Mus musculus

0 known processes

Plekhg4

pleckstrin homology domain containing, family G (with RhoGef domain) member 4

(Aliases: mFLJ00068,4931414L13Rik,AI448583)

Plekhg4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 103 0.111
regulation of cellular amino acid metabolic process GO:0006521 5 0.070
male gamete generation GO:0048232 285 0.070
spermatogenesis GO:0007283 284 0.059
amine metabolic process GO:0009308 45 0.057
regionalization GO:0003002 337 0.054
cellular ketone metabolic process GO:0042180 84 0.052
dna metabolic process GO:0006259 303 0.050
nucleobase containing small molecule metabolic process GO:0055086 352 0.049
regulation of cellular ketone metabolic process GO:0010565 66 0.049
peptidyl amino acid modification GO:0018193 336 0.049
fertilization GO:0009566 127 0.048
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.046
macromolecule catabolic process GO:0009057 281 0.045
cellular nitrogen compound catabolic process GO:0044270 280 0.041
cellular macromolecule catabolic process GO:0044265 206 0.041
regulation of transferase activity GO:0051338 263 0.040
cell adhesion GO:0007155 329 0.040
renal system development GO:0072001 225 0.040
positive regulation of cell development GO:0010720 237 0.040
regulation of cell adhesion GO:0030155 154 0.040
regulation of cellular amine metabolic process GO:0033238 20 0.039
negative regulation of molecular function GO:0044092 258 0.038
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.036
cellular amine metabolic process GO:0044106 44 0.036
regulation of protein kinase activity GO:0045859 232 0.034
regulation of cellular catabolic process GO:0031329 242 0.033
pole plasm assembly GO:0007315 2 0.032
sensory organ morphogenesis GO:0090596 242 0.031
aromatic compound catabolic process GO:0019439 286 0.030
cellular protein catabolic process GO:0044257 155 0.030
extracellular matrix organization GO:0030198 147 0.029
spermatid development GO:0007286 108 0.029
negative regulation of protein metabolic process GO:0051248 282 0.028
mitotic chromosome condensation GO:0007076 1 0.028
inorganic cation transmembrane transport GO:0098662 207 0.028
protein maturation GO:0051604 176 0.027
nucleotide metabolic process GO:0009117 332 0.027
regulation of vesicle mediated transport GO:0060627 139 0.027
protein catabolic process GO:0030163 221 0.027
kidney development GO:0001822 213 0.026
negative regulation of cellular protein metabolic process GO:0032269 247 0.026
urogenital system development GO:0001655 261 0.025
meiosis i GO:0007127 60 0.025
positive regulation of transferase activity GO:0051347 167 0.025
divalent metal ion transport GO:0070838 172 0.025
protein processing GO:0016485 163 0.024
purine nucleotide metabolic process GO:0006163 302 0.024
glycosyl compound metabolic process GO:1901657 246 0.024
purine ribonucleoside metabolic process GO:0046128 241 0.024
cation transport GO:0006812 399 0.023
positive regulation of cellular amine metabolic process GO:0033240 5 0.023
nucleoside phosphate metabolic process GO:0006753 338 0.023
segmentation GO:0035282 93 0.023
meiotic nuclear division GO:0007126 115 0.023
meiotic cell cycle GO:0051321 122 0.023
regulation of neuron differentiation GO:0045664 281 0.023
carbohydrate metabolic process GO:0005975 230 0.023
respiratory tube development GO:0030323 167 0.023
oocyte axis specification GO:0007309 2 0.023
cation transmembrane transport GO:0098655 266 0.022
exocytosis GO:0006887 121 0.022
respiratory system development GO:0060541 190 0.022
purine nucleoside catabolic process GO:0006152 205 0.022
nucleoside metabolic process GO:0009116 246 0.022
germ cell development GO:0007281 185 0.022
nuclear division GO:0000280 158 0.022
chemotaxis GO:0006935 247 0.022
ribose phosphate metabolic process GO:0019693 291 0.022
intracellular protein transport GO:0006886 204 0.022
male meiosis GO:0007140 37 0.021
stem cell development GO:0048864 219 0.021
protein localization to organelle GO:0033365 185 0.021
organelle fission GO:0048285 170 0.021
heterocycle catabolic process GO:0046700 280 0.021
organic cyclic compound catabolic process GO:1901361 295 0.021
ribonucleotide catabolic process GO:0009261 208 0.021
positive regulation of neuron differentiation GO:0045666 141 0.021
adaptive immune response GO:0002250 155 0.021
extracellular structure organization GO:0043062 148 0.021
neuron death GO:0070997 154 0.021
oocyte construction GO:0007308 2 0.021
negative regulation of protein modification process GO:0031400 163 0.021
placenta development GO:0001890 140 0.020
epithelial tube morphogenesis GO:0060562 303 0.020
camera type eye development GO:0043010 266 0.020
membrane organization GO:0061024 245 0.020
modification dependent macromolecule catabolic process GO:0043632 133 0.020
lateral inhibition GO:0046331 1 0.020
ribonucleoside metabolic process GO:0009119 245 0.020
protein modification by small protein conjugation GO:0032446 187 0.020
leukocyte differentiation GO:0002521 342 0.020
ribonucleotide metabolic process GO:0009259 291 0.019
blood circulation GO:0008015 195 0.019
positive regulation of nervous system development GO:0051962 221 0.019
synaptic transmission GO:0007268 329 0.019
positive regulation of protein modification process GO:0031401 299 0.019
mrna metabolic process GO:0016071 84 0.019
striated muscle tissue development GO:0014706 293 0.019
lymphocyte differentiation GO:0030098 242 0.019
microtubule based process GO:0007017 236 0.019
oxidation reduction process GO:0055114 342 0.019
cellular lipid metabolic process GO:0044255 323 0.019
spermatid differentiation GO:0048515 115 0.019
purine nucleoside triphosphate metabolic process GO:0009144 226 0.019
rna processing GO:0006396 105 0.019
organonitrogen compound catabolic process GO:1901565 264 0.018
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.018
dna methylation involved in gamete generation GO:0043046 15 0.018
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.018
positive regulation of programmed cell death GO:0043068 218 0.018
positive regulation of kinase activity GO:0033674 155 0.018
small gtpase mediated signal transduction GO:0007264 97 0.018
stem cell differentiation GO:0048863 268 0.018
gland development GO:0048732 330 0.018
divalent inorganic cation transport GO:0072511 178 0.018
protein targeting GO:0006605 143 0.018
regulation of cell cycle GO:0051726 281 0.018
retina development in camera type eye GO:0060041 119 0.018
peptidyl tyrosine phosphorylation GO:0018108 143 0.018
ribonucleoside triphosphate metabolic process GO:0009199 220 0.018
regulation of response to wounding GO:1903034 189 0.018
transmission of nerve impulse GO:0019226 76 0.018
monocarboxylic acid metabolic process GO:0032787 191 0.017
protein ubiquitination GO:0016567 171 0.017
neuron apoptotic process GO:0051402 142 0.017
ribonucleoside catabolic process GO:0042454 206 0.017
chromatin organization GO:0006325 206 0.017
mrna processing GO:0006397 63 0.017
response to organonitrogen compound GO:0010243 246 0.017
leukocyte mediated immunity GO:0002443 174 0.017
cellularization GO:0007349 1 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.017
regulation of apoptotic signaling pathway GO:2001233 197 0.017
female gonad development GO:0008585 71 0.017
nucleoside phosphate catabolic process GO:1901292 222 0.017
nucleoside triphosphate metabolic process GO:0009141 230 0.017
regulation of intracellular transport GO:0032386 159 0.017
positive regulation of cellular catabolic process GO:0031331 148 0.017
regulation of defense response GO:0031347 233 0.016
reactive oxygen species metabolic process GO:0072593 84 0.016
response to organic cyclic compound GO:0014070 198 0.016
maternal determination of anterior posterior axis embryo GO:0008358 2 0.016
development of primary sexual characteristics GO:0045137 143 0.016
sensory perception GO:0007600 245 0.016
methylation GO:0032259 134 0.016
posttranscriptional regulation of gene expression GO:0010608 155 0.016
organophosphate catabolic process GO:0046434 232 0.016
inorganic ion transmembrane transport GO:0098660 234 0.016
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.016
embryonic epithelial tube formation GO:0001838 130 0.016
cellular response to organonitrogen compound GO:0071417 145 0.016
heart morphogenesis GO:0003007 178 0.016
g protein coupled receptor signaling pathway GO:0007186 243 0.016
positive regulation of growth GO:0045927 104 0.016
negative regulation of protein phosphorylation GO:0001933 126 0.016
purine nucleotide catabolic process GO:0006195 211 0.016
cytokine production GO:0001816 319 0.016
skeletal system development GO:0001501 356 0.016
embryonic organ morphogenesis GO:0048562 276 0.016
modification dependent protein catabolic process GO:0019941 133 0.015
cell cell recognition GO:0009988 44 0.015
apoptotic signaling pathway GO:0097190 306 0.015
b cell activation GO:0042113 161 0.015
purine ribonucleotide metabolic process GO:0009150 290 0.015
immune effector process GO:0002252 321 0.015
connective tissue development GO:0061448 179 0.015
ubiquitin dependent protein catabolic process GO:0006511 129 0.015
digestive system development GO:0055123 200 0.015
cellular ion homeostasis GO:0006873 165 0.015
nephron development GO:0072006 109 0.015
organonitrogen compound biosynthetic process GO:1901566 192 0.015
muscle cell differentiation GO:0042692 261 0.015
ribonucleoside triphosphate catabolic process GO:0009203 199 0.015
positive regulation of cell death GO:0010942 224 0.015
single fertilization GO:0007338 82 0.015
rna interference GO:0016246 2 0.015
purine nucleoside metabolic process GO:0042278 241 0.015
organic anion transport GO:0015711 137 0.015
regulation of neuron death GO:1901214 134 0.015
regulation of protein processing GO:0070613 96 0.015
regulation of mapk cascade GO:0043408 248 0.015
regulation of cellular protein catabolic process GO:1903362 61 0.015
nucleotide catabolic process GO:0009166 217 0.015
cytoplasmic transport GO:0016482 234 0.014
skeletal system morphogenesis GO:0048705 203 0.014
endocytosis GO:0006897 168 0.014
regulation of protein catabolic process GO:0042176 108 0.014
regulation of membrane potential GO:0042391 192 0.014
gonad development GO:0008406 141 0.014
multicellular organism growth GO:0035264 161 0.014
regulation of hormone levels GO:0010817 211 0.014
lung development GO:0030324 164 0.014
lymphocyte mediated immunity GO:0002449 139 0.014
regulation of cell activation GO:0050865 289 0.014
purine ribonucleotide catabolic process GO:0009154 208 0.014
cellular chemical homeostasis GO:0055082 215 0.014
single organism cell adhesion GO:0098602 156 0.014
dna recombination GO:0006310 92 0.014
circulatory system process GO:0003013 197 0.014
protein modification by small protein conjugation or removal GO:0070647 207 0.014
regulation of nucleotide metabolic process GO:0006140 169 0.014
oocyte anterior posterior axis specification GO:0007314 2 0.014
regulation of purine nucleotide metabolic process GO:1900542 169 0.014
cellular carbohydrate metabolic process GO:0044262 119 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.014
renal tubule development GO:0061326 87 0.014
neural tube development GO:0021915 160 0.014
purine containing compound metabolic process GO:0072521 311 0.013
histone modification GO:0016570 159 0.013
sensory system development GO:0048880 3 0.013
establishment of protein localization to organelle GO:0072594 118 0.013
nucleoside monophosphate metabolic process GO:0009123 85 0.013
sperm egg recognition GO:0035036 37 0.013
neuronal action potential GO:0019228 54 0.013
negative regulation of cellular amine metabolic process GO:0033239 1 0.013
regulation of protein localization GO:0032880 231 0.013
developmental growth involved in morphogenesis GO:0060560 138 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.013
regulation of neuron projection development GO:0010975 169 0.013
alcohol metabolic process GO:0006066 116 0.013
regulation of kinase activity GO:0043549 249 0.013
regulation of protein serine threonine kinase activity GO:0071900 157 0.013
negative regulation of neuron apoptotic process GO:0043524 92 0.013
nucleoside catabolic process GO:0009164 206 0.013
regulation of exocytosis GO:0017157 61 0.013
alpha amino acid metabolic process GO:1901605 59 0.013
negative regulation of phosphorylation GO:0042326 166 0.013
nucleoside triphosphate catabolic process GO:0009143 205 0.013
anion transport GO:0006820 177 0.013
skin development GO:0043588 220 0.013
anatomical structure homeostasis GO:0060249 145 0.013
regulation of proteolysis GO:0030162 164 0.013
male meiosis i GO:0007141 16 0.013
embryonic placenta development GO:0001892 98 0.013
mesodermal cell migration GO:0008078 4 0.013
purine nucleoside triphosphate catabolic process GO:0009146 203 0.013
organelle localization GO:0051640 179 0.013
regulation of organelle organization GO:0033043 289 0.013
ras protein signal transduction GO:0007265 77 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.013
positive regulation of cell adhesion GO:0045785 80 0.013
positive regulation of protein kinase activity GO:0045860 144 0.013
peptidyl serine modification GO:0018209 83 0.013
negative regulation of cell proliferation GO:0008285 296 0.013
mitotic cell cycle process GO:1903047 159 0.012
ameboidal type cell migration GO:0001667 128 0.012
hematopoietic progenitor cell differentiation GO:0002244 143 0.012
cardiac ventricle development GO:0003231 83 0.012
response to growth factor GO:0070848 198 0.012
proteasomal protein catabolic process GO:0010498 98 0.012
mitotic cell cycle GO:0000278 195 0.012
endomembrane system organization GO:0010256 147 0.012
cell recognition GO:0008037 83 0.012
meiotic cell cycle process GO:1903046 77 0.012
cell activation involved in immune response GO:0002263 126 0.012
macromolecule methylation GO:0043414 120 0.012
carbohydrate derivative catabolic process GO:1901136 231 0.012
peptidyl tyrosine modification GO:0018212 145 0.012
regulation of inflammatory response GO:0050727 147 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
transmembrane transport GO:0055085 412 0.012
mesenchymal cell differentiation GO:0048762 107 0.012
regulation of secretion GO:0051046 274 0.012
regulation of system process GO:0044057 200 0.012
regulation of transmembrane transport GO:0034762 128 0.012
leukocyte activation involved in immune response GO:0002366 126 0.012
sequestering of calcium ion GO:0051208 18 0.012
inflammatory response GO:0006954 244 0.012
calcium ion transmembrane transport GO:0070588 85 0.012
ion transmembrane transport GO:0034220 361 0.012
regulation of cytokine production GO:0001817 266 0.012
organic hydroxy compound metabolic process GO:1901615 203 0.012
positive regulation of immune effector process GO:0002699 107 0.012
sequestering of metal ion GO:0051238 19 0.012
mesoderm development GO:0007498 100 0.011
regulation of leukocyte mediated immunity GO:0002703 104 0.011
multicellular organismal signaling GO:0035637 91 0.011
negative regulation of neuron death GO:1901215 98 0.011
retina morphogenesis in camera type eye GO:0060042 45 0.011
cellular metal ion homeostasis GO:0006875 151 0.011
intracellular mrna localization GO:0008298 4 0.011
adult behavior GO:0030534 135 0.011
regulation of binding GO:0051098 111 0.011
maintenance of location GO:0051235 89 0.011
nucleocytoplasmic transport GO:0006913 139 0.011
response to radiation GO:0009314 165 0.011
fat cell differentiation GO:0045444 160 0.011
small molecule biosynthetic process GO:0044283 132 0.011
skeletal muscle organ development GO:0060538 163 0.011
regulation of mitotic cell cycle GO:0007346 126 0.011
bmp signaling pathway GO:0030509 93 0.011
angiogenesis GO:0001525 201 0.011
positive regulation of cell projection organization GO:0031346 95 0.011
cellular homeostasis GO:0019725 240 0.011
regulation of mrna metabolic process GO:1903311 43 0.011
ossification GO:0001503 216 0.011
forebrain development GO:0030900 302 0.011
regulation of purine nucleotide catabolic process GO:0033121 122 0.011
carbohydrate derivative biosynthetic process GO:1901137 183 0.011
cell substrate adhesion GO:0031589 130 0.011
regulation of cell cycle process GO:0010564 160 0.011
purine ribonucleoside catabolic process GO:0046130 205 0.011
microtubule cytoskeleton organization GO:0000226 157 0.011
ribonucleoside monophosphate metabolic process GO:0009161 80 0.011
positive regulation of leukocyte mediated immunity GO:0002705 70 0.011
positive regulation of neuron projection development GO:0010976 79 0.011
engulfment of apoptotic cell GO:0043652 3 0.011
pirna metabolic process GO:0034587 12 0.011
coagulation GO:0050817 78 0.011
gastrulation GO:0007369 116 0.011
development of primary female sexual characteristics GO:0046545 73 0.011
chromatin modification GO:0016568 187 0.011
positive regulation of protein phosphorylation GO:0001934 242 0.011
neuron projection guidance GO:0097485 141 0.011
digestive tract morphogenesis GO:0048546 147 0.011
carboxylic acid biosynthetic process GO:0046394 86 0.011
oogenesis GO:0048477 56 0.010
binding of sperm to zona pellucida GO:0007339 34 0.010
negative regulation of intracellular signal transduction GO:1902532 167 0.010
multi multicellular organism process GO:0044706 109 0.010
neural tube formation GO:0001841 108 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.010
kidney epithelium development GO:0072073 121 0.010
rho protein signal transduction GO:0007266 32 0.010
nephron epithelium development GO:0072009 92 0.010
regulation of ion transmembrane transport GO:0034765 119 0.010
glycoprotein metabolic process GO:0009100 116 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.010
locomotory behavior GO:0007626 195 0.010
sulfur compound metabolic process GO:0006790 100 0.010
epithelial tube formation GO:0072175 130 0.010
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.010
negative regulation of phosphorus metabolic process GO:0010563 184 0.010
negative regulation of transferase activity GO:0051348 85 0.010
muscle tissue development GO:0060537 308 0.010

Plekhg4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.049
nervous system disease DOID:863 0 0.049
sensory system disease DOID:0050155 0 0.027
eye and adnexa disease DOID:1492 0 0.017
eye disease DOID:5614 0 0.014
musculoskeletal system disease DOID:17 0 0.012
retinal disease DOID:5679 0 0.012
retinal degeneration DOID:8466 0 0.012