|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.995
|
Fly |
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.989
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.982
|
|
|
|
membrane depolarization during action potential
|
GO:0086010 |
10 |
0.976
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.973
|
|
|
|
asymmetric neuroblast division
|
GO:0055059 |
1 |
0.966
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.962
|
Human |
|
|
cell development
|
GO:0048468 |
328 |
0.956
|
Human Fly |
|
|
growth
|
GO:0040007 |
202 |
0.952
|
|
|
|
establishment or maintenance of microtubule cytoskeleton polarity
|
GO:0030951 |
2 |
0.944
|
Fly |
|
|
oogenesis
|
GO:0048477 |
2 |
0.943
|
Fly |
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.939
|
Fly |
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.929
|
Human |
|
|
dna replication
|
GO:0006260 |
116 |
0.918
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.915
|
|
|
|
sodium ion transmembrane transport
|
GO:0035725 |
59 |
0.908
|
|
|
|
cell fate determination
|
GO:0001709 |
3 |
0.904
|
Worm Fly |
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.893
|
Fly |
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.876
|
Fly |
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.864
|
Worm |
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.851
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.846
|
Human |
|
|
dna dependent dna replication
|
GO:0006261 |
44 |
0.841
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
207 |
0.822
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.814
|
|
|
|
sodium ion transport
|
GO:0006814 |
61 |
0.791
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.791
|
Fly |
|
|
female gamete generation
|
GO:0007292 |
2 |
0.788
|
Fly |
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.773
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.765
|
|
|
|
cellular potassium ion transport
|
GO:0071804 |
60 |
0.760
|
Human |
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.753
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.751
|
Fly |
|
|
neuroblast division
|
GO:0055057 |
1 |
0.745
|
|
|
|
neuronal stem cell division
|
GO:0036445 |
1 |
0.745
|
|
|
|
establishment or maintenance of cytoskeleton polarity
|
GO:0030952 |
3 |
0.744
|
Fly |
|
|
neuroblast proliferation
|
GO:0007405 |
4 |
0.741
|
|
|
|
regulation of sodium ion transmembrane transporter activity
|
GO:2000649 |
17 |
0.725
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.720
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.717
|
|
|
|
potassium ion transmembrane transport
|
GO:0071805 |
60 |
0.713
|
Human |
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
83 |
0.712
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.703
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.698
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.686
|
|
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.685
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.678
|
Human |
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.671
|
|
|
|
regulation of cell diameter
|
GO:0060305 |
1 |
0.663
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.662
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.662
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.653
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.648
|
|
|
|
stem cell division
|
GO:0017145 |
2 |
0.644
|
|
|
|
protein dephosphorylation
|
GO:0006470 |
81 |
0.641
|
Human |
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.636
|
Fly |
|
|
potassium ion transport
|
GO:0006813 |
62 |
0.631
|
Human |
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.630
|
Fly |
|
|
glucocorticoid catabolic process
|
GO:0006713 |
1 |
0.627
|
|
|
|
regulation of peptidyl serine dephosphorylation
|
GO:1902308 |
2 |
0.612
|
Human |
|
|
regulation of membrane repolarization
|
GO:0060306 |
16 |
0.612
|
Human |
|
|
nuclear transport
|
GO:0051169 |
179 |
0.603
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.597
|
Human |
|
|
establishment or maintenance of cell polarity
|
GO:0007163 |
31 |
0.595
|
Worm Fly |
|
|
membrane repolarization
|
GO:0086009 |
23 |
0.588
|
Human |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.574
|
Human |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.568
|
Fly |
|
|
cell projection organization
|
GO:0030030 |
252 |
0.560
|
|
|
|
steroid catabolic process
|
GO:0006706 |
10 |
0.557
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.548
|
Human |
|
|
establishment or maintenance of apical basal cell polarity
|
GO:0035088 |
2 |
0.533
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.531
|
|
|
|
nuclear migration
|
GO:0007097 |
1 |
0.522
|
Worm |
|
|
regulation of neuron projection development
|
GO:0010975 |
57 |
0.513
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.512
|
|
|
|
asymmetric stem cell division
|
GO:0098722 |
1 |
0.505
|
|
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
194 |
0.505
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.493
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.492
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.490
|
Worm |
|
|
lipid catabolic process
|
GO:0016042 |
84 |
0.489
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.478
|
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.465
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.462
|
Human |
|
|
monovalent inorganic cation transport
|
GO:0015672 |
128 |
0.461
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.461
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.460
|
Human |
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.458
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.458
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.457
|
|
|
|
positive regulation of dna templated transcription elongation
|
GO:0032786 |
18 |
0.455
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.447
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.446
|
Human |
|
|
negative regulation of myotube differentiation
|
GO:0010832 |
4 |
0.443
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.439
|
Worm |
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.439
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.436
|
|
|
|
negative regulation of cell size
|
GO:0045792 |
3 |
0.435
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.424
|
Fly |
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.419
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.415
|
Human |
|
|
regulation of sodium ion transport
|
GO:0002028 |
24 |
0.410
|
|
|
|
peptidyl serine dephosphorylation
|
GO:0070262 |
2 |
0.403
|
Human |
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.401
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.397
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.395
|
Fly |
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.380
|
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
90 |
0.364
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.360
|
|
|
|
oocyte maturation
|
GO:0001556 |
1 |
0.350
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.347
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.346
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.332
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.328
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.328
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.320
|
|
|
|
stem cell development
|
GO:0048864 |
69 |
0.318
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.313
|
Human |
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.309
|
Fly |
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.306
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.305
|
|
|
|
regulation of sodium ion transmembrane transport
|
GO:1902305 |
23 |
0.305
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.305
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.303
|
|
|
|
regulation of potassium ion transmembrane transport
|
GO:1901379 |
20 |
0.303
|
Human |
|
|
regulation of potassium ion transport
|
GO:0043266 |
24 |
0.298
|
Human |
|
|
generation of neurons
|
GO:0048699 |
152 |
0.297
|
Human |
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.296
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.294
|
Worm Fly |
|
|
cell junction organization
|
GO:0034330 |
79 |
0.294
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.289
|
|
|
|
glucocorticoid metabolic process
|
GO:0008211 |
10 |
0.282
|
|
|
|
positive regulation of meiotic cell cycle
|
GO:0051446 |
2 |
0.279
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.277
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.277
|
Worm |
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.276
|
|
|
|
somatic stem cell division
|
GO:0048103 |
1 |
0.276
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.258
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.257
|
Human |
|
|
release of cytochrome c from mitochondria
|
GO:0001836 |
35 |
0.255
|
Human |
|
|
maintenance of protein location
|
GO:0045185 |
57 |
0.254
|
Human |
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.247
|
|
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.247
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.246
|
|
|
|
cation transmembrane transport
|
GO:0098655 |
238 |
0.245
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.245
|
Fly |
|
|
cytoplasmic sequestering of protein
|
GO:0051220 |
12 |
0.244
|
Human |
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.243
|
|
|
|
oxidation reduction process
|
GO:0055114 |
396 |
0.241
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.236
|
Worm Fly |
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.236
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
4 |
0.233
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.233
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.231
|
|
|
|
dna replication initiation
|
GO:0006270 |
6 |
0.229
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.226
|
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
72 |
0.225
|
|
|
|
monosaccharide metabolic process
|
GO:0005996 |
74 |
0.225
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.224
|
|
|
|
male meiosis
|
GO:0007140 |
1 |
0.223
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.221
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.219
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.218
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.218
|
|
|
|
cytokinesis
|
GO:0000910 |
96 |
0.217
|
|
|
|
photoreceptor cell differentiation
|
GO:0046530 |
2 |
0.216
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.214
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.213
|
Fly |
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.210
|
Human |
|
|
plasma membrane organization
|
GO:0007009 |
115 |
0.208
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.203
|
Human |
|
|
regulation of transcription factor import into nucleus
|
GO:0042990 |
39 |
0.202
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.202
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.200
|
|
|
|
regulation of potassium ion transmembrane transporter activity
|
GO:1901016 |
16 |
0.198
|
Human |
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.198
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.198
|
Worm Fly |
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
231 |
0.197
|
|
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
40 |
0.193
|
|
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.189
|
Worm |
|
|
anterior posterior axis specification embryo
|
GO:0008595 |
2 |
0.188
|
|
|
|
establishment of cell polarity
|
GO:0030010 |
22 |
0.187
|
Worm |
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.186
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.184
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.184
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.184
|
Human |
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.181
|
|
|
|
cellular response to uv
|
GO:0034644 |
32 |
0.178
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.177
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.176
|
|
|
|
tor signaling
|
GO:0031929 |
39 |
0.176
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.176
|
Worm Fly |
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.175
|
Worm |
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.175
|
Human |
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.175
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.172
|
|
|
|
somatic muscle development
|
GO:0007525 |
1 |
0.171
|
|
|
|
positive regulation of small gtpase mediated signal transduction
|
GO:0051057 |
12 |
0.166
|
Fly |
|
|
establishment of nucleus localization
|
GO:0040023 |
1 |
0.163
|
Worm |
|
|
neural tube formation
|
GO:0001841 |
3 |
0.163
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.162
|
|
|
|
transcription factor import into nucleus
|
GO:0042991 |
40 |
0.161
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.159
|
|
|
|
positive regulation of anoikis
|
GO:2000210 |
4 |
0.157
|
|
|
|
cellular component disassembly
|
GO:0022411 |
92 |
0.154
|
|
|
|
limbic system development
|
GO:0021761 |
3 |
0.153
|
|
|
|
regulation of epithelial to mesenchymal transition
|
GO:0010717 |
37 |
0.153
|
|
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.152
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.151
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.151
|
Worm |
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.150
|
Human |
|
|
response to uv
|
GO:0009411 |
73 |
0.149
|
|
|
|
cell fate commitment
|
GO:0045165 |
27 |
0.148
|
Worm Fly |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.146
|
Human |
|
|
glycogen metabolic process
|
GO:0005977 |
22 |
0.146
|
|
|
|
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation
|
GO:0003257 |
3 |
0.144
|
|
|
|
cell migration involved in sprouting angiogenesis
|
GO:0002042 |
19 |
0.144
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.142
|
Worm |
|
|
peptidyl lysine modification
|
GO:0018205 |
144 |
0.142
|
|
|
|
epithelial cell migration
|
GO:0010631 |
119 |
0.140
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.140
|
Worm Fly |
|
|
endocytosis
|
GO:0006897 |
159 |
0.139
|
Worm |
|
|
muscle structure development
|
GO:0061061 |
98 |
0.139
|
|
|
|
cell projection assembly
|
GO:0030031 |
126 |
0.138
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.137
|
|
|
|
regulation of meiotic cell cycle
|
GO:0051445 |
4 |
0.136
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.136
|
Human |
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.136
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.134
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.134
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.131
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.131
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.130
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.128
|
|
|
|
mesenchymal cell development
|
GO:0014031 |
50 |
0.128
|
|
|
|
negative regulation of peptidyl serine dephosphorylation
|
GO:1902309 |
1 |
0.128
|
Human |
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.127
|
Fly |
|
|
positive regulation of cell projection organization
|
GO:0031346 |
64 |
0.127
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.126
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.126
|
|
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.125
|
Human |
|
|
positive regulation of protein import into nucleus
|
GO:0042307 |
46 |
0.124
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.123
|
|
|
|
positive regulation of neuron projection development
|
GO:0010976 |
34 |
0.123
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.122
|
|
|
|
gastrulation
|
GO:0007369 |
51 |
0.122
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.120
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.119
|
Human |
|
|
digestive tract development
|
GO:0048565 |
75 |
0.119
|
|
|
|
regulation of neurotransmitter secretion
|
GO:0046928 |
3 |
0.119
|
|
|
|
maintenance of location in cell
|
GO:0051651 |
62 |
0.119
|
Human |
|
|
digestive system development
|
GO:0055123 |
75 |
0.118
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.117
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.117
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.116
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.115
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.115
|
Human |
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.114
|
|
|
|
protein localization to plasma membrane
|
GO:0072659 |
93 |
0.113
|
|
|
|
cell cycle arrest
|
GO:0007050 |
71 |
0.113
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.113
|
|
|
|
tripartite regional subdivision
|
GO:0007351 |
2 |
0.113
|
|
|
|
tissue migration
|
GO:0090130 |
119 |
0.112
|
|
|
|
meiosis i
|
GO:0007127 |
4 |
0.112
|
|
|
|
corticosteroid receptor signaling pathway
|
GO:0031958 |
5 |
0.111
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.111
|
Human |
|
|
cellular carbohydrate metabolic process
|
GO:0044262 |
84 |
0.109
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.108
|
Human |
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.108
|
|
|
|
synaptic transmission
|
GO:0007268 |
61 |
0.106
|
Human |
|
|
generation of precursor metabolites and energy
|
GO:0006091 |
68 |
0.106
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.106
|
|
|
|
negative regulation of exit from mitosis
|
GO:0001100 |
1 |
0.106
|
|
|
|
meiotic chromosome segregation
|
GO:0045132 |
4 |
0.106
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.105
|
|
|
|
regulation of epithelial cell migration
|
GO:0010632 |
93 |
0.104
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.103
|
Human |
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.102
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.102
|
Fly |
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.100
|
Human |
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.100
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.099
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.099
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.098
|
|
|
|
mitotic nuclear division
|
GO:0007067 |
119 |
0.096
|
|
|
|
positive regulation of transcription elongation from rna polymerase ii promoter
|
GO:0032968 |
10 |
0.095
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.095
|
|
|
|
nuclear division
|
GO:0000280 |
128 |
0.095
|
Worm |
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.095
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.095
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.095
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.095
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.094
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.094
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.093
|
|
|
|
negative regulation of protein transport
|
GO:0051224 |
75 |
0.093
|
Human |
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.092
|
Human |
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.092
|
Human |
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.090
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.090
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
56 |
0.089
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.089
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.088
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.086
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.086
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.086
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.085
|
Human |
|
|
endothelial cell migration
|
GO:0043542 |
86 |
0.085
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.085
|
|
|
|
microtubule organizing center organization
|
GO:0031023 |
62 |
0.085
|
|
|
|
positive regulation of endothelial cell migration
|
GO:0010595 |
39 |
0.084
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
66 |
0.084
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.083
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.083
|
Human |
|
|
positive regulation of peptidyl serine phosphorylation
|
GO:0033138 |
42 |
0.083
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.083
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
79 |
0.082
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.082
|
Fly |
|
|
defense response
|
GO:0006952 |
315 |
0.082
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.081
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.080
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.079
|
|
|
|
mesenchymal to epithelial transition involved in metanephros morphogenesis
|
GO:0003337 |
4 |
0.078
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.078
|
|
|
|
cell junction assembly
|
GO:0034329 |
67 |
0.078
|
|
|
|
negative regulation of dephosphorylation
|
GO:0035305 |
63 |
0.077
|
Human |
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.077
|
|
|
|
negative regulation of chromatin silencing
|
GO:0031936 |
4 |
0.077
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.077
|
|
|
|
peptidyl tyrosine dephosphorylation
|
GO:0035335 |
36 |
0.075
|
|
|
|
renal system development
|
GO:0072001 |
63 |
0.073
|
|
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
4 |
0.073
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.073
|
|
|
|
single fertilization
|
GO:0007338 |
11 |
0.073
|
Worm |
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.072
|
|
|
|
negative regulation of ubiquitin protein ligase activity involved in mitotic cell cycle
|
GO:0051436 |
4 |
0.072
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.072
|
|
|
|
positive regulation of cell division
|
GO:0051781 |
59 |
0.072
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.070
|
|
|
|
intracellular steroid hormone receptor signaling pathway
|
GO:0030518 |
61 |
0.070
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.069
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
72 |
0.069
|
|
|
|
centrosome organization
|
GO:0051297 |
58 |
0.069
|
|
|
|
axon cargo transport
|
GO:0008088 |
2 |
0.069
|
|
|
|
protein dna complex subunit organization
|
GO:0071824 |
80 |
0.068
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.068
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.068
|
|
|
|
regulation of synaptic transmission
|
GO:0050804 |
11 |
0.068
|
Human |
|
|
cell cell junction organization
|
GO:0045216 |
69 |
0.068
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
27 |
0.067
|
|
|
|
brain development
|
GO:0007420 |
97 |
0.067
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.067
|
|
|
|
receptor mediated endocytosis
|
GO:0006898 |
84 |
0.067
|
Worm |
|
|
establishment or maintenance of bipolar cell polarity
|
GO:0061245 |
2 |
0.067
|
|
|
|
visual learning
|
GO:0008542 |
1 |
0.067
|
|
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.067
|
|
|
|
regulation of protein localization to plasma membrane
|
GO:1903076 |
40 |
0.066
|
|
|
|
midbrain development
|
GO:0030901 |
45 |
0.066
|
|
|
|
regulation of protein dephosphorylation
|
GO:0035304 |
18 |
0.066
|
Human |
|
|
regulation of exocytosis
|
GO:0017157 |
46 |
0.066
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.066
|
Worm |
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.066
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
76 |
0.064
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.064
|
|
|
|
cellular response to mechanical stimulus
|
GO:0071260 |
39 |
0.063
|
|
|
|
positive regulation of cytokinesis
|
GO:0032467 |
29 |
0.063
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.063
|
|
|
|
protein acylation
|
GO:0043543 |
138 |
0.063
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.062
|
Human |
|
|
positive regulation of blood vessel endothelial cell migration
|
GO:0043536 |
16 |
0.061
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.060
|
|
|
|
blood vessel endothelial cell migration
|
GO:0043534 |
42 |
0.060
|
|
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.059
|
Worm Fly |
|
|
head development
|
GO:0060322 |
108 |
0.058
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.058
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.057
|
|
|
|
positive regulation of neurogenesis
|
GO:0050769 |
49 |
0.057
|
|
|
|
pattern specification process
|
GO:0007389 |
43 |
0.057
|
Worm Fly |
|
|
anoikis
|
GO:0043276 |
22 |
0.057
|
|
|
|
eye photoreceptor cell differentiation
|
GO:0001754 |
2 |
0.057
|
|
|
|
regulation of dendrite development
|
GO:0050773 |
18 |
0.056
|
|
|
|
chromosome segregation
|
GO:0007059 |
114 |
0.056
|
Fly |
|
|
cell maturation
|
GO:0048469 |
11 |
0.056
|
Fly |
|
|
regulation of cytokinesis
|
GO:0032465 |
45 |
0.056
|
|
|
|
protein kinase b signaling
|
GO:0043491 |
69 |
0.056
|
|
|
|
regulation of protein kinase b signaling
|
GO:0051896 |
61 |
0.056
|
|
|
|
maintenance of protein location in cell
|
GO:0032507 |
56 |
0.055
|
Human |
|
|
rna processing
|
GO:0006396 |
255 |
0.055
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.055
|
Human |
|
|
polysaccharide metabolic process
|
GO:0005976 |
33 |
0.055
|
|
|
|
developmental process involved in reproduction
|
GO:0003006 |
66 |
0.054
|
Fly |
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.054
|
|
|
|
specification of axis polarity
|
GO:0065001 |
1 |
0.054
|
Worm |
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.054
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.053
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
41 |
0.053
|
|
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.053
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.053
|
|
|
|
termination of signal transduction
|
GO:0023021 |
3 |
0.052
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.052
|
|
|
|
muscle organ development
|
GO:0007517 |
56 |
0.052
|
|
|
|
rac protein signal transduction
|
GO:0016601 |
12 |
0.051
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.051
|
Human |
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.051
|
|
|
|
stem cell differentiation
|
GO:0048863 |
93 |
0.051
|
|
|
|
vesicle transport along microtubule
|
GO:0047496 |
4 |
0.051
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.051
|
|
|
|
positive regulation of calcium ion transport
|
GO:0051928 |
51 |
0.050
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.050
|
Human |
|
|
glucocorticoid receptor signaling pathway
|
GO:0042921 |
5 |
0.049
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.049
|
Human |
|
|
epithelial tube morphogenesis
|
GO:0060562 |
38 |
0.049
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.049
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.049
|
Human |
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.049
|
|
|
|
nucleus localization
|
GO:0051647 |
1 |
0.049
|
Worm |
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.048
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.048
|
|
|
|
dna damage checkpoint
|
GO:0000077 |
68 |
0.048
|
|
|
|
regulation of axonogenesis
|
GO:0050770 |
16 |
0.048
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.048
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.048
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.048
|
Human |
|
|
positive regulation of synaptic transmission
|
GO:0050806 |
4 |
0.047
|
|
|
|
regulation of cardiac muscle contraction by calcium ion signaling
|
GO:0010882 |
3 |
0.047
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.047
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.047
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.047
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.047
|
|
|
|
positive regulation of superoxide anion generation
|
GO:0032930 |
4 |
0.046
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.046
|
Human |
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.045
|
|
|
|
striated muscle cell differentiation
|
GO:0051146 |
43 |
0.045
|
|
|
|
regulation of stem cell differentiation
|
GO:2000736 |
56 |
0.045
|
|
|
|
mitotic cell cycle checkpoint
|
GO:0007093 |
68 |
0.045
|
|
|
|
regulation of synaptic vesicle transport
|
GO:1902803 |
3 |
0.045
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.045
|
|
|
|
muscle contraction
|
GO:0006936 |
73 |
0.045
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.045
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.044
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.044
|
Human |
|
|
negative regulation of locomotion
|
GO:0040013 |
118 |
0.043
|
|
|
|
centriole assembly
|
GO:0098534 |
14 |
0.043
|
|
|
|
system process
|
GO:0003008 |
349 |
0.043
|
Fly |
|
|
positive regulation of angiogenesis
|
GO:0045766 |
51 |
0.043
|
|
|
|
regulation of neural precursor cell proliferation
|
GO:2000177 |
4 |
0.043
|
|
|
|
regulation of mitosis
|
GO:0007088 |
63 |
0.043
|
|
|
|
negative regulation of microtubule polymerization or depolymerization
|
GO:0031111 |
17 |
0.042
|
|
|
|
peroxisome organization
|
GO:0007031 |
28 |
0.042
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.042
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.042
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.042
|
Human |
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.042
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.042
|
|
|
|
regulation of branching involved in ureteric bud morphogenesis
|
GO:0090189 |
3 |
0.041
|
|
|
|
positive regulation of lipid biosynthetic process
|
GO:0046889 |
22 |
0.041
|
|
|
|
regulation of behavior
|
GO:0050795 |
82 |
0.041
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.041
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.041
|
|
|
|
mitochondrion distribution
|
GO:0048311 |
3 |
0.041
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.041
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.041
|
|
|
|
neuron projection morphogenesis
|
GO:0048812 |
50 |
0.041
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.040
|
|
|
|
positive regulation of embryonic development
|
GO:0040019 |
6 |
0.040
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.040
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.040
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.040
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.040
|
|
|
|
nuclear import
|
GO:0051170 |
106 |
0.040
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.040
|
|
|
|
epithelium migration
|
GO:0090132 |
119 |
0.040
|
|
|
|
stem cell proliferation
|
GO:0072089 |
25 |
0.040
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.039
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.039
|
|
|
|
epithelial to mesenchymal transition
|
GO:0001837 |
48 |
0.039
|
|
|
|
hindbrain development
|
GO:0030902 |
3 |
0.039
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.039
|
|
|
|
regulation of peptidyl serine phosphorylation
|
GO:0033135 |
50 |
0.038
|
|
|
|
regulation of blood circulation
|
GO:1903522 |
59 |
0.038
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.038
|
|
|
|
negative regulation of cardiac muscle cell apoptotic process
|
GO:0010667 |
2 |
0.038
|
|
|
|
keratinization
|
GO:0031424 |
2 |
0.038
|
|
|
|
multicellular organismal response to stress
|
GO:0033555 |
1 |
0.038
|
|
|
|
regulation of protein import into nucleus
|
GO:0042306 |
78 |
0.038
|
|
|
|
regulation of embryonic development
|
GO:0045995 |
20 |
0.037
|
|
|
|
establishment of organelle localization
|
GO:0051656 |
59 |
0.037
|
Worm |
|
|
membrane depolarization
|
GO:0051899 |
26 |
0.037
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.037
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.037
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.037
|
|
|
|
negative regulation of protein ubiquitination
|
GO:0031397 |
35 |
0.037
|
|
