Homo sapiens

19 known processes

UBE2H

ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)

(Aliases: UBC8,E2-20K,UBCH2,UBCH)

UBE2H biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification by small protein conjugation GO:0032446 342 0.977
protein ubiquitination GO:0016567 314 0.950
modification dependent protein catabolic process GO:0019941 209 0.886
Yeast Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.813
Yeast Mouse
cellular macromolecule catabolic process GO:0044265 380 0.648
Yeast Mouse
modification dependent macromolecule catabolic process GO:0043632 212 0.585
Yeast Mouse
protein k48 linked ubiquitination GO:0070936 38 0.526
cellular protein catabolic process GO:0044257 261 0.444
Yeast Mouse
protein catabolic process GO:0030163 325 0.393
Yeast Mouse
protein autoubiquitination GO:0051865 37 0.329
ubiquitin dependent protein catabolic process GO:0006511 206 0.230
Yeast Mouse
carbohydrate metabolic process GO:0005975 207 0.209
Yeast
glycoprotein biosynthetic process GO:0009101 91 0.166
purine ribonucleotide catabolic process GO:0009154 404 0.160
protein polyubiquitination GO:0000209 110 0.133
purine nucleoside triphosphate metabolic process GO:0009144 412 0.123
macromolecule glycosylation GO:0043413 63 0.112
organophosphate catabolic process GO:0046434 430 0.107
nucleoside triphosphate metabolic process GO:0009141 422 0.098
nucleotide catabolic process GO:0009166 408 0.094
protein glycosylation GO:0006486 62 0.091
gtp metabolic process GO:0046039 239 0.090
ribonucleoside triphosphate metabolic process GO:0009199 412 0.088
amine metabolic process GO:0009308 44 0.079
negative regulation of protein processing GO:0010955 142 0.078
nucleoside triphosphate catabolic process GO:0009143 394 0.076
single organism carbohydrate metabolic process GO:0044723 193 0.075
Yeast
purine ribonucleoside catabolic process GO:0046130 398 0.074
cellular amine metabolic process GO:0044106 41 0.072
glycosylation GO:0070085 71 0.071
carbohydrate derivative biosynthetic process GO:1901137 207 0.070
nucleoside catabolic process GO:0009164 408 0.068
cellular macromolecular complex assembly GO:0034622 324 0.067
nucleoside phosphate catabolic process GO:1901292 412 0.066
purine nucleoside triphosphate catabolic process GO:0009146 392 0.066
ribonucleoside catabolic process GO:0042454 406 0.064
system process GO:0003008 349 0.063
purine containing compound catabolic process GO:0072523 411 0.063
purine nucleotide catabolic process GO:0006195 405 0.062
cellular amino acid metabolic process GO:0006520 116 0.062
negative regulation of cellular protein metabolic process GO:0032269 353 0.061
dosage compensation GO:0007549 3 0.061
positive regulation of cellular amine metabolic process GO:0033240 7 0.060
purine nucleoside catabolic process GO:0006152 398 0.060
ribonucleotide catabolic process GO:0009261 405 0.059
regulation of cellular amino acid metabolic process GO:0006521 6 0.057
nervous system development GO:0007399 293 0.056
negative regulation of protein metabolic process GO:0051248 391 0.055
determination of adult lifespan GO:0008340 2 0.054
gtp catabolic process GO:0006184 237 0.054
oogenesis GO:0048477 2 0.050
glycoprotein metabolic process GO:0009100 110 0.050
cellular ketone metabolic process GO:0042180 80 0.050
Yeast
wnt signaling pathway GO:0016055 156 0.050
oocyte development GO:0048599 1 0.050
purine ribonucleoside metabolic process GO:0046128 437 0.049
positive regulation of transport GO:0051050 336 0.049
guanosine containing compound catabolic process GO:1901069 239 0.049
regulation of cellular ketone metabolic process GO:0010565 50 0.049
Yeast
generation of neurons GO:0048699 152 0.047
positive regulation of wnt signaling pathway GO:0030177 54 0.045
negative regulation of multicellular organismal process GO:0051241 317 0.045
regulation of cell differentiation GO:0045595 393 0.044
protein processing GO:0016485 226 0.043
response to oxygen containing compound GO:1901700 369 0.042
negative regulation of catalytic activity GO:0043086 335 0.042
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.042
Yeast
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.041
Yeast Mouse
post embryonic development GO:0009791 2 0.041
regulation of cellular amine metabolic process GO:0033238 11 0.040
negative regulation of gliogenesis GO:0014014 3 0.040
female gamete generation GO:0007292 2 0.040
regulation of reactive oxygen species metabolic process GO:2000377 41 0.038
cell development GO:0048468 328 0.038
regulation of protein kinase activity GO:0045859 289 0.037
regulation of canonical wnt signaling pathway GO:0060828 88 0.037
ribonucleoside triphosphate catabolic process GO:0009203 391 0.037
negative regulation of developmental process GO:0051093 247 0.037
metal ion transport GO:0030001 272 0.036
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.036
negative regulation of phosphate metabolic process GO:0045936 267 0.036
negative regulation of cellular component organization GO:0051129 235 0.035
multicellular organismal aging GO:0010259 3 0.035
negative regulation of axonogenesis GO:0050771 4 0.034
reactive oxygen species metabolic process GO:0072593 75 0.034
protein maturation GO:0051604 233 0.034
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.034
regulation of transferase activity GO:0051338 355 0.034
mapk cascade GO:0000165 288 0.033
rna splicing GO:0008380 131 0.033
proteasomal protein catabolic process GO:0010498 176 0.032
Yeast Mouse
neurogenesis GO:0022008 169 0.032
negative regulation of cell differentiation GO:0045596 171 0.031
regulation of kinase activity GO:0043549 314 0.031
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.031
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.031
positive regulation of locomotion GO:0040017 186 0.031
regulation of locomotion GO:0040012 329 0.030
oocyte differentiation GO:0009994 2 0.030
vesicle mediated transport GO:0016192 371 0.030
regulation of proteolysis GO:0030162 293 0.030
negative regulation of programmed cell death GO:0043069 321 0.030
response to abiotic stimulus GO:0009628 336 0.030
negative regulation of protein modification process GO:0031400 200 0.030
endosomal transport GO:0016197 129 0.029
negative regulation of phosphorus metabolic process GO:0010563 267 0.028
regulation of cellular component biogenesis GO:0044087 281 0.028
negative regulation of protein maturation GO:1903318 142 0.028
positive regulation of cellular catabolic process GO:0031331 284 0.028
signal transduction by phosphorylation GO:0023014 297 0.028
rna processing GO:0006396 255 0.027
secretion by cell GO:0032940 226 0.027
regulation of protein complex assembly GO:0043254 147 0.027
regulation of protein ubiquitination GO:0031396 95 0.027
cell adhesion GO:0007155 325 0.026
regulation of cell development GO:0060284 161 0.026
mrna metabolic process GO:0016071 175 0.026
defense response GO:0006952 315 0.026
cation transport GO:0006812 331 0.025
regulation of wnt signaling pathway GO:0030111 123 0.025
reproductive process GO:0022414 106 0.025
regulation of cell migration GO:0030334 289 0.025
negative regulation of locomotion GO:0040013 118 0.025
regulation of protein maturation GO:1903317 150 0.025
posttranscriptional regulation of gene expression GO:0010608 213 0.025
positive regulation of developmental process GO:0051094 314 0.025
transmembrane transport GO:0055085 399 0.025
positive regulation of hydrolase activity GO:0051345 331 0.025
regulation of membrane potential GO:0042391 95 0.024
dephosphorylation GO:0016311 209 0.024
canonical wnt signaling pathway GO:0060070 116 0.024
protein monoubiquitination GO:0006513 39 0.024
regulation of neurogenesis GO:0050767 82 0.024
circulatory system development GO:0072359 262 0.024
immune response GO:0006955 307 0.024
protein destabilization GO:0031648 12 0.024
intracellular receptor signaling pathway GO:0030522 104 0.023
glycosyl compound catabolic process GO:1901658 413 0.023
negative regulation of viral process GO:0048525 66 0.023
negative regulation of apoptotic process GO:0043066 316 0.023
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.023
protein acylation GO:0043543 138 0.023
regulation of cell motility GO:2000145 299 0.023
regulation of protein processing GO:0070613 150 0.023
regulation of cellular response to stress GO:0080135 244 0.023
positive regulation of protein phosphorylation GO:0001934 313 0.022
neurotransmitter secretion GO:0007269 4 0.022
positive regulation of organelle organization GO:0010638 195 0.022
regulation of glial cell proliferation GO:0060251 4 0.022
reactive oxygen species biosynthetic process GO:1903409 4 0.022
regulation of transmembrane transport GO:0034762 139 0.022
response to biotic stimulus GO:0009607 276 0.022
regulation of cellular component movement GO:0051270 334 0.022
mrna processing GO:0006397 133 0.021
biological adhesion GO:0022610 331 0.021
positive regulation of catabolic process GO:0009896 310 0.021
compound eye development GO:0048749 1 0.021
regulation of neurotransmitter secretion GO:0046928 3 0.021
negative regulation of hydrolase activity GO:0051346 182 0.021
negative regulation of cell proliferation GO:0008285 228 0.021
spermatid differentiation GO:0048515 4 0.021
locomotory behavior GO:0007626 1 0.021
multi organism cellular process GO:0044764 156 0.021
regulation of nucleotide metabolic process GO:0006140 269 0.020
ion transmembrane transport GO:0034220 338 0.020
cytokine production GO:0001816 247 0.020
negative regulation of cell death GO:0060548 345 0.020
defense response to fungus GO:0050832 4 0.020
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.020
regulation of cytokine production GO:0001817 232 0.020
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.020
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.020
blastoderm segmentation GO:0007350 2 0.020
spermatid development GO:0007286 4 0.020
regulation of viral process GO:0050792 103 0.019
actin filament based process GO:0030029 224 0.019
regulation of apoptotic signaling pathway GO:2001233 175 0.019
protein k63 linked ubiquitination GO:0070534 31 0.019
secretion GO:0046903 254 0.019
innate immune response GO:0045087 178 0.019
response to external biotic stimulus GO:0043207 261 0.019
mitotic cell cycle GO:0000278 326 0.019
regulation of cytoskeleton organization GO:0051493 177 0.019
negative regulation of intracellular signal transduction GO:1902532 183 0.019
regulation of secretion GO:0051046 194 0.019
defense response to other organism GO:0098542 129 0.019
protein localization to organelle GO:0033365 280 0.019
cellular protein complex assembly GO:0043623 188 0.019
positive regulation of mapk cascade GO:0043410 190 0.019
regulation of endopeptidase activity GO:0052548 170 0.019
synaptic vesicle endocytosis GO:0048488 2 0.019
single organism cellular localization GO:1902580 332 0.019
cell growth GO:0016049 160 0.019
negative regulation of multi organism process GO:0043901 92 0.018
inorganic ion transmembrane transport GO:0098660 231 0.018
neuromuscular junction development GO:0007528 3 0.018
reactive nitrogen species metabolic process GO:2001057 3 0.018
protein acetylation GO:0006473 116 0.018
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.018
endocytosis GO:0006897 159 0.018
regulation of mapk cascade GO:0043408 262 0.018
cell division GO:0051301 168 0.018
actin filament organization GO:0007015 128 0.018
monovalent inorganic cation transport GO:0015672 128 0.017
neuron differentiation GO:0030182 138 0.017
synaptic vesicle recycling GO:0036465 3 0.017
interspecies interaction between organisms GO:0044419 156 0.017
protein polymerization GO:0051258 71 0.017
chromatin modification GO:0016568 298 0.017
rho protein signal transduction GO:0007266 26 0.017
cellular response to growth factor stimulus GO:0071363 197 0.017
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.017
positive regulation of transferase activity GO:0051347 227 0.016
actin cytoskeleton organization GO:0030036 207 0.016
regulation of protein stability GO:0031647 87 0.016
memory GO:0007613 3 0.016
cardiovascular system development GO:0072358 262 0.016
positive regulation of cellular component movement GO:0051272 181 0.016
cellular response to oxygen containing compound GO:1901701 276 0.016
negative regulation of transport GO:0051051 176 0.016
protein adp ribosylation GO:0006471 9 0.016
regulation of anatomical structure morphogenesis GO:0022603 286 0.016
post embryonic organ development GO:0048569 1 0.016
regulation of dna metabolic process GO:0051052 153 0.016
cellular cation homeostasis GO:0030003 163 0.016
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.016
negative regulation of proteolysis GO:0045861 132 0.016
positive regulation of cell death GO:0010942 263 0.016
negative regulation of protein phosphorylation GO:0001933 140 0.016
actin mediated cell contraction GO:0070252 12 0.016
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.016
positive regulation of phosphorylation GO:0042327 394 0.016
notch receptor processing GO:0007220 2 0.015
regulation of intracellular transport GO:0032386 195 0.015
regulation of synaptic vesicle transport GO:1902803 3 0.015
regulation of nervous system development GO:0051960 88 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.015
negative regulation of cell migration GO:0030336 102 0.015
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.015
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.015
viral process GO:0016032 146 0.015
adult locomotory behavior GO:0008344 1 0.015
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.015
cation transmembrane transport GO:0098655 238 0.015
segmentation GO:0035282 4 0.015
ras protein signal transduction GO:0007265 73 0.015
regulation of gene expression epigenetic GO:0040029 73 0.015
positive regulation of kinase activity GO:0033674 204 0.015
cellular component morphogenesis GO:0032989 314 0.015
positive regulation of programmed cell death GO:0043068 249 0.015
immune effector process GO:0002252 159 0.015
rhythmic behavior GO:0007622 2 0.015
regulation of ion transmembrane transport GO:0034765 132 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.015
positive regulation of apoptotic process GO:0043065 246 0.015
cell morphogenesis GO:0000902 296 0.015
positive regulation of cellular component organization GO:0051130 376 0.015
positive regulation of cell cycle GO:0045787 140 0.014
anatomical structure formation involved in morphogenesis GO:0048646 284 0.014
positive regulation of protein complex assembly GO:0031334 86 0.014
protein deubiquitination GO:0016579 79 0.014
regulation of purine nucleotide catabolic process GO:0033121 205 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
morphogenesis of embryonic epithelium GO:0016331 4 0.014
regeneration GO:0031099 4 0.014
microtubule based process GO:0007017 210 0.014
regulation of purine nucleotide metabolic process GO:1900542 264 0.014
regulation of cellular response to growth factor stimulus GO:0090287 76 0.014
regulation of peptidase activity GO:0052547 180 0.014
blastocyst development GO:0001824 3 0.014
negative regulation of glial cell proliferation GO:0060253 2 0.014
lung alveolus development GO:0048286 4 0.014
regulation of actin filament based process GO:0032970 141 0.014
negative regulation of axon extension GO:0030517 2 0.014
atp catabolic process GO:0006200 157 0.014
regulation of ion transport GO:0043269 189 0.014
protein targeting to nucleus GO:0044744 104 0.014
negative regulation of nervous system development GO:0051961 28 0.014
regulation of cell growth GO:0001558 135 0.014
ribonucleoside monophosphate metabolic process GO:0009161 187 0.014
cytoplasmic transport GO:0016482 379 0.014
positive regulation of nucleotide metabolic process GO:0045981 230 0.013
endomembrane system organization GO:0010256 196 0.013
positive regulation of apoptotic signaling pathway GO:2001235 70 0.013
regulation of cell adhesion GO:0030155 166 0.013
cellular response to dna damage stimulus GO:0006974 379 0.013
neural crest cell development GO:0014032 3 0.013
organelle fission GO:0048285 149 0.013
anterior posterior axis specification embryo GO:0008595 2 0.013
regulation of nucleotide catabolic process GO:0030811 205 0.013
atp metabolic process GO:0046034 176 0.013
positive regulation of cell proliferation GO:0008284 301 0.013
response to fungus GO:0009620 4 0.013
nucleus localization GO:0051647 1 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.013
negative regulation of cell motility GO:2000146 104 0.013
response to cytokine GO:0034097 232 0.013
regulation of vesicle mediated transport GO:0060627 130 0.013
negative regulation of catabolic process GO:0009895 104 0.013
regulation of multi organism process GO:0043900 157 0.013
ribonucleoprotein complex biogenesis GO:0022613 116 0.013
regulation of cell morphogenesis GO:0022604 153 0.013
positive regulation of protein kinase activity GO:0045860 190 0.013
cellular lipid metabolic process GO:0044255 303 0.013
regulation of actin filament polymerization GO:0030833 50 0.013
rna splicing via transesterification reactions GO:0000375 90 0.013
hindlimb morphogenesis GO:0035137 2 0.013
receptor internalization GO:0031623 43 0.013
mitotic cell cycle process GO:1903047 286 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.012
negative regulation of phosphatase activity GO:0010923 61 0.012
regulation of cellular component size GO:0032535 82 0.012
synaptic vesicle exocytosis GO:0016079 3 0.012
cell type specific apoptotic process GO:0097285 125 0.012
purine nucleoside monophosphate catabolic process GO:0009128 158 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
endocardial cushion development GO:0003197 3 0.012
hematopoietic or lymphoid organ development GO:0048534 186 0.012
regulation of protein localization GO:0032880 296 0.012
positive regulation of nervous system development GO:0051962 54 0.012
protein oligomerization GO:0051259 173 0.012
response to virus GO:0009615 126 0.012
exocytosis GO:0006887 71 0.012
negative regulation of cell development GO:0010721 48 0.012
nucleoside monophosphate metabolic process GO:0009123 191 0.012
negative regulation of peptidase activity GO:0010466 91 0.012
regulation of myelination GO:0031641 1 0.012
notch signaling pathway GO:0007219 31 0.012
response to axon injury GO:0048678 1 0.012
protein targeting GO:0006605 187 0.012
regulation of dephosphorylation GO:0035303 96 0.012
regulation of meiotic cell cycle GO:0051445 4 0.012
positive regulation of cellular component biogenesis GO:0044089 158 0.012
cerebellum development GO:0021549 2 0.012
ameboidal type cell migration GO:0001667 135 0.012
peripheral nervous system development GO:0007422 2 0.012
negative regulation of transferase activity GO:0051348 124 0.012
regulation of epithelial cell migration GO:0010632 93 0.012
regulation of binding GO:0051098 111 0.012
regulation of protein catabolic process GO:0042176 155 0.012
establishment of organelle localization GO:0051656 59 0.012
response to other organism GO:0051707 261 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
potassium ion transport GO:0006813 62 0.012
negative regulation of apoptotic signaling pathway GO:2001234 97 0.012
regulation of anatomical structure size GO:0090066 101 0.012
tripartite regional subdivision GO:0007351 2 0.012
somatic muscle development GO:0007525 1 0.012
nuclear division GO:0000280 128 0.011
regulation of cysteine type endopeptidase activity GO:2000116 127 0.011
purine nucleoside monophosphate metabolic process GO:0009126 186 0.011
positive regulation of peptidase activity GO:0010952 88 0.011
regulation of translation GO:0006417 89 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.011
negative regulation of protein kinase activity GO:0006469 98 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.011
regulation of androgen receptor signaling pathway GO:0060765 18 0.011
anion transmembrane transport GO:0098656 76 0.011
peptidyl tyrosine modification GO:0018212 170 0.011
viral life cycle GO:0019058 132 0.011
protein autophosphorylation GO:0046777 123 0.011
negative regulation of cellular component movement GO:0051271 106 0.011
single organism reproductive process GO:0044702 98 0.011
negative regulation of neurogenesis GO:0050768 26 0.011
photoreceptor cell differentiation GO:0046530 2 0.011
maintenance of location GO:0051235 112 0.011
tissue regeneration GO:0042246 3 0.011
protein homooligomerization GO:0051260 100 0.011
negative regulation of growth GO:0045926 97 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.011
nuclear transport GO:0051169 179 0.011
meiotic chromosome segregation GO:0045132 4 0.011
response to oxidative stress GO:0006979 121 0.011
transmission of nerve impulse GO:0019226 11 0.011
negative regulation of endopeptidase activity GO:0010951 84 0.011
hindbrain development GO:0030902 3 0.011
metal ion homeostasis GO:0055065 169 0.011
positive regulation of cell migration GO:0030335 172 0.011
calcium ion transport GO:0006816 147 0.011
negative regulation of cell growth GO:0030308 83 0.011
intracellular protein transport GO:0006886 270 0.011
cellular ion homeostasis GO:0006873 168 0.011
positive regulation of cell motility GO:2000147 177 0.011
immune system development GO:0002520 195 0.011
regulation of intracellular steroid hormone receptor signaling pathway GO:0033143 32 0.011
regulation of synaptic plasticity GO:0048167 3 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.011
regulation of actin cytoskeleton organization GO:0032956 116 0.011
signal transduction by p53 class mediator GO:0072331 72 0.011
regulation of gtp catabolic process GO:0033124 180 0.010
nucleoside monophosphate catabolic process GO:0009125 159 0.010
apoptotic signaling pathway GO:0097190 268 0.010
regulation of synaptic vesicle exocytosis GO:2000300 2 0.010
anion transport GO:0006820 161 0.010
ribonucleoprotein complex subunit organization GO:0071826 81 0.010
anterior posterior axis specification GO:0009948 2 0.010
positive regulation of synaptic transmission GO:0050806 4 0.010
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.010
cell part morphogenesis GO:0032990 137 0.010
negative regulation of cellular catabolic process GO:0031330 83 0.010
cellular chemical homeostasis GO:0055082 180 0.010
syncytium formation by plasma membrane fusion GO:0000768 2 0.010
cellular homeostasis GO:0019725 196 0.010
circadian behavior GO:0048512 2 0.010
organophosphate biosynthetic process GO:0090407 163 0.010
response to oxygen levels GO:0070482 100 0.010

UBE2H disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.071
disease of cellular proliferation DOID:14566 174 0.071
cardiovascular system disease DOID:1287 106 0.027
disease of metabolism DOID:0014667 295 0.024
gastrointestinal system cancer DOID:3119 52 0.021
organ system cancer DOID:0050686 164 0.021
inherited metabolic disorder DOID:655 242 0.019
heart disease DOID:114 68 0.018
artery disease DOID:0050828 23 0.016
vascular disease DOID:178 25 0.016
sensory system disease DOID:0050155 203 0.013
nervous system disease DOID:863 431 0.013
musculoskeletal system disease DOID:17 223 0.012
connective tissue disease DOID:65 109 0.012
central nervous system disease DOID:331 186 0.011
brain disease DOID:936 73 0.011
bone disease DOID:0080001 88 0.010