Homo sapiens

161 known processes

XRCC3

X-ray repair complementing defective repair in Chinese hamster cells 3

(Aliases: CMM6)

XRCC3 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
double strand break repair via homologous recombination GO:0000724 50 0.902
dna recombination GO:0006310 77 0.845
double strand break repair GO:0006302 101 0.820
dna repair GO:0006281 198 0.775
recombinational repair GO:0000725 50 0.738
oogenesis GO:0048477 2 0.525
Fly
male meiosis GO:0007140 1 0.491
anterior posterior axis specification GO:0009948 2 0.429
Fly
specification of axis polarity GO:0065001 1 0.395
Fly
cellular response to dna damage stimulus GO:0006974 379 0.382
atp catabolic process GO:0006200 157 0.294
regulation of double strand break repair via homologous recombination GO:0010569 11 0.278
mitotic cell cycle GO:0000278 326 0.267
nucleoside phosphate catabolic process GO:1901292 412 0.255
ribonucleotide catabolic process GO:0009261 405 0.233
ribonucleoside monophosphate metabolic process GO:0009161 187 0.224
nucleoside monophosphate catabolic process GO:0009125 159 0.218
purine nucleoside catabolic process GO:0006152 398 0.201
purine nucleoside monophosphate catabolic process GO:0009128 158 0.201
g2 m transition of mitotic cell cycle GO:0000086 41 0.197
ribonucleoside monophosphate catabolic process GO:0009158 158 0.197
purine nucleoside triphosphate catabolic process GO:0009146 392 0.183
glycosyl compound catabolic process GO:1901658 413 0.181
cell development GO:0048468 328 0.180
Fly
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.175
nucleoside monophosphate metabolic process GO:0009123 191 0.174
nucleoside triphosphate catabolic process GO:0009143 394 0.170
purine ribonucleotide catabolic process GO:0009154 404 0.168
positive regulation of cell cycle GO:0045787 140 0.166
purine ribonucleoside catabolic process GO:0046130 398 0.159
atp metabolic process GO:0046034 176 0.148
female gamete generation GO:0007292 2 0.148
Fly
positive regulation of mitotic cell cycle GO:0045931 60 0.140
positive regulation of cell cycle process GO:0090068 106 0.139
purine ribonucleoside metabolic process GO:0046128 437 0.136
regulation of cell cycle GO:0051726 393 0.130
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.125
ribonucleoside triphosphate metabolic process GO:0009199 412 0.121
ribonucleoside catabolic process GO:0042454 406 0.119
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.112
purine nucleoside monophosphate metabolic process GO:0009126 186 0.099
reciprocal dna recombination GO:0035825 4 0.095
purine nucleotide catabolic process GO:0006195 405 0.091
regulation of cell cycle phase transition GO:1901987 126 0.090
positive regulation of cellular amine metabolic process GO:0033240 7 0.090
regulation of cellular amine metabolic process GO:0033238 11 0.088
cellular ketone metabolic process GO:0042180 80 0.085
post embryonic development GO:0009791 2 0.084
regulation of cellular amino acid metabolic process GO:0006521 6 0.082
regionalization GO:0003002 29 0.081
Fly
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.081
determination of adult lifespan GO:0008340 2 0.079
nucleoside catabolic process GO:0009164 408 0.077
purine nucleoside triphosphate metabolic process GO:0009144 412 0.077
response to radiation GO:0009314 151 0.076
internal peptidyl lysine acetylation GO:0018393 97 0.075
cell cycle g2 m phase transition GO:0044839 43 0.073
cellular amine metabolic process GO:0044106 41 0.073
amine metabolic process GO:0009308 44 0.073
cellular macromolecule catabolic process GO:0044265 380 0.072
organophosphate catabolic process GO:0046434 430 0.070
response to abiotic stimulus GO:0009628 336 0.070
nucleoside triphosphate metabolic process GO:0009141 422 0.069
regulation of cellular ketone metabolic process GO:0010565 50 0.068
ribonucleoside triphosphate catabolic process GO:0009203 391 0.067
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.067
telomere maintenance GO:0000723 32 0.063
dna geometric change GO:0032392 32 0.063
cellular macromolecular complex assembly GO:0034622 324 0.063
regulation of cell cycle process GO:0010564 266 0.062
cellular response to endogenous stimulus GO:0071495 336 0.062
multicellular organismal aging GO:0010259 3 0.059
reproductive process GO:0022414 106 0.054
Fly
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.054
negative regulation of apoptotic process GO:0043066 316 0.052
telomere organization GO:0032200 33 0.052
positive regulation of catabolic process GO:0009896 310 0.051
cellular amino acid metabolic process GO:0006520 116 0.050
purine containing compound catabolic process GO:0072523 411 0.050
dna replication GO:0006260 116 0.048
peptidyl lysine modification GO:0018205 144 0.047
regulation of g2 m transition of mitotic cell cycle GO:0010389 20 0.045
protein stabilization GO:0050821 64 0.044
anatomical structure homeostasis GO:0060249 100 0.044
intracellular mrna localization GO:0008298 1 0.044
Fly
reciprocal meiotic recombination GO:0007131 4 0.042
protein dna complex assembly GO:0065004 64 0.041
nucleotide catabolic process GO:0009166 408 0.040
oocyte differentiation GO:0009994 2 0.040
Fly
segmentation GO:0035282 4 0.040
covalent chromatin modification GO:0016569 254 0.039
oocyte development GO:0048599 1 0.039
regulation of protein stability GO:0031647 87 0.039
cell fate determination GO:0001709 3 0.039
Fly
regulation of mitotic cell cycle GO:0007346 189 0.039
apoptotic signaling pathway GO:0097190 268 0.039
meiotic chromosome segregation GO:0045132 4 0.038
positive regulation of hydrolase activity GO:0051345 331 0.038
cellular response to oxygen containing compound GO:1901701 276 0.036
response to oxygen containing compound GO:1901700 369 0.036
oocyte maturation GO:0001556 1 0.035
histone modification GO:0016570 251 0.035
positive regulation of mitotic cell cycle phase transition GO:1901992 19 0.035
rna localization GO:0006403 41 0.034
Fly
negative regulation of multicellular organismal process GO:0051241 317 0.034
nervous system development GO:0007399 293 0.034
single organism reproductive process GO:0044702 98 0.033
Fly
mitotic cell cycle process GO:1903047 286 0.033
immune response GO:0006955 307 0.033
mitotic cell cycle phase transition GO:0044772 162 0.032
dna catabolic process GO:0006308 49 0.031
immune system development GO:0002520 195 0.030
sister chromatid segregation GO:0000819 54 0.030
morphogenesis of embryonic epithelium GO:0016331 4 0.030
positive regulation of cell proliferation GO:0008284 301 0.030
dorsal ventral axis specification GO:0009950 7 0.030
Fly
spermatid development GO:0007286 4 0.029
positive regulation of g2 m transition of mitotic cell cycle GO:0010971 8 0.029
central nervous system development GO:0007417 123 0.028
developmental process involved in reproduction GO:0003006 66 0.028
Fly
dna catabolic process endonucleolytic GO:0000737 37 0.028
negative regulation of phosphate metabolic process GO:0045936 267 0.028
negative regulation of cell death GO:0060548 345 0.027
response to organic cyclic compound GO:0014070 204 0.027
spermatid differentiation GO:0048515 4 0.027
cellular response to radiation GO:0071478 65 0.027
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.027
protein acylation GO:0043543 138 0.026
response to ionizing radiation GO:0010212 65 0.026
epithelium development GO:0060429 227 0.026
mapk cascade GO:0000165 288 0.026
multicellular organismal reproductive process GO:0048609 40 0.025
Fly
negative regulation of programmed cell death GO:0043069 321 0.025
positive regulation of immune system process GO:0002684 283 0.024
dna duplex unwinding GO:0032508 30 0.024
positive regulation of cellular catabolic process GO:0031331 284 0.024
cell cell signaling GO:0007267 155 0.024
organ formation GO:0048645 3 0.023
ion transmembrane transport GO:0034220 338 0.023
positive regulation of programmed cell death GO:0043068 249 0.023
positive regulation of cellular component organization GO:0051130 376 0.023
regulation of cellular response to stress GO:0080135 244 0.022
cell morphogenesis GO:0000902 296 0.022
chromatin modification GO:0016568 298 0.022
head development GO:0060322 108 0.022
lipid metabolic process GO:0006629 381 0.022
hemopoiesis GO:0030097 180 0.022
negative regulation of hydrolase activity GO:0051346 182 0.021
cell cycle checkpoint GO:0000075 117 0.021
somatic stem cell maintenance GO:0035019 4 0.021
cellular response to nitrogen compound GO:1901699 144 0.021
sister chromatid cohesion GO:0007062 24 0.021
cerebellum development GO:0021549 2 0.021
regulation of mapk cascade GO:0043408 262 0.021
response to nitrogen compound GO:1901698 184 0.021
neuromuscular junction development GO:0007528 3 0.021
dorsal ventral pattern formation GO:0009953 15 0.020
Fly
transmembrane transport GO:0055085 399 0.020
negative regulation of developmental process GO:0051093 247 0.020
regulation of nucleotide metabolic process GO:0006140 269 0.020
regulation of cellular component size GO:0032535 82 0.020
histone acetylation GO:0016573 93 0.019
negative regulation of phosphorus metabolic process GO:0010563 267 0.019
regulation of cellular component biogenesis GO:0044087 281 0.019
dna integrity checkpoint GO:0031570 71 0.019
intrinsic apoptotic signaling pathway GO:0097193 127 0.019
positive regulation of nucleoside metabolic process GO:0045979 186 0.019
response to external biotic stimulus GO:0043207 261 0.019
cellular response to organic cyclic compound GO:0071407 127 0.019
response to drug GO:0042493 81 0.019
positive regulation of nucleotide metabolic process GO:0045981 230 0.019
regulation of dna metabolic process GO:0051052 153 0.019
hematopoietic or lymphoid organ development GO:0048534 186 0.018
response to growth factor GO:0070848 205 0.018
cell projection organization GO:0030030 252 0.018
positive regulation of cellular component movement GO:0051272 181 0.018
positive regulation of leukocyte activation GO:0002696 80 0.018
blastoderm segmentation GO:0007350 2 0.017
cellular response to abiotic stimulus GO:0071214 117 0.017
strand invasion GO:0042148 2 0.017
motor neuron axon guidance GO:0008045 2 0.017
regeneration GO:0031099 4 0.017
neuron differentiation GO:0030182 138 0.017
cell differentiation in spinal cord GO:0021515 1 0.017
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.017
membrane organization GO:0061024 292 0.017
regulation of purine nucleotide metabolic process GO:1900542 264 0.017
regulation of purine nucleotide catabolic process GO:0033121 205 0.017
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.017
dna conformation change GO:0071103 113 0.017
neural tube formation GO:0001841 3 0.016
small gtpase mediated signal transduction GO:0007264 78 0.016
negative regulation of catalytic activity GO:0043086 335 0.016
response to lipid GO:0033993 206 0.016
generation of neurons GO:0048699 152 0.016
spermatogenesis GO:0007283 22 0.016
chemical homeostasis GO:0048878 306 0.016
rna processing GO:0006396 255 0.016
dna packaging GO:0006323 77 0.016
leukocyte differentiation GO:0002521 98 0.016
metencephalon development GO:0022037 2 0.016
cytoplasmic transport GO:0016482 379 0.016
dna biosynthetic process GO:0071897 40 0.016
internal protein amino acid acetylation GO:0006475 101 0.016
regulation of cellular component movement GO:0051270 334 0.016
cellular lipid metabolic process GO:0044255 303 0.015
intracellular protein transport GO:0006886 270 0.015
positive regulation of phosphorylation GO:0042327 394 0.015
regulation of kinase activity GO:0043549 314 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.015
morphogenesis of a polarized epithelium GO:0001738 3 0.015
cellular cation homeostasis GO:0030003 163 0.015
positive regulation of transport GO:0051050 336 0.015
positive regulation of apoptotic process GO:0043065 246 0.015
histone threonine phosphorylation GO:0035405 7 0.015
regulation of transferase activity GO:0051338 355 0.015
positive regulation of cell death GO:0010942 263 0.015
response to inorganic substance GO:0010035 127 0.015
organ morphogenesis GO:0009887 147 0.015
regulation of dna repair GO:0006282 47 0.014
dna dependent dna replication maintenance of fidelity GO:0045005 14 0.014
regulation of response to external stimulus GO:0032101 222 0.014
anatomical structure formation involved in morphogenesis GO:0048646 284 0.014
Fly
monocarboxylic acid metabolic process GO:0032787 185 0.014
establishment of planar polarity GO:0001736 3 0.014
tube closure GO:0060606 3 0.014
response to uv GO:0009411 73 0.014
response to fungus GO:0009620 4 0.014
embryonic epithelial tube formation GO:0001838 4 0.014
positive regulation of ruffle assembly GO:1900029 4 0.014
ion homeostasis GO:0050801 230 0.014
regulation of cardioblast differentiation GO:0051890 4 0.014
secretion GO:0046903 254 0.014
hindbrain development GO:0030902 3 0.014
chromosome segregation GO:0007059 114 0.014
positive regulation of cell migration GO:0030335 172 0.014
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.014
brain development GO:0007420 97 0.014
negative regulation of transport GO:0051051 176 0.014
regulation of reactive oxygen species metabolic process GO:2000377 41 0.014
cellular response to lipid GO:0071396 127 0.014
locomotory behavior GO:0007626 1 0.014
regulation of cell differentiation GO:0045595 393 0.014
establishment of tissue polarity GO:0007164 3 0.014
response to other organism GO:0051707 261 0.013
regulation of cell migration GO:0030334 289 0.013
microtubule based process GO:0007017 210 0.013
regulation of nucleotide catabolic process GO:0030811 205 0.013
regulation of double strand break repair GO:2000779 22 0.013
signal transduction by phosphorylation GO:0023014 297 0.013
peptidyl lysine acetylation GO:0018394 101 0.013
regulation of establishment of protein localization GO:0070201 242 0.013
reactive oxygen species biosynthetic process GO:1903409 4 0.013
positive regulation of cell activation GO:0050867 81 0.013
pattern specification process GO:0007389 43 0.013
Fly
response to light stimulus GO:0009416 87 0.013
positive regulation of epithelial cell migration GO:0010634 55 0.013
cell projection morphogenesis GO:0048858 129 0.013
positive regulation of cell cycle phase transition GO:1901989 22 0.013
mitochondrion organization GO:0007005 156 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
cell growth GO:0016049 160 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
spinal cord development GO:0021510 4 0.012
regulation of endopeptidase activity GO:0052548 170 0.012
regulation of protein serine threonine kinase activity GO:0071900 179 0.012
dephosphorylation GO:0016311 209 0.012
protein oligomerization GO:0051259 173 0.012
regulation of dna recombination GO:0000018 23 0.012
protein ubiquitination GO:0016567 314 0.012
regulation of anatomical structure size GO:0090066 101 0.012
single organism carbohydrate metabolic process GO:0044723 193 0.012
positive regulation of cell size GO:0045793 3 0.012
response to organonitrogen compound GO:0010243 156 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
inner ear morphogenesis GO:0042472 4 0.012
regulation of immune response GO:0050776 201 0.012
protein catabolic process GO:0030163 325 0.012
regulation of mitotic cell cycle phase transition GO:1901990 118 0.012
negative regulation of cellular protein metabolic process GO:0032269 353 0.012
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.012
negative regulation of protein metabolic process GO:0051248 391 0.012
carboxylic acid biosynthetic process GO:0046394 97 0.012
multi organism reproductive process GO:0044703 54 0.012
Fly
leukocyte activation GO:0045321 164 0.012
immune effector process GO:0002252 159 0.012
regulation of cell development GO:0060284 161 0.012
dna damage checkpoint GO:0000077 68 0.012
organonitrogen compound biosynthetic process GO:1901566 200 0.012
receptor mediated endocytosis GO:0006898 84 0.012
peripheral nervous system development GO:0007422 2 0.012
regulation of dna replication GO:0006275 68 0.012
negative regulation of protein modification process GO:0031400 200 0.012
primary neural tube formation GO:0014020 3 0.012
cellular response to organonitrogen compound GO:0071417 124 0.012
positive regulation of nucleotide catabolic process GO:0030813 185 0.011
endodermal cell fate commitment GO:0001711 4 0.011
posttranscriptional regulation of gene expression GO:0010608 213 0.011
neuron fate commitment GO:0048663 2 0.011
epithelial cell migration GO:0010631 119 0.011
positive regulation of immune response GO:0050778 159 0.011
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.011
regulation of response to dna damage stimulus GO:2001020 94 0.011
cardiovascular system development GO:0072358 262 0.011
protein acetylation GO:0006473 116 0.011
base excision repair GO:0006284 21 0.011
regulation of protein kinase activity GO:0045859 289 0.011
epithelium migration GO:0090132 119 0.011
t cell differentiation in thymus GO:0033077 4 0.011
aging GO:0007568 66 0.011
cellular component morphogenesis GO:0032989 314 0.011
taxis GO:0042330 157 0.011
organophosphate biosynthetic process GO:0090407 163 0.011
negative regulation of transferase activity GO:0051348 124 0.011
cellular homeostasis GO:0019725 196 0.011
regulation of intracellular transport GO:0032386 195 0.011
organic acid biosynthetic process GO:0016053 97 0.011
reactive oxygen species metabolic process GO:0072593 75 0.011
cell part morphogenesis GO:0032990 137 0.011
prostate gland development GO:0030850 3 0.011
neural tube closure GO:0001843 3 0.011
positive regulation of locomotion GO:0040017 186 0.011
regulation of epithelial cell migration GO:0010632 93 0.011
somitogenesis GO:0001756 2 0.011
epithelial cell proliferation GO:0050673 128 0.010
lymphocyte activation GO:0046649 133 0.010
single organism membrane organization GO:0044802 268 0.010
rho protein signal transduction GO:0007266 26 0.010
compound eye development GO:0048749 1 0.010
neurotransmitter secretion GO:0007269 4 0.010
cell activation GO:0001775 213 0.010
negative regulation of mitotic cell cycle GO:0045930 102 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.010
circulatory system development GO:0072359 262 0.010
peptidyl serine modification GO:0018209 106 0.010
regulation of lymphocyte activation GO:0051249 103 0.010
cd4 positive alpha beta t cell differentiation GO:0043367 4 0.010
regulation of phosphatase activity GO:0010921 81 0.010
forebrain neuron differentiation GO:0021879 3 0.010
carbohydrate metabolic process GO:0005975 207 0.010
positive regulation of mapk cascade GO:0043410 190 0.010
pituitary gland development GO:0021983 2 0.010
memory GO:0007613 3 0.010
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.010
cation transport GO:0006812 331 0.010
meiosis i GO:0007127 4 0.010
actin filament based process GO:0030029 224 0.010
t cell activation GO:0042110 99 0.010
embryo development GO:0009790 123 0.010
secretion by cell GO:0032940 226 0.010
reactive nitrogen species metabolic process GO:2001057 3 0.010

XRCC3 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.290
hematopoietic system disease DOID:74 100 0.290
bone marrow disease DOID:4961 31 0.121
cancer DOID:162 167 0.110
disease of cellular proliferation DOID:14566 174 0.110
organ system cancer DOID:0050686 164 0.110
congenital hypoplastic anemia DOID:1342 26 0.105
aplastic anemia DOID:12449 30 0.105
anemia DOID:2355 55 0.105
musculoskeletal system disease DOID:17 223 0.104
connective tissue disease DOID:65 109 0.052
bone disease DOID:0080001 88 0.050
bone development disease DOID:0080006 55 0.049
dysostosis DOID:1934 22 0.046
endocrine gland cancer DOID:170 26 0.025
breast cancer DOID:1612 21 0.022
thoracic cancer DOID:5093 21 0.022
central nervous system disease DOID:331 186 0.015
nervous system disease DOID:863 431 0.015
gastrointestinal system cancer DOID:3119 52 0.015
disease of metabolism DOID:0014667 295 0.013
neurodegenerative disease DOID:1289 102 0.012
integumentary system disease DOID:16 43 0.011
sensory system disease DOID:0050155 203 0.010
eye and adnexa disease DOID:1492 150 0.010
large intestine cancer DOID:5672 29 0.010
intestinal cancer DOID:10155 29 0.010
colorectal cancer DOID:9256 29 0.010