Mus musculus

37 known processes

Pold1

polymerase (DNA directed), delta 1, catalytic subunit

(Aliases: 125kDa)

Pold1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna repair GO:0006281 107 0.969
dna metabolic process GO:0006259 303 0.961
cellular response to dna damage stimulus GO:0006974 207 0.960
dna recombination GO:0006310 92 0.901
base excision repair GO:0006284 9 0.818
meiotic cell cycle process GO:1903046 77 0.639
meiotic nuclear division GO:0007126 115 0.625
recombinational repair GO:0000725 21 0.616
nuclear division GO:0000280 158 0.538
chromatin organization GO:0006325 206 0.529
double strand break repair GO:0006302 48 0.497
mitotic sister chromatid cohesion GO:0007064 1 0.487
response to radiation GO:0009314 165 0.485
nuclear dna replication GO:0033260 3 0.478
double strand break repair via homologous recombination GO:0000724 21 0.437
regulation of mitotic cell cycle phase transition GO:1901990 73 0.424
dna integrity checkpoint GO:0031570 28 0.396
chromatin silencing GO:0006342 15 0.380
regulation of cell cycle process GO:0010564 160 0.377
intra s dna damage checkpoint GO:0031573 4 0.361
nucleobase containing small molecule metabolic process GO:0055086 352 0.353
regulation of circadian sleep wake cycle GO:0042749 3 0.349
regulation of cell cycle GO:0051726 281 0.335
mitotic cell cycle process GO:1903047 159 0.308
chromosome segregation GO:0007059 48 0.308
lateral inhibition GO:0046331 1 0.293
dna dependent dna replication GO:0006261 24 0.292
somatic diversification of immune receptors via somatic mutation GO:0002566 8 0.277
telomere maintenance GO:0000723 19 0.275
purine nucleoside catabolic process GO:0006152 205 0.274
circadian temperature homeostasis GO:0060086 2 0.269
heterochromatin organization GO:0070828 4 0.264
organelle fission GO:0048285 170 0.263
double strand break repair via nonhomologous end joining GO:0006303 10 0.242
meiosis i GO:0007127 60 0.237
mitotic cell cycle GO:0000278 195 0.235
regulation of transcription by chromatin organization GO:0034401 0 0.235
sister chromatid cohesion GO:0007062 12 0.234
glycosyl compound metabolic process GO:1901657 246 0.228
heterocycle catabolic process GO:0046700 280 0.225
Yeast
nucleoside monophosphate metabolic process GO:0009123 85 0.222
meiotic cell cycle GO:0051321 122 0.200
reciprocal dna recombination GO:0035825 16 0.183
dna unwinding involved in dna replication GO:0006268 5 0.176
purine containing compound metabolic process GO:0072521 311 0.172
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.172
dna damage checkpoint GO:0000077 26 0.169
cell cycle g2 m phase transition GO:0044839 20 0.168
somatic hypermutation of immunoglobulin genes GO:0016446 7 0.167
ribonucleoside triphosphate metabolic process GO:0009199 220 0.165
purine ribonucleoside metabolic process GO:0046128 241 0.160
gene silencing GO:0016458 38 0.157
nucleoside triphosphate catabolic process GO:0009143 205 0.156
regulation of circadian rhythm GO:0042752 58 0.153
dna replication GO:0006260 52 0.150
negative regulation of mitotic cell cycle GO:0045930 58 0.149
regulation of chromosome organization GO:0033044 83 0.148
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.147
purine nucleotide metabolic process GO:0006163 302 0.146
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.141
nucleoside phosphate catabolic process GO:1901292 222 0.140
mitotic nuclear division GO:0007067 48 0.138
regulation of binding GO:0051098 111 0.133
negative regulation of molecular function GO:0044092 258 0.132
nucleoside metabolic process GO:0009116 246 0.130
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.124
cellular amino acid metabolic process GO:0006520 103 0.124
cell cycle checkpoint GO:0000075 47 0.121
nucleoside catabolic process GO:0009164 206 0.120
negative regulation of gene expression epigenetic GO:0045814 15 0.119
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.117
regulation of organelle organization GO:0033043 289 0.113
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.112
purine nucleoside triphosphate catabolic process GO:0009146 203 0.110
atp catabolic process GO:0006200 55 0.106
ribonucleotide metabolic process GO:0009259 291 0.106
nucleoside triphosphate metabolic process GO:0009141 230 0.097
regulation of cellular catabolic process GO:0031329 242 0.096
translesion synthesis GO:0019985 1 0.095
carbohydrate derivative catabolic process GO:1901136 231 0.092
negative regulation of chromatin silencing GO:0031936 1 0.087
meiotic chromosome segregation GO:0045132 19 0.085
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.084
intrinsic apoptotic signaling pathway GO:0097193 132 0.083
dna duplex unwinding GO:0032508 7 0.083
organonitrogen compound catabolic process GO:1901565 264 0.082
ribonucleoside catabolic process GO:0042454 206 0.080
nucleoside monophosphate catabolic process GO:0009125 59 0.078
organophosphate catabolic process GO:0046434 232 0.077
mitotic sister chromatid segregation GO:0000070 14 0.077
chromosome organization involved in meiosis GO:0070192 39 0.075
ribonucleoside triphosphate catabolic process GO:0009203 199 0.074
regulation of mitotic cell cycle GO:0007346 126 0.072
ribonucleoside monophosphate metabolic process GO:0009161 80 0.071
purine ribonucleotide catabolic process GO:0009154 208 0.070
regulation of cell cycle phase transition GO:1901987 77 0.068
purine ribonucleoside catabolic process GO:0046130 205 0.068
purine ribonucleotide metabolic process GO:0009150 290 0.067
immunoglobulin production GO:0002377 73 0.067
dna geometric change GO:0032392 7 0.066
rhythmic process GO:0048511 174 0.065
glycosyl compound catabolic process GO:1901658 206 0.064
sister chromatid segregation GO:0000819 20 0.063
dna biosynthetic process GO:0071897 22 0.063
Human Yeast
ribonucleoside metabolic process GO:0009119 245 0.062
production of molecular mediator of immune response GO:0002440 103 0.062
regulation of hydrolase activity GO:0051336 246 0.060
purine nucleoside triphosphate metabolic process GO:0009144 226 0.060
meiotic sister chromatid segregation GO:0045144 6 0.059
cellular nitrogen compound catabolic process GO:0044270 280 0.059
Yeast
development of primary sexual characteristics GO:0045137 143 0.059
respiratory tube development GO:0030323 167 0.057
organic cyclic compound catabolic process GO:1901361 295 0.055
Yeast
copulation GO:0007620 7 0.053
circadian rhythm GO:0007623 114 0.050
multicellular organismal homeostasis GO:0048871 164 0.050
protein processing GO:0016485 163 0.049
regulation of chromatin silencing GO:0031935 2 0.047
locomotory behavior GO:0007626 195 0.046
gonad development GO:0008406 141 0.045
meiosis ii GO:0007135 7 0.045
protein polymerization GO:0051258 57 0.044
somatic diversification of immunoglobulins GO:0016445 43 0.044
male meiosis GO:0007140 37 0.044
dna replication initiation GO:0006270 5 0.043
regulation of chromosome segregation GO:0051983 21 0.043
regulation of dna dependent dna replication initiation GO:0030174 3 0.042
purine nucleotide catabolic process GO:0006195 211 0.042
negative regulation of cell cycle GO:0045786 123 0.042
morphogenesis of a branching structure GO:0001763 203 0.041
purine nucleoside monophosphate metabolic process GO:0009126 81 0.040
cellular response to interleukin 4 GO:0071353 21 0.039
negative regulation of binding GO:0051100 39 0.039
purine nucleoside metabolic process GO:0042278 241 0.037
response to light stimulus GO:0009416 135 0.037
camera type eye development GO:0043010 266 0.037
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.037
lung development GO:0030324 164 0.036
dna endoreduplication GO:0042023 4 0.036
signal transduction involved in dna damage checkpoint GO:0072422 3 0.036
ribose phosphate metabolic process GO:0019693 291 0.035
organelle localization GO:0051640 179 0.035
positive regulation of hydrolase activity GO:0051345 148 0.035
somatic diversification of immune receptors GO:0002200 53 0.035
cell cycle g1 s phase transition GO:0044843 57 0.034
respiratory system development GO:0060541 190 0.034
oogenesis GO:0048477 56 0.034
regulation of cell cycle g2 m phase transition GO:1902749 10 0.034
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.033
dna conformation change GO:0071103 37 0.033
negative regulation of cell proliferation GO:0008285 296 0.032
positive regulation of organelle organization GO:0010638 128 0.032
microtubule based process GO:0007017 236 0.032
cellular response to abiotic stimulus GO:0071214 56 0.032
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.032
nucleoside phosphate metabolic process GO:0006753 338 0.031
negative regulation of cellular protein metabolic process GO:0032269 247 0.031
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.031
inner cell mass cell proliferation GO:0001833 15 0.031
purine containing compound catabolic process GO:0072523 213 0.031
response to inorganic substance GO:0010035 96 0.031
microtubule cytoskeleton organization GO:0000226 157 0.031
protein localization to chromosome GO:0034502 6 0.031
digestive system development GO:0055123 200 0.031
positive regulation of cellular amine metabolic process GO:0033240 5 0.030
adaptive immune response GO:0002250 155 0.030
ribonucleotide catabolic process GO:0009261 208 0.030
nucleotide metabolic process GO:0009117 332 0.029
histone modification GO:0016570 159 0.029
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.029
negative regulation of hydrolase activity GO:0051346 71 0.028
endocytosis GO:0006897 168 0.028
Worm
apoptotic signaling pathway GO:0097190 306 0.028
positive regulation of transferase activity GO:0051347 167 0.028
purine nucleoside monophosphate catabolic process GO:0009128 58 0.028
morphogenesis of a branching epithelium GO:0061138 193 0.028
cellular response to cytokine stimulus GO:0071345 189 0.028
negative regulation of nucleoside metabolic process GO:0045978 11 0.028
rhythmic behavior GO:0007622 15 0.027
regulation of transferase activity GO:0051338 263 0.027
protein localization to chromatin GO:0071168 3 0.027
positive regulation of protein modification process GO:0031401 299 0.027
cell division GO:0051301 120 0.027
Worm
regulation of nuclear cell cycle dna replication GO:0033262 2 0.026
female gamete generation GO:0007292 74 0.026
cellular protein complex assembly GO:0043623 116 0.026
mitotic chromosome condensation GO:0007076 1 0.026
anatomical structure homeostasis GO:0060249 145 0.025
g2 m transition of mitotic cell cycle GO:0000086 20 0.025
cellular ketone metabolic process GO:0042180 84 0.025
epithelial tube morphogenesis GO:0060562 303 0.025
ribonucleoside monophosphate catabolic process GO:0009158 57 0.025
atp metabolic process GO:0046034 75 0.025
b cell activation GO:0042113 161 0.024
mating behavior GO:0007617 20 0.024
snrna metabolic process GO:0016073 1 0.024
negative regulation of gene silencing GO:0060969 2 0.024
negative regulation of protein modification process GO:0031400 163 0.024
negative regulation of dna binding GO:0043392 20 0.024
regulation of anatomical structure size GO:0090066 178 0.024
negative regulation of cell cycle phase transition GO:1901988 48 0.024
nucleobase biosynthetic process GO:0046112 3 0.024
response to testosterone GO:0033574 3 0.023
membrane organization GO:0061024 245 0.023
protein dna complex subunit organization GO:0071824 28 0.023
aromatic compound catabolic process GO:0019439 286 0.023
Yeast
alpha amino acid metabolic process GO:1901605 59 0.023
digestive tract development GO:0048565 190 0.023
positive regulation of cell cycle phase transition GO:1901989 17 0.023
regulation of dna dependent dna replication GO:0090329 8 0.023
multicellular organismal aging GO:0010259 24 0.023
organonitrogen compound biosynthetic process GO:1901566 192 0.022
nucleotide catabolic process GO:0009166 217 0.022
regulation of dna binding GO:0051101 39 0.022
positive regulation of protein phosphorylation GO:0001934 242 0.022
negative regulation of purine nucleotide metabolic process GO:1900543 16 0.022
membrane disassembly GO:0030397 1 0.022
covalent chromatin modification GO:0016569 163 0.022
male gamete generation GO:0048232 285 0.021
cellular amine metabolic process GO:0044106 44 0.021
regulation of protein localization GO:0032880 231 0.021
positive regulation of mitotic metaphase anaphase transition GO:0045842 2 0.021
histone methylation GO:0016571 71 0.021
regulation of apoptotic signaling pathway GO:2001233 197 0.021
b cell activation involved in immune response GO:0002312 50 0.020
digestive tract morphogenesis GO:0048546 147 0.020
lymphocyte mediated immunity GO:0002449 139 0.020
regulation of protein kinase activity GO:0045859 232 0.020
regulation of nucleoside metabolic process GO:0009118 130 0.020
immunoglobulin mediated immune response GO:0016064 69 0.020
leukocyte activation involved in immune response GO:0002366 126 0.020
regulation of cellular amino acid metabolic process GO:0006521 5 0.020
stem cell proliferation GO:0072089 117 0.019
nucleus organization GO:0006997 45 0.019
gliogenesis GO:0042063 141 0.019
response to organonitrogen compound GO:0010243 246 0.019
amine metabolic process GO:0009308 45 0.019
protein localization to organelle GO:0033365 185 0.019
pharynx development GO:0060465 1 0.019
cofactor metabolic process GO:0051186 80 0.018
branching morphogenesis of an epithelial tube GO:0048754 159 0.018
intracellular protein transport GO:0006886 204 0.018
regulation of cysteine type endopeptidase activity GO:2000116 65 0.018
circadian behavior GO:0048512 13 0.018
response to lipopolysaccharide GO:0032496 128 0.018
protein maturation GO:0051604 176 0.018
response to interleukin 4 GO:0070670 23 0.017
negative regulation of cell development GO:0010721 169 0.017
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.017
actin filament polymerization GO:0030041 44 0.017
regulation of cytokine production GO:0001817 266 0.017
leukocyte mediated immunity GO:0002443 174 0.017
positive regulation of cell death GO:0010942 224 0.017
dna replication checkpoint GO:0000076 2 0.017
maintenance of epithelial cell apical basal polarity GO:0045199 2 0.016
oxidation reduction process GO:0055114 342 0.016
regulation of meiotic cell cycle GO:0051445 34 0.016
response to growth factor GO:0070848 198 0.016
positive regulation of fibroblast proliferation GO:0048146 20 0.016
peptidyl amino acid modification GO:0018193 336 0.016
l serine metabolic process GO:0006563 2 0.016
lymphocyte activation involved in immune response GO:0002285 93 0.016
regulation of transcription regulatory region dna binding GO:2000677 9 0.016
regulation of g2 m transition of mitotic cell cycle GO:0010389 10 0.016
macromolecule catabolic process GO:0009057 281 0.016
Yeast
multi organism behavior GO:0051705 62 0.015
regulation of dna replication GO:0006275 17 0.015
glial cell differentiation GO:0010001 131 0.015
dna packaging GO:0006323 30 0.015
telomere maintenance via telomere lengthening GO:0010833 4 0.015
protein modification by small protein conjugation GO:0032446 187 0.015
circadian sleep wake cycle GO:0042745 5 0.015
snrna processing GO:0016180 1 0.015
telomere maintenance via telomerase GO:0007004 1 0.015
gland development GO:0048732 330 0.015
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.015
cellular response to growth factor stimulus GO:0071363 197 0.015
cellular response to inorganic substance GO:0071241 37 0.015
regulation of cellular amine metabolic process GO:0033238 20 0.015
positive regulation of chromosome organization GO:2001252 33 0.014
response to ionizing radiation GO:0010212 42 0.014
regulation of lymphocyte proliferation GO:0050670 117 0.014
immune effector process GO:0002252 321 0.014
regulation of proteolysis GO:0030162 164 0.014
negative regulation of phosphorylation GO:0042326 166 0.014
regulation of cell division GO:0051302 76 0.014
negative regulation of transcription regulatory region dna binding GO:2000678 7 0.014
cell activation involved in immune response GO:0002263 126 0.014
negative regulation of phosphate metabolic process GO:0045936 184 0.014
temperature homeostasis GO:0001659 26 0.014
response to transforming growth factor beta GO:0071559 88 0.014
antimicrobial peptide biosynthetic process GO:0002777 2 0.014
peptidyl lysine modification GO:0018205 77 0.013
isotype switching GO:0045190 36 0.013
positive regulation of nervous system development GO:0051962 221 0.013
cell cell signaling involved in cell fate commitment GO:0045168 35 0.013
peptidyl serine phosphorylation GO:0018105 74 0.013
regulation of cellular ketone metabolic process GO:0010565 66 0.013
nuclear envelope organization GO:0006998 11 0.013
negative regulation of protein metabolic process GO:0051248 282 0.013
spermatogenesis GO:0007283 284 0.013
regulation of nucleotide catabolic process GO:0030811 122 0.013
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.013
response to temperature stimulus GO:0009266 55 0.013
blastocyst development GO:0001824 80 0.013
regulation of secretion by cell GO:1903530 249 0.013
negative regulation of histone h3 k9 methylation GO:0051573 4 0.013
non recombinational repair GO:0000726 10 0.013
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.012
cellular response to hormone stimulus GO:0032870 150 0.012
mating GO:0007618 27 0.012
b cell mediated immunity GO:0019724 71 0.012
cell maturation GO:0048469 127 0.012
negative regulation of organelle organization GO:0010639 90 0.012
amide transport GO:0042886 138 0.012
positive regulation of programmed cell death GO:0043068 218 0.012
protein ubiquitination GO:0016567 171 0.012
mitotic cell cycle checkpoint GO:0007093 31 0.012
cellular homeostasis GO:0019725 240 0.012
cellular response to radiation GO:0071478 28 0.012
cytokine production GO:0001816 319 0.012
organism emergence from protective structure GO:0071684 4 0.012
Worm
g1 s transition of mitotic cell cycle GO:0000082 57 0.012
regulation of actin polymerization or depolymerization GO:0008064 45 0.012
pyrimidine nucleobase metabolic process GO:0006206 3 0.012
positive regulation of apoptotic process GO:0043065 217 0.012
endomembrane system organization GO:0010256 147 0.012
response to oxidative stress GO:0006979 123 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.011
divalent metal ion transport GO:0070838 172 0.011
transmembrane transport GO:0055085 412 0.011
positive regulation of cellular catabolic process GO:0031331 148 0.011
protein modification by small protein conjugation or removal GO:0070647 207 0.011
spindle assembly involved in female meiosis GO:0007056 3 0.011
response to reactive oxygen species GO:0000302 56 0.011
regulation of chromatin modification GO:1903308 57 0.011
negative regulation of kinase activity GO:0033673 81 0.011
gene conversion GO:0035822 2 0.011
positive regulation of histone modification GO:0031058 28 0.011
regulation of purine nucleotide metabolic process GO:1900542 169 0.011
locomotor rhythm GO:0045475 8 0.011
hematopoietic stem cell proliferation GO:0071425 13 0.011
regulation of atp metabolic process GO:1903578 17 0.011
tricarboxylic acid metabolic process GO:0072350 5 0.011
positive regulation of chromosome segregation GO:0051984 4 0.011
innate immune response GO:0045087 157 0.011
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 2 0.011
histone lysine methylation GO:0034968 50 0.011
positive regulation of immune effector process GO:0002699 107 0.011
mitotic g1 dna damage checkpoint GO:0031571 4 0.010
chromosome separation GO:0051304 14 0.010
divalent inorganic cation transport GO:0072511 178 0.010
sensory organ morphogenesis GO:0090596 242 0.010
regulation of multi organism process GO:0043900 111 0.010
genitalia development GO:0048806 37 0.010
regulation of homeostatic process GO:0032844 182 0.010
regulation of sister chromatid cohesion GO:0007063 5 0.010
nucleobase metabolic process GO:0009112 7 0.010
multi multicellular organism process GO:0044706 109 0.010
cellular response to organonitrogen compound GO:0071417 145 0.010

Pold1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.266
Human
disease of cellular proliferation DOID:14566 0 0.266
Human
disease of metabolism DOID:0014667 0 0.082
inherited metabolic disorder DOID:655 0 0.082
organ system cancer DOID:0050686 0 0.054
Human
large intestine cancer DOID:5672 0 0.028
Human
gastrointestinal system cancer DOID:3119 0 0.028
Human
intestinal cancer DOID:10155 0 0.028
Human
disease of anatomical entity DOID:7 0 0.021
nervous system disease DOID:863 0 0.021
central nervous system disease DOID:331 0 0.020
neurodegenerative disease DOID:1289 0 0.011