|
|
cell development
|
GO:0048468 |
328 |
1.000
|
Human Yeast Fly |
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.999
|
Human |
|
|
negative regulation of protein dephosphorylation
|
GO:0035308 |
3 |
0.999
|
Human |
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.999
|
Human |
|
|
cell fate determination
|
GO:0001709 |
3 |
0.999
|
Worm Fly |
|
|
mapk cascade
|
GO:0000165 |
288 |
0.998
|
Fly |
|
|
potassium ion transport
|
GO:0006813 |
62 |
0.997
|
Human |
|
|
synaptic transmission
|
GO:0007268 |
61 |
0.997
|
Human |
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.997
|
Fly |
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.995
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.995
|
Fly |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.994
|
Fly |
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.994
|
Worm |
|
|
establishment of organelle localization
|
GO:0051656 |
59 |
0.994
|
Worm |
|
|
nervous system development
|
GO:0007399 |
293 |
0.993
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.991
|
Human |
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.990
|
Human |
|
|
nuclear division
|
GO:0000280 |
128 |
0.990
|
Worm |
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.990
|
Yeast Fly |
|
|
oogenesis
|
GO:0048477 |
2 |
0.990
|
Fly |
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.988
|
Worm |
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.986
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.985
|
Yeast Mouse Fly |
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.984
|
Human Yeast |
|
|
growth
|
GO:0040007 |
202 |
0.977
|
Yeast |
|
|
monovalent inorganic cation transport
|
GO:0015672 |
128 |
0.977
|
Human |
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.974
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.974
|
Fly |
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.969
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.969
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.965
|
Human |
|
|
muscle structure development
|
GO:0061061 |
98 |
0.964
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.964
|
Fly |
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.960
|
Worm |
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.959
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.957
|
Worm Fly |
|
|
negative regulation of ubiquitin protein ligase activity involved in mitotic cell cycle
|
GO:0051436 |
4 |
0.955
|
Yeast |
|
|
female gamete generation
|
GO:0007292 |
2 |
0.954
|
Fly |
|
|
establishment or maintenance of cytoskeleton polarity
|
GO:0030952 |
3 |
0.953
|
Fly |
|
|
establishment or maintenance of microtubule cytoskeleton polarity
|
GO:0030951 |
2 |
0.952
|
Fly |
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.945
|
Human |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.943
|
|
|
|
steroid catabolic process
|
GO:0006706 |
10 |
0.938
|
Human |
|
|
cell projection organization
|
GO:0030030 |
252 |
0.935
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.935
|
Human Yeast |
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.934
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.930
|
Fly |
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.928
|
Human |
|
|
sodium ion transport
|
GO:0006814 |
61 |
0.926
|
Human |
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.926
|
Human |
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.926
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.923
|
Fly |
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.922
|
Fly |
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.919
|
Yeast |
|
|
sodium ion transmembrane transport
|
GO:0035725 |
59 |
0.919
|
Human |
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
231 |
0.913
|
Human |
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.912
|
Fly |
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.910
|
|
|
|
potassium ion transmembrane transport
|
GO:0071805 |
60 |
0.907
|
Human |
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.907
|
Worm |
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.902
|
Yeast Worm Fly |
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.902
|
|
|
|
microtubule organizing center organization
|
GO:0031023 |
62 |
0.902
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.901
|
Worm |
|
|
action potential
|
GO:0001508 |
34 |
0.901
|
Human |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.897
|
Human Yeast |
|
|
regulation of peptidyl serine dephosphorylation
|
GO:1902308 |
2 |
0.897
|
Human |
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.896
|
|
|
|
single fertilization
|
GO:0007338 |
11 |
0.896
|
Worm |
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.893
|
Worm |
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.891
|
Yeast |
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.888
|
Human Yeast |
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.884
|
|
|
|
establishment of nucleus localization
|
GO:0040023 |
1 |
0.877
|
Worm |
|
|
nucleus localization
|
GO:0051647 |
1 |
0.871
|
Worm |
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.866
|
Fly |
|
|
cation transport
|
GO:0006812 |
331 |
0.864
|
Human |
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.860
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.854
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.851
|
Human |
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.850
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.849
|
|
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
194 |
0.849
|
Human |
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.833
|
|
|
|
anterior posterior axis specification embryo
|
GO:0008595 |
2 |
0.832
|
|
|
|
nuclear migration
|
GO:0007097 |
1 |
0.827
|
Worm |
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.813
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.808
|
Human |
|
|
pattern specification process
|
GO:0007389 |
43 |
0.808
|
Worm Fly |
|
|
post embryonic development
|
GO:0009791 |
2 |
0.806
|
Worm |
|
|
nuclear transport
|
GO:0051169 |
179 |
0.806
|
|
|
|
dna replication initiation
|
GO:0006270 |
6 |
0.803
|
Yeast |
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.802
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.795
|
Yeast Worm Fly |
|
|
membrane depolarization during action potential
|
GO:0086010 |
10 |
0.792
|
Human |
|
|
stem cell development
|
GO:0048864 |
69 |
0.789
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.783
|
Human |
|
|
regulation of potassium ion transmembrane transport
|
GO:1901379 |
20 |
0.768
|
Human |
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.765
|
Human |
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.764
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.760
|
|
|
|
protein dna complex subunit organization
|
GO:0071824 |
80 |
0.750
|
Yeast |
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.747
|
Fly |
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.745
|
|
|
|
establishment or maintenance of cell polarity
|
GO:0007163 |
31 |
0.738
|
Worm Fly |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.729
|
Human Yeast |
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.728
|
Fly |
|
|
developmental process involved in reproduction
|
GO:0003006 |
66 |
0.727
|
Yeast Fly |
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.726
|
Human |
|
|
cytoplasmic sequestering of protein
|
GO:0051220 |
12 |
0.718
|
Human |
|
|
neurological system process
|
GO:0050877 |
163 |
0.717
|
Fly |
|
|
tor signaling
|
GO:0031929 |
39 |
0.707
|
|
|
|
protein folding
|
GO:0006457 |
38 |
0.706
|
Fly |
|
|
cation transmembrane transport
|
GO:0098655 |
238 |
0.700
|
Human |
|
|
microtubule based process
|
GO:0007017 |
210 |
0.697
|
Worm Fly |
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.685
|
|
|
|
multicellular organism reproduction
|
GO:0032504 |
42 |
0.680
|
Worm Fly |
|
|
positive regulation of transcription elongation from rna polymerase ii promoter
|
GO:0032968 |
10 |
0.680
|
|
|
|
cognition
|
GO:0050890 |
43 |
0.668
|
Fly |
|
|
positive regulation of dna templated transcription elongation
|
GO:0032786 |
18 |
0.661
|
|
|
|
release of cytochrome c from mitochondria
|
GO:0001836 |
35 |
0.658
|
Human |
|
|
establishment of cell polarity
|
GO:0030010 |
22 |
0.650
|
Worm |
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.645
|
Human |
|
|
stem cell differentiation
|
GO:0048863 |
93 |
0.639
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.636
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.634
|
Human |
|
|
cellular component disassembly
|
GO:0022411 |
92 |
0.632
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.631
|
|
|
|
system process
|
GO:0003008 |
349 |
0.630
|
Fly |
|
|
regulation of neuron death
|
GO:1901214 |
56 |
0.621
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.620
|
|
|
|
positive regulation of small gtpase mediated signal transduction
|
GO:0051057 |
12 |
0.612
|
Fly |
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.611
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.607
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.602
|
Human |
|
|
regulation of cell division
|
GO:0051302 |
116 |
0.602
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.602
|
Human |
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.600
|
Human |
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.599
|
Human |
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.597
|
Human |
|
|
maintenance of protein location
|
GO:0045185 |
57 |
0.597
|
Human |
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.591
|
Human |
|
|
response to hormone
|
GO:0009725 |
175 |
0.587
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.585
|
Yeast |
|
|
embryo development
|
GO:0009790 |
123 |
0.584
|
Worm Fly |
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.583
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.579
|
Yeast |
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.575
|
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
72 |
0.571
|
Human |
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.562
|
Yeast Worm Fly |
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.561
|
Yeast Worm |
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.558
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.557
|
Human |
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.554
|
|
|
|
midbrain development
|
GO:0030901 |
45 |
0.551
|
|
|
|
transcription elongation from rna polymerase ii promoter
|
GO:0006368 |
18 |
0.538
|
|
|
|
microtubule based movement
|
GO:0007018 |
32 |
0.535
|
|
|
|
corticosteroid receptor signaling pathway
|
GO:0031958 |
5 |
0.535
|
Human |
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.535
|
|
|
|
striated muscle cell differentiation
|
GO:0051146 |
43 |
0.529
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.526
|
|
|
|
negative regulation of exit from mitosis
|
GO:0001100 |
1 |
0.524
|
|
|
|
substantia nigra development
|
GO:0021762 |
45 |
0.519
|
|
|
|
regulation of membrane repolarization
|
GO:0060306 |
16 |
0.515
|
Human |
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.511
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.507
|
Fly |
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.505
|
Yeast |
|
|
spermatid development
|
GO:0007286 |
4 |
0.500
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.500
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.493
|
Human |
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.492
|
Human |
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.491
|
Human |
|
|
response to drug
|
GO:0042493 |
81 |
0.485
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.484
|
Mouse |
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.479
|
Human |
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.479
|
|
|
|
mrna processing
|
GO:0006397 |
133 |
0.473
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.471
|
|
|
|
cytokinesis
|
GO:0000910 |
96 |
0.470
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.464
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.461
|
Worm |
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.456
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.451
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.446
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.445
|
Worm |
|
|
regulation of dendrite development
|
GO:0050773 |
18 |
0.443
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.439
|
Human |
|
|
regulation of mitosis
|
GO:0007088 |
63 |
0.437
|
|
|
|
glucocorticoid metabolic process
|
GO:0008211 |
10 |
0.431
|
Human |
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
85 |
0.431
|
|
|
|
regulation of synaptic transmission
|
GO:0050804 |
11 |
0.428
|
Human |
|
|
cellular carbohydrate metabolic process
|
GO:0044262 |
84 |
0.423
|
Yeast |
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.421
|
|
|
|
establishment of spindle localization
|
GO:0051293 |
12 |
0.415
|
Worm |
|
|
multicellular organismal reproductive process
|
GO:0048609 |
40 |
0.409
|
Worm Fly |
|
|
cellular potassium ion transport
|
GO:0071804 |
60 |
0.404
|
Human |
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.403
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.401
|
Human |
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.401
|
|
|
|
chromosome segregation
|
GO:0007059 |
114 |
0.398
|
Fly |
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.393
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.390
|
Human Yeast |
|
|
negative regulation of peptidyl serine dephosphorylation
|
GO:1902309 |
1 |
0.380
|
Human |
|
|
response to starvation
|
GO:0042594 |
59 |
0.375
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.365
|
|
|
|
regulation of nuclear division
|
GO:0051783 |
65 |
0.364
|
|
|
|
regulation of protein kinase b signaling
|
GO:0051896 |
61 |
0.361
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.361
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.360
|
Human Yeast |
|
|
regulation of neuron projection development
|
GO:0010975 |
57 |
0.359
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.357
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.356
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.355
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.352
|
Human |
|
|
metal ion transport
|
GO:0030001 |
272 |
0.350
|
Human |
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.350
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.347
|
|
|
|
gliogenesis
|
GO:0042063 |
21 |
0.346
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.343
|
Human |
|
|
negative regulation of ubiquitin protein transferase activity
|
GO:0051444 |
8 |
0.343
|
Yeast |
|
|
protein dna complex assembly
|
GO:0065004 |
64 |
0.343
|
Yeast |
|
|
regulation of intracellular protein transport
|
GO:0033157 |
123 |
0.342
|
|
|
|
glucocorticoid catabolic process
|
GO:0006713 |
1 |
0.338
|
Human |
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.338
|
|
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.323
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.319
|
|
|
|
learning or memory
|
GO:0007611 |
13 |
0.319
|
Fly |
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.318
|
|
|
|
mitotic cell cycle checkpoint
|
GO:0007093 |
68 |
0.317
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.316
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.312
|
Human |
|
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.310
|
Human |
|
|
regionalization
|
GO:0003002 |
29 |
0.309
|
Worm |
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.307
|
|
|
|
regulation of sodium ion transport
|
GO:0002028 |
24 |
0.307
|
Human |
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.307
|
|
|
|
meiotic chromosome segregation
|
GO:0045132 |
4 |
0.306
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.305
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.302
|
|
|
|
neuron death
|
GO:0070997 |
65 |
0.301
|
|
|
|
regulation of meiotic cell cycle
|
GO:0051445 |
4 |
0.301
|
|
|
|
neural tube formation
|
GO:0001841 |
3 |
0.301
|
|
|
|
tripartite regional subdivision
|
GO:0007351 |
2 |
0.300
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.299
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.299
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.299
|
|
|
|
anterior posterior pattern specification
|
GO:0009952 |
9 |
0.297
|
Worm |
|
|
aggresome assembly
|
GO:0070842 |
4 |
0.291
|
|
|
|
specification of axis polarity
|
GO:0065001 |
1 |
0.286
|
Worm |
|
|
regulation of potassium ion transport
|
GO:0043266 |
24 |
0.285
|
Human |
|
|
developmental maturation
|
GO:0021700 |
28 |
0.279
|
Fly |
|
|
nuclear import
|
GO:0051170 |
106 |
0.279
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.278
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
66 |
0.278
|
|
|
|
centrosome organization
|
GO:0051297 |
58 |
0.277
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.277
|
|
|
|
negative regulation of neuron apoptotic process
|
GO:0043524 |
23 |
0.275
|
|
|
|
embryonic cranial skeleton morphogenesis
|
GO:0048701 |
6 |
0.275
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.275
|
Human |
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.270
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.270
|
|
|
|
actin filament bundle organization
|
GO:0061572 |
54 |
0.265
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.264
|
|
|
|
exocytosis
|
GO:0006887 |
71 |
0.262
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.258
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.256
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.256
|
Yeast |
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.247
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.242
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.239
|
|
|
|
cell fate specification
|
GO:0001708 |
8 |
0.237
|
Worm |
|
|
circulatory system process
|
GO:0003013 |
113 |
0.236
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.233
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.231
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.228
|
|
|
|
female sex determination
|
GO:0030237 |
1 |
0.226
|
|
|
|
head development
|
GO:0060322 |
108 |
0.222
|
|
|
|
cellular response to peptide
|
GO:1901653 |
59 |
0.219
|
|
|
|
male gamete generation
|
GO:0048232 |
22 |
0.216
|
|
|
|
autophagy
|
GO:0006914 |
88 |
0.216
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.214
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.213
|
|
|
|
negative regulation of protein transport
|
GO:0051224 |
75 |
0.211
|
Human |
|
|
dna dependent dna replication
|
GO:0006261 |
44 |
0.210
|
Yeast |
|
|
heart process
|
GO:0003015 |
62 |
0.209
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.209
|
|
|
|
neural nucleus development
|
GO:0048857 |
47 |
0.207
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.207
|
|
|
|
meiotic nuclear division
|
GO:0007126 |
10 |
0.205
|
Worm |
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.205
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.204
|
Human |
|
|
osteoblast differentiation
|
GO:0001649 |
92 |
0.202
|
|
|
|
dendrite development
|
GO:0016358 |
24 |
0.200
|
|
|
|
cellular process involved in reproduction in multicellular organism
|
GO:0022412 |
15 |
0.200
|
Fly |
|
|
intracellular steroid hormone receptor signaling pathway
|
GO:0030518 |
61 |
0.199
|
Human |
|
|
cell adhesion
|
GO:0007155 |
325 |
0.198
|
|
|
|
protein polymerization
|
GO:0051258 |
71 |
0.192
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.191
|
|
|
|
embryonic pattern specification
|
GO:0009880 |
5 |
0.190
|
|
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
40 |
0.189
|
|
|
|
membrane depolarization
|
GO:0051899 |
26 |
0.188
|
Human |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.188
|
Human Yeast |
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.188
|
|
|
|
ossification
|
GO:0001503 |
121 |
0.183
|
|
|
|
reproduction
|
GO:0000003 |
63 |
0.182
|
Yeast Worm Fly |
|
|
response to temperature stimulus
|
GO:0009266 |
22 |
0.181
|
Fly |
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.179
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.178
|
Yeast |
|
|
chromatin organization
|
GO:0006325 |
351 |
0.178
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.178
|
Worm |
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.177
|
|
|
|
axis specification
|
GO:0009798 |
12 |
0.175
|
Worm Fly |
|
|
ribonucleotide biosynthetic process
|
GO:0009260 |
81 |
0.174
|
|
|
|
multi organism reproductive process
|
GO:0044703 |
54 |
0.172
|
Yeast Worm Fly |
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.169
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.168
|
|
|
|
rna splicing via transesterification reactions
|
GO:0000375 |
90 |
0.168
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.167
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.167
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.166
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.164
|
|
|
|
mrna metabolic process
|
GO:0016071 |
175 |
0.164
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.162
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.160
|
|
|
|
blood circulation
|
GO:0008015 |
113 |
0.159
|
|
|
|
gamete generation
|
GO:0007276 |
25 |
0.159
|
Fly |
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.159
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.159
|
Human |
|
|
limbic system development
|
GO:0021761 |
3 |
0.158
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.158
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.157
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.157
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.156
|
Human |
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.156
|
|
|
|
membrane repolarization
|
GO:0086009 |
23 |
0.152
|
Human |
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.152
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.152
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.150
|
Human |
|
|
regulation of dna templated transcription elongation
|
GO:0032784 |
23 |
0.150
|
|
|
|
maintenance of location in cell
|
GO:0051651 |
62 |
0.149
|
Human |
|
|
response to calcium ion
|
GO:0051592 |
46 |
0.148
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.146
|
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.146
|
Human |
|
|
response to extracellular stimulus
|
GO:0009991 |
85 |
0.144
|
|
|
|
visual behavior
|
GO:0007632 |
2 |
0.142
|
|
|
|
mitotic nuclear division
|
GO:0007067 |
119 |
0.138
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.137
|
|
|
|
peptidyl serine dephosphorylation
|
GO:0070262 |
2 |
0.137
|
Human |
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.137
|
Yeast Fly |
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.136
|
Human |
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.135
|
Human |
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.135
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.134
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.133
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.133
|
|
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
83 |
0.132
|
|
|
|
protein stabilization
|
GO:0050821 |
64 |
0.131
|
Fly |
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.130
|
|
|
|
dna damage checkpoint
|
GO:0000077 |
68 |
0.129
|
Yeast |
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.128
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.127
|
Human |
|
|
germ cell development
|
GO:0007281 |
8 |
0.127
|
Fly |
|
|
purine containing compound biosynthetic process
|
GO:0072522 |
88 |
0.127
|
|
|
|
negative regulation of dephosphorylation
|
GO:0035305 |
63 |
0.127
|
Human |
|
|
secretion
|
GO:0046903 |
254 |
0.125
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.125
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.125
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.124
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.122
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.121
|
|
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.120
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.120
|
|
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.118
|
Human |
|
|
negative regulation of cellular catabolic process
|
GO:0031330 |
83 |
0.117
|
|
|
|
myotube differentiation
|
GO:0014902 |
22 |
0.117
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.117
|
|
|
|
energy reserve metabolic process
|
GO:0006112 |
22 |
0.115
|
Yeast |
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.114
|
|
|
|
dna replication dependent nucleosome assembly
|
GO:0006335 |
32 |
0.112
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.111
|
|
|
|
glucocorticoid receptor signaling pathway
|
GO:0042921 |
5 |
0.110
|
Human |
|
|
protein dephosphorylation
|
GO:0006470 |
81 |
0.107
|
Human |
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.106
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.106
|
Human |
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.105
|
|
|
|
establishment of spindle orientation
|
GO:0051294 |
9 |
0.105
|
Worm |
|
|
establishment of mitotic spindle localization
|
GO:0040001 |
8 |
0.105
|
Worm |
|
|
muscle cell development
|
GO:0055001 |
29 |
0.104
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.104
|
|
|
|
regulation of autophagy
|
GO:0010506 |
52 |
0.103
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
207 |
0.101
|
Yeast |
|
|
chordate embryonic development
|
GO:0043009 |
34 |
0.099
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.099
|
|
|
|
adenylate cyclase activating g protein coupled receptor signaling pathway
|
GO:0007189 |
18 |
0.098
|
|
|
|
positive regulation of ras protein signal transduction
|
GO:0046579 |
12 |
0.098
|
Fly |
|
|
adenylate cyclase modulating g protein coupled receptor signaling pathway
|
GO:0007188 |
43 |
0.098
|
|
|
|
dna packaging
|
GO:0006323 |
77 |
0.097
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.097
|
|
|
|
positive regulation of meiotic cell cycle
|
GO:0051446 |
2 |
0.095
|
|
|
|
hippocampus development
|
GO:0021766 |
1 |
0.095
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.095
|
Human |
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.094
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.094
|
|
|
|
cellular response to insulin stimulus
|
GO:0032869 |
41 |
0.093
|
|
|
|
generation of precursor metabolites and energy
|
GO:0006091 |
68 |
0.093
|
Yeast |
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.093
|
|
|
|
rna localization
|
GO:0006403 |
41 |
0.090
|
|
|
|
positive regulation of nucleotide biosynthetic process
|
GO:0030810 |
38 |
0.089
|
|
|
|
regulation of cyclic nucleotide metabolic process
|
GO:0030799 |
63 |
0.089
|
|
|
|
cellular response to extracellular stimulus
|
GO:0031668 |
72 |
0.089
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.089
|
Worm |
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.089
|
Human |
|
|
centrosome cycle
|
GO:0007098 |
32 |
0.089
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.089
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.088
|
|
|
|
cell fate commitment
|
GO:0045165 |
27 |
0.087
|
Worm Fly |
|
|
response to lipid
|
GO:0033993 |
206 |
0.087
|
|
|
|
primary neural tube formation
|
GO:0014020 |
3 |
0.086
|
|
|
|
cell maturation
|
GO:0048469 |
11 |
0.086
|
Fly |
|
|
axon cargo transport
|
GO:0008088 |
2 |
0.086
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.085
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.085
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
35 |
0.085
|
|
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.083
|
|
|
|
establishment of mitotic spindle orientation
|
GO:0000132 |
7 |
0.083
|
Worm |
|
|
regulation of ligase activity
|
GO:0051340 |
29 |
0.082
|
Yeast |
|
|
single organism behavior
|
GO:0044708 |
28 |
0.082
|
Fly |
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.082
|
Yeast |
|
|
regulation of embryonic development
|
GO:0045995 |
20 |
0.082
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.080
|
|
|
|
positive regulation of cell morphogenesis involved in differentiation
|
GO:0010770 |
50 |
0.077
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.077
|
|
|
|
regulation of oocyte development
|
GO:0060281 |
1 |
0.077
|
|
|
|
chromatin assembly or disassembly
|
GO:0006333 |
78 |
0.077
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.076
|
|
|
|
glycogen metabolic process
|
GO:0005977 |
22 |
0.075
|
Yeast |
|
|
neuron apoptotic process
|
GO:0051402 |
39 |
0.075
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
3 |
0.075
|
|
|
|
negative regulation of rho gtpase activity
|
GO:0034259 |
4 |
0.074
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.074
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.073
|
|
|
|
purine nucleotide biosynthetic process
|
GO:0006164 |
84 |
0.073
|
|
|
|
embryonic organ morphogenesis
|
GO:0048562 |
24 |
0.073
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.072
|
|
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
24 |
0.072
|
|
|
|
regulation of cyclin dependent protein serine threonine kinase activity
|
GO:0000079 |
36 |
0.072
|
|
|
|
wound healing
|
GO:0042060 |
115 |
0.071
|
|
|
|
regulation of protein import into nucleus
|
GO:0042306 |
78 |
0.070
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.070
|
|
|
|
spermatogenesis
|
GO:0007283 |
22 |
0.070
|
|
|
|
embryo development ending in birth or egg hatching
|
GO:0009792 |
34 |
0.069
|
Worm |
|
|
embryonic epithelial tube formation
|
GO:0001838 |
4 |
0.068
|
|
|
|
hormone secretion
|
GO:0046879 |
65 |
0.068
|
|
|
|
response to nutrient levels
|
GO:0031667 |
81 |
0.067
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.067
|
Human |
|
|
rna processing
|
GO:0006396 |
255 |
0.067
|
|
|
|
cellular response to metal ion
|
GO:0071248 |
43 |
0.066
|
|
|
|
striated muscle cell development
|
GO:0055002 |
27 |
0.066
|
|
|
|
response to parathyroid hormone
|
GO:0071107 |
3 |
0.066
|
|
|
|
regulation of stem cell differentiation
|
GO:2000736 |
56 |
0.065
|
|
|
|
cellular glucan metabolic process
|
GO:0006073 |
22 |
0.064
|
Yeast |
|
|
negative regulation of neuron death
|
GO:1901215 |
32 |
0.064
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.064
|
|
|
|
positive regulation of neuron projection development
|
GO:0010976 |
34 |
0.064
|
|
|
|
negative regulation of protein complex assembly
|
GO:0031333 |
43 |
0.063
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.063
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.062
|
|
|
|
muscle tissue development
|
GO:0060537 |
62 |
0.062
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.062
|
|
|
|
regulation of sodium ion transmembrane transporter activity
|
GO:2000649 |
17 |
0.061
|
Human |
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.061
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.061
|
|
|
|
muscle organ development
|
GO:0007517 |
56 |
0.061
|
|
|
|
cardiac muscle tissue development
|
GO:0048738 |
39 |
0.060
|
|
|
|
signal release
|
GO:0023061 |
70 |
0.060
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.060
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.060
|
Yeast |
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
56 |
0.059
|
|
|
|
cellular response to inorganic substance
|
GO:0071241 |
45 |
0.059
|
|
|
|
visual learning
|
GO:0008542 |
1 |
0.059
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.059
|
|
|
|
erbb signaling pathway
|
GO:0038127 |
44 |
0.059
|
|
|
|
dna templated transcription elongation
|
GO:0006354 |
25 |
0.059
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.058
|
Worm Fly |
|
|
negative regulation of protein modification by small protein conjugation or removal
|
GO:1903321 |
41 |
0.058
|
Yeast |
|
|
fertilization
|
GO:0009566 |
12 |
0.058
|
Worm |
|
|
regulation of epithelial cell migration
|
GO:0010632 |
93 |
0.058
|
|
|
|
rna interference
|
GO:0016246 |
4 |
0.057
|
|
|
|
regulation of dendrite morphogenesis
|
GO:0048814 |
11 |
0.057
|
|
|
|
response to peptide
|
GO:1901652 |
65 |
0.057
|
|
