Homo sapiens

38 known processes

XPO1

exportin 1 (CRM1 homolog, yeast)

(Aliases: DKFZp686B1823,CRM1,emb)

XPO1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
microtubule cytoskeleton organization GO:0000226 176 0.869
Mouse Fly
post embryonic development GO:0009791 2 0.770
Worm
nucleocytoplasmic transport GO:0006913 176 0.540
embryo development GO:0009790 123 0.516
Worm
response to oxygen containing compound GO:1901700 369 0.506
mitotic cell cycle GO:0000278 326 0.495
nuclear export GO:0051168 69 0.478
female gamete generation GO:0007292 2 0.475
microtubule based process GO:0007017 210 0.462
Mouse Fly
regulation of cell cycle GO:0051726 393 0.457
Mouse
chromatin modification GO:0016568 298 0.413
cytoplasmic transport GO:0016482 379 0.402
cellular response to oxygen containing compound GO:1901701 276 0.376
response to nitrogen compound GO:1901698 184 0.376
single organism cellular localization GO:1902580 332 0.336
positive regulation of cellular component organization GO:0051130 376 0.319
cellular response to nitrogen compound GO:1901699 144 0.313
establishment of protein localization to organelle GO:0072594 172 0.304
regulation of microtubule cytoskeleton organization GO:0070507 61 0.293
Mouse
protein import into nucleus GO:0006606 104 0.285
nuclear transport GO:0051169 179 0.280
mitotic spindle organization GO:0007052 27 0.279
protein targeting to nucleus GO:0044744 104 0.266
rna transport GO:0050658 39 0.264
Yeast
regulation of cytoskeleton organization GO:0051493 177 0.261
Mouse
response to hormone GO:0009725 175 0.247
posttranscriptional regulation of gene expression GO:0010608 213 0.242
regulation of mitotic cell cycle GO:0007346 189 0.236
protein localization to organelle GO:0033365 280 0.229
Yeast Mouse
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.218
cellular macromolecular complex assembly GO:0034622 324 0.214
protein export from nucleus GO:0006611 29 0.213
centrosome organization GO:0051297 58 0.209
Mouse Fly
cellular response to dna damage stimulus GO:0006974 379 0.206
regulation of microtubule based process GO:0032886 74 0.197
Mouse
single organism nuclear import GO:1902593 104 0.192
ribonucleoside monophosphate metabolic process GO:0009161 187 0.189
mitotic nuclear division GO:0007067 119 0.189
cellular response to endogenous stimulus GO:0071495 336 0.182
protein targeting GO:0006605 187 0.181
organelle fission GO:0048285 149 0.180
nuclear import GO:0051170 106 0.179
protein complex disassembly GO:0043241 52 0.179
positive regulation of cellular amine metabolic process GO:0033240 7 0.177
response to biotic stimulus GO:0009607 276 0.174
intracellular protein transport GO:0006886 270 0.168
protein localization to nucleus GO:0034504 136 0.166
Mouse
rna processing GO:0006396 255 0.166
amine metabolic process GO:0009308 44 0.164
mitotic cell cycle process GO:1903047 286 0.163
nuclear division GO:0000280 128 0.163
vesicle mediated transport GO:0016192 371 0.161
positive regulation of organelle organization GO:0010638 195 0.157
negative regulation of cellular protein metabolic process GO:0032269 353 0.150
positive regulation of transport GO:0051050 336 0.148
response to abiotic stimulus GO:0009628 336 0.147
Fly
oogenesis GO:0048477 2 0.139
negative regulation of cellular component organization GO:0051129 235 0.139
regulation of cell cycle process GO:0010564 266 0.138
Mouse
spindle organization GO:0007051 53 0.138
nervous system development GO:0007399 293 0.136
negative regulation of cell death GO:0060548 345 0.134
mitotic dna replication checkpoint GO:0033314 2 0.132
rna interference GO:0016246 4 0.130
cellular component morphogenesis GO:0032989 314 0.126
response to organic cyclic compound GO:0014070 204 0.126
regulation of cellular amine metabolic process GO:0033238 11 0.125
regulation of peptidase activity GO:0052547 180 0.124
nls bearing protein import into nucleus GO:0006607 2 0.124
determination of adult lifespan GO:0008340 2 0.120
protein import GO:0017038 130 0.118
negative regulation of organelle organization GO:0010639 126 0.115
establishment of rna localization GO:0051236 39 0.114
Yeast
negative regulation of protein metabolic process GO:0051248 391 0.114
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.113
negative regulation of phosphate metabolic process GO:0045936 267 0.112
nucleobase containing compound transport GO:0015931 51 0.112
Yeast
response to other organism GO:0051707 261 0.112
negative regulation of apoptotic process GO:0043066 316 0.110
atp catabolic process GO:0006200 157 0.110
cellular amine metabolic process GO:0044106 41 0.108
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.107
spermatid development GO:0007286 4 0.105
cellular protein complex assembly GO:0043623 188 0.105
purine nucleoside monophosphate catabolic process GO:0009128 158 0.104
cellular amino acid metabolic process GO:0006520 116 0.103
regulation of proteolysis GO:0030162 293 0.100
cell cycle checkpoint GO:0000075 117 0.100
rna splicing via transesterification reactions GO:0000375 90 0.098
negative regulation of phosphorus metabolic process GO:0010563 267 0.096
nitrogen compound transport GO:0071705 191 0.096
Yeast
regulation of nuclear division GO:0051783 65 0.095
mrna splicing via spliceosome GO:0000398 89 0.094
covalent chromatin modification GO:0016569 254 0.094
chromatin organization GO:0006325 351 0.093
negative regulation of microtubule polymerization or depolymerization GO:0031111 17 0.091
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.091
posttranscriptional gene silencing GO:0016441 25 0.086
regulation of cytoplasmic transport GO:1903649 149 0.084
Mouse
microtubule polymerization or depolymerization GO:0031109 37 0.083
nucleus organization GO:0006997 28 0.082
regulation of protein targeting GO:1903533 91 0.082
negative regulation of kinase activity GO:0033673 106 0.082
macromolecule methylation GO:0043414 97 0.080
gene silencing GO:0016458 49 0.080
regulation of mitosis GO:0007088 63 0.079
macromolecular complex disassembly GO:0032984 60 0.078
negative regulation of cell cycle phase transition GO:1901988 89 0.077
negative regulation of cell differentiation GO:0045596 171 0.077
regulation of endopeptidase activity GO:0052548 170 0.075
regulation of gene expression epigenetic GO:0040029 73 0.073
negative regulation of catalytic activity GO:0043086 335 0.072
regulation of cell differentiation GO:0045595 393 0.072
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.071
Rat
spermatid differentiation GO:0048515 4 0.071
regulation of protein localization to nucleus GO:1900180 85 0.071
regulation of cellular amino acid metabolic process GO:0006521 6 0.069
cell morphogenesis GO:0000902 296 0.069
chemotaxis GO:0006935 157 0.067
protein depolymerization GO:0051261 30 0.066
regulation of cell division GO:0051302 116 0.064
dna repair GO:0006281 198 0.063
receptor mediated endocytosis GO:0006898 84 0.063
cellular component disassembly GO:0022411 92 0.063
regulation of viral genome replication GO:0045069 48 0.062
cellular ketone metabolic process GO:0042180 80 0.062
negative regulation of programmed cell death GO:0043069 321 0.061
negative regulation of transport GO:0051051 176 0.059
regulation of protein import into nucleus GO:0042306 78 0.059
positive regulation of hydrolase activity GO:0051345 331 0.059
regulation of protein localization GO:0032880 296 0.059
Mouse
neurogenesis GO:0022008 169 0.059
activation of cysteine type endopeptidase activity GO:0097202 57 0.058
cellular response to hormone stimulus GO:0032870 125 0.058
protein maturation GO:0051604 233 0.058
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.058
positive regulation of protein transport GO:0051222 135 0.057
chromatin remodeling GO:0006338 55 0.056
response to lipid GO:0033993 206 0.055
response to organonitrogen compound GO:0010243 156 0.055
negative regulation of phosphorylation GO:0042326 174 0.055
cell cycle phase transition GO:0044770 173 0.054
dna recombination GO:0006310 77 0.054
centrosome duplication GO:0051298 28 0.054
Mouse Fly
negative regulation of cell cycle GO:0045786 193 0.053
rna splicing GO:0008380 131 0.051
regulation of protein kinase activity GO:0045859 289 0.050
negative regulation of developmental process GO:0051093 247 0.050
regulation of protein complex assembly GO:0043254 147 0.050
cell type specific apoptotic process GO:0097285 125 0.049
dna conformation change GO:0071103 113 0.049
cellular response to organic cyclic compound GO:0071407 127 0.049
cellular carbohydrate metabolic process GO:0044262 84 0.048
centrosome cycle GO:0007098 32 0.048
Mouse Fly
ossification GO:0001503 121 0.047
spindle elongation GO:0051231 4 0.047
oocyte differentiation GO:0009994 2 0.046
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.045
negative regulation of cell cycle process GO:0010948 121 0.045
peptidyl serine phosphorylation GO:0018105 101 0.044
response to cytokine GO:0034097 232 0.044
oocyte development GO:0048599 1 0.044
negative regulation of protein complex disassembly GO:0043242 20 0.044
mitotic spindle elongation GO:0000022 4 0.043
response to radiation GO:0009314 151 0.043
regulation of translation GO:0006417 89 0.043
nucleic acid transport GO:0050657 39 0.043
Yeast
mrna metabolic process GO:0016071 175 0.042
cellular response to cytokine stimulus GO:0071345 181 0.042
regulation of dna metabolic process GO:0051052 153 0.042
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.042
organelle assembly GO:0070925 176 0.042
Fly
negative regulation of cytoskeleton organization GO:0051494 45 0.041
positive regulation of protein complex assembly GO:0031334 86 0.041
histone modification GO:0016570 251 0.041
enzyme linked receptor protein signaling pathway GO:0007167 303 0.041
multicellular organismal aging GO:0010259 3 0.041
regulation of mitotic cell cycle phase transition GO:1901990 118 0.041
regulation of cellular component biogenesis GO:0044087 281 0.040
regulation of growth GO:0040008 165 0.040
meiosis i GO:0007127 4 0.040
peptidyl serine modification GO:0018209 106 0.039
mitotic cell cycle checkpoint GO:0007093 68 0.039
regulation of establishment of protein localization GO:0070201 242 0.039
Mouse
gene silencing by rna GO:0031047 26 0.039
positive regulation of intracellular transport GO:0032388 104 0.039
posttranscriptional gene silencing by rna GO:0035194 25 0.039
regulation of response to dna damage stimulus GO:2001020 94 0.039
microtubule depolymerization GO:0007019 18 0.038
intracellular receptor signaling pathway GO:0030522 104 0.038
regulation of cell growth GO:0001558 135 0.037
response to lipopolysaccharide GO:0032496 70 0.036
positive regulation of phosphorylation GO:0042327 394 0.036
negative regulation of protein phosphorylation GO:0001933 140 0.036
purine nucleoside triphosphate catabolic process GO:0009146 392 0.036
response to external biotic stimulus GO:0043207 261 0.036
maintenance of location GO:0051235 112 0.035
regulation of intracellular protein transport GO:0033157 123 0.035
Mouse
rna localization GO:0006403 41 0.035
Yeast
embryo development ending in birth or egg hatching GO:0009792 34 0.035
Worm
cellular lipid metabolic process GO:0044255 303 0.034
microtubule organizing center organization GO:0031023 62 0.034
Mouse Fly
protein methylation GO:0006479 74 0.034
immune response GO:0006955 307 0.033
cell division GO:0051301 168 0.033
Worm
regulation of cellular ketone metabolic process GO:0010565 50 0.033
positive regulation of cellular component biogenesis GO:0044089 158 0.033
positive regulation of intracellular protein transport GO:0090316 76 0.033
defense response GO:0006952 315 0.032
regulation of viral process GO:0050792 103 0.032
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.032
positive regulation of immune system process GO:0002684 283 0.032
metaphase plate congression GO:0051310 18 0.032
cellular protein complex disassembly GO:0043624 36 0.032
multicellular organismal reproductive process GO:0048609 40 0.031
regulation of multi organism process GO:0043900 157 0.031
regulation of intracellular transport GO:0032386 195 0.031
Mouse
cell activation GO:0001775 213 0.031
regulation of centrosome cycle GO:0046605 15 0.030
Mouse
cell part morphogenesis GO:0032990 137 0.030
regulation of meiosis GO:0040020 3 0.030
secretion GO:0046903 254 0.030
cell projection organization GO:0030030 252 0.029
nucleoside phosphate catabolic process GO:1901292 412 0.029
lipid metabolic process GO:0006629 381 0.029
regulation of cell cycle phase transition GO:1901987 126 0.029
histone phosphorylation GO:0016572 16 0.029
actin filament based process GO:0030029 224 0.029
regulation of cysteine type endopeptidase activity GO:2000116 127 0.029
negative regulation of transferase activity GO:0051348 124 0.029
regulation of cytokine production GO:0001817 232 0.029
purine ribonucleoside metabolic process GO:0046128 437 0.029
negative regulation of protein modification process GO:0031400 200 0.028
reproductive structure development GO:0048608 55 0.028
organelle localization GO:0051640 84 0.028
cell cycle g2 m phase transition GO:0044839 43 0.028
regulation of rna splicing GO:0043484 62 0.028
positive regulation of cell development GO:0010720 92 0.028
sex differentiation GO:0007548 45 0.027
reproduction GO:0000003 63 0.027
Worm
regulation of kinase activity GO:0043549 314 0.027
response to steroid hormone GO:0048545 80 0.027
interspecies interaction between organisms GO:0044419 156 0.027
nucleoside monophosphate metabolic process GO:0009123 191 0.027
lymphocyte activation GO:0046649 133 0.027
positive regulation of protein import into nucleus GO:0042307 46 0.026
g2 m transition of mitotic cell cycle GO:0000086 41 0.026
regulation of histone h3 k27 methylation GO:0061085 4 0.026
spindle assembly GO:0051225 29 0.026
nucleotide catabolic process GO:0009166 408 0.026
chemical homeostasis GO:0048878 306 0.026
regulation of protein depolymerization GO:1901879 22 0.026
growth GO:0040007 202 0.026
atp metabolic process GO:0046034 176 0.026
negative regulation of chromosome organization GO:2001251 48 0.025
regulation of mrna processing GO:0050684 48 0.025
system process GO:0003008 349 0.025
regeneration GO:0031099 4 0.025
protein dna complex assembly GO:0065004 64 0.025
mrna processing GO:0006397 133 0.025
response to alcohol GO:0097305 64 0.025
protein processing GO:0016485 226 0.025
nucleoside triphosphate catabolic process GO:0009143 394 0.025
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.024
cell development GO:0048468 328 0.024
taxis GO:0042330 157 0.024
cellular response to peptide GO:1901653 59 0.024
neuron differentiation GO:0030182 138 0.024
regulation of meiotic cell cycle GO:0051445 4 0.024
regulation of mrna splicing via spliceosome GO:0048024 32 0.024
regulation of nucleocytoplasmic transport GO:0046822 98 0.023
Mouse
neuron projection development GO:0031175 106 0.023
reproductive system development GO:0061458 56 0.023
mononuclear cell proliferation GO:0032943 71 0.023
ribonucleoside catabolic process GO:0042454 406 0.023
response to growth factor GO:0070848 205 0.023
signal transduction by phosphorylation GO:0023014 297 0.022
response to inorganic substance GO:0010035 127 0.022
development of primary sexual characteristics GO:0045137 35 0.022
single organism reproductive process GO:0044702 98 0.022
developmental process involved in reproduction GO:0003006 66 0.022
positive regulation of proteolysis GO:0045862 142 0.022
cellular response to peptide hormone stimulus GO:0071375 56 0.022
reproductive process GO:0022414 106 0.022
negative regulation of protein depolymerization GO:1901880 17 0.022
positive regulation of cellular catabolic process GO:0031331 284 0.022
cell morphogenesis involved in differentiation GO:0000904 144 0.022
regulation of locomotion GO:0040012 329 0.022
ameboidal type cell migration GO:0001667 135 0.022
negative regulation of cytoplasmic transport GO:1903650 46 0.022
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.022
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.022
regulation of neuron death GO:1901214 56 0.021
regulation of protein catabolic process GO:0042176 155 0.021
Mouse
neurological system process GO:0050877 163 0.020
methylation GO:0032259 106 0.020
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.020
neuron apoptotic process GO:0051402 39 0.020
neuron development GO:0048666 113 0.020
dsrna fragmentation GO:0031050 13 0.020
cellular response to insulin stimulus GO:0032869 41 0.020
gonad development GO:0008406 34 0.020
purine nucleoside triphosphate metabolic process GO:0009144 412 0.019
generation of neurons GO:0048699 152 0.019
positive regulation of cytoplasmic transport GO:1903651 82 0.019
response to alkaloid GO:0043279 20 0.019
negative regulation of neuron death GO:1901215 32 0.019
cell projection morphogenesis GO:0048858 129 0.019
cellular response to abiotic stimulus GO:0071214 117 0.018
establishment or maintenance of cell polarity GO:0007163 31 0.018
mitotic cell cycle phase transition GO:0044772 162 0.018
ribonucleoside monophosphate catabolic process GO:0009158 158 0.018
peptidyl threonine modification GO:0018210 45 0.018
dna packaging GO:0006323 77 0.018
response to insulin GO:0032868 45 0.018
negative regulation of neuron apoptotic process GO:0043524 23 0.018
mitotic centrosome separation GO:0007100 1 0.017
nucleoside monophosphate catabolic process GO:0009125 159 0.017
generation of precursor metabolites and energy GO:0006091 68 0.017
regulation of cellular response to stress GO:0080135 244 0.017
Fly
regulation of protein processing GO:0070613 150 0.017
small gtpase mediated signal transduction GO:0007264 78 0.016
negative regulation of mitotic cell cycle GO:0045930 102 0.016
positive regulation of cell cycle process GO:0090068 106 0.016
male gamete generation GO:0048232 22 0.016
aging GO:0007568 66 0.016
endocytosis GO:0006897 159 0.016
stem cell differentiation GO:0048863 93 0.015
dna integrity checkpoint GO:0031570 71 0.015
microtubule polymerization GO:0046785 18 0.015
central nervous system development GO:0007417 123 0.015
zymogen activation GO:0031638 70 0.015
immune effector process GO:0002252 159 0.015
regulation of cell shape GO:0008360 48 0.015
organophosphate catabolic process GO:0046434 430 0.015
cellular homeostasis GO:0019725 196 0.015
neuron death GO:0070997 65 0.015
cell adhesion GO:0007155 325 0.015
rna catabolic process GO:0006401 71 0.015
positive regulation of cell cycle GO:0045787 140 0.015
muscle cell differentiation GO:0042692 63 0.015
protein polymerization GO:0051258 71 0.015
leukocyte proliferation GO:0070661 74 0.015
regulation of cell development GO:0060284 161 0.015
neuron projection morphogenesis GO:0048812 50 0.015
response to bacterium GO:0009617 144 0.014
actin cytoskeleton organization GO:0030036 207 0.014
negative regulation of microtubule depolymerization GO:0007026 12 0.014
anatomical structure formation involved in morphogenesis GO:0048646 284 0.014
cellular response to lipid GO:0071396 127 0.014
mapk cascade GO:0000165 288 0.014
sensory perception GO:0007600 103 0.014
meiotic nuclear division GO:0007126 10 0.014
regulation of cell migration GO:0030334 289 0.014
neuroblast proliferation GO:0007405 4 0.014
behavior GO:0007610 112 0.014
cell junction organization GO:0034330 79 0.014
multi organism reproductive process GO:0044703 54 0.014
multicellular organism reproduction GO:0032504 42 0.014
regulation of protein transport GO:0051223 213 0.013
Mouse
spindle assembly involved in mitosis GO:0090307 12 0.013
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.013
response to molecule of bacterial origin GO:0002237 82 0.013
regulation of mrna metabolic process GO:1903311 53 0.013
mitotic dna integrity checkpoint GO:0044774 30 0.013
regulation of body fluid levels GO:0050878 99 0.013
regulation of anatomical structure morphogenesis GO:0022603 286 0.013
ribonucleoprotein complex biogenesis GO:0022613 116 0.013
mitotic dna damage checkpoint GO:0044773 28 0.013
negative regulation of dna metabolic process GO:0051053 57 0.012
regulation of neuron apoptotic process GO:0043523 35 0.012
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.012
regulation of homeostatic process GO:0032844 121 0.012
alternative mrna splicing via spliceosome GO:0000380 27 0.012
sexual reproduction GO:0019953 37 0.012
brain development GO:0007420 97 0.012
stem cell development GO:0048864 69 0.012
i kappab kinase nf kappab signaling GO:0007249 166 0.012
maintenance of protein location in cell GO:0032507 56 0.012
positive regulation of cell differentiation GO:0045597 211 0.012
ribosome assembly GO:0042255 9 0.012
negative regulation of protein kinase activity GO:0006469 98 0.012
cognition GO:0050890 43 0.012
ribonucleoprotein complex subunit organization GO:0071826 81 0.012
viral life cycle GO:0019058 132 0.012
leukocyte activation GO:0045321 164 0.012
response to peptide hormone GO:0043434 61 0.012
regulation of protein binding GO:0043393 66 0.012
positive regulation of protein phosphorylation GO:0001934 313 0.012
positive regulation of mitotic cell cycle GO:0045931 60 0.011
segmentation GO:0035282 4 0.011
cellular response to oxidative stress GO:0034599 85 0.011
response to virus GO:0009615 126 0.011
negative regulation of growth GO:0045926 97 0.011
developmental growth involved in morphogenesis GO:0060560 23 0.011
associative learning GO:0008306 1 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.011
ribonucleotide catabolic process GO:0009261 405 0.011
positive regulation of kinase activity GO:0033674 204 0.011
positive regulation of cell proliferation GO:0008284 301 0.011
cellular macromolecule catabolic process GO:0044265 380 0.011
ribosomal small subunit export from nucleus GO:0000056 3 0.011
apoptotic signaling pathway GO:0097190 268 0.011
response to temperature stimulus GO:0009266 22 0.011
carbohydrate metabolic process GO:0005975 207 0.011
lipid localization GO:0010876 106 0.011
positive regulation of transferase activity GO:0051347 227 0.011
membrane organization GO:0061024 292 0.011
negative regulation of intracellular transport GO:0032387 60 0.011
dna replication GO:0006260 116 0.011
protein alkylation GO:0008213 74 0.011
single organism carbohydrate metabolic process GO:0044723 193 0.011
myeloid cell differentiation GO:0030099 117 0.010
axon development GO:0061564 34 0.010
skin development GO:0043588 76 0.010
establishment of cell polarity GO:0030010 22 0.010
regulation of response to cytokine stimulus GO:0060759 46 0.010
actin filament based movement GO:0030048 17 0.010
cell growth GO:0016049 160 0.010
peptidyl tyrosine phosphorylation GO:0018108 170 0.010
positive regulation of catabolic process GO:0009896 310 0.010

XPO1 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.025
nervous system disease DOID:863 431 0.025