Mus musculus

41 known processes

H2afx

H2A histone family, member X

(Aliases: AW228881,Hist5-2ax,H2A.X,H2ax)

H2afx biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 0.991
nuclear division GO:0000280 158 0.956
meiotic nuclear division GO:0007126 115 0.937
meiosis i GO:0007127 60 0.933
meiotic cell cycle process GO:1903046 77 0.921
organelle fission GO:0048285 170 0.885
synapsis GO:0007129 34 0.880
meiotic cell cycle GO:0051321 122 0.832
mitotic cell cycle GO:0000278 195 0.812
microtubule cytoskeleton organization GO:0000226 157 0.769
microtubule based process GO:0007017 236 0.739
response to radiation GO:0009314 165 0.726
chromatin organization GO:0006325 206 0.671
cellular response to dna damage stimulus GO:0006974 207 0.637
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.561
spindle assembly involved in female meiosis GO:0007056 3 0.540
chromosome organization involved in meiosis GO:0070192 39 0.513
regulation of mitotic cell cycle GO:0007346 126 0.508
chromatin modification GO:0016568 187 0.500
dna repair GO:0006281 107 0.490
regulation of cell cycle GO:0051726 281 0.478
protein localization to organelle GO:0033365 185 0.466
protein complex disassembly GO:0043241 40 0.453
regulation of microtubule based process GO:0032886 52 0.452
ubiquitin dependent protein catabolic process GO:0006511 129 0.431
regulation of mitotic cell cycle phase transition GO:1901990 73 0.409
mitotic cell cycle process GO:1903047 159 0.409
mitotic nuclear division GO:0007067 48 0.401
spindle assembly involved in mitosis GO:0090307 4 0.376
spindle assembly involved in meiosis GO:0090306 4 0.370
regulation of organelle organization GO:0033043 289 0.369
amine metabolic process GO:0009308 45 0.351
mitotic cytokinesis GO:0000281 4 0.351
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.349
spindle midzone assembly GO:0051255 1 0.340
regulation of protein localization GO:0032880 231 0.334
regulation of intracellular protein transport GO:0033157 82 0.334
regulation of ubiquitin protein ligase activity involved in mitotic cell cycle GO:0051439 1 0.331
microtubule polymerization or depolymerization GO:0031109 26 0.324
cell division GO:0051301 120 0.321
protein localization to chromosome GO:0034502 6 0.321
positive regulation of cellular catabolic process GO:0031331 148 0.312
gene silencing GO:0016458 38 0.310
Yeast
regulation of mitotic spindle organization GO:0060236 2 0.300
histone serine phosphorylation GO:0035404 5 0.299
negative regulation of cell cycle GO:0045786 123 0.283
proteasomal protein catabolic process GO:0010498 98 0.277
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 2 0.273
protein processing GO:0016485 163 0.262
regulation of cellular catabolic process GO:0031329 242 0.257
cyclin catabolic process GO:0008054 1 0.251
microtubule depolymerization GO:0007019 15 0.249
negative regulation of phosphorus metabolic process GO:0010563 184 0.244
positive regulation of chromosome segregation GO:0051984 4 0.244
regulation of cell division GO:0051302 76 0.243
regulation of cell cycle process GO:0010564 160 0.242
cellular protein catabolic process GO:0044257 155 0.241
organelle localization GO:0051640 179 0.229
protein depolymerization GO:0051261 34 0.223
chromosome segregation GO:0007059 48 0.221
cell cycle checkpoint GO:0000075 47 0.215
Human
regulation of exit from mitosis GO:0007096 1 0.215
peptidyl amino acid modification GO:0018193 336 0.211
aromatic compound catabolic process GO:0019439 286 0.211
macromolecule catabolic process GO:0009057 281 0.206
regulation of dna replication GO:0006275 17 0.205
negative regulation of organelle organization GO:0010639 90 0.204
protein ubiquitination GO:0016567 171 0.203
dna replication GO:0006260 52 0.201
mitotic sister chromatid segregation GO:0000070 14 0.199
response to ionizing radiation GO:0010212 42 0.199
negative regulation of phosphate metabolic process GO:0045936 184 0.199
positive regulation of cell cycle GO:0045787 92 0.193
negative regulation of microtubule polymerization or depolymerization GO:0031111 15 0.193
covalent chromatin modification GO:0016569 163 0.193
regulation of spindle organization GO:0090224 2 0.190
protein modification by small protein conjugation or removal GO:0070647 207 0.184
spindle assembly GO:0051225 13 0.170
macromolecular complex disassembly GO:0032984 43 0.168
cajal body organization GO:0030576 1 0.167
positive regulation of protein modification process GO:0031401 299 0.165
establishment of protein localization to organelle GO:0072594 118 0.160
negative regulation of cellular component organization GO:0051129 194 0.159
histone phosphorylation GO:0016572 9 0.158
regulation of chromosome organization GO:0033044 83 0.158
regulation of ubiquitin protein transferase activity GO:0051438 7 0.158
regulation of binding GO:0051098 111 0.157
regulation of protein transport GO:0051223 163 0.155
dephosphorylation GO:0016311 129 0.155
dna conformation change GO:0071103 37 0.153
regulation of transferase activity GO:0051338 263 0.151
protein catabolic process GO:0030163 221 0.151
cellular amine metabolic process GO:0044106 44 0.150
regulation of multi organism process GO:0043900 111 0.149
single organism nuclear import GO:1902593 95 0.148
dna integrity checkpoint GO:0031570 28 0.146
Human
regulation of protein import into nucleus GO:0042306 52 0.143
mitotic centrosome separation GO:0007100 4 0.143
negative regulation of cell cycle phase transition GO:1901988 48 0.142
negative regulation of molecular function GO:0044092 258 0.139
regulation of cellular response to stress GO:0080135 159 0.138
nuclear transport GO:0051169 139 0.137
regulation of cytoplasmic transport GO:1903649 112 0.137
positive regulation of ubiquitin protein transferase activity GO:0051443 4 0.135
regulation of microtubule polymerization or depolymerization GO:0031110 20 0.135
regulation of chromatin modification GO:1903308 57 0.134
recombinational repair GO:0000725 21 0.134
organelle assembly GO:0070925 177 0.134
positive regulation of exit from mitosis GO:0031536 1 0.133
nucleocytoplasmic transport GO:0006913 139 0.133
intracellular protein transport GO:0006886 204 0.131
cytoplasmic transport GO:0016482 234 0.131
negative regulation of cellular protein metabolic process GO:0032269 247 0.131
protein localization to nucleus GO:0034504 121 0.130
female meiosis i GO:0007144 7 0.129
positive regulation of mitosis GO:0045840 14 0.125
spindle organization GO:0007051 28 0.124
regulation of kinase activity GO:0043549 249 0.123
dna packaging GO:0006323 30 0.121
regulation of purine nucleotide catabolic process GO:0033121 122 0.120
establishment of organelle localization GO:0051656 122 0.119
regulation of nuclear division GO:0051783 56 0.116
regulation of cytoskeleton organization GO:0051493 122 0.110
regulation of protein complex disassembly GO:0043244 28 0.108
positive regulation of cell cycle process GO:0090068 61 0.108
muscle tissue development GO:0060537 308 0.101
dendrite development GO:0016358 115 0.101
guanosine containing compound metabolic process GO:1901068 144 0.099
meiotic spindle organization GO:0000212 9 0.098
negative regulation of microtubule depolymerization GO:0007026 13 0.097
regulation of cellular amine metabolic process GO:0033238 20 0.096
protein targeting GO:0006605 143 0.095
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.095
centrosome separation GO:0051299 4 0.094
negative regulation of mitotic cell cycle GO:0045930 58 0.089
microtubule based movement GO:0007018 84 0.088
regulation of nucleotide metabolic process GO:0006140 169 0.086
spindle assembly involved in female meiosis i GO:0007057 2 0.085
regulation of nucleocytoplasmic transport GO:0046822 73 0.085
positive regulation of fibroblast proliferation GO:0048146 20 0.085
regulation of smad protein import into nucleus GO:0060390 3 0.085
negative regulation of cell cycle process GO:0010948 69 0.083
peptidyl threonine phosphorylation GO:0018107 31 0.083
regulation of protein kinase activity GO:0045859 232 0.081
cellular nitrogen compound catabolic process GO:0044270 280 0.081
small gtpase mediated signal transduction GO:0007264 97 0.081
activation of anaphase promoting complex activity GO:0051488 1 0.080
regulation of double strand break repair via nonhomologous end joining GO:2001032 2 0.078
germ cell development GO:0007281 185 0.078
positive regulation of organelle organization GO:0010638 128 0.077
protein import into nucleus GO:0006606 95 0.076
astral microtubule organization GO:0030953 3 0.076
cellular protein complex disassembly GO:0043624 36 0.075
protein modification by small protein conjugation GO:0032446 187 0.073
metaphase plate congression GO:0051310 2 0.073
negative regulation of phosphorylation GO:0042326 166 0.073
regulation of cellular ketone metabolic process GO:0010565 66 0.072
protein maturation GO:0051604 176 0.072
regulation of microtubule cytoskeleton organization GO:0070507 37 0.071
regulation of protein depolymerization GO:1901879 26 0.071
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.070
regulation of attachment of spindle microtubules to kinetochore GO:0051988 3 0.069
nucleoside triphosphate metabolic process GO:0009141 230 0.068
regulation of cell cycle phase transition GO:1901987 77 0.068
negative regulation of protein modification process GO:0031400 163 0.067
regulation of establishment of protein localization GO:0070201 181 0.067
synaptonemal complex organization GO:0070193 15 0.067
organic cyclic compound catabolic process GO:1901361 295 0.066
cellular homeostasis GO:0019725 240 0.066
maintenance of location GO:0051235 89 0.066
protein localization to chromosome centromeric region GO:0071459 1 0.065
nuclear import GO:0051170 95 0.065
regulation of hydrolase activity GO:0051336 246 0.065
purine containing compound catabolic process GO:0072523 213 0.065
regulation of protein targeting GO:1903533 61 0.064
regulation of nucleoside metabolic process GO:0009118 130 0.064
centrosome organization GO:0051297 26 0.064
protein import GO:0017038 101 0.064
development of primary sexual characteristics GO:0045137 143 0.063
regulation of cellular amino acid metabolic process GO:0006521 5 0.063
cellular response to light stimulus GO:0071482 19 0.062
protein localization to chromatin GO:0071168 3 0.062
regulation of histone modification GO:0031056 56 0.061
stem cell development GO:0048864 219 0.061
heterocycle catabolic process GO:0046700 280 0.061
dna recombination GO:0006310 92 0.059
cytokinesis GO:0000910 17 0.059
regulation of chromosome segregation GO:0051983 21 0.059
organonitrogen compound biosynthetic process GO:1901566 192 0.059
ras protein signal transduction GO:0007265 77 0.058
regulation of fibroblast proliferation GO:0048145 34 0.058
negative regulation of cell proliferation GO:0008285 296 0.057
positive regulation of cell division GO:0051781 31 0.057
carbohydrate derivative biosynthetic process GO:1901137 183 0.056
rna interference GO:0016246 2 0.055
response to organic cyclic compound GO:0014070 198 0.055
positive regulation of chromosome organization GO:2001252 33 0.055
g1 s transition of mitotic cell cycle GO:0000082 57 0.055
cellular response to lipid GO:0071396 145 0.054
maintenance of location in cell GO:0051651 24 0.054
positive regulation of cellular amine metabolic process GO:0033240 5 0.054
nucleoside phosphate catabolic process GO:1901292 222 0.053
oocyte maturation GO:0001556 18 0.053
regulation of protein serine threonine kinase activity GO:0071900 157 0.053
regulation of ran gtpase activity GO:0032316 3 0.053
negative regulation of chromosome organization GO:2001251 30 0.052
multi organism behavior GO:0051705 62 0.052
cell cycle comprising mitosis without cytokinesis GO:0033301 1 0.052
regulation of intracellular transport GO:0032386 159 0.052
leukocyte homeostasis GO:0001776 79 0.052
attachment of spindle microtubules to kinetochore GO:0008608 4 0.051
cellular ketone metabolic process GO:0042180 84 0.050
fibroblast proliferation GO:0048144 35 0.049
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.049
response to gamma radiation GO:0010332 22 0.049
regulation of defense response to bacterium GO:1900424 3 0.049
positive regulation of intracellular transport GO:0032388 70 0.048
regulation of microtubule depolymerization GO:0031114 13 0.048
response to organonitrogen compound GO:0010243 246 0.048
modification dependent protein catabolic process GO:0019941 133 0.048
purine ribonucleoside catabolic process GO:0046130 205 0.047
sister chromatid segregation GO:0000819 20 0.047
negative regulation of proteolysis GO:0045861 74 0.046
regulation of protein localization to nucleus GO:1900180 60 0.046
positive regulation of histone modification GO:0031058 28 0.046
cytokinetic process GO:0032506 2 0.046
cellular amino acid metabolic process GO:0006520 103 0.046
female meiotic division GO:0007143 21 0.045
negative regulation of protein metabolic process GO:0051248 282 0.045
regulation of nucleotide catabolic process GO:0030811 122 0.045
positive regulation of proteolysis GO:0045862 85 0.044
positive regulation of intracellular protein transport GO:0090316 42 0.044
gene silencing by rna GO:0031047 19 0.044
mitotic cell cycle checkpoint GO:0007093 31 0.043
carbohydrate metabolic process GO:0005975 230 0.043
positive regulation of cytoplasmic transport GO:1903651 40 0.043
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.042
response to iron ion GO:0010039 4 0.042
oxidation reduction process GO:0055114 342 0.042
purine nucleoside catabolic process GO:0006152 205 0.041
peptidyl threonine modification GO:0018210 31 0.041
nucleus organization GO:0006997 45 0.041
peptidyl serine phosphorylation GO:0018105 74 0.041
microtubule polymerization GO:0046785 12 0.041
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.041
regulation of meiotic cell cycle GO:0051445 34 0.041
purine containing compound metabolic process GO:0072521 311 0.040
positive regulation of mitotic cell cycle GO:0045931 41 0.039
centrosome duplication GO:0051298 16 0.038
modification dependent macromolecule catabolic process GO:0043632 133 0.038
double strand break repair via nonhomologous end joining GO:0006303 10 0.038
neural tube development GO:0021915 160 0.037
regulation of mitotic metaphase anaphase transition GO:0030071 8 0.037
protein polymerization GO:0051258 57 0.037
cellular response to radiation GO:0071478 28 0.036
nucleoside catabolic process GO:0009164 206 0.036
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.036
cellular protein complex assembly GO:0043623 116 0.036
viral process GO:0016032 41 0.036
camera type eye development GO:0043010 266 0.035
cellular macromolecule catabolic process GO:0044265 206 0.035
asymmetric stem cell division GO:0098722 3 0.035
negative regulation of hydrolase activity GO:0051346 71 0.035
histone modification GO:0016570 159 0.035
cellular response to hormone stimulus GO:0032870 150 0.034
macromolecule glycosylation GO:0043413 55 0.034
hatching GO:0035188 4 0.034
positive regulation of mitotic metaphase anaphase transition GO:0045842 2 0.034
purine ribonucleotide metabolic process GO:0009150 290 0.034
mitotic spindle assembly checkpoint GO:0007094 7 0.034
endocytosis GO:0006897 168 0.033
regulation of protein binding GO:0043393 60 0.033
cellular response to glucose stimulus GO:0071333 45 0.033
response to superoxide GO:0000303 16 0.033
protein autoprocessing GO:0016540 2 0.032
cleavage furrow formation GO:0036089 2 0.032
negative regulation of nucleoside metabolic process GO:0045978 11 0.032
positive regulation of protein kinase activity GO:0045860 144 0.032
regulation of mitotic sister chromatid segregation GO:0033047 12 0.032
positive regulation of hydrolase activity GO:0051345 148 0.032
negative regulation of kinase activity GO:0033673 81 0.031
stem cell differentiation GO:0048863 268 0.031
regulation of endopeptidase activity GO:0052548 89 0.031
hematopoietic progenitor cell differentiation GO:0002244 143 0.031
organism emergence from protective structure GO:0071684 4 0.031
generation of precursor metabolites and energy GO:0006091 103 0.031
response to reactive oxygen species GO:0000302 56 0.031
response to decreased oxygen levels GO:0036293 59 0.030
double strand break repair GO:0006302 48 0.030
g2 dna damage checkpoint GO:0031572 8 0.030
regulation of atp metabolic process GO:1903578 17 0.030
negative regulation of protein phosphorylation GO:0001933 126 0.030
negative regulation of intracellular protein transport GO:0090317 27 0.030
base excision repair GO:0006284 9 0.030
regulation of response to dna damage stimulus GO:2001020 34 0.030
cellular amide metabolic process GO:0043603 58 0.030
response to inorganic substance GO:0010035 96 0.030
regulation of proteolysis GO:0030162 164 0.030
cell cycle g1 s phase transition GO:0044843 57 0.030
regulation of protein maturation GO:1903317 96 0.029
establishment or maintenance of cell polarity GO:0007163 86 0.029
positive regulation of transferase activity GO:0051347 167 0.029
mitotic chromosome condensation GO:0007076 1 0.029
metaphase anaphase transition of mitotic cell cycle GO:0007091 9 0.029
regulation of cell cycle checkpoint GO:1901976 9 0.029
cellular chemical homeostasis GO:0055082 215 0.028
multi multicellular organism process GO:0044706 109 0.028
axonogenesis GO:0007409 274 0.028
negative regulation of purine nucleotide catabolic process GO:0033122 9 0.028
cell aging GO:0007569 35 0.028
regulation of cell motility GO:2000145 236 0.028
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.028
nucleobase containing small molecule metabolic process GO:0055086 352 0.028
apoptotic signaling pathway GO:0097190 306 0.027
energy derivation by oxidation of organic compounds GO:0015980 77 0.027
striated muscle tissue development GO:0014706 293 0.027
ossification GO:0001503 216 0.027
regulation of homeostatic process GO:0032844 182 0.027
positive regulation of dna repair GO:0045739 3 0.027
regulation of chromatin organization GO:1902275 57 0.027
ribonucleotide metabolic process GO:0009259 291 0.027
carbohydrate homeostasis GO:0033500 128 0.027
leukocyte differentiation GO:0002521 342 0.027
purine nucleoside triphosphate metabolic process GO:0009144 226 0.027
nitrogen compound transport GO:0071705 271 0.027
glycosyl compound metabolic process GO:1901657 246 0.027
regulation of proteasomal protein catabolic process GO:0061136 46 0.027
response to peptide GO:1901652 136 0.026
antibacterial peptide biosynthetic process GO:0002780 2 0.026
negative regulation of cellular protein catabolic process GO:1903363 22 0.026
regulation of cellular protein catabolic process GO:1903362 61 0.026
cation transport GO:0006812 399 0.026
response to oxygen levels GO:0070482 62 0.026
cardiocyte differentiation GO:0035051 87 0.026
positive regulation of antimicrobial peptide production GO:0002225 1 0.026
positive regulation of cell cycle phase transition GO:1901989 17 0.026
posttranscriptional regulation of gene expression GO:0010608 155 0.025
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.025
response to growth factor GO:0070848 198 0.025
negative regulation of cell development GO:0010721 169 0.025
nucleoside metabolic process GO:0009116 246 0.025
intracellular transport of virus GO:0075733 1 0.025
regulation of protein processing GO:0070613 96 0.025
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.025
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.025
cellular response to peptide hormone stimulus GO:0071375 92 0.025
meiotic cytokinesis GO:0033206 5 0.025
asymmetric neuroblast division GO:0055059 1 0.025
cellular response to monosaccharide stimulus GO:0071326 47 0.025
maintenance of protein location in cell GO:0032507 20 0.025
cell cycle g2 m phase transition GO:0044839 20 0.024
cellular response to growth factor stimulus GO:0071363 197 0.024
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.024
positive regulation of chromatin modification GO:1903310 28 0.024
positive regulation of binding GO:0051099 49 0.024
negative regulation of cytoskeleton organization GO:0051494 36 0.024
cell type specific apoptotic process GO:0097285 268 0.024
cellular response to acid chemical GO:0071229 68 0.024
actomyosin structure organization GO:0031032 56 0.024
positive regulation of programmed cell death GO:0043068 218 0.024
gonad development GO:0008406 141 0.024
hexose metabolic process GO:0019318 98 0.024
meiotic chromosome segregation GO:0045132 19 0.024
organophosphate catabolic process GO:0046434 232 0.024
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.024
positive regulation of multi organism process GO:0043902 26 0.023
positive regulation of gtp catabolic process GO:0033126 85 0.023
response to oxidative stress GO:0006979 123 0.023
dna damage checkpoint GO:0000077 26 0.023
Human
positive regulation of nuclear division GO:0051785 27 0.023
chromatin disassembly GO:0031498 1 0.023
peptidyl serine modification GO:0018209 83 0.023
nucleotide metabolic process GO:0009117 332 0.023
skeletal system development GO:0001501 356 0.023
negative regulation of protein maturation GO:1903318 79 0.023
positive regulation of antimicrobial humoral response GO:0002760 2 0.022
neuron migration GO:0001764 122 0.022
regulation of mapk cascade GO:0043408 248 0.022
ribose phosphate metabolic process GO:0019693 291 0.022
ribonucleoside metabolic process GO:0009119 245 0.022
regulation of dna dependent dna replication GO:0090329 8 0.022
antibacterial peptide production GO:0002778 2 0.022
negative regulation of intracellular transport GO:0032387 38 0.022
positive regulation of synaptic plasticity GO:0031915 4 0.022
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.022
connective tissue development GO:0061448 179 0.022
muscle cell differentiation GO:0042692 261 0.022
cellular response to hexose stimulus GO:0071331 47 0.022
response to uv GO:0009411 44 0.021
telomere maintenance via telomerase GO:0007004 1 0.021
regulation of synaptic plasticity GO:0048167 87 0.021
regulation of ras protein signal transduction GO:0046578 114 0.021
epithelial cell proliferation GO:0050673 174 0.021
female gamete generation GO:0007292 74 0.021
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.021
positive regulation of protein transport GO:0051222 93 0.021
innate immune response GO:0045087 157 0.021
cellular response to organonitrogen compound GO:0071417 145 0.021
defense response to bacterium GO:0042742 119 0.021
positive regulation of cell death GO:0010942 224 0.021
antimicrobial peptide biosynthetic process GO:0002777 2 0.021
oocyte differentiation GO:0009994 35 0.021
regulation of neuron differentiation GO:0045664 281 0.020
posttranscriptional gene silencing GO:0016441 10 0.020
rna processing GO:0006396 105 0.020
cellular response to insulin stimulus GO:0032869 78 0.020
positive regulation of defense response to bacterium GO:1900426 1 0.020
cellular response to organic cyclic compound GO:0071407 87 0.020
purine ribonucleoside metabolic process GO:0046128 241 0.020
regulation of defense response GO:0031347 233 0.020
positive regulation of protein phosphorylation GO:0001934 242 0.020
mitotic g2 dna damage checkpoint GO:0007095 8 0.020
negative regulation of nucleotide catabolic process GO:0030812 9 0.020
non recombinational repair GO:0000726 10 0.019
positive regulation of protein localization to nucleus GO:1900182 30 0.019
cell fate commitment GO:0045165 210 0.019
positive regulation of nucleotide metabolic process GO:0045981 114 0.019
negative regulation of purine nucleotide metabolic process GO:1900543 16 0.019
positive regulation of response to dna damage stimulus GO:2001022 14 0.019
regulation of secretion by cell GO:1903530 249 0.019
maintenance of protein location in nucleus GO:0051457 2 0.019
response to peptide hormone GO:0043434 127 0.019
regulation of protein catabolic process GO:0042176 108 0.018
organonitrogen compound catabolic process GO:1901565 264 0.018
negative regulation of gene expression epigenetic GO:0045814 15 0.018
Yeast
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.018
stem cell proliferation GO:0072089 117 0.018
gtp catabolic process GO:0006184 143 0.018
organ growth GO:0035265 117 0.018
mrna metabolic process GO:0016071 84 0.018
ventricular cardiac muscle cell development GO:0055015 11 0.018
negative regulation of atpase activity GO:0032780 2 0.017
synaptonemal complex assembly GO:0007130 13 0.017
circulatory system process GO:0003013 197 0.017
response to acid chemical GO:0001101 111 0.017
regulation of purine nucleotide metabolic process GO:1900542 169 0.017
negative regulation of protein dephosphorylation GO:0035308 2 0.017
defense response to other organism GO:0098542 197 0.017
negative regulation of protein complex disassembly GO:0043242 22 0.017
forebrain development GO:0030900 302 0.017
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 15 0.017
g2 m transition of mitotic cell cycle GO:0000086 20 0.017
regulation of secretion GO:0051046 274 0.017
nucleotide excision repair GO:0006289 13 0.017
fertilization GO:0009566 127 0.017
digestive tract development GO:0048565 190 0.017
retina development in camera type eye GO:0060041 119 0.017
body morphogenesis GO:0010171 45 0.016
locomotory behavior GO:0007626 195 0.016
peptide transport GO:0015833 133 0.016
histone acetylation GO:0016573 41 0.016
positive regulation of cellular protein catabolic process GO:1903364 34 0.016
chromosome separation GO:0051304 14 0.016
microtubule nucleation GO:0007020 2 0.016
regulation of reactive oxygen species metabolic process GO:2000377 40 0.016
cellular response to hypoxia GO:0071456 17 0.016
cellular response to peptide GO:1901653 92 0.016
negative regulation of nucleocytoplasmic transport GO:0046823 23 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.016
amide transport GO:0042886 138 0.016
positive regulation of protein catabolic process GO:0045732 60 0.016
wnt signaling pathway GO:0016055 188 0.016
axon guidance GO:0007411 141 0.016
lateral inhibition GO:0046331 1 0.016
regulation of carbohydrate metabolic process GO:0006109 75 0.016
apoptotic mitochondrial changes GO:0008637 48 0.016
carbohydrate derivative catabolic process GO:1901136 231 0.016
response to alcohol GO:0097305 48 0.015
regulation of stress activated mapk cascade GO:0032872 69 0.015
peptide hormone secretion GO:0030072 109 0.015
cell cycle arrest GO:0007050 37 0.015
negative regulation of cellular catabolic process GO:0031330 47 0.015
germline cell cycle switching mitotic to meiotic cell cycle GO:0051729 1 0.015
interspecies interaction between organisms GO:0044419 83 0.015
positive regulation of protein modification by small protein conjugation or removal GO:1903322 30 0.015
regulation of cell projection organization GO:0031344 206 0.015
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.015
positive regulation of ran gtpase activity GO:0032853 3 0.015
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.015
regulation of neuron projection development GO:0010975 169 0.015
positive regulation of immune effector process GO:0002699 107 0.015
negative regulation of protein transport GO:0051224 46 0.015

H2afx disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.098
cancer DOID:162 0 0.049
large intestine cancer DOID:5672 0 0.044
colon cancer DOID:219 0 0.044
gastrointestinal system cancer DOID:3119 0 0.044
intestinal cancer DOID:10155 0 0.044
organ system cancer DOID:0050686 0 0.044
colorectal cancer DOID:9256 0 0.044
congenital hypoplastic anemia DOID:1342 0 0.035
immune system disease DOID:2914 0 0.035
aplastic anemia DOID:12449 0 0.035
disease of anatomical entity DOID:7 0 0.035
bone marrow disease DOID:4961 0 0.035
anemia DOID:2355 0 0.035
hematopoietic system disease DOID:74 0 0.035