Homo sapiens

182 known processes

WRN

Werner syndrome, RecQ helicase-like

(Aliases: DKFZp686C2056,RECQ3,RECQL3,RECQL2)

WRN biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 379 0.998
double strand break repair via single strand annealing GO:0045002 4 0.995
telomere maintenance GO:0000723 32 0.991
anatomical structure homeostasis GO:0060249 100 0.991
double strand break repair GO:0006302 101 0.986
telomere organization GO:0032200 33 0.985
dna repair GO:0006281 198 0.957
dna biosynthetic process GO:0071897 40 0.954
telomere maintenance via recombination GO:0000722 4 0.938
dna replication GO:0006260 116 0.907
dna conformation change GO:0071103 113 0.890
positive regulation of dna metabolic process GO:0051054 73 0.887
dna recombination GO:0006310 77 0.873
recombinational repair GO:0000725 50 0.864
non recombinational repair GO:0000726 14 0.861
base excision repair GO:0006284 21 0.847
double strand break repair via homologous recombination GO:0000724 50 0.840
mitotic recombination GO:0006312 8 0.817
covalent chromatin modification GO:0016569 254 0.771
cellular response to endogenous stimulus GO:0071495 336 0.759
mitotic cell cycle phase transition GO:0044772 162 0.728
regulation of dna metabolic process GO:0051052 153 0.691
negative regulation of dna metabolic process GO:0051053 57 0.676
regulation of response to dna damage stimulus GO:2001020 94 0.669
chromatin organization GO:0006325 351 0.637
meiosis i GO:0007127 4 0.627
histone acetylation GO:0016573 93 0.623
histone modification GO:0016570 251 0.615
cellular response to organonitrogen compound GO:0071417 124 0.612
response to uv GO:0009411 73 0.608
response to organonitrogen compound GO:0010243 156 0.607
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.605
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.599
reciprocal meiotic recombination GO:0007131 4 0.565
microtubule based process GO:0007017 210 0.553
response to abiotic stimulus GO:0009628 336 0.542
peptidyl lysine acetylation GO:0018394 101 0.523
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.519
negative regulation of cell cycle process GO:0010948 121 0.498
chromatin modification GO:0016568 298 0.496
purine ribonucleoside catabolic process GO:0046130 398 0.494
cell cycle checkpoint GO:0000075 117 0.493
protein dna complex assembly GO:0065004 64 0.487
response to oxygen containing compound GO:1901700 369 0.485
signal transduction in response to dna damage GO:0042770 57 0.484
regulation of cell cycle GO:0051726 393 0.471
purine nucleoside triphosphate catabolic process GO:0009146 392 0.455
regulation of cellular response to stress GO:0080135 244 0.442
hemopoiesis GO:0030097 180 0.442
ribonucleoside triphosphate metabolic process GO:0009199 412 0.440
cellular response to nitrogen compound GO:1901699 144 0.439
cell aging GO:0007569 52 0.438
dna double strand break processing GO:0000729 10 0.435
glycosyl compound catabolic process GO:1901658 413 0.434
regulation of double strand break repair via homologous recombination GO:0010569 11 0.427
positive regulation of immune system process GO:0002684 283 0.420
telomere maintenance via telomere lengthening GO:0010833 9 0.418
negative regulation of cell death GO:0060548 345 0.412
mitotic dna integrity checkpoint GO:0044774 30 0.404
response to peptide GO:1901652 65 0.387
telomere capping GO:0016233 5 0.385
intracellular protein transport GO:0006886 270 0.377
reciprocal dna recombination GO:0035825 4 0.377
g2 dna damage checkpoint GO:0031572 26 0.366
regulation of mitotic cell cycle GO:0007346 189 0.362
regulation of double strand break repair GO:2000779 22 0.355
nucleotide excision repair GO:0006289 31 0.346
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.346
cellular response to radiation GO:0071478 65 0.340
dna catabolic process GO:0006308 49 0.332
positive regulation of transport GO:0051050 336 0.327
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.327
single organism cellular localization GO:1902580 332 0.324
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.312
telomere maintenance via telomerase GO:0007004 8 0.311
nucleoside catabolic process GO:0009164 408 0.303
circulatory system development GO:0072359 262 0.301
nucleotide catabolic process GO:0009166 408 0.300
purine ribonucleotide catabolic process GO:0009154 404 0.298
ribonucleoside catabolic process GO:0042454 406 0.292
mitotic cell cycle checkpoint GO:0007093 68 0.289
nucleoside phosphate catabolic process GO:1901292 412 0.287
internal protein amino acid acetylation GO:0006475 101 0.286
purine containing compound catabolic process GO:0072523 411 0.286
cellular response to insulin stimulus GO:0032869 41 0.278
negative regulation of catalytic activity GO:0043086 335 0.278
organelle fission GO:0048285 149 0.275
regulation of cell cycle process GO:0010564 266 0.266
double strand break repair via nonhomologous end joining GO:0006303 10 0.266
atp metabolic process GO:0046034 176 0.255
signal transduction by p53 class mediator GO:0072331 72 0.251
positive regulation of programmed cell death GO:0043068 249 0.251
immune system development GO:0002520 195 0.250
single strand break repair GO:0000012 6 0.249
vasculature development GO:0001944 181 0.245
viral process GO:0016032 146 0.245
purine nucleoside triphosphate metabolic process GO:0009144 412 0.242
negative regulation of telomere maintenance GO:0032205 9 0.241
internal peptidyl lysine acetylation GO:0018393 97 0.239
negative regulation of cell cycle GO:0045786 193 0.233
regulation of dna repair GO:0006282 47 0.229
protein homooligomerization GO:0051260 100 0.228
determination of adult lifespan GO:0008340 2 0.226
Worm
cellular response to peptide hormone stimulus GO:0071375 56 0.226
cell cycle phase transition GO:0044770 173 0.223
protein acetylation GO:0006473 116 0.216
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.211
regulation of lymphocyte activation GO:0051249 103 0.208
cellular response to ionizing radiation GO:0071479 32 0.208
enzyme linked receptor protein signaling pathway GO:0007167 303 0.207
dna integrity checkpoint GO:0031570 71 0.204
cellular response to oxygen containing compound GO:1901701 276 0.202
histone h3 acetylation GO:0043966 45 0.200
dna packaging GO:0006323 77 0.198
response to nitrogen compound GO:1901698 184 0.197
nuclear division GO:0000280 128 0.188
rna processing GO:0006396 255 0.187
carbohydrate metabolic process GO:0005975 207 0.187
positive regulation of protein transport GO:0051222 135 0.184
cellular component morphogenesis GO:0032989 314 0.184
dna damage checkpoint GO:0000077 68 0.181
single organism carbohydrate metabolic process GO:0044723 193 0.180
mitotic nuclear division GO:0007067 119 0.178
response to light stimulus GO:0009416 87 0.175
regulation of chromosome organization GO:0033044 103 0.174
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.174
protein dna complex subunit organization GO:0071824 80 0.172
response to radiation GO:0009314 151 0.168
dna dependent dna replication GO:0006261 44 0.166
histone phosphorylation GO:0016572 16 0.165
response to peptide hormone GO:0043434 61 0.163
cellular response to hormone stimulus GO:0032870 125 0.161
negative regulation of protein maturation GO:1903318 142 0.160
protein autoprocessing GO:0016540 4 0.158
regulation of proteolysis GO:0030162 293 0.157
positive regulation of response to dna damage stimulus GO:2001022 43 0.152
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.151
regulation of growth rate GO:0040009 1 0.151
Mouse
positive regulation of telomere maintenance GO:0032206 4 0.150
protein localization to organelle GO:0033365 280 0.146
negative regulation of cell cycle phase transition GO:1901988 89 0.146
cardiovascular system development GO:0072358 262 0.145
purine nucleoside monophosphate catabolic process GO:0009128 158 0.143
nucleoside triphosphate catabolic process GO:0009143 394 0.142
regulation of lymphocyte proliferation GO:0050670 64 0.141
establishment of protein localization to organelle GO:0072594 172 0.141
microtubule cytoskeleton organization GO:0000226 176 0.138
response to hormone GO:0009725 175 0.136
regulation of transcription by chromatin organization GO:0034401 1 0.135
protein localization to chromosome telomeric region GO:0070198 6 0.134
actin filament based process GO:0030029 224 0.133
response to alkaloid GO:0043279 20 0.132
dna ligation GO:0006266 10 0.132
ribonucleoside monophosphate catabolic process GO:0009158 158 0.131
positive regulation of catabolic process GO:0009896 310 0.131
negative regulation of organelle organization GO:0010639 126 0.128
response to external biotic stimulus GO:0043207 261 0.126
regulation of cell cycle phase transition GO:1901987 126 0.126
cellular response to growth factor stimulus GO:0071363 197 0.126
nucleoside monophosphate catabolic process GO:0009125 159 0.126
negative regulation of apoptotic process GO:0043066 316 0.125
negative regulation of phosphorus metabolic process GO:0010563 267 0.123
macromolecule glycosylation GO:0043413 63 0.123
postreplication repair GO:0006301 12 0.122
regulation of homeostatic process GO:0032844 121 0.122
histone h4 acetylation GO:0043967 47 0.121
leukocyte activation GO:0045321 164 0.121
positive regulation of cellular amine metabolic process GO:0033240 7 0.120
positive regulation of immune response GO:0050778 159 0.119
cell morphogenesis GO:0000902 296 0.116
negative regulation of mitotic cell cycle GO:0045930 102 0.115
purine nucleoside catabolic process GO:0006152 398 0.112
regulation of transferase activity GO:0051338 355 0.111
negative regulation of cellular protein metabolic process GO:0032269 353 0.110
regulation of dna replication GO:0006275 68 0.110
regulation of cellular amine metabolic process GO:0033238 11 0.109
organophosphate catabolic process GO:0046434 430 0.107
regulation of mitotic cell cycle phase transition GO:1901990 118 0.106
regulation of cellular ketone metabolic process GO:0010565 50 0.103
regulation of protein complex assembly GO:0043254 147 0.103
negative regulation of programmed cell death GO:0043069 321 0.102
cellular macromolecule catabolic process GO:0044265 380 0.100
response to bacterium GO:0009617 144 0.099
chromatin assembly or disassembly GO:0006333 78 0.099
response to caffeine GO:0031000 3 0.097
mitochondrion organization GO:0007005 156 0.097
positive regulation of developmental process GO:0051094 314 0.097
Worm
protein adp ribosylation GO:0006471 9 0.096
positive regulation of transcription regulatory region dna binding GO:2000679 8 0.096
nucleoside triphosphate metabolic process GO:0009141 422 0.095
dna duplex unwinding GO:0032508 30 0.095
regulation of response to external stimulus GO:0032101 222 0.093
mitotic cell cycle process GO:1903047 286 0.093
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.093
replicative cell aging GO:0001302 3 0.092
Mouse
cytoplasmic transport GO:0016482 379 0.092
mitotic cell cycle GO:0000278 326 0.091
chromosome segregation GO:0007059 114 0.091
protein glycosylation GO:0006486 62 0.091
positive regulation of apoptotic process GO:0043065 246 0.090
cellular ketone metabolic process GO:0042180 80 0.090
dna damage response detection of dna damage GO:0042769 3 0.089
thymocyte apoptotic process GO:0070242 2 0.089
regulation of cell motility GO:2000145 299 0.088
aging GO:0007568 66 0.087
positive regulation of dna replication GO:0045740 35 0.087
transmembrane transport GO:0055085 399 0.086
cellular macromolecular complex assembly GO:0034622 324 0.086
apoptotic signaling pathway GO:0097190 268 0.081
cellular amino acid metabolic process GO:0006520 116 0.081
negative regulation of telomere maintenance via telomerase GO:0032211 5 0.080
response to insulin GO:0032868 45 0.080
hematopoietic or lymphoid organ development GO:0048534 186 0.079
positive regulation of chromosome organization GO:2001252 41 0.078
negative regulation of hydrolase activity GO:0051346 182 0.078
nervous system development GO:0007399 293 0.077
lymphocyte activation GO:0046649 133 0.077
positive regulation of leukocyte activation GO:0002696 80 0.076
response to wounding GO:0009611 168 0.076
hematopoietic stem cell differentiation GO:0060218 4 0.075
negative regulation of dna replication GO:0008156 29 0.075
cell activation GO:0001775 213 0.074
regulation of leukocyte activation GO:0002694 115 0.074
response to gamma radiation GO:0010332 14 0.074
generation of precursor metabolites and energy GO:0006091 68 0.073
protein catabolic process GO:0030163 325 0.072
response to inorganic substance GO:0010035 127 0.072
mitotic dna damage checkpoint GO:0044773 28 0.071
response to other organism GO:0051707 261 0.071
regulation of protein localization GO:0032880 296 0.070
blood vessel morphogenesis GO:0048514 162 0.069
regulation of dna recombination GO:0000018 23 0.069
regulation of histone modification GO:0031056 47 0.069
peptidyl serine modification GO:0018209 106 0.068
regulation of intracellular transport GO:0032386 195 0.067
protein acylation GO:0043543 138 0.066
purine nucleotide catabolic process GO:0006195 405 0.065
amine metabolic process GO:0009308 44 0.065
ribonucleoside triphosphate catabolic process GO:0009203 391 0.064
protein oligomerization GO:0051259 173 0.064
growth GO:0040007 202 0.064
Mouse Worm
leukocyte differentiation GO:0002521 98 0.064
positive regulation of homeostatic process GO:0032846 47 0.063
chromosome condensation GO:0030261 15 0.063
negative regulation of protein metabolic process GO:0051248 391 0.063
glycosylation GO:0070085 71 0.063
proteasomal protein catabolic process GO:0010498 176 0.062
g2 m transition of mitotic cell cycle GO:0000086 41 0.062
regulation of cellular component movement GO:0051270 334 0.061
cellular response to oxidative stress GO:0034599 85 0.061
rna dependent dna replication GO:0006278 16 0.060
tissue homeostasis GO:0001894 63 0.059
negative regulation of t cell apoptotic process GO:0070233 4 0.059
negative regulation of cell proliferation GO:0008285 228 0.059
cellular response to peptide GO:1901653 59 0.058
regulation of vasculature development GO:1901342 97 0.058
positive regulation of binding GO:0051099 45 0.058
regulation of secretion by cell GO:1903530 177 0.057
positive regulation of secretion by cell GO:1903532 108 0.056
chemical homeostasis GO:0048878 306 0.056
positive regulation of intracellular protein transport GO:0090316 76 0.056
cellular homeostasis GO:0019725 196 0.054
viral life cycle GO:0019058 132 0.054
regulation of secretion GO:0051046 194 0.054
lipid biosynthetic process GO:0008610 177 0.054
regulation of cellular amino acid metabolic process GO:0006521 6 0.054
dna catabolic process exonucleolytic GO:0000738 17 0.053
positive regulation of cell death GO:0010942 263 0.053
response to growth factor GO:0070848 205 0.053
mitotic sister chromatid segregation GO:0000070 53 0.053
multi organism cellular process GO:0044764 156 0.053
regulation of carbohydrate metabolic process GO:0006109 54 0.052
peptidyl lysine modification GO:0018205 144 0.052
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.051
negative regulation of multicellular organismal process GO:0051241 317 0.051
positive regulation of feeding behavior GO:2000253 1 0.051
nucleocytoplasmic transport GO:0006913 176 0.051
regulation of cellular component biogenesis GO:0044087 281 0.050
response to nutrient levels GO:0031667 81 0.049
positive regulation of cellular catabolic process GO:0031331 284 0.049
regulation of chromatin organization GO:1902275 56 0.049
protein targeting GO:0006605 187 0.049
response to biotic stimulus GO:0009607 276 0.049
methylation GO:0032259 106 0.048
oxidation reduction process GO:0055114 396 0.048
cellular amine metabolic process GO:0044106 41 0.048
regulation of angiogenesis GO:0045765 92 0.047
cell cycle arrest GO:0007050 71 0.047
response to oxidative stress GO:0006979 121 0.047
lipid metabolic process GO:0006629 381 0.047
regulation of nucleoside metabolic process GO:0009118 209 0.047
response to ionizing radiation GO:0010212 65 0.046
glycoprotein metabolic process GO:0009100 110 0.045
atp catabolic process GO:0006200 157 0.045
cell projection organization GO:0030030 252 0.044
positive regulation of ras gtpase activity GO:0032320 117 0.044
regulation of protein serine threonine kinase activity GO:0071900 179 0.043
carbohydrate derivative biosynthetic process GO:1901137 207 0.043
intrinsic apoptotic signaling pathway GO:0097193 127 0.042
stem cell differentiation GO:0048863 93 0.042
tissue regeneration GO:0042246 3 0.042
positive regulation of gtpase activity GO:0043547 166 0.041
negative regulation of cell differentiation GO:0045596 171 0.041
purine ribonucleotide biosynthetic process GO:0009152 79 0.041
defense response to bacterium GO:0042742 63 0.040
t cell activation GO:0042110 99 0.040
positive regulation of myeloid cell apoptotic process GO:0033034 2 0.040
response to organic cyclic compound GO:0014070 204 0.039
histone h2a phosphorylation GO:1990164 3 0.039
blood vessel development GO:0001568 172 0.039
negative regulation of chromosome organization GO:2001251 48 0.039
leukocyte apoptotic process GO:0071887 31 0.039
regulation of binding GO:0051098 111 0.039
glycoprotein biosynthetic process GO:0009101 91 0.039
negative regulation of response to dna damage stimulus GO:2001021 33 0.039
cellular response to reactive oxygen species GO:0034614 50 0.039
negative regulation of phosphorylation GO:0042326 174 0.039
mismatch repair GO:0006298 15 0.038
dna synthesis involved in dna repair GO:0000731 6 0.038
regulation of kinase activity GO:0043549 314 0.038
modification dependent protein catabolic process GO:0019941 209 0.038
regulation of immune response GO:0050776 201 0.037
response to transforming growth factor beta GO:0071559 94 0.037
rna interference GO:0016246 4 0.037
lymphocyte proliferation GO:0046651 70 0.037
protein maturation GO:0051604 233 0.037
regulation of feeding behavior GO:0060259 3 0.036
cell part morphogenesis GO:0032990 137 0.036
multicellular organismal homeostasis GO:0048871 67 0.036
mrna processing GO:0006397 133 0.036
secretion by cell GO:0032940 226 0.035
neuron death GO:0070997 65 0.035
cellular response to organic cyclic compound GO:0071407 127 0.035
cellular response to light stimulus GO:0071482 34 0.035
positive regulation of cellular component organization GO:0051130 376 0.035
negative regulation of transferase activity GO:0051348 124 0.035
positive regulation of lymphocyte activation GO:0051251 73 0.034
positive regulation of protein complex assembly GO:0031334 86 0.034
nuclear import GO:0051170 106 0.034
secretion GO:0046903 254 0.034
defense response to other organism GO:0098542 129 0.034
female gamete generation GO:0007292 2 0.033
negative regulation of cell division GO:0051782 31 0.033
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.033
negative regulation of proteolysis GO:0045861 132 0.033
regulation of establishment of protein localization GO:0070201 242 0.033
guanosine containing compound catabolic process GO:1901069 239 0.032
cytokine production GO:0001816 247 0.032
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.032
regulation of viral process GO:0050792 103 0.032
ubiquitin dependent protein catabolic process GO:0006511 206 0.032
cell growth GO:0016049 160 0.032
protein import GO:0017038 130 0.032
regulation of t cell activation GO:0050863 77 0.031
histone h3 k9 modification GO:0061647 11 0.031
meiotic cell cycle GO:0051321 13 0.031
intracellular receptor signaling pathway GO:0030522 104 0.031
regulation of growth GO:0040008 165 0.031
Mouse Worm
positive regulation of intracellular transport GO:0032388 104 0.031
negative regulation of phosphate metabolic process GO:0045936 267 0.031
purine nucleoside monophosphate metabolic process GO:0009126 186 0.031
regulation of viral genome replication GO:0045069 48 0.030
positive regulation of cell activation GO:0050867 81 0.030
cellular senescence GO:0090398 34 0.030
ribonucleotide catabolic process GO:0009261 405 0.029
hexose metabolic process GO:0019318 55 0.029
replication fork processing GO:0031297 13 0.029
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.029
cellular response to extracellular stimulus GO:0031668 72 0.029
anatomical structure formation involved in morphogenesis GO:0048646 284 0.028
striated muscle contraction GO:0006941 52 0.028
protein poly adp ribosylation GO:0070212 3 0.027
regulation of protein localization to nucleus GO:1900180 85 0.027
organonitrogen compound biosynthetic process GO:1901566 200 0.027
lipid localization GO:0010876 106 0.027
cellular response to abiotic stimulus GO:0071214 117 0.027
positive regulation of phosphorylation GO:0042327 394 0.027
protein autophosphorylation GO:0046777 123 0.027
dna geometric change GO:0032392 32 0.026
dna damage induced protein phosphorylation GO:0006975 5 0.026
negative regulation of intracellular signal transduction GO:1902532 183 0.026
positive regulation of cell proliferation GO:0008284 301 0.026
protein processing GO:0016485 226 0.026
interspecies interaction between organisms GO:0044419 156 0.025
regulation of anatomical structure morphogenesis GO:0022603 286 0.025
activin receptor signaling pathway GO:0032924 24 0.025
regulation of mononuclear cell proliferation GO:0032944 65 0.025
regulation of glucose metabolic process GO:0010906 28 0.025
regulation of protein maturation GO:1903317 150 0.025
regulation of gtp catabolic process GO:0033124 180 0.025
protein modification by small protein removal GO:0070646 92 0.025
positive regulation of mapk cascade GO:0043410 190 0.024
system process GO:0003008 349 0.024
ribonucleoside monophosphate metabolic process GO:0009161 187 0.024
regulation of protein processing GO:0070613 150 0.024
regulation of cytoskeleton organization GO:0051493 177 0.024
regulation of leukocyte apoptotic process GO:2000106 25 0.024
maintenance of location GO:0051235 112 0.024
rna localization GO:0006403 41 0.023
positive regulation of organelle organization GO:0010638 195 0.023
positive regulation of transferase activity GO:0051347 227 0.023
cation homeostasis GO:0055080 189 0.023
regulation of cytokine production GO:0001817 232 0.023
mitotic g2 dna damage checkpoint GO:0007095 7 0.023
negative regulation of double strand break repair GO:2000780 7 0.023
regulation of protein targeting GO:1903533 91 0.023
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.023
negative regulation of thymocyte apoptotic process GO:0070244 1 0.022
membrane organization GO:0061024 292 0.022
protein targeting to nucleus GO:0044744 104 0.022
regulation of cellular response to growth factor stimulus GO:0090287 76 0.022
establishment of organelle localization GO:0051656 59 0.022
muscle contraction GO:0006936 73 0.022
immune response GO:0006955 307 0.022
cellular response to external stimulus GO:0071496 111 0.022
negative regulation of vasculature development GO:1901343 43 0.021
cellular response to uv GO:0034644 32 0.021
monosaccharide metabolic process GO:0005996 74 0.021
dna strand elongation involved in dna replication GO:0006271 3 0.021
ion transmembrane transport GO:0034220 338 0.021
response to purine containing compound GO:0014074 40 0.021
n terminal protein amino acid modification GO:0031365 13 0.021
protein import into nucleus GO:0006606 104 0.021
positive regulation of cellular component biogenesis GO:0044089 158 0.021
negative regulation of endopeptidase activity GO:0010951 84 0.021
regulation of hormone levels GO:0010817 125 0.020
angiogenesis GO:0001525 147 0.020
cellular carbohydrate metabolic process GO:0044262 84 0.020
gtp catabolic process GO:0006184 237 0.020
signal transduction involved in regulation of gene expression GO:0023019 1 0.020
endomembrane system organization GO:0010256 196 0.020
regulation of stress activated mapk cascade GO:0032872 84 0.020
chromatin silencing at rdna GO:0000183 5 0.020
regulation of telomere maintenance via telomerase GO:0032210 6 0.019
regulation of purine nucleotide catabolic process GO:0033121 205 0.019
regulation of telomere maintenance GO:0032204 13 0.019
cell cycle g2 m phase transition GO:0044839 43 0.019
regulation of intracellular protein transport GO:0033157 123 0.019
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.019
positive regulation of cell cycle GO:0045787 140 0.019
regulation of leukocyte proliferation GO:0070663 67 0.019
extrinsic apoptotic signaling pathway GO:0097191 119 0.019
regulation of chromatin modification GO:1903308 51 0.019
positive regulation of leukocyte proliferation GO:0070665 48 0.018
regulation of cell growth GO:0001558 135 0.018
regulation of cell activation GO:0050865 125 0.018
regulation of gene expression epigenetic GO:0040029 73 0.018
gtp metabolic process GO:0046039 239 0.018
meiotic cell cycle process GO:1903046 8 0.018
regulation of nervous system development GO:0051960 88 0.018
regulation of actin filament based process GO:0032970 141 0.018
chromatin remodeling at centromere GO:0031055 2 0.018
immune effector process GO:0002252 159 0.018
rho protein signal transduction GO:0007266 26 0.017
macromolecule methylation GO:0043414 97 0.017
gene silencing GO:0016458 49 0.017
actin cytoskeleton organization GO:0030036 207 0.017
dna catabolic process endonucleolytic GO:0000737 37 0.017
positive regulation of secretion GO:0051047 116 0.017
posttranscriptional regulation of gene expression GO:0010608 213 0.017
defense response GO:0006952 315 0.017
regulation of lymphocyte apoptotic process GO:0070228 15 0.017
negative regulation of immune system process GO:0002683 136 0.017
ameboidal type cell migration GO:0001667 135 0.017
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.017
guanosine containing compound metabolic process GO:1901068 244 0.017
regulation of protein transport GO:0051223 213 0.017
positive regulation of cytoplasmic transport GO:1903651 82 0.017
negative regulation of apoptotic signaling pathway GO:2001234 97 0.016
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.016
response to hyperoxia GO:0055093 4 0.016
negative regulation of cell growth GO:0030308 83 0.016
regulation of b cell activation GO:0050864 24 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.016
regulation of protein import into nucleus GO:0042306 78 0.016
oocyte development GO:0048599 1 0.016
response to extracellular stimulus GO:0009991 85 0.016
regulation of nucleocytoplasmic transport GO:0046822 98 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.016
regulation of multi organism process GO:0043900 157 0.016
regulation of cell differentiation GO:0045595 393 0.016
cellular protein catabolic process GO:0044257 261 0.016
defense response to gram negative bacterium GO:0050829 14 0.016

WRN disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.865
cancer DOID:162 167 0.350
organ system cancer DOID:0050686 164 0.350
endocrine gland cancer DOID:170 26 0.110
breast cancer DOID:1612 21 0.044
thoracic cancer DOID:5093 21 0.044
disease of metabolism DOID:0014667 295 0.040
nervous system disease DOID:863 431 0.036
neuropathy DOID:870 52 0.036
gastrointestinal system cancer DOID:3119 52 0.016