528 3 0.015
organic acid biosynthetic process GO:0016053 97 0.014
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.014
cellular response to external stimulus GO:0071496 111 0.014
protein processing GO:0016485 226 0.014
positive regulation of ubiquitin protein transferase activity GO:0051443 18 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
double strand break repair via homologous recombination GO:0000724 50 0.014
immune effector process GO:0002252 159 0.014
negative regulation of ion transport GO:0043271 39 0.014
cellular response to light stimulus GO:0071482 34 0.014
cation transport GO:0006812 331 0.014
metaphase anaphase transition of cell cycle GO:0044784 21 0.013
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.013
spindle assembly GO:0051225 29 0.013
regulation of cellular ketone metabolic process GO:0010565 50 0.013
positive regulation of immune response GO:0050778 159 0.013
mitochondrion organization GO:0007005 156 0.013
cellular component morphogenesis GO:0032989 314 0.013
peptidyl lysine acetylation GO:0018394 101 0.013
regulation of protein localization GO:0032880 296 0.013
positive regulation of cytoplasmic transport GO:1903651 82 0.013
positive regulation of protein complex assembly GO:0031334 86 0.012
potassium ion transmembrane transport GO:0071805 60 0.012
spermatid differentiation GO:0048515 4 0.012
extrinsic apoptotic signaling pathway GO:0097191 119 0.012
mitotic cell cycle phase transition GO:0044772 162 0.012
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.012
regulation of chromosome organization GO:0033044 103 0.012
oogenesis GO:0048477 2 0.012
post embryonic development GO:0009791 2 0.012
cellular response to oxidative stress GO:0034599 85 0.012
locomotory behavior GO:0007626 1 0.012
protein deubiquitination GO:0016579 79 0.012
nervous system development GO:0007399 293 0.012
response to external biotic stimulus GO:0043207 261 0.012
neuron differentiation GO:0030182 138 0.012
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.012
regulation of protein deubiquitination GO:0090085 4 0.011
central nervous system development GO:0007417 123 0.011
regulation of cellular amine metabolic process GO:0033238 11 0.011
negative regulation of apoptotic process GO:0043066 316 0.011
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.011
embryo development GO:0009790 123 0.011
regulation of protein polyubiquitination GO:1902914 8 0.011
regulation of protein targeting GO:1903533 91 0.011
trna processing GO:0008033 23 0.011
negative regulation of protein secretion GO:0050709 29 0.011
regulation of membrane potential GO:0042391 95 0.011
regulation of cysteine type endopeptidase activity GO:2000116 127 0.011
metal ion transport GO:0030001 272 0.010
regulation of ion transport GO:0043269 189 0.010
negative regulation of alpha beta t cell activation GO:0046636 3 0.010
ribosome biogenesis GO:0042254 48 0.010
nuclear import GO:0051170 106 0.010

UBE2D2 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.092
nervous system disease DOID:863 431 0.092
retinal disease DOID:5679 118 0.035
eye and adnexa disease DOID:1492 150 0.035
eye disease DOID:5614 149 0.035
retinal degeneration DOID:8466 89 0.030