Homo sapiens

78 known processes

ZAP70

zeta-chain (TCR) associated protein kinase 70kDa

(Aliases: STD,FLJ17670,SRK,FLJ17679,TZK,ZAP-70)

ZAP70 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of t cell receptor signaling pathway GO:0050856 7 0.999
t cell selection GO:0045058 4 0.999
regulation of antigen receptor mediated signaling pathway GO:0050854 10 0.996
t cell receptor signaling pathway GO:0050852 21 0.996
Mouse
antigen receptor mediated signaling pathway GO:0050851 38 0.995
Mouse
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.993
Mouse
regulation of cellular amine metabolic process GO:0033238 11 0.988
leukocyte activation GO:0045321 164 0.982
activation of immune response GO:0002253 114 0.976
Mouse
t cell activation GO:0042110 99 0.970
positive regulation of lymphocyte proliferation GO:0050671 46 0.956
Mouse
natural killer cell proliferation GO:0001787 4 0.949
positive regulation of immune system process GO:0002684 283 0.935
regulation of calcium mediated signaling GO:0050848 17 0.920
Mouse
positive regulation of calcium mediated signaling GO:0050850 10 0.908
Mouse
negative regulation of t cell receptor signaling pathway GO:0050860 4 0.906
cellular amino acid metabolic process GO:0006520 116 0.904
peptidyl tyrosine modification GO:0018212 170 0.895
positive regulation of cell activation GO:0050867 81 0.888
regulation of lymphocyte activation GO:0051249 103 0.873
leukocyte proliferation GO:0070661 74 0.867
Mouse
amine metabolic process GO:0009308 44 0.838
regulation of t cell activation GO:0050863 77 0.830
regulation of cell activation GO:0050865 125 0.821
peptidyl tyrosine phosphorylation GO:0018108 170 0.807
calcium mediated signaling GO:0019722 44 0.801
Mouse
positive regulation of alpha beta t cell activation GO:0046635 10 0.796
Mouse
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.745
immune response regulating signaling pathway GO:0002764 97 0.745
Mouse
positive regulation of immune response GO:0050778 159 0.744
Mouse
regulation of lymphocyte proliferation GO:0050670 64 0.695
Mouse
positive regulation of smooth muscle contraction GO:0045987 5 0.682
positive regulation of interferon gamma production GO:0032729 26 0.681
lymphocyte apoptotic process GO:0070227 20 0.665
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.643
immune response activating signal transduction GO:0002757 90 0.624
Mouse
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.604
Mouse
regulation of leukocyte proliferation GO:0070663 67 0.578
Mouse
negative regulation of smoothened signaling pathway GO:0045879 3 0.545
mononuclear cell proliferation GO:0032943 71 0.510
Mouse
regulation of leukocyte activation GO:0002694 115 0.505
cell activation GO:0001775 213 0.505
leukocyte differentiation GO:0002521 98 0.455
positive regulation of interleukin 4 production GO:0032753 3 0.454
negative regulation of catalytic activity GO:0043086 335 0.452
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.448
lymphocyte activation GO:0046649 133 0.421
regulation of hormone levels GO:0010817 125 0.410
regulation of transferase activity GO:0051338 355 0.406
regulation of immune response GO:0050776 201 0.403
Mouse
cell type specific apoptotic process GO:0097285 125 0.391
peptidyl tyrosine dephosphorylation GO:0035335 36 0.371
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.369
positive regulation of cellular amine metabolic process GO:0033240 7 0.364
hematopoietic or lymphoid organ development GO:0048534 186 0.361
memory GO:0007613 3 0.331
alpha beta t cell differentiation GO:0046632 7 0.329
Mouse
purine nucleoside catabolic process GO:0006152 398 0.316
secretion GO:0046903 254 0.309
response to organonitrogen compound GO:0010243 156 0.305
negative regulation of calcium mediated signaling GO:0050849 4 0.301
lymphocyte proliferation GO:0046651 70 0.292
Mouse
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 20 0.277
positive regulation of muscle contraction GO:0045933 6 0.273
positive regulation of leukocyte activation GO:0002696 80 0.262
positive regulation of lipid metabolic process GO:0045834 50 0.261
enzyme linked receptor protein signaling pathway GO:0007167 303 0.255
regulation of cellular amino acid metabolic process GO:0006521 6 0.252
t cell differentiation GO:0030217 29 0.252
regulation of reactive oxygen species metabolic process GO:2000377 41 0.250
regulation of mononuclear cell proliferation GO:0032944 65 0.247
Mouse
positive regulation of cell proliferation GO:0008284 301 0.231
Mouse
regulation of cellular ketone metabolic process GO:0010565 50 0.222
protein autophosphorylation GO:0046777 123 0.215
Mouse
smoothened signaling pathway GO:0007224 14 0.209
cellular amine metabolic process GO:0044106 41 0.199
tolerance induction GO:0002507 6 0.196
regulation of uterine smooth muscle contraction GO:0070472 1 0.189
regulation of interleukin 4 production GO:0032673 7 0.187
response to interleukin 15 GO:0070672 6 0.186
positive regulation of tyrosine phosphorylation of stat5 protein GO:0042523 11 0.183
regulation of protein serine threonine kinase activity GO:0071900 179 0.179
positive regulation of kinase activity GO:0033674 204 0.177
alpha beta t cell proliferation GO:0046633 5 0.175
Mouse
hemopoiesis GO:0030097 180 0.164
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.164
Fly
immune response GO:0006955 307 0.158
cytokine biosynthetic process GO:0042089 37 0.156
positive regulation of alpha beta t cell proliferation GO:0046641 5 0.155
Mouse
positive regulation of interleukin 2 production GO:0032743 11 0.154
regulation of icosanoid secretion GO:0032303 4 0.153
actin filament organization GO:0007015 128 0.151
zinc ion homeostasis GO:0055069 12 0.147
regulation of t cell proliferation GO:0042129 42 0.138
Mouse
lymphocyte differentiation GO:0030098 35 0.137
gamma delta t cell activation GO:0046629 3 0.127
positive regulation of antigen receptor mediated signaling pathway GO:0050857 3 0.125
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.124
cellular response to dna damage stimulus GO:0006974 379 0.123
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.123
regulation of alpha beta t cell differentiation GO:0046637 5 0.121
Mouse
endothelial cell migration GO:0043542 86 0.119
Zebrafish
regulation of t cell differentiation GO:0045580 19 0.118
positive regulation of t cell receptor signaling pathway GO:0050862 2 0.116
lymphocyte costimulation GO:0031294 7 0.110
negative regulation of intracellular signal transduction GO:1902532 183 0.109
regulation of blood coagulation GO:0030193 42 0.108
positive regulation of protein kinase b signaling GO:0051897 42 0.103
cellular ketone metabolic process GO:0042180 80 0.102
heart development GO:0007507 95 0.100
organ morphogenesis GO:0009887 147 0.100
leukocyte apoptotic process GO:0071887 31 0.099
t cell tolerance induction GO:0002517 4 0.099
positive regulation of cytokine biosynthetic process GO:0042108 25 0.099
regulation of kinase activity GO:0043549 314 0.095
regeneration GO:0031099 4 0.093
regulation of smooth muscle contraction GO:0006940 5 0.093
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.093
caveolin mediated endocytosis GO:0072584 4 0.091
t cell costimulation GO:0031295 7 0.091
regulation of t cell tolerance induction GO:0002664 4 0.087
positive regulation of gamma delta t cell activation GO:0046645 1 0.087
negative regulation of developmental process GO:0051093 247 0.086
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.085
Fly
positive regulation of apoptotic process GO:0043065 246 0.084
negative regulation of phosphorus metabolic process GO:0010563 267 0.077
negative regulation of phosphate metabolic process GO:0045936 267 0.075
determination of adult lifespan GO:0008340 2 0.074
cellular response to nitrogen compound GO:1901699 144 0.071
peptide transport GO:0015833 74 0.068
regulation of cell growth GO:0001558 135 0.068
positive regulation of cytokine mediated signaling pathway GO:0001961 12 0.068
cellular chemical homeostasis GO:0055082 180 0.067
cellular response to interleukin 15 GO:0071350 6 0.066
cell growth GO:0016049 160 0.064
Fly
cellular divalent inorganic cation homeostasis GO:0072503 128 0.064
negative regulation of cellular amine metabolic process GO:0033239 3 0.063
signal transduction by phosphorylation GO:0023014 297 0.063
Fly
negative regulation of programmed cell death GO:0043069 321 0.063
metal ion transport GO:0030001 272 0.062
uterine smooth muscle contraction GO:0070471 1 0.062
thymic t cell selection GO:0045061 2 0.062
regulation of interferon gamma production GO:0032649 36 0.062
negative regulation of t cell activation GO:0050868 18 0.062
long term memory GO:0007616 2 0.062
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.061
response to peptide GO:1901652 65 0.061
positive regulation of tolerance induction GO:0002645 2 0.060
negative regulation of protein kinase activity GO:0006469 98 0.060
positive regulation of transport GO:0051050 336 0.057
regulation of mapk cascade GO:0043408 262 0.057
positive regulation of leukocyte differentiation GO:1902107 37 0.056
establishment of protein localization to membrane GO:0090150 121 0.056
cellular response to hormone stimulus GO:0032870 125 0.055
cytokine metabolic process GO:0042107 38 0.055
positive regulation of apoptotic signaling pathway GO:2001235 70 0.055
regulation of tolerance induction GO:0002643 4 0.055
interferon gamma production GO:0032609 39 0.054
protein polymerization GO:0051258 71 0.053
cell development GO:0048468 328 0.052
Fly
dephosphorylation GO:0016311 209 0.052
response to cytokine GO:0034097 232 0.049
cytokine production GO:0001816 247 0.049
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.048
positive regulation of b cell proliferation GO:0030890 12 0.047
regulation of erbb signaling pathway GO:1901184 27 0.047
positive regulation of map kinase activity GO:0043406 80 0.047
protein secretion GO:0009306 98 0.047
cellular senescence GO:0090398 34 0.046
response to abiotic stimulus GO:0009628 336 0.045
positive regulation of t cell differentiation GO:0045582 11 0.045
cytokine mediated signaling pathway GO:0019221 109 0.045
positive regulation of mononuclear cell proliferation GO:0032946 47 0.044
Mouse
organic hydroxy compound metabolic process GO:1901615 147 0.044
response to nitrogen compound GO:1901698 184 0.043
regulation of b cell receptor signaling pathway GO:0050855 4 0.043
regulation of map kinase activity GO:0043405 108 0.043
positive regulation of leukocyte proliferation GO:0070665 48 0.043
Mouse
regulation of actin filament based process GO:0032970 141 0.041
response to radiation GO:0009314 151 0.041
phosphatidylinositol mediated signaling GO:0048015 55 0.041
lipid biosynthetic process GO:0008610 177 0.040
second messenger mediated signaling GO:0019932 78 0.040
Mouse
regulation of sequestering of calcium ion GO:0051282 41 0.040
lipid metabolic process GO:0006629 381 0.039
negative regulation of proteolysis GO:0045861 132 0.039
cell cycle phase transition GO:0044770 173 0.038
muscle contraction GO:0006936 73 0.038
associative learning GO:0008306 1 0.038
protein ubiquitination GO:0016567 314 0.038
cellular response to organonitrogen compound GO:0071417 124 0.037
sequestering of calcium ion GO:0051208 17 0.037
lymphocyte homeostasis GO:0002260 4 0.037
oocyte differentiation GO:0009994 2 0.037
tissue regeneration GO:0042246 3 0.037
interleukin 4 production GO:0032633 7 0.037
negative regulation of antigen receptor mediated signaling pathway GO:0050858 6 0.037
regulation of smoothened signaling pathway GO:0008589 6 0.037
positive regulation of catabolic process GO:0009896 310 0.036
cellular macromolecular complex assembly GO:0034622 324 0.035
single organism cellular localization GO:1902580 332 0.035
Human
response to insulin GO:0032868 45 0.035
regulation of protein ubiquitination GO:0031396 95 0.035
mitotic cell cycle process GO:1903047 286 0.035
insulin receptor signaling pathway GO:0008286 23 0.034
organic acid biosynthetic process GO:0016053 97 0.034
multicellular organismal homeostasis GO:0048871 67 0.034
protein maturation GO:0051604 233 0.033
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.033
protein targeting GO:0006605 187 0.033
Human
negative regulation of kinase activity GO:0033673 106 0.033
regulation of lymphocyte apoptotic process GO:0070228 15 0.033
reactive nitrogen species metabolic process GO:2001057 3 0.032
actin filament based process GO:0030029 224 0.032
protein modification by small protein conjugation GO:0032446 342 0.032
positive regulation of cd4 positive alpha beta t cell activation GO:2000516 3 0.032
positive regulation of alpha beta t cell differentiation GO:0046638 4 0.031
Mouse
regulation of response to dna damage stimulus GO:2001020 94 0.031
reactive oxygen species metabolic process GO:0072593 75 0.031
organophosphate catabolic process GO:0046434 430 0.031
regulation of transmembrane transporter activity GO:0022898 74 0.030
negative regulation of protein metabolic process GO:0051248 391 0.030
insulin like growth factor receptor signaling pathway GO:0048009 13 0.030
digestive tract morphogenesis GO:0048546 56 0.030
regulation of erk1 and erk2 cascade GO:0070372 99 0.030
t cell proliferation GO:0042098 45 0.030
Mouse
protein targeting to nucleus GO:0044744 104 0.029
Human
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.029
cell projection organization GO:0030030 252 0.029
Fly
melanin metabolic process GO:0006582 1 0.029
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.029
regulation of cytokine mediated signaling pathway GO:0001959 41 0.029
integrin mediated signaling pathway GO:0007229 32 0.029
negative regulation of transport GO:0051051 176 0.029
cellular response to abiotic stimulus GO:0071214 117 0.029
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.029
b cell receptor signaling pathway GO:0050853 18 0.029
regulation of cell differentiation GO:0045595 393 0.029
forebrain generation of neurons GO:0021872 3 0.028
calcium ion transport GO:0006816 147 0.028
signal transduction in response to dna damage GO:0042770 57 0.028
regulation of protein localization GO:0032880 296 0.027
positive regulation of lymphocyte activation GO:0051251 73 0.027
regulation of protein targeting GO:1903533 91 0.027
neurogenesis GO:0022008 169 0.027
Fly
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.027
positive regulation of interleukin 2 biosynthetic process GO:0045086 5 0.027
negative regulation of protein processing GO:0010955 142 0.026
regulation of cellular component biogenesis GO:0044087 281 0.026
mapk cascade GO:0000165 288 0.025
Fly
negative regulation of protein modification process GO:0031400 200 0.025
positive regulation of phosphorylation GO:0042327 394 0.025
positive regulation of interferon gamma mediated signaling pathway GO:0060335 2 0.025
alpha beta t cell activation GO:0046631 15 0.025
Mouse
glycoprotein metabolic process GO:0009100 110 0.025
regulation of blood pressure GO:0008217 30 0.025
regulation of protein import into nucleus GO:0042306 78 0.025
epidermal growth factor receptor signaling pathway GO:0007173 39 0.025
endothelial cell proliferation GO:0001935 65 0.024
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.024
response to zinc ion GO:0010043 12 0.024
cellular response to oxygen containing compound GO:1901701 276 0.024
transition metal ion homeostasis GO:0055076 31 0.024
regulation of binding GO:0051098 111 0.023
mrna metabolic process GO:0016071 175 0.023
stress fiber assembly GO:0043149 40 0.023
motor neuron axon guidance GO:0008045 2 0.023
regulation of cytokine biosynthetic process GO:0042035 35 0.023
apoptotic signaling pathway GO:0097190 268 0.023
negative regulation of cellular protein metabolic process GO:0032269 353 0.022
neuron differentiation GO:0030182 138 0.022
Fly
regulation of natural killer cell activation GO:0032814 9 0.022
regulation of gamma delta t cell activation GO:0046643 1 0.022
regulation of actin filament bundle assembly GO:0032231 36 0.022
nitrogen compound transport GO:0071705 191 0.022
regulation of endothelial cell apoptotic process GO:2000351 24 0.022
positive regulation of developmental process GO:0051094 314 0.022
positive regulation of secretion GO:0051047 116 0.022
regulation of interleukin 6 mediated signaling pathway GO:0070103 3 0.022
mitotic cell cycle phase transition GO:0044772 162 0.022
cell projection assembly GO:0030031 126 0.022
regulation of locomotion GO:0040012 329 0.021
Zebrafish
cell cell junction organization GO:0045216 69 0.021
regulation of cytokine secretion GO:0050707 57 0.021
mating GO:0007618 1 0.020
cell matrix adhesion GO:0007160 85 0.020
monosaccharide metabolic process GO:0005996 74 0.020
protein import into nucleus GO:0006606 104 0.020
Human
purine nucleoside triphosphate metabolic process GO:0009144 412 0.020
cellular component morphogenesis GO:0032989 314 0.020
Fly
regulation of cardiac muscle cell proliferation GO:0060043 4 0.020
actin filament polymerization GO:0030041 45 0.020
negative regulation of peptidase activity GO:0010466 91 0.020
blood vessel endothelial cell migration GO:0043534 42 0.019
Zebrafish
divalent inorganic cation homeostasis GO:0072507 136 0.019
negative regulation of protein phosphorylation GO:0001933 140 0.019
regulation of b cell activation GO:0050864 24 0.019
circulatory system process GO:0003013 113 0.019
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.019
protein homooligomerization GO:0051260 100 0.019
response to hydrogen peroxide GO:0042542 40 0.019
tor signaling GO:0031929 39 0.019
glycoprotein biosynthetic process GO:0009101 91 0.019
cellular lipid metabolic process GO:0044255 303 0.019
lipid localization GO:0010876 106 0.019
positive regulation of t cell tolerance induction GO:0002666 2 0.019
mrna catabolic process GO:0006402 56 0.019
interleukin 15 mediated signaling pathway GO:0035723 1 0.019
regulation of blood vessel endothelial cell migration GO:0043535 30 0.019
Zebrafish
response to mechanical stimulus GO:0009612 51 0.019
negative regulation of type i interferon mediated signaling pathway GO:0060339 4 0.018
tube development GO:0035295 125 0.018
negative regulation of protein tyrosine kinase activity GO:0061099 13 0.018
positive regulation of cell death GO:0010942 263 0.018
chemical homeostasis GO:0048878 306 0.018
vascular process in circulatory system GO:0003018 29 0.018
polysaccharide metabolic process GO:0005976 33 0.018
neuromuscular junction development GO:0007528 3 0.018
post embryonic organ development GO:0048569 1 0.018
short term memory GO:0007614 1 0.018
positive regulation of hydrolase activity GO:0051345 331 0.018
negative regulation of cell cycle process GO:0010948 121 0.017
purine nucleoside triphosphate catabolic process GO:0009146 392 0.017
regulation of epidermal growth factor activated receptor activity GO:0007176 14 0.017
positive regulation of cytokine production GO:0001819 167 0.017
regulation of anatomical structure morphogenesis GO:0022603 286 0.017
Zebrafish Fly
regulation of lymphocyte differentiation GO:0045619 22 0.017
positive regulation of t cell proliferation GO:0042102 33 0.017
Mouse
response to fungus GO:0009620 4 0.017
cellular response to radiation GO:0071478 65 0.017
regulation of response to cytokine stimulus GO:0060759 46 0.017
multicellular organismal aging GO:0010259 3 0.017
tissue morphogenesis GO:0048729 96 0.017
Fly
regulation of cell motility GO:2000145 299 0.017
Zebrafish
regulation of protein localization to plasma membrane GO:1903076 40 0.017
nucleoside triphosphate catabolic process GO:0009143 394 0.017
actin polymerization or depolymerization GO:0008154 56 0.017
early endosome to late endosome transport GO:0045022 21 0.017
regulation of receptor activity GO:0010469 47 0.017
negative regulation of map kinase activity GO:0043407 27 0.017
platelet derived growth factor receptor beta signaling pathway GO:0035791 4 0.017
regulation of epidermal growth factor receptor signaling pathway GO:0042058 27 0.017
serotonin transport GO:0006837 3 0.017
post embryonic development GO:0009791 2 0.016
coagulation GO:0050817 78 0.016
regulation of secretion by cell GO:1903530 177 0.016
protein localization to organelle GO:0033365 280 0.016
Human
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 11 0.016
regulation of canonical wnt signaling pathway GO:0060828 88 0.016
small gtpase mediated signal transduction GO:0007264 78 0.016
cellular metal ion homeostasis GO:0006875 146 0.016
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.016
negative regulation of cell motility GO:2000146 104 0.016
protein acylation GO:0043543 138 0.016
mitochondrion organization GO:0007005 156 0.016
hindbrain development GO:0030902 3 0.016
divalent inorganic cation transport GO:0072511 158 0.016
reactive oxygen species biosynthetic process GO:1903409 4 0.016
canonical wnt signaling pathway GO:0060070 116 0.016
dna repair GO:0006281 198 0.016
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.016
divalent metal ion transport GO:0070838 152 0.016
positive regulation of programmed cell death GO:0043068 249 0.016
small molecule biosynthetic process GO:0044283 157 0.016
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.016
regulation of cell cycle phase transition GO:1901987 126 0.016
extrinsic apoptotic signaling pathway GO:0097191 119 0.016
regulation of epithelial cell migration GO:0010632 93 0.016
Zebrafish
embryo development GO:0009790 123 0.016
Fly
positive regulation of nucleoside metabolic process GO:0045979 186 0.015
protein processing GO:0016485 226 0.015
myeloid leukocyte differentiation GO:0002573 60 0.015
actin filament bundle organization GO:0061572 54 0.015
cell cell recognition GO:0009988 4 0.015
negative regulation of growth GO:0045926 97 0.015
segmentation GO:0035282 4 0.015
positive regulation of b cell differentiation GO:0045579 1 0.015
regulation of purine nucleotide metabolic process GO:1900542 264 0.015
maintenance of location GO:0051235 112 0.015
growth GO:0040007 202 0.015
Fly
ceramide metabolic process GO:0006672 25 0.015
cell part morphogenesis GO:0032990 137 0.015
Fly
cell cell signaling GO:0007267 155 0.015
carboxylic acid biosynthetic process GO:0046394 97 0.015
regulation of leukocyte apoptotic process GO:2000106 25 0.015
response to interleukin 13 GO:0035962 4 0.015
fatty acid derivative biosynthetic process GO:1901570 18 0.015
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.015
heart process GO:0003015 62 0.015
nuclear import GO:0051170 106 0.015
Human
regulation of caveolin mediated endocytosis GO:2001286 2 0.015
regulation of protein kinase activity GO:0045859 289 0.014
mesenchyme development GO:0060485 59 0.014
negative regulation of phosphorylation GO:0042326 174 0.014
jak stat cascade GO:0007259 46 0.014
regulation of system process GO:0044057 101 0.014
response to peptide hormone GO:0043434 61 0.014
regulation of dna repair GO:0006282 47 0.014
regulation of cell shape GO:0008360 48 0.014
Fly
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.014
neural crest cell migration GO:0001755 2 0.014
regulation of glycoprotein metabolic process GO:1903018 19 0.014
regulation of ion homeostasis GO:2000021 73 0.014
neuron development GO:0048666 113 0.014
Fly
digestive tract development GO:0048565 75 0.014
lipid transport GO:0006869 90 0.014
purine ribonucleoside catabolic process GO:0046130 398 0.013
amide transport GO:0042886 76 0.013
regulation of defense response GO:0031347 154 0.013
stem cell development GO:0048864 69 0.013
regulation of interleukin 2 biosynthetic process GO:0045076 7 0.013
positive regulation of cell growth GO:0030307 48 0.013
positive regulation of ossification GO:0045778 32 0.013
secretion by cell GO:0032940 226 0.013
cellular homeostasis GO:0019725 196 0.013
regulation of cell adhesion GO:0030155 166 0.013
glucose metabolic process GO:0006006 45 0.013
positive regulation of protein kinase activity GO:0045860 190 0.013
epidermis morphogenesis GO:0048730 3 0.013
negative regulation of receptor activity GO:2000272 15 0.013
positive regulation of t cell activation GO:0050870 54 0.013
oogenesis GO:0048477 2 0.013
Fly
regulation of nucleoside metabolic process GO:0009118 209 0.013
positive regulation of dna repair GO:0045739 25 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
cell morphogenesis involved in differentiation GO:0000904 144 0.013
lipid modification GO:0030258 84 0.013
cell junction assembly GO:0034329 67 0.013
peptidyl serine modification GO:0018209 106 0.013
cellular response to growth factor stimulus GO:0071363 197 0.013
positive regulation of jnk cascade GO:0046330 52 0.013
endomembrane system organization GO:0010256 196 0.013
regulation of endothelial cell migration GO:0010594 67 0.013
Zebrafish
regulation of transporter activity GO:0032409 82 0.012
peripheral nervous system development GO:0007422 2 0.012
regulation of stress activated mapk cascade GO:0032872 84 0.012
modification dependent macromolecule catabolic process GO:0043632 212 0.012
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.012
positive regulation of endopeptidase activity GO:0010950 84 0.012
negative regulation of blood pressure GO:0045776 3 0.012
carboxylic acid catabolic process GO:0046395 71 0.012
lymphocyte mediated immunity GO:0002449 48 0.012
positive regulation of innate immune response GO:0045089 79 0.012
glial cell migration GO:0008347 4 0.012
calcium ion homeostasis GO:0055074 122 0.012
regulation of mitotic cell cycle GO:0007346 189 0.012
cellular protein catabolic process GO:0044257 261 0.012
striated muscle cell differentiation GO:0051146 43 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.012
protein catabolic process GO:0030163 325 0.012
regulation of cellular response to stress GO:0080135 244 0.012
regulation of astrocyte chemotaxis GO:2000458 1 0.012
cd4 positive alpha beta t cell differentiation GO:0043367 4 0.012
hormone transport GO:0009914 68 0.012
ribonucleoside triphosphate catabolic process GO:0009203 391 0.012
inositol trisphosphate metabolic process GO:0032957 2 0.012
ribonucleoside triphosphate metabolic process GO:0009199 412 0.012
system process GO:0003008 349 0.012
nucleoside triphosphate metabolic process GO:0009141 422 0.012
endosomal transport GO:0016197 129 0.012
regulation of cytokine production GO:0001817 232 0.012
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.012
regulation of osteoblast differentiation GO:0045667 38 0.012
rna processing GO:0006396 255 0.012
negative regulation of cell differentiation GO:0045596 171 0.012
rhythmic behavior GO:0007622 2 0.012
regulation of cytoplasmic transport GO:1903649 149 0.012
metencephalon development GO:0022037 2 0.012
neuron projection development GO:0031175 106 0.012
Fly
positive regulation of lipid biosynthetic process GO:0046889 22 0.011
regulation of proteolysis GO:0030162 293 0.011
negative regulation of response to cytokine stimulus GO:0060761 25 0.011
positive regulation of cell motility GO:2000147 177 0.011
Zebrafish
single organism nuclear import GO:1902593 104 0.011
Human
regulation of protein maturation GO:1903317 150 0.011
monocarboxylic acid biosynthetic process GO:0072330 67 0.011
rab protein signal transduction GO:0032482 4 0.011
platelet degranulation GO:0002576 2 0.011
negative regulation of leukocyte activation GO:0002695 26 0.011
response to drug GO:0042493 81 0.011

ZAP70 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.916
carbohydrate metabolism disease DOID:0050013 32 0.858
acquired metabolic disease DOID:0060158 58 0.858
immune system disease DOID:2914 155 0.518
hypersensitivity reaction disease DOID:0060056 25 0.518
hypersensitivity reaction type ii disease DOID:417 19 0.214
lupus erythematosus DOID:8857 12 0.182
systemic lupus erythematosus DOID:9074 12 0.182
musculoskeletal system disease DOID:17 223 0.182
connective tissue disease DOID:65 109 0.182
glucose metabolism disease DOID:4194 32 0.071
cancer DOID:162 167 0.031
disease of cellular proliferation DOID:14566 174 0.031
organ system cancer DOID:0050686 164 0.031
bone disease DOID:0080001 88 0.014
diabetes mellitus DOID:9351 31 0.014