Homo sapiens

133 known processes

UPF1

UPF1 regulator of nonsense transcripts homolog (yeast)

(Aliases: RENT1,NORF1,FLJ43809,FLJ46894,pNORF1,KIAA0221,HUPF1)

UPF1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mrna catabolic process GO:0006402 56 1.000
mrna metabolic process GO:0016071 175 1.000
rna catabolic process GO:0006401 71 1.000
nuclear transcribed mrna catabolic process GO:0000956 48 1.000
cellular macromolecule catabolic process GO:0044265 380 1.000
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 23 1.000
male genitalia development GO:0030539 1 0.983
translation GO:0006412 132 0.914
female gamete generation GO:0007292 2 0.892
intracellular mrna localization GO:0008298 1 0.884
Yeast
regulation of translation GO:0006417 89 0.866
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.730
posttranscriptional regulation of gene expression GO:0010608 213 0.670
posttranscriptional gene silencing by rna GO:0035194 25 0.636
Worm
rna phosphodiester bond hydrolysis GO:0090501 35 0.626
anatomical structure homeostasis GO:0060249 100 0.621
anterior posterior axis specification GO:0009948 2 0.585
reproductive process GO:0022414 106 0.564
Worm
rna localization GO:0006403 41 0.551
Yeast
telomere maintenance GO:0000723 32 0.535
oocyte differentiation GO:0009994 2 0.505
blastoderm segmentation GO:0007350 2 0.475
ribonucleoprotein complex biogenesis GO:0022613 116 0.475
multicellular organismal aging GO:0010259 3 0.456
mrna processing GO:0006397 133 0.455
anterior posterior axis specification embryo GO:0008595 2 0.425
rna processing GO:0006396 255 0.395
telomere organization GO:0032200 33 0.377
ribonucleoprotein complex assembly GO:0022618 78 0.349
oocyte development GO:0048599 1 0.342
segmentation GO:0035282 4 0.301
negative regulation of gene silencing by rna GO:0060967 3 0.297
defense response to fungus GO:0050832 4 0.286
single organism cellular localization GO:1902580 332 0.269
nuclear transcribed mrna catabolic process no go decay GO:0070966 2 0.262
glycerophospholipid metabolic process GO:0006650 84 0.261
sex differentiation GO:0007548 45 0.229
Worm
regulation of meiotic cell cycle GO:0051445 4 0.216
post embryonic development GO:0009791 2 0.207
positive regulation of translation GO:0045727 35 0.207
regulation of cell maturation GO:1903429 3 0.201
vesicle mediated transport GO:0016192 371 0.200
memory GO:0007613 3 0.200
tripartite regional subdivision GO:0007351 2 0.196
phosphatidylinositol metabolic process GO:0046488 53 0.196
negative regulation of posttranscriptional gene silencing GO:0060149 3 0.181
determination of adult lifespan GO:0008340 2 0.176
oogenesis GO:0048477 2 0.173
ribonucleoprotein complex disassembly GO:0032988 7 0.156
single organism reproductive process GO:0044702 98 0.138
Worm
cellular lipid metabolic process GO:0044255 303 0.133
cytoplasmic mrna processing body assembly GO:0033962 10 0.132
methylation GO:0032259 106 0.131
dephosphorylation GO:0016311 209 0.123
mitotic cell cycle process GO:1903047 286 0.105
enzyme linked receptor protein signaling pathway GO:0007167 303 0.101
embryo development GO:0009790 123 0.100
Zebrafish Worm
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.099
reproductive system development GO:0061458 56 0.092
Worm
protein autophosphorylation GO:0046777 123 0.090
defense response GO:0006952 315 0.089
translational initiation GO:0006413 48 0.085
response to fungus GO:0009620 4 0.085
lipid metabolic process GO:0006629 381 0.085
regulation of mrna processing GO:0050684 48 0.078
rna interference GO:0016246 4 0.077
Worm
developmental process involved in reproduction GO:0003006 66 0.074
Worm
gene silencing by mirna GO:0035195 23 0.073
wnt signaling pathway GO:0016055 156 0.073
phospholipid metabolic process GO:0006644 99 0.072
organelle assembly GO:0070925 176 0.066
receptor mediated endocytosis GO:0006898 84 0.064
nucleoside catabolic process GO:0009164 408 0.063
nucleoside phosphate catabolic process GO:1901292 412 0.063
phosphatidylinositol phosphorylation GO:0046854 24 0.063
telomere assembly GO:0032202 5 0.061
cell cell signaling GO:0007267 155 0.061
glycerolipid metabolic process GO:0046486 107 0.061
protein complex disassembly GO:0043241 52 0.060
rna splicing GO:0008380 131 0.060
primary mirna processing GO:0031053 3 0.059
behavior GO:0007610 112 0.058
cell development GO:0048468 328 0.057
dna replication GO:0006260 116 0.057
gonad development GO:0008406 34 0.054
Worm
ribonucleoprotein complex subunit organization GO:0071826 81 0.054
cellular response to dna damage stimulus GO:0006974 379 0.053
lipid modification GO:0030258 84 0.051
reproductive structure development GO:0048608 55 0.050
Worm
development of primary sexual characteristics GO:0045137 35 0.050
Worm
nucleobase containing compound transport GO:0015931 51 0.047
regulation of cell cycle GO:0051726 393 0.045
regulation of meiosis GO:0040020 3 0.045
response to external biotic stimulus GO:0043207 261 0.043
rna export from nucleus GO:0006405 33 0.043
reproduction GO:0000003 63 0.042
posttranscriptional gene silencing GO:0016441 25 0.041
Worm
intracellular protein transport GO:0006886 270 0.041
gene silencing GO:0016458 49 0.040
Yeast Worm
nucleoside monophosphate catabolic process GO:0009125 159 0.040
aging GO:0007568 66 0.039
regulation of mrna metabolic process GO:1903311 53 0.038
regulation of wnt signaling pathway GO:0030111 123 0.037
defense response to other organism GO:0098542 129 0.036
pattern specification process GO:0007389 43 0.035
regulation of gene expression epigenetic GO:0040029 73 0.035
Yeast Mouse Worm
embryonic axis specification GO:0000578 5 0.035
microtubule cytoskeleton organization GO:0000226 176 0.034
vesicle localization GO:0051648 26 0.034
regulation of dna metabolic process GO:0051052 153 0.033
synaptic transmission GO:0007268 61 0.032
regulation of growth GO:0040008 165 0.032
nuclear division GO:0000280 128 0.032
organophosphate catabolic process GO:0046434 430 0.032
protein methylation GO:0006479 74 0.031
establishment of rna localization GO:0051236 39 0.031
neural crest cell development GO:0014032 3 0.031
gene silencing by rna GO:0031047 26 0.029
Worm
neuromuscular synaptic transmission GO:0007274 5 0.029
ncrna metabolic process GO:0034660 108 0.029
locomotory behavior GO:0007626 1 0.029
rna 3 end processing GO:0031123 35 0.029
hemopoiesis GO:0030097 180 0.029
nucleic acid transport GO:0050657 39 0.028
protein alkylation GO:0008213 74 0.028
positive regulation of transferase activity GO:0051347 227 0.028
purine nucleoside monophosphate catabolic process GO:0009128 158 0.027
regulation of apoptotic signaling pathway GO:2001233 175 0.027
regulation of cell division GO:0051302 116 0.027
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.026
nuclear transport GO:0051169 179 0.026
cellular macromolecular complex assembly GO:0034622 324 0.026
cellular amine metabolic process GO:0044106 41 0.025
regionalization GO:0003002 29 0.024
regulation of cell differentiation GO:0045595 393 0.024
regulation of locomotion GO:0040012 329 0.024
protein localization to organelle GO:0033365 280 0.024
negative regulation of programmed cell death GO:0043069 321 0.024
regulation of dephosphorylation GO:0035303 96 0.024
telomere maintenance via telomerase GO:0007004 8 0.024
negative regulation of mrna catabolic process GO:1902373 4 0.024
hormone metabolic process GO:0042445 61 0.024
mrna transport GO:0051028 30 0.023
cellular amino acid metabolic process GO:0006520 116 0.023
response to other organism GO:0051707 261 0.023
microtubule based process GO:0007017 210 0.023
mating GO:0007618 1 0.023
organelle fission GO:0048285 149 0.023
protein targeting GO:0006605 187 0.023
sexual reproduction GO:0019953 37 0.023
regulation of cellular amino acid metabolic process GO:0006521 6 0.022
embryo development ending in birth or egg hatching GO:0009792 34 0.022
positive regulation of cell death GO:0010942 263 0.021
dna repair GO:0006281 198 0.021
viral process GO:0016032 146 0.021
reactive oxygen species metabolic process GO:0072593 75 0.020
nucleocytoplasmic transport GO:0006913 176 0.020
cellular protein complex disassembly GO:0043624 36 0.020
spermatid differentiation GO:0048515 4 0.020
nitrogen compound transport GO:0071705 191 0.020
positive regulation of cellular amine metabolic process GO:0033240 7 0.020
macromolecule methylation GO:0043414 97 0.020
negative regulation of cellular component organization GO:0051129 235 0.020
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.020
histone mrna catabolic process GO:0071044 10 0.019
multi organism reproductive process GO:0044703 54 0.019
embryonic morphogenesis GO:0048598 85 0.019
Worm
negative regulation of multi organism process GO:0043901 92 0.019
cytoplasmic transport GO:0016482 379 0.019
negative regulation of cellular amine metabolic process GO:0033239 3 0.019
cellular component disassembly GO:0022411 92 0.019
hematopoietic or lymphoid organ development GO:0048534 186 0.018
cellular ketone metabolic process GO:0042180 80 0.018
adult locomotory behavior GO:0008344 1 0.018
spermatid development GO:0007286 4 0.018
synaptic vesicle localization GO:0097479 5 0.018
purine ribonucleoside metabolic process GO:0046128 437 0.017
cell morphogenesis GO:0000902 296 0.017
neurological system process GO:0050877 163 0.017
covalent chromatin modification GO:0016569 254 0.017
mrna splicing via spliceosome GO:0000398 89 0.016
regulation of nuclear division GO:0051783 65 0.016
modification dependent macromolecule catabolic process GO:0043632 212 0.016
growth GO:0040007 202 0.016
male sex differentiation GO:0046661 25 0.016
immune system development GO:0002520 195 0.016
regulation of cellular amine metabolic process GO:0033238 11 0.015
spindle elongation GO:0051231 4 0.015
response to organic cyclic compound GO:0014070 204 0.015
nuclear export GO:0051168 69 0.015
regulation of homeostatic process GO:0032844 121 0.015
regulation of cell development GO:0060284 161 0.015
peripheral nervous system development GO:0007422 2 0.015
mitotic cell cycle GO:0000278 326 0.015
alternative mrna splicing via spliceosome GO:0000380 27 0.015
rna phosphodiester bond hydrolysis endonucleolytic GO:0090502 15 0.015
rna transport GO:0050658 39 0.015
regulation of transferase activity GO:0051338 355 0.014
system process GO:0003008 349 0.014
chordate embryonic development GO:0043009 34 0.014
negative regulation of viral genome replication GO:0045071 35 0.014
single organism membrane organization GO:0044802 268 0.014
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.014
long term memory GO:0007616 2 0.014
cytoplasmic translational initiation GO:0002183 6 0.014
mapk cascade GO:0000165 288 0.014
skeletal system development GO:0001501 79 0.013
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.013
establishment of protein localization to plasma membrane GO:0090002 68 0.013
regulation of multi organism process GO:0043900 157 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
negative regulation of apoptotic signaling pathway GO:2001234 97 0.013
nucleoside triphosphate metabolic process GO:0009141 422 0.013
negative regulation of apoptotic process GO:0043066 316 0.013
amine metabolic process GO:0009308 44 0.013
lipid phosphorylation GO:0046834 31 0.013
endocytosis GO:0006897 159 0.013
negative regulation of locomotion GO:0040013 118 0.013
synaptic vesicle transport GO:0048489 5 0.013
circadian sleep wake cycle process GO:0022410 2 0.012
cell growth GO:0016049 160 0.012
rna splicing via transesterification reactions GO:0000375 90 0.012
meiosis i GO:0007127 4 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.012
multicellular organismal reproductive process GO:0048609 40 0.012
rhythmic behavior GO:0007622 2 0.012
positive regulation of wnt signaling pathway GO:0030177 54 0.012
interspecies interaction between organisms GO:0044419 156 0.012
monocarboxylic acid metabolic process GO:0032787 185 0.011
gamete generation GO:0007276 25 0.011
cell division GO:0051301 168 0.011
regulation of cell growth GO:0001558 135 0.011
7 methylguanosine mrna capping GO:0006370 7 0.011
mitotic spindle elongation GO:0000022 4 0.011
positive regulation of apoptotic process GO:0043065 246 0.011
protein catabolic process GO:0030163 325 0.011
ribonucleoside monophosphate metabolic process GO:0009161 187 0.011
reactive nitrogen species metabolic process GO:2001057 3 0.011
proteasomal protein catabolic process GO:0010498 176 0.011
cellular response to starvation GO:0009267 58 0.011
circadian behavior GO:0048512 2 0.011
cellular response to nitrogen compound GO:1901699 144 0.011
ncrna catabolic process GO:0034661 14 0.011
regulation of cell activation GO:0050865 125 0.011
regulation of protein catabolic process GO:0042176 155 0.011
positive regulation of mapk cascade GO:0043410 190 0.011
lymphocyte homeostasis GO:0002260 4 0.011
establishment of vesicle localization GO:0051650 23 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.011
regulation of cellular ketone metabolic process GO:0010565 50 0.011
regulation of mrna splicing via spliceosome GO:0048024 32 0.011
negative regulation of cell death GO:0060548 345 0.011
macroautophagy GO:0016236 39 0.011
regulation of viral process GO:0050792 103 0.011
negative regulation of cellular protein metabolic process GO:0032269 353 0.011
multicellular organismal homeostasis GO:0048871 67 0.011
epidermis morphogenesis GO:0048730 3 0.010
immune response GO:0006955 307 0.010
regulation of autophagy GO:0010506 52 0.010
rrna metabolic process GO:0016072 40 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.010
atp metabolic process GO:0046034 176 0.010
ras protein signal transduction GO:0007265 73 0.010
sleep GO:0030431 2 0.010
ubiquitin dependent protein catabolic process GO:0006511 206 0.010

UPF1 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.084
disease of cellular proliferation DOID:14566 174 0.084
organ system cancer DOID:0050686 164 0.084
central nervous system disease DOID:331 186 0.061
neurodegenerative disease DOID:1289 102 0.061
nervous system disease DOID:863 431 0.061