Homo sapiens

0 known processes

WHSC1

Wolf-Hirschhorn syndrome candidate 1

(Aliases: FLJ23286,TRX5,WHS,REIIBP,KIAA1090,MGC176638,MMSET,NSD2)

WHSC1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitotic cell cycle process GO:1903047 286 0.982
chromatin modification GO:0016568 298 0.930
Human Zebrafish Mouse Fly
mitotic cell cycle GO:0000278 326 0.860
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.833
Mouse
chromatin organization GO:0006325 351 0.636
Human Zebrafish Mouse Fly
regulation of mitotic cell cycle GO:0007346 189 0.614
microtubule cytoskeleton organization GO:0000226 176 0.572
microtubule based process GO:0007017 210 0.454
determination of adult lifespan GO:0008340 2 0.433
endomembrane system organization GO:0010256 196 0.430
mitotic nuclear division GO:0007067 119 0.410
regulation of microtubule cytoskeleton organization GO:0070507 61 0.394
regulation of cell cycle GO:0051726 393 0.390
nuclear division GO:0000280 128 0.362
cellular component disassembly GO:0022411 92 0.354
negative regulation of cell cycle GO:0045786 193 0.350
oogenesis GO:0048477 2 0.329
behavior GO:0007610 112 0.325
establishment of nucleus localization GO:0040023 1 0.311
generation of neurons GO:0048699 152 0.302
regulation of cell cycle phase transition GO:1901987 126 0.256
cellular response to dna damage stimulus GO:0006974 379 0.253
Mouse
regulation of chromosome segregation GO:0051983 44 0.240
single organism cellular localization GO:1902580 332 0.229
neuron differentiation GO:0030182 138 0.225
mitotic cell cycle phase transition GO:0044772 162 0.221
regulation of cell cycle process GO:0010564 266 0.209
protein localization to nucleus GO:0034504 136 0.202
locomotory behavior GO:0007626 1 0.198
membrane organization GO:0061024 292 0.195
dna packaging GO:0006323 77 0.186
nervous system development GO:0007399 293 0.185
positive regulation of cell differentiation GO:0045597 211 0.184
positive regulation of cellular component organization GO:0051130 376 0.175
chromatin silencing GO:0006342 12 0.164
negative regulation of cell cycle process GO:0010948 121 0.160
chromatin assembly or disassembly GO:0006333 78 0.159
regulation of cellular component biogenesis GO:0044087 281 0.155
chromatin remodeling GO:0006338 55 0.154
histone modification GO:0016570 251 0.154
Human Zebrafish Mouse Fly
cell projection organization GO:0030030 252 0.152
post embryonic development GO:0009791 2 0.148
organelle fission GO:0048285 149 0.146
neurogenesis GO:0022008 169 0.145
cell development GO:0048468 328 0.144
nuclear migration GO:0007097 1 0.141
intracellular mrna localization GO:0008298 1 0.140
cell cycle phase transition GO:0044770 173 0.138
neuron projection development GO:0031175 106 0.136
meiosis i GO:0007127 4 0.133
cellular component morphogenesis GO:0032989 314 0.133
chromosome segregation GO:0007059 114 0.131
cell morphogenesis involved in differentiation GO:0000904 144 0.130
nucleus localization GO:0051647 1 0.130
anatomical structure formation involved in morphogenesis GO:0048646 284 0.128
negative regulation of cell differentiation GO:0045596 171 0.125
protein localization to organelle GO:0033365 280 0.122
microtubule organizing center organization GO:0031023 62 0.122
regulation of microtubule based process GO:0032886 74 0.121
meiotic chromosome segregation GO:0045132 4 0.119
organ morphogenesis GO:0009887 147 0.118
Mouse
negative regulation of cellular component organization GO:0051129 235 0.117
central nervous system development GO:0007417 123 0.115
reproductive structure development GO:0048608 55 0.114
centrosome organization GO:0051297 58 0.113
developmental growth GO:0048589 48 0.111
dna conformation change GO:0071103 113 0.110
female gamete generation GO:0007292 2 0.108
mitotic nuclear envelope reassembly GO:0007084 3 0.108
gonad development GO:0008406 34 0.106
sister chromatid segregation GO:0000819 54 0.105
cell part morphogenesis GO:0032990 137 0.098
vesicle mediated transport GO:0016192 371 0.098
single organism membrane organization GO:0044802 268 0.096
oocyte differentiation GO:0009994 2 0.093
atp dependent chromatin remodeling GO:0043044 25 0.093
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.092
multicellular organismal aging GO:0010259 3 0.090
cell projection morphogenesis GO:0048858 129 0.088
adult locomotory behavior GO:0008344 1 0.086
cellular macromolecular complex assembly GO:0034622 324 0.083
negative regulation of mitotic cell cycle GO:0045930 102 0.082
positive regulation of cell death GO:0010942 263 0.076
endocytosis GO:0006897 159 0.073
embryo development GO:0009790 123 0.070
Zebrafish
nuclear envelope reassembly GO:0031468 3 0.068
multi multicellular organism process GO:0044706 18 0.066
posttranscriptional regulation of gene expression GO:0010608 213 0.065
cell morphogenesis GO:0000902 296 0.062
nucleus organization GO:0006997 28 0.058
single organism reproductive process GO:0044702 98 0.058
organelle assembly GO:0070925 176 0.057
spindle organization GO:0007051 53 0.056
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.053
reproduction GO:0000003 63 0.051
digestive system development GO:0055123 75 0.051
tube morphogenesis GO:0035239 95 0.051
neuron development GO:0048666 113 0.050
positive regulation of developmental process GO:0051094 314 0.048
Mouse
segmentation GO:0035282 4 0.047
reproductive process GO:0022414 106 0.047
sensory organ development GO:0007423 52 0.047
negative regulation of chromatin silencing GO:0031936 4 0.046
oocyte development GO:0048599 1 0.046
microtubule nucleation GO:0007020 6 0.046
positive regulation of programmed cell death GO:0043068 249 0.045
axon development GO:0061564 34 0.045
cellular protein complex assembly GO:0043623 188 0.044
meiotic cell cycle GO:0051321 13 0.043
cell cycle checkpoint GO:0000075 117 0.042
regulation of cytoskeleton organization GO:0051493 177 0.042
pharynx development GO:0060465 1 0.041
male meiosis GO:0007140 1 0.040
negative regulation of microtubule polymerization or depolymerization GO:0031111 17 0.040
protein catabolic process GO:0030163 325 0.039
microtubule polymerization or depolymerization GO:0031109 37 0.039
macromolecular complex disassembly GO:0032984 60 0.038
mitotic sister chromatid segregation GO:0000070 53 0.038
development of primary sexual characteristics GO:0045137 35 0.038
mrna metabolic process GO:0016071 175 0.037
ribosome assembly GO:0042255 9 0.037
spermatid development GO:0007286 4 0.037
maintenance of location GO:0051235 112 0.036
digestive tract development GO:0048565 75 0.036
peptidyl lysine modification GO:0018205 144 0.036
Human Mouse
spermatid differentiation GO:0048515 4 0.035
response to oxidative stress GO:0006979 121 0.035
protein complex disassembly GO:0043241 52 0.035
regulation of protein complex assembly GO:0043254 147 0.035
regulation of mitotic cell cycle phase transition GO:1901990 118 0.034
cell cell signaling GO:0007267 155 0.033
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.033
regulation of growth GO:0040008 165 0.032
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.031
gene silencing GO:0016458 49 0.030
blastocyst development GO:0001824 3 0.030
multicellular organismal reproductive process GO:0048609 40 0.030
dna replication GO:0006260 116 0.030
negative regulation of cellular protein metabolic process GO:0032269 353 0.029
negative regulation of programmed cell death GO:0043069 321 0.029
protein localization to chromosome GO:0034502 30 0.029
regulation of gene expression epigenetic GO:0040029 73 0.029
negative regulation of cell cycle phase transition GO:1901988 89 0.028
neuron projection morphogenesis GO:0048812 50 0.028
striated muscle myosin thick filament assembly GO:0071688 2 0.028
positive regulation of cellular component biogenesis GO:0044089 158 0.028
mitotic spindle organization GO:0007052 27 0.028
myosin filament organization GO:0031033 2 0.028
positive regulation of cellular catabolic process GO:0031331 284 0.027
regionalization GO:0003002 29 0.027
purine nucleoside catabolic process GO:0006152 398 0.027
epithelium development GO:0060429 227 0.027
multicellular organism reproduction GO:0032504 42 0.027
head development GO:0060322 108 0.026
mitotic g1 dna damage checkpoint GO:0031571 17 0.026
negative regulation of intracellular signal transduction GO:1902532 183 0.026
establishment of organelle localization GO:0051656 59 0.026
regulation of cell development GO:0060284 161 0.026
embryo development ending in birth or egg hatching GO:0009792 34 0.026
Zebrafish
regulation of multi organism process GO:0043900 157 0.026
reproductive system development GO:0061458 56 0.026
digestive tract morphogenesis GO:0048546 56 0.025
meiotic nuclear division GO:0007126 10 0.025
positive regulation of organelle organization GO:0010638 195 0.025
regulation of cell differentiation GO:0045595 393 0.024
response to abiotic stimulus GO:0009628 336 0.024
multi organism behavior GO:0051705 14 0.024
sex differentiation GO:0007548 45 0.024
negative regulation of apoptotic process GO:0043066 316 0.024
cellular amino acid metabolic process GO:0006520 116 0.023
multi organism reproductive process GO:0044703 54 0.023
cell cycle arrest GO:0007050 71 0.023
rna interference GO:0016246 4 0.023
double strand break repair GO:0006302 101 0.023
Mouse
myosin filament assembly GO:0031034 2 0.023
brain development GO:0007420 97 0.022
response to fungus GO:0009620 4 0.022
regulation of cellular ketone metabolic process GO:0010565 50 0.022
regulation of neural precursor cell proliferation GO:2000177 4 0.022
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.021
negative regulation of developmental process GO:0051093 247 0.021
cell division GO:0051301 168 0.021
response to cytokine GO:0034097 232 0.021
mrna processing GO:0006397 133 0.020
chemical homeostasis GO:0048878 306 0.020
cellular ketone metabolic process GO:0042180 80 0.020
chromosome condensation GO:0030261 15 0.020
interspecies interaction between organisms GO:0044419 156 0.020
positive regulation of proteolysis GO:0045862 142 0.020
negative regulation of cell death GO:0060548 345 0.020
rna splicing GO:0008380 131 0.020
anterior posterior axis specification GO:0009948 2 0.020
nucleoside triphosphate catabolic process GO:0009143 394 0.019
amine metabolic process GO:0009308 44 0.019
response to oxygen containing compound GO:1901700 369 0.019
positive regulation of apoptotic process GO:0043065 246 0.019
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.019
intrinsic apoptotic signaling pathway GO:0097193 127 0.019
regulation of cell cycle g1 s phase transition GO:1902806 42 0.018
developmental process involved in reproduction GO:0003006 66 0.018
muscle cell differentiation GO:0042692 63 0.018
maintenance of protein location in cell GO:0032507 56 0.018
intracellular protein transport GO:0006886 270 0.018
negative regulation of organelle organization GO:0010639 126 0.018
purine nucleoside monophosphate catabolic process GO:0009128 158 0.018
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.018
regulation of mitosis GO:0007088 63 0.017
blood vessel development GO:0001568 172 0.017
positive regulation of mitotic cell cycle GO:0045931 60 0.017
attachment of mitotic spindle microtubules to kinetochore GO:0051315 3 0.017
response to reactive oxygen species GO:0000302 61 0.017
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.017
negative regulation of cytoskeleton organization GO:0051494 45 0.017
regulation of meiotic cell cycle GO:0051445 4 0.017
response to drug GO:0042493 81 0.017
cytoplasmic transport GO:0016482 379 0.016
nucleoside monophosphate catabolic process GO:0009125 159 0.016
nucleoside triphosphate metabolic process GO:0009141 422 0.016
peptidyl tyrosine phosphorylation GO:0018108 170 0.016
cellular response to endogenous stimulus GO:0071495 336 0.016
regulation of cellular amine metabolic process GO:0033238 11 0.016
centrosome cycle GO:0007098 32 0.016
striated muscle cell differentiation GO:0051146 43 0.016
regulation of proteolysis GO:0030162 293 0.016
chemotaxis GO:0006935 157 0.016
maintenance of location in cell GO:0051651 62 0.016
regulation of cellular component movement GO:0051270 334 0.016
regulation of multicellular organism growth GO:0040014 8 0.015
nuclear import GO:0051170 106 0.015
tissue morphogenesis GO:0048729 96 0.015
response to hypoxia GO:0001666 96 0.015
muscle organ development GO:0007517 56 0.015
regulation of establishment of protein localization GO:0070201 242 0.015
Mouse
cell cycle g1 s phase transition GO:0044843 80 0.015
regulation of reproductive process GO:2000241 15 0.015
growth GO:0040007 202 0.015
eye development GO:0001654 42 0.015
protein complex localization GO:0031503 31 0.014
regulation of neurogenesis GO:0050767 82 0.014
nuclear membrane organization GO:0071763 1 0.014
atp catabolic process GO:0006200 157 0.014
signal transduction by p53 class mediator GO:0072331 72 0.014
dna templated transcription initiation GO:0006352 35 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.014
branching morphogenesis of an epithelial tube GO:0048754 19 0.014
retina development in camera type eye GO:0060041 15 0.014
receptor mediated endocytosis GO:0006898 84 0.014
intracellular receptor signaling pathway GO:0030522 104 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.013
negative regulation of phosphorus metabolic process GO:0010563 267 0.013
genitalia development GO:0048806 10 0.013
actin filament based movement GO:0030048 17 0.013
mitotic cell cycle checkpoint GO:0007093 68 0.013
positive regulation of protein catabolic process GO:0045732 75 0.013
cofactor metabolic process GO:0051186 87 0.013
blood vessel morphogenesis GO:0048514 162 0.013
chromatin remodeling at centromere GO:0031055 2 0.013
ribonucleoside monophosphate catabolic process GO:0009158 158 0.013
negative regulation of gene expression epigenetic GO:0045814 19 0.013
enzyme linked receptor protein signaling pathway GO:0007167 303 0.013
regulation of homeostatic process GO:0032844 121 0.012
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.012
purine nucleoside triphosphate metabolic process GO:0009144 412 0.012
histone exchange GO:0043486 3 0.012
nucleoside catabolic process GO:0009164 408 0.012
embryonic placenta development GO:0001892 1 0.012
negative regulation of protein metabolic process GO:0051248 391 0.012
establishment or maintenance of cell polarity GO:0007163 31 0.012
modification dependent protein catabolic process GO:0019941 209 0.012
anterior posterior axis specification embryo GO:0008595 2 0.012
regulation of small gtpase mediated signal transduction GO:0051056 156 0.012
sexual reproduction GO:0019953 37 0.012
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.011
muscle structure development GO:0061061 98 0.011
microtubule cytoskeleton organization involved in mitosis GO:1902850 15 0.011
camera type eye development GO:0043010 25 0.011
cell fate commitment GO:0045165 27 0.011
protein ubiquitination GO:0016567 314 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.011
regulation of ras protein signal transduction GO:0046578 155 0.011
neuromuscular junction development GO:0007528 3 0.011
organelle localization GO:0051640 84 0.011
neural crest cell development GO:0014032 3 0.011
mitotic spindle stabilization GO:0043148 2 0.011
positive regulation of protein transport GO:0051222 135 0.011
protein import GO:0017038 130 0.011
organonitrogen compound biosynthetic process GO:1901566 200 0.011
protein dephosphorylation GO:0006470 81 0.011
epithelial cell differentiation GO:0030855 141 0.011
cellular protein complex disassembly GO:0043624 36 0.011
negative regulation of protein complex disassembly GO:0043242 20 0.011
nitrogen compound transport GO:0071705 191 0.011
positive regulation of transferase activity GO:0051347 227 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.011
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.011
molting cycle GO:0042303 28 0.011
regulation of apoptotic signaling pathway GO:2001233 175 0.011
response to decreased oxygen levels GO:0036293 96 0.011
ras protein signal transduction GO:0007265 73 0.011
adult behavior GO:0030534 18 0.010
positive regulation of cellular amine metabolic process GO:0033240 7 0.010
mitotic chromosome condensation GO:0007076 11 0.010
atp metabolic process GO:0046034 176 0.010
nucleocytoplasmic transport GO:0006913 176 0.010
positive regulation of growth GO:0045927 58 0.010
cell aging GO:0007569 52 0.010

WHSC1 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.068
Human
disease of cellular proliferation DOID:14566 174 0.068
Human
organ system cancer DOID:0050686 164 0.034
Human
central nervous system disease DOID:331 186 0.021
neurodegenerative disease DOID:1289 102 0.021
nervous system disease DOID:863 431 0.021
musculoskeletal system disease DOID:17 223 0.021