Homo sapiens

47 known processes

WDR5

WD repeat domain 5

(Aliases: SWD3,BIG-3)

WDR5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin modification GO:0016568 298 1.000
chromatin organization GO:0006325 351 1.000
histone modification GO:0016570 251 1.000
protein alkylation GO:0008213 74 1.000
covalent chromatin modification GO:0016569 254 1.000
histone methylation GO:0016571 60 1.000
protein acetylation GO:0006473 116 1.000
histone h3 k4 methylation GO:0051568 27 1.000
histone h4 k8 acetylation GO:0043982 15 1.000
histone lysine methylation GO:0034968 50 1.000
protein methylation GO:0006479 74 1.000
internal peptidyl lysine acetylation GO:0018393 97 1.000
internal protein amino acid acetylation GO:0006475 101 1.000
peptidyl lysine methylation GO:0018022 37 1.000
peptidyl lysine acetylation GO:0018394 101 1.000
protein acylation GO:0043543 138 1.000
histone acetylation GO:0016573 93 1.000
peptidyl lysine modification GO:0018205 144 1.000
histone h3 acetylation GO:0043966 45 1.000
methylation GO:0032259 106 1.000
macromolecule methylation GO:0043414 97 0.999
cellular ketone metabolic process GO:0042180 80 0.997
Mouse
cellular amino acid metabolic process GO:0006520 116 0.995
peptidyl lysine dimethylation GO:0018027 3 0.992
histone h3 k4 trimethylation GO:0080182 7 0.991
histone h4 k5 acetylation GO:0043981 15 0.986
histone h4 k16 acetylation GO:0043984 14 0.983
amine metabolic process GO:0009308 44 0.963
intracellular estrogen receptor signaling pathway GO:0030520 23 0.960
regulation of histone acetylation GO:0035065 19 0.941
multicellular organismal aging GO:0010259 3 0.931
Worm
histone h4 acetylation GO:0043967 47 0.923
regulation of histone modification GO:0031056 47 0.909
regulation of gene expression epigenetic GO:0040029 73 0.881
response to estrogen GO:0043627 47 0.858
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.856
cell development GO:0048468 328 0.843
Rat
regulation of cellular amino acid metabolic process GO:0006521 6 0.838
cell cycle checkpoint GO:0000075 117 0.817
Fly
regulation of chromatin organization GO:1902275 56 0.790
regulation of intracellular estrogen receptor signaling pathway GO:0033146 13 0.772
negative regulation of catalytic activity GO:0043086 335 0.749
transdifferentiation GO:0060290 2 0.741
Worm
protein processing GO:0016485 226 0.726
regulation of chromosome organization GO:0033044 103 0.707
regulation of chromatin modification GO:1903308 51 0.705
determination of adult lifespan GO:0008340 2 0.690
Worm
immune system development GO:0002520 195 0.685
response to radiation GO:0009314 151 0.681
regulation of peptidyl lysine acetylation GO:2000756 22 0.675
chordate embryonic development GO:0043009 34 0.670
regulation of cellular ketone metabolic process GO:0010565 50 0.667
Mouse
cellular amine metabolic process GO:0044106 41 0.663
hematopoietic or lymphoid organ development GO:0048534 186 0.660
regulation of cellular amine metabolic process GO:0033238 11 0.643
peptidyl lysine trimethylation GO:0018023 10 0.629
chromatin silencing GO:0006342 12 0.619
positive regulation of histone modification GO:0031058 29 0.614
dna repair GO:0006281 198 0.596
positive regulation of cellular component organization GO:0051130 376 0.573
positive regulation of growth GO:0045927 58 0.539
positive regulation of chromosome organization GO:2001252 41 0.539
response to organic cyclic compound GO:0014070 204 0.537
growth GO:0040007 202 0.527
response to hormone GO:0009725 175 0.514
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.495
heart morphogenesis GO:0003007 48 0.451
response to lipid GO:0033993 206 0.444
dna conformation change GO:0071103 113 0.440
taxis GO:0042330 157 0.434
single organism reproductive process GO:0044702 98 0.426
Worm
nervous system development GO:0007399 293 0.422
Rat Fly
protein stabilization GO:0050821 64 0.421
negative regulation of cell cycle GO:0045786 193 0.417
Fly
female gamete generation GO:0007292 2 0.411
response to steroid hormone GO:0048545 80 0.410
compound eye development GO:0048749 1 0.400
positive regulation of chromatin modification GO:1903310 30 0.398
cellular component morphogenesis GO:0032989 314 0.367
telomere organization GO:0032200 33 0.357
embryo development GO:0009790 123 0.346
dna modification GO:0006304 27 0.332
erythrocyte development GO:0048821 3 0.327
regulation of cell cycle GO:0051726 393 0.319
Fly
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.308
Fly
dna damage checkpoint GO:0000077 68 0.302
Fly
reproductive process GO:0022414 106 0.296
Worm
gene silencing GO:0016458 49 0.295
cell fate commitment GO:0045165 27 0.293
blastoderm segmentation GO:0007350 2 0.288
oogenesis GO:0048477 2 0.286
positive regulation of organelle organization GO:0010638 195 0.286
protein ubiquitination GO:0016567 314 0.282
gonad development GO:0008406 34 0.267
Worm
hemopoiesis GO:0030097 180 0.257
chromatin remodeling GO:0006338 55 0.256
Fly
positive regulation of cell proliferation GO:0008284 301 0.245
regulation of cell differentiation GO:0045595 393 0.238
cardiovascular system development GO:0072358 262 0.238
aging GO:0007568 66 0.231
Worm
negative regulation of interleukin 2 production GO:0032703 7 0.230
regulation of response to dna damage stimulus GO:2001020 94 0.222
neuron projection development GO:0031175 106 0.222
Rat
negative regulation of cellular protein metabolic process GO:0032269 353 0.212
oocyte differentiation GO:0009994 2 0.212
regulation of protein acetylation GO:1901983 25 0.202
negative regulation of proteolysis GO:0045861 132 0.190
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.177
mitotic nuclear division GO:0007067 119 0.173
regulation of histone h3 k4 methylation GO:0051569 10 0.161
cellular response to abiotic stimulus GO:0071214 117 0.158
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.158
protein modification by small protein conjugation GO:0032446 342 0.155
segmentation GO:0035282 4 0.155
regulation of protein processing GO:0070613 150 0.150
embryonic organ development GO:0048568 36 0.138
chromatin mediated maintenance of transcription GO:0048096 2 0.137
cell morphogenesis involved in differentiation GO:0000904 144 0.135
developmental growth GO:0048589 48 0.132
development of primary sexual characteristics GO:0045137 35 0.129
Worm
cell projection morphogenesis GO:0048858 129 0.128
oocyte development GO:0048599 1 0.127
positive regulation of endopeptidase activity GO:0010950 84 0.126
chromatin assembly or disassembly GO:0006333 78 0.125
regulation of cell growth GO:0001558 135 0.125
post embryonic development GO:0009791 2 0.125
Worm
cell part morphogenesis GO:0032990 137 0.125
positive regulation of peptidase activity GO:0010952 88 0.122
telomere maintenance GO:0000723 32 0.114
cellular response to dna damage stimulus GO:0006974 379 0.113
Fly
regulation of cell division GO:0051302 116 0.113
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.105
regulation of histone methylation GO:0031060 16 0.102
blood vessel development GO:0001568 172 0.102
mitotic cell cycle process GO:1903047 286 0.102
Fly
cell projection organization GO:0030030 252 0.101
Rat
generation of neurons GO:0048699 152 0.101
Rat
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.100
negative regulation of cell cycle process GO:0010948 121 0.100
Fly
negative regulation of gene expression epigenetic GO:0045814 19 0.100
cellular protein catabolic process GO:0044257 261 0.100
regulation of endopeptidase activity GO:0052548 170 0.099
cell growth GO:0016049 160 0.098
posttranscriptional regulation of gene expression GO:0010608 213 0.093
dna methylation or demethylation GO:0044728 19 0.093
embryonic pattern specification GO:0009880 5 0.088
positive regulation of gene expression epigenetic GO:0045815 7 0.087
negative regulation of apoptotic process GO:0043066 316 0.085
central nervous system development GO:0007417 123 0.085
neuron projection morphogenesis GO:0048812 50 0.085
positive regulation of cell growth GO:0030307 48 0.083
somatic stem cell maintenance GO:0035019 4 0.083
regulation of wnt signaling pathway GO:0030111 123 0.080
reproduction GO:0000003 63 0.079
Worm
regulation of peptidase activity GO:0052547 180 0.079
negative regulation of protein metabolic process GO:0051248 391 0.078
reproductive system development GO:0061458 56 0.078
Worm
regulation of cysteine type endopeptidase activity GO:2000116 127 0.076
positive regulation of cellular amine metabolic process GO:0033240 7 0.075
ribonucleoside monophosphate metabolic process GO:0009161 187 0.074
anatomical structure homeostasis GO:0060249 100 0.072
chemotaxis GO:0006935 157 0.071
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.071
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.069
regulation of cell cycle process GO:0010564 266 0.069
Fly
regulation of osteoblast differentiation GO:0045667 38 0.069
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 10 0.066
positive regulation of catabolic process GO:0009896 310 0.063
positive regulation of programmed cell death GO:0043068 249 0.063
cell cycle phase transition GO:0044770 173 0.061
Fly
cell cell signaling GO:0007267 155 0.061
regulation of growth GO:0040008 165 0.060
regulation of protein ubiquitination GO:0031396 95 0.060
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.060
multi organism reproductive process GO:0044703 54 0.059
neuron differentiation GO:0030182 138 0.058
Rat
sex differentiation GO:0007548 45 0.058
Worm
response to abiotic stimulus GO:0009628 336 0.056
axon development GO:0061564 34 0.056
response to ionizing radiation GO:0010212 65 0.055
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 17 0.055
cellular response to radiation GO:0071478 65 0.054
dna integrity checkpoint GO:0031570 71 0.052
Fly
negative regulation of transferase activity GO:0051348 124 0.051
negative regulation of protein processing GO:0010955 142 0.051
ncrna processing GO:0034470 83 0.051
in utero embryonic development GO:0001701 8 0.051
positive regulation of proteolysis GO:0045862 142 0.050
regulation of protein catabolic process GO:0042176 155 0.050
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.049
chromosome segregation GO:0007059 114 0.049
locomotory behavior GO:0007626 1 0.048
multicellular organismal reproductive process GO:0048609 40 0.048
regulation of cellular protein catabolic process GO:1903362 96 0.047
neuron development GO:0048666 113 0.047
Rat
axonogenesis GO:0007409 31 0.044
protein maturation GO:0051604 233 0.044
regulation of transporter activity GO:0032409 82 0.043
positive regulation of dna templated transcription elongation GO:0032786 18 0.042
regulation of proteolysis GO:0030162 293 0.042
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.042
negative regulation of cellular component organization GO:0051129 235 0.041
multicellular organism reproduction GO:0032504 42 0.041
dna packaging GO:0006323 77 0.040
positive regulation of developmental process GO:0051094 314 0.040
regulation of cellular response to stress GO:0080135 244 0.039
regionalization GO:0003002 29 0.039
negative regulation of phosphorus metabolic process GO:0010563 267 0.039
negative regulation of protein maturation GO:1903318 142 0.039
regulation of dna metabolic process GO:0051052 153 0.039
blastocyst development GO:0001824 3 0.037
response to other organism GO:0051707 261 0.037
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.037
ribosome biogenesis GO:0042254 48 0.036
regulation of protein stability GO:0031647 87 0.036
modification dependent protein catabolic process GO:0019941 209 0.035
protein catabolic process GO:0030163 325 0.035
regulation of dna repair GO:0006282 47 0.035
sister chromatid segregation GO:0000819 54 0.035
double strand break repair GO:0006302 101 0.034
organ growth GO:0035265 12 0.034
ribonucleoside triphosphate metabolic process GO:0009199 412 0.034
developmental process involved in reproduction GO:0003006 66 0.032
Worm
proteasomal protein catabolic process GO:0010498 176 0.032
axon guidance GO:0007411 12 0.031
vasculature development GO:0001944 181 0.031
palate development GO:0060021 13 0.031
nucleotide catabolic process GO:0009166 408 0.030
purine nucleoside triphosphate metabolic process GO:0009144 412 0.030
negative regulation of multicellular organismal process GO:0051241 317 0.030
Worm
mitotic dna damage checkpoint GO:0044773 28 0.030
Fly
purine nucleoside monophosphate metabolic process GO:0009126 186 0.030
ribosomal large subunit biogenesis GO:0042273 10 0.030
negative regulation of stem cell differentiation GO:2000737 22 0.029
inner ear morphogenesis GO:0042472 4 0.029
protein modification by small protein removal GO:0070646 92 0.028
negative regulation of cell death GO:0060548 345 0.028
regulation of protein localization GO:0032880 296 0.028
positive regulation of protein catabolic process GO:0045732 75 0.028
sensory organ development GO:0007423 52 0.028
regulation of cellular component biogenesis GO:0044087 281 0.027
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.027
dna replication GO:0006260 116 0.026
regulation of cell cycle phase transition GO:1901987 126 0.026
Fly
regulation of protein complex assembly GO:0043254 147 0.026
embryo development ending in birth or egg hatching GO:0009792 34 0.026
regulation of mitotic cell cycle GO:0007346 189 0.026
Fly
reproductive structure development GO:0048608 55 0.026
Worm
regulation of mitotic cell cycle phase transition GO:1901990 118 0.026
Fly
dna alkylation GO:0006305 7 0.026
regulation of transcription from rna polymerase i promoter GO:0006356 10 0.026
nucleoside triphosphate metabolic process GO:0009141 422 0.024
regulation of hormone levels GO:0010817 125 0.024
mitotic cell cycle GO:0000278 326 0.024
Fly
protein monoubiquitination GO:0006513 39 0.024
regulation of organ growth GO:0046620 7 0.024
response to light stimulus GO:0009416 87 0.024
positive regulation of histone h3 k9 methylation GO:0051574 3 0.024
cell division GO:0051301 168 0.023
negative regulation of developmental process GO:0051093 247 0.023
Worm
gamete generation GO:0007276 25 0.023
ubiquitin dependent protein catabolic process GO:0006511 206 0.023
wnt signaling pathway GO:0016055 156 0.022
cell morphogenesis GO:0000902 296 0.022
ribonucleoside catabolic process GO:0042454 406 0.022
positive regulation of hydrolase activity GO:0051345 331 0.022
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.022
protein localization to organelle GO:0033365 280 0.021
interleukin 2 production GO:0032623 20 0.021
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.021
memory GO:0007613 3 0.021
negative regulation of protein kinase activity GO:0006469 98 0.020
regulation of cytoskeleton organization GO:0051493 177 0.019
regulation of protein binding GO:0043393 66 0.019
negative regulation of wnt signaling pathway GO:0030178 69 0.018
ribonucleoside monophosphate catabolic process GO:0009158 158 0.018
regulation of dna templated transcription in response to stress GO:0043620 18 0.018
positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 5 0.018
stress activated protein kinase signaling cascade GO:0031098 94 0.017
behavior GO:0007610 112 0.017
blood vessel morphogenesis GO:0048514 162 0.017
head development GO:0060322 108 0.017
single organism membrane organization GO:0044802 268 0.017
cellular response to organic cyclic compound GO:0071407 127 0.016
genitalia development GO:0048806 10 0.016
regulation of dna biosynthetic process GO:2000278 18 0.016
negative regulation of cellular protein catabolic process GO:1903363 38 0.016
regulation of cytoplasmic transport GO:1903649 149 0.016
histone arginine methylation GO:0034969 6 0.016
enzyme linked receptor protein signaling pathway GO:0007167 303 0.016
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.016
immune response GO:0006955 307 0.016
regulation of protein maturation GO:1903317 150 0.015
regulation of proteasomal protein catabolic process GO:0061136 87 0.015
brain development GO:0007420 97 0.015
cellular response to uv GO:0034644 32 0.015
embryonic organ morphogenesis GO:0048562 24 0.015
regulation of intracellular steroid hormone receptor signaling pathway GO:0033143 32 0.014
negative regulation of protein modification process GO:0031400 200 0.014
regulation of growth hormone secretion GO:0060123 3 0.014
cellular process involved in reproduction in multicellular organism GO:0022412 15 0.014
negative regulation of phosphorylation GO:0042326 174 0.014
mrna metabolic process GO:0016071 175 0.014
dendrite development GO:0016358 24 0.014
skeletal system development GO:0001501 79 0.014
Mouse
sexual reproduction GO:0019953 37 0.014
neuron projection guidance GO:0097485 12 0.013
nucleoside triphosphate catabolic process GO:0009143 394 0.013
negative regulation of programmed cell death GO:0043069 321 0.013
atp metabolic process GO:0046034 176 0.013
nucleoside phosphate catabolic process GO:1901292 412 0.013
regulation of dna replication GO:0006275 68 0.013
central nervous system neuron axonogenesis GO:0021955 3 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
positive regulation of intracellular steroid hormone receptor signaling pathway GO:0033145 7 0.012
signal release GO:0023061 70 0.012
embryonic skeletal system morphogenesis GO:0048704 9 0.012
purine nucleoside catabolic process GO:0006152 398 0.012
positive regulation of cell cycle process GO:0090068 106 0.012
myeloid cell differentiation GO:0030099 117 0.012
positive regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0036091 3 0.012
viral process GO:0016032 146 0.011
negative regulation of cell differentiation GO:0045596 171 0.011
positive regulation of cell death GO:0010942 263 0.011
artery morphogenesis GO:0048844 7 0.011
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.011
purine nucleoside triphosphate catabolic process GO:0009146 392 0.011
cytokine production GO:0001816 247 0.011
response to growth factor GO:0070848 205 0.011
regulation of developmental growth GO:0048638 30 0.010
ncrna metabolic process GO:0034660 108 0.010
regulation of mitosis GO:0007088 63 0.010

WDR5 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of mental health DOID:150 70 0.023
cognitive disorder DOID:1561 29 0.023
sensory system disease DOID:0050155 203 0.011
nervous system disease DOID:863 431 0.011