Mus musculus

0 known processes

Phc3

polyhomeotic-like 3 (Drosophila)

(Aliases: E030046K01Rik,Edr3,Hph3)

Phc3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of immature t cell proliferation GO:0033091 4 0.493
dna metabolic process GO:0006259 303 0.316
chromatin modification GO:0016568 187 0.294
regionalization GO:0003002 337 0.231
histone modification GO:0016570 159 0.222
cell cycle comprising mitosis without cytokinesis GO:0033301 1 0.198
Fly
dna alkylation GO:0006305 43 0.193
protein modification by small protein conjugation GO:0032446 187 0.160
gene silencing GO:0016458 38 0.150
Fly
protein modification by small protein conjugation or removal GO:0070647 207 0.142
covalent chromatin modification GO:0016569 163 0.138
chromatin organization GO:0006325 206 0.131
histone h2a ubiquitination GO:0033522 3 0.099
macromolecule methylation GO:0043414 120 0.086
protein methylation GO:0006479 81 0.081
dna methylation GO:0006306 43 0.080
forebrain development GO:0030900 302 0.079
protein ubiquitination GO:0016567 171 0.079
response to oxidative stress GO:0006979 123 0.074
apoptotic signaling pathway GO:0097190 306 0.072
trunk segmentation GO:0035290 4 0.072
germ cell development GO:0007281 185 0.069
Fly
leukocyte differentiation GO:0002521 342 0.064
camera type eye development GO:0043010 266 0.063
peptidyl amino acid modification GO:0018193 336 0.062
regulation of apoptotic signaling pathway GO:2001233 197 0.061
skeletal system development GO:0001501 356 0.060
purine containing compound metabolic process GO:0072521 311 0.057
histone methylation GO:0016571 71 0.052
peptidyl lysine modification GO:0018205 77 0.051
organic cyclic compound catabolic process GO:1901361 295 0.050
t cell activation GO:0042110 289 0.049
leukocyte proliferation GO:0070661 172 0.048
ras protein signal transduction GO:0007265 77 0.047
regulation of cell activation GO:0050865 289 0.046
neural tube patterning GO:0021532 43 0.045
small gtpase mediated signal transduction GO:0007264 97 0.044
mitotic cell cycle GO:0000278 195 0.044
Fly
methylation GO:0032259 134 0.044
axonogenesis GO:0007409 274 0.043
purine ribonucleotide metabolic process GO:0009150 290 0.042
purine ribonucleoside catabolic process GO:0046130 205 0.041
nucleoside phosphate metabolic process GO:0006753 338 0.041
response to inorganic substance GO:0010035 96 0.041
cellular response to lipid GO:0071396 145 0.040
Mouse
cellular amino acid metabolic process GO:0006520 103 0.040
lymphocyte differentiation GO:0030098 242 0.040
nucleotide metabolic process GO:0009117 332 0.039
protein alkylation GO:0008213 81 0.039
ribose phosphate metabolic process GO:0019693 291 0.039
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.037
neural tube development GO:0021915 160 0.037
ribonucleotide metabolic process GO:0009259 291 0.037
dendrite development GO:0016358 115 0.036
t cell differentiation in thymus GO:0033077 77 0.036
nucleoside catabolic process GO:0009164 206 0.035
positive regulation of cell activation GO:0050867 158 0.034
regulation of cellular amine metabolic process GO:0033238 20 0.034
gland development GO:0048732 330 0.033
regulation of t cell activation GO:0050863 170 0.033
cellular ketone metabolic process GO:0042180 84 0.033
purine nucleotide metabolic process GO:0006163 302 0.033
embryonic organ morphogenesis GO:0048562 276 0.033
nucleobase containing small molecule metabolic process GO:0055086 352 0.032
dna recombination GO:0006310 92 0.032
regulation of lymphocyte activation GO:0051249 240 0.031
developmental maturation GO:0021700 193 0.031
female gamete generation GO:0007292 74 0.031
Fly
embryonic skeletal system morphogenesis GO:0048704 91 0.031
skeletal system morphogenesis GO:0048705 203 0.030
regulation of lymphocyte proliferation GO:0050670 117 0.030
regulation of t cell proliferation GO:0042129 92 0.030
telencephalon development GO:0021537 186 0.030
regulation of transferase activity GO:0051338 263 0.029
posttranscriptional regulation of gene expression GO:0010608 155 0.029
histone monoubiquitination GO:0010390 3 0.029
dna modification GO:0006304 50 0.029
negative regulation of protein modification process GO:0031400 163 0.028
b cell proliferation GO:0042100 53 0.028
positive regulation of b cell activation GO:0050871 49 0.027
t cell differentiation GO:0030217 174 0.027
cellular response to dna damage stimulus GO:0006974 207 0.027
regulation of organelle organization GO:0033043 289 0.027
purine ribonucleoside metabolic process GO:0046128 241 0.026
regulation of leukocyte proliferation GO:0070663 121 0.026
cellular lipid metabolic process GO:0044255 323 0.026
nucleoside triphosphate metabolic process GO:0009141 230 0.026
response to organic cyclic compound GO:0014070 198 0.026
Fly
negative regulation of cellular component organization GO:0051129 194 0.026
stem cell development GO:0048864 219 0.026
cell maturation GO:0048469 127 0.026
segmentation GO:0035282 93 0.026
cation transport GO:0006812 399 0.025
cellular amine metabolic process GO:0044106 44 0.025
cellular response to oxidative stress GO:0034599 76 0.025
response to radiation GO:0009314 165 0.025
heterocycle catabolic process GO:0046700 280 0.025
intrinsic apoptotic signaling pathway GO:0097193 132 0.025
positive regulation of protein modification process GO:0031401 299 0.025
cell division GO:0051301 120 0.024
glycosyl compound metabolic process GO:1901657 246 0.024
immune effector process GO:0002252 321 0.024
positive regulation of t cell proliferation GO:0042102 52 0.024
t cell proliferation GO:0042098 120 0.024
positive regulation of cell development GO:0010720 237 0.024
b cell activation GO:0042113 161 0.024
chemotaxis GO:0006935 247 0.024
rho protein signal transduction GO:0007266 32 0.023
nucleotide catabolic process GO:0009166 217 0.023
purine containing compound catabolic process GO:0072523 213 0.023
regulation of leukocyte differentiation GO:1902105 159 0.023
positive regulation of t cell differentiation GO:0045582 52 0.023
stem cell differentiation GO:0048863 268 0.023
purine nucleoside triphosphate metabolic process GO:0009144 226 0.023
sensory perception GO:0007600 245 0.023
male gamete generation GO:0048232 285 0.023
Mouse
purine nucleoside triphosphate catabolic process GO:0009146 203 0.022
histone ubiquitination GO:0016574 10 0.022
central nervous system neuron differentiation GO:0021953 162 0.022
Fly
regulation of cell motility GO:2000145 236 0.022
ribonucleoside triphosphate metabolic process GO:0009199 220 0.022
cytokine production GO:0001816 319 0.022
histone acetylation GO:0016573 41 0.022
nucleoside metabolic process GO:0009116 246 0.022
embryonic skeletal system development GO:0048706 120 0.022
negative regulation of apoptotic signaling pathway GO:2001234 104 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.022
response to organonitrogen compound GO:0010243 246 0.022
ribonucleoside catabolic process GO:0042454 206 0.022
purine nucleoside catabolic process GO:0006152 205 0.022
regulation of neuron differentiation GO:0045664 281 0.021
histone h2a monoubiquitination GO:0035518 1 0.021
intracellular receptor signaling pathway GO:0030522 74 0.021
regulation of cell cycle GO:0051726 281 0.021
spermatogenesis GO:0007283 284 0.021
Mouse
signal transduction by p53 class mediator GO:0072331 51 0.021
stem cell maintenance GO:0019827 130 0.021
positive regulation of cellular amine metabolic process GO:0033240 5 0.021
regulation of b cell activation GO:0050864 81 0.021
oocyte construction GO:0007308 2 0.021
glycosyl compound catabolic process GO:1901658 206 0.021
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.021
regulation of t cell differentiation GO:0045580 83 0.021
dna repair GO:0006281 107 0.021
regulation of cellular ketone metabolic process GO:0010565 66 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.020
oocyte axis specification GO:0007309 2 0.020
carbohydrate derivative catabolic process GO:1901136 231 0.020
cellular homeostasis GO:0019725 240 0.020
neuron maturation GO:0042551 29 0.020
response to acid chemical GO:0001101 111 0.020
Mouse
myeloid cell differentiation GO:0030099 233 0.020
chromatin silencing GO:0006342 15 0.020
muscle tissue development GO:0060537 308 0.019
nucleoside phosphate catabolic process GO:1901292 222 0.019
locomotory behavior GO:0007626 195 0.019
protein catabolic process GO:0030163 221 0.019
muscle cell differentiation GO:0042692 261 0.019
response to reactive oxygen species GO:0000302 56 0.019
muscle cell development GO:0055001 133 0.019
cellular macromolecule catabolic process GO:0044265 206 0.019
regulation of cellular component biogenesis GO:0044087 181 0.019
response to ionizing radiation GO:0010212 42 0.019
transmembrane transport GO:0055085 412 0.019
negative regulation of molecular function GO:0044092 258 0.019
positive regulation of leukocyte differentiation GO:1902107 86 0.019
purine ribonucleotide catabolic process GO:0009154 208 0.019
regulation of protein stability GO:0031647 52 0.018
oxidation reduction process GO:0055114 342 0.018
nucleoside triphosphate catabolic process GO:0009143 205 0.018
amine metabolic process GO:0009308 45 0.018
regulation of mapk cascade GO:0043408 248 0.018
negative regulation of organelle organization GO:0010639 90 0.018
positive regulation of protein phosphorylation GO:0001934 242 0.018
positive regulation of lymphocyte activation GO:0051251 140 0.018
positive regulation of lymphocyte differentiation GO:0045621 61 0.018
blood circulation GO:0008015 195 0.018
regulation of cellular amino acid metabolic process GO:0006521 5 0.018
membrane organization GO:0061024 245 0.018
cellular protein catabolic process GO:0044257 155 0.018
smoothened signaling pathway GO:0007224 105 0.018
cell type specific apoptotic process GO:0097285 268 0.018
purine nucleotide catabolic process GO:0006195 211 0.017
negative regulation of protein metabolic process GO:0051248 282 0.017
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.017
ribonucleoside metabolic process GO:0009119 245 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.017
cellular response to abiotic stimulus GO:0071214 56 0.017
ossification GO:0001503 216 0.017
histone lysine methylation GO:0034968 50 0.017
cell growth GO:0016049 130 0.017
spermatid differentiation GO:0048515 115 0.017
axon guidance GO:0007411 141 0.017
positive regulation of nervous system development GO:0051962 221 0.017
fat cell differentiation GO:0045444 160 0.017
skeletal muscle organ development GO:0060538 163 0.016
rostrocaudal neural tube patterning GO:0021903 12 0.016
humoral immune response GO:0006959 57 0.016
cell fate commitment GO:0045165 210 0.016
epithelial cell development GO:0002064 159 0.016
Fly
ion transmembrane transport GO:0034220 361 0.016
blood vessel morphogenesis GO:0048514 285 0.016
regulation of secretion by cell GO:1903530 249 0.016
spermatid development GO:0007286 108 0.016
macromolecule catabolic process GO:0009057 281 0.016
embryonic epithelial tube formation GO:0001838 130 0.016
lymphocyte proliferation GO:0046651 164 0.016
aromatic compound catabolic process GO:0019439 286 0.015
regulation of secretion GO:0051046 274 0.015
organonitrogen compound catabolic process GO:1901565 264 0.015
intracellular mrna localization GO:0008298 4 0.015
compound eye development GO:0048749 1 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.015
neuron projection guidance GO:0097485 141 0.015
striated muscle cell development GO:0055002 125 0.015
positive regulation of leukocyte proliferation GO:0070665 73 0.015
neuron migration GO:0001764 122 0.015
muscle system process GO:0003012 141 0.015
double strand break repair GO:0006302 48 0.015
stem cell division GO:0017145 30 0.015
negative regulation of cellular protein metabolic process GO:0032269 247 0.015
mitotic cell cycle embryonic GO:0045448 5 0.015
Fly
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.015
pallium development GO:0021543 120 0.015
regulation of ras protein signal transduction GO:0046578 114 0.015
negative regulation of intracellular signal transduction GO:1902532 167 0.015
endodermal cell fate specification GO:0001714 4 0.014
regulation of multi organism process GO:0043900 111 0.014
myeloid leukocyte differentiation GO:0002573 119 0.014
purine nucleoside metabolic process GO:0042278 241 0.014
circulatory system process GO:0003013 197 0.014
negative regulation of nervous system development GO:0051961 156 0.014
positive regulation of immature t cell proliferation in thymus GO:0033092 3 0.014
ribonucleotide catabolic process GO:0009261 208 0.014
g protein coupled receptor signaling pathway GO:0007186 243 0.014
actin cytoskeleton organization GO:0030036 220 0.014
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.014
regulation of cell migration GO:0030334 219 0.014
gtp catabolic process GO:0006184 143 0.014
respiratory system development GO:0060541 190 0.014
organophosphate catabolic process GO:0046434 232 0.014
hindbrain development GO:0030902 128 0.014
regulation of cytokine production GO:0001817 266 0.014
regulation of kinase activity GO:0043549 249 0.014
rna interference GO:0016246 2 0.014
nitrogen compound transport GO:0071705 271 0.014
mapk cascade GO:0000165 281 0.014
ribonucleoside triphosphate catabolic process GO:0009203 199 0.014
cation transmembrane transport GO:0098655 266 0.013
cellular nitrogen compound catabolic process GO:0044270 280 0.013
guanosine containing compound metabolic process GO:1901068 144 0.013
organonitrogen compound biosynthetic process GO:1901566 192 0.013
cerebral cortex development GO:0021987 86 0.013
guanosine containing compound catabolic process GO:1901069 144 0.013
regulation of membrane potential GO:0042391 192 0.013
internal protein amino acid acetylation GO:0006475 42 0.013
leukocyte mediated immunity GO:0002443 174 0.013
response to hydrogen peroxide GO:0042542 32 0.013
multi multicellular organism process GO:0044706 109 0.013
positive regulation of cell death GO:0010942 224 0.013
cellular component assembly involved in morphogenesis GO:0010927 139 0.013
regulation of purine nucleotide metabolic process GO:1900542 169 0.013
regulation of cell projection organization GO:0031344 206 0.013
rhythmic process GO:0048511 174 0.013
carbohydrate derivative biosynthetic process GO:1901137 183 0.013
positive regulation of apoptotic process GO:0043065 217 0.013
rna localization GO:0006403 23 0.013
meiotic cell cycle GO:0051321 122 0.013
development of primary sexual characteristics GO:0045137 143 0.013
epithelial cell proliferation GO:0050673 174 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.013
segment specification GO:0007379 15 0.013
lateral inhibition GO:0046331 1 0.013
fertilization GO:0009566 127 0.013
digestive system development GO:0055123 200 0.013
oogenesis GO:0048477 56 0.013
Fly
mitotic cell cycle process GO:1903047 159 0.013
proteasomal protein catabolic process GO:0010498 98 0.013
cytoplasmic transport GO:0016482 234 0.013
cell cycle g1 s phase transition GO:0044843 57 0.013
regulation of hormone levels GO:0010817 211 0.013
posttranscriptional gene silencing by rna GO:0035194 10 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.012
negative regulation of phosphate metabolic process GO:0045936 184 0.012
negative regulation of phosphorus metabolic process GO:0010563 184 0.012
regulation of protein localization GO:0032880 231 0.012
regulation of protein kinase activity GO:0045859 232 0.012
hematopoietic progenitor cell differentiation GO:0002244 143 0.012
positive regulation of neuron differentiation GO:0045666 141 0.012
divalent inorganic cation transport GO:0072511 178 0.012
pharynx development GO:0060465 1 0.012
organelle fission GO:0048285 170 0.012
positive regulation of t cell activation GO:0050870 101 0.012
protein acylation GO:0043543 64 0.012
regulation of protein complex assembly GO:0043254 83 0.012
nuclear division GO:0000280 158 0.012
lymphocyte mediated immunity GO:0002449 139 0.012
positive regulation of lymphocyte proliferation GO:0050671 70 0.012
negative regulation of cell proliferation GO:0008285 296 0.012
regulation of striated muscle cell differentiation GO:0051153 81 0.012
tube formation GO:0035148 140 0.012
cellular chemical homeostasis GO:0055082 215 0.012
regulation of homeostatic process GO:0032844 182 0.012
peptidyl lysine acetylation GO:0018394 45 0.012
muscle contraction GO:0006936 101 0.012
anatomical structure homeostasis GO:0060249 145 0.012
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.011
regulation of wnt signaling pathway GO:0030111 123 0.011
striated muscle tissue development GO:0014706 293 0.011
positive regulation of mapk cascade GO:0043410 170 0.011
neural precursor cell proliferation GO:0061351 121 0.011
gtp metabolic process GO:0046039 144 0.011
regulation of hydrolase activity GO:0051336 246 0.011
homeostasis of number of cells GO:0048872 210 0.011
regulation of lymphocyte differentiation GO:0045619 107 0.011
positive regulation of growth GO:0045927 104 0.011
retina development in camera type eye GO:0060041 119 0.011
wound healing GO:0042060 157 0.011
urogenital system development GO:0001655 261 0.011
endomembrane system organization GO:0010256 147 0.011
mitotic cytokinesis GO:0000281 4 0.011
angiogenesis GO:0001525 201 0.011
regulation of neuron projection development GO:0010975 169 0.011
regulation of nucleotide catabolic process GO:0030811 122 0.011
glucose homeostasis GO:0042593 128 0.011
learning or memory GO:0007611 148 0.011
cellular response to acid chemical GO:0071229 68 0.011
Mouse
regulation of nucleotide metabolic process GO:0006140 169 0.011
positive regulation of kinase activity GO:0033674 155 0.011
negative regulation of gene expression epigenetic GO:0045814 15 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
multicellular organism growth GO:0035264 161 0.011
modification dependent protein catabolic process GO:0019941 133 0.011
sensory organ morphogenesis GO:0090596 242 0.011
synapse organization GO:0050808 125 0.011
gene silencing by rna GO:0031047 19 0.011
single fertilization GO:0007338 82 0.011
chromatin remodeling GO:0006338 32 0.011
positive regulation of t cell differentiation in thymus GO:0033089 13 0.011
neuron death GO:0070997 154 0.011
negative regulation of phosphorylation GO:0042326 166 0.010
cellular response to cytokine stimulus GO:0071345 189 0.010
ear development GO:0043583 200 0.010
cellular response to hormone stimulus GO:0032870 150 0.010
cellular response to lipopolysaccharide GO:0071222 77 0.010
protein targeting GO:0006605 143 0.010
tissue remodeling GO:0048771 102 0.010
endocytosis GO:0006897 168 0.010
alpha beta t cell differentiation GO:0046632 69 0.010
lipid biosynthetic process GO:0008610 179 0.010
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.010
immature t cell proliferation GO:0033079 8 0.010

Phc3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.035
nervous system disease DOID:863 0 0.035
central nervous system disease DOID:331 0 0.020
neurodegenerative disease DOID:1289 0 0.016
disease of metabolism DOID:0014667 0 0.012
disease of cellular proliferation DOID:14566 0 0.011
cancer DOID:162 0 0.011
organ system cancer DOID:0050686 0 0.011