Mus musculus

32 known processes

Xrn2

5'-3' exoribonuclease 2

Xrn2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 207 0.437
regulation of cell cycle process GO:0010564 160 0.200
regulation of cellular component biogenesis GO:0044087 181 0.188
dna metabolic process GO:0006259 303 0.140
nuclear division GO:0000280 158 0.127
regulation of organelle organization GO:0033043 289 0.126
dna repair GO:0006281 107 0.125
meiotic cell cycle GO:0051321 122 0.117
regulation of cell cycle GO:0051726 281 0.105
chromatin organization GO:0006325 206 0.104
cellular ketone metabolic process GO:0042180 84 0.088
spermatogenesis GO:0007283 284 0.083
chromosome organization involved in meiosis GO:0070192 39 0.083
organelle fission GO:0048285 170 0.075
meiotic nuclear division GO:0007126 115 0.074
germ cell development GO:0007281 185 0.069
organophosphate catabolic process GO:0046434 232 0.067
regulation of cell division GO:0051302 76 0.065
regulation of cellular ketone metabolic process GO:0010565 66 0.064
gene silencing by rna GO:0031047 19 0.054
gonad development GO:0008406 141 0.052
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 1 0.051
mitotic cell cycle GO:0000278 195 0.051
mitotic cell cycle process GO:1903047 159 0.051
rna processing GO:0006396 105 0.050
development of primary sexual characteristics GO:0045137 143 0.048
microtubule cytoskeleton organization GO:0000226 157 0.048
regulation of chromatin modification GO:1903308 57 0.048
regulation of mrna processing GO:0050684 41 0.046
regulation of cell activation GO:0050865 289 0.046
posttranscriptional regulation of gene expression GO:0010608 155 0.045
oocyte axis specification GO:0007309 2 0.045
cellular response to cytokine stimulus GO:0071345 189 0.045
mrna metabolic process GO:0016071 84 0.044
negative regulation of cellular component organization GO:0051129 194 0.041
ion transmembrane transport GO:0034220 361 0.040
regulation of protein complex assembly GO:0043254 83 0.040
regulation of mitotic cell cycle phase transition GO:1901990 73 0.037
cellular amino acid metabolic process GO:0006520 103 0.037
mrna processing GO:0006397 63 0.037
rna interference GO:0016246 2 0.036
male gamete generation GO:0048232 285 0.036
regulation of mitotic cell cycle GO:0007346 126 0.036
negative regulation of cell cycle GO:0045786 123 0.036
cellular response to lipid GO:0071396 145 0.036
regulation of lymphocyte activation GO:0051249 240 0.035
g1 s transition of mitotic cell cycle GO:0000082 57 0.035
response to radiation GO:0009314 165 0.034
positive regulation of organelle organization GO:0010638 128 0.034
apoptotic signaling pathway GO:0097190 306 0.034
stem cell differentiation GO:0048863 268 0.033
endonucleolytic cleavage of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000479 1 0.032
stem cell development GO:0048864 219 0.030
negative regulation of protein metabolic process GO:0051248 282 0.030
maturation of 5 8s rrna GO:0000460 1 0.030
regulation of lymphocyte proliferation GO:0050670 117 0.029
regulation of chromosome organization GO:0033044 83 0.028
regulation of cellular amine metabolic process GO:0033238 20 0.027
modification dependent macromolecule catabolic process GO:0043632 133 0.027
posttranscriptional gene silencing GO:0016441 10 0.027
cellular amine metabolic process GO:0044106 44 0.027
microtubule nucleation GO:0007020 2 0.026
microtubule based process GO:0007017 236 0.026
positive regulation of apoptotic process GO:0043065 217 0.025
cell division GO:0051301 120 0.025
regulation of cellular response to stress GO:0080135 159 0.025
regulation of cellular amino acid metabolic process GO:0006521 5 0.025
cellular response to gamma radiation GO:0071480 4 0.024
translation GO:0006412 93 0.024
meiotic cell cycle process GO:1903046 77 0.024
regulation of response to dna damage stimulus GO:2001020 34 0.024
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.023
intracellular mrna localization GO:0008298 4 0.023
chromosome segregation GO:0007059 48 0.023
regulation of chromatin organization GO:1902275 57 0.023
erythrocyte differentiation GO:0030218 88 0.023
regulation of nuclear division GO:0051783 56 0.023
histone lysine methylation GO:0034968 50 0.023
organic cyclic compound catabolic process GO:1901361 295 0.023
positive regulation of protein modification process GO:0031401 299 0.023
mitotic nuclear division GO:0007067 48 0.023
cellular response to radiation GO:0071478 28 0.023
spermatid development GO:0007286 108 0.023
lymphocyte proliferation GO:0046651 164 0.022
homeostasis of number of cells GO:0048872 210 0.022
ossification GO:0001503 216 0.022
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.022
nucleoside monophosphate metabolic process GO:0009123 85 0.022
negative regulation of immune system process GO:0002683 209 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.022
negative regulation of leukocyte proliferation GO:0070664 46 0.022
rna localization GO:0006403 23 0.021
positive regulation of lymphocyte activation GO:0051251 140 0.021
positive regulation of apoptotic signaling pathway GO:2001235 95 0.021
ncrna processing GO:0034470 26 0.021
compound eye development GO:0048749 1 0.021
inflammatory response GO:0006954 244 0.021
cellularization GO:0007349 1 0.021
regulation of cell cycle phase transition GO:1901987 77 0.021
negative regulation of organelle organization GO:0010639 90 0.021
positive regulation of cellular amine metabolic process GO:0033240 5 0.020
ribose phosphate metabolic process GO:0019693 291 0.020
negative regulation of cellular protein metabolic process GO:0032269 247 0.020
peptidyl amino acid modification GO:0018193 336 0.020
positive regulation of cell cycle process GO:0090068 61 0.020
myeloid cell differentiation GO:0030099 233 0.020
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.020
aromatic compound catabolic process GO:0019439 286 0.020
regulation of binding GO:0051098 111 0.020
carbohydrate derivative catabolic process GO:1901136 231 0.019
response to organic cyclic compound GO:0014070 198 0.019
protein localization to organelle GO:0033365 185 0.019
oocyte construction GO:0007308 2 0.019
organic hydroxy compound metabolic process GO:1901615 203 0.019
synapse organization GO:0050808 125 0.019
regulation of meiotic cell cycle GO:0051445 34 0.019
rna splicing via transesterification reactions GO:0000375 43 0.018
heterochromatin organization GO:0070828 4 0.018
nucleotide metabolic process GO:0009117 332 0.018
regulation of neuron death GO:1901214 134 0.018
regulation of mrna splicing via spliceosome GO:0048024 32 0.018
amine metabolic process GO:0009308 45 0.018
regulation of system process GO:0044057 200 0.018
cellular homeostasis GO:0019725 240 0.018
nitrogen compound transport GO:0071705 271 0.017
chromatin modification GO:0016568 187 0.017
regulation of apoptotic signaling pathway GO:2001233 197 0.017
nucleoside phosphate metabolic process GO:0006753 338 0.017
response to acid chemical GO:0001101 111 0.017
intrinsic apoptotic signaling pathway GO:0097193 132 0.017
leukocyte differentiation GO:0002521 342 0.016
leukocyte proliferation GO:0070661 172 0.016
protein import GO:0017038 101 0.016
rna splicing GO:0008380 54 0.016
microtubule organizing center organization GO:0031023 28 0.016
negative regulation of protein processing GO:0010955 79 0.016
nuclear import GO:0051170 95 0.016
response to organonitrogen compound GO:0010243 246 0.016
positive regulation of transferase activity GO:0051347 167 0.016
ribonucleotide catabolic process GO:0009261 208 0.016
mitotic chromosome condensation GO:0007076 1 0.016
regulation of homeostatic process GO:0032844 182 0.016
regulation of cellular catabolic process GO:0031329 242 0.015
sensory perception GO:0007600 245 0.015
ribonucleotide metabolic process GO:0009259 291 0.015
regulation of kinase activity GO:0043549 249 0.015
nuclear transport GO:0051169 139 0.015
response to light stimulus GO:0009416 135 0.015
actin cytoskeleton organization GO:0030036 220 0.015
protein localization to nucleus GO:0034504 121 0.015
extracellular structure organization GO:0043062 148 0.015
purine ribonucleotide metabolic process GO:0009150 290 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.015
ribonucleoside catabolic process GO:0042454 206 0.015
ribonucleoside triphosphate metabolic process GO:0009199 220 0.015
spermatid differentiation GO:0048515 115 0.015
regulation of protein localization GO:0032880 231 0.015
protein ubiquitination GO:0016567 171 0.015
cation transmembrane transport GO:0098655 266 0.015
dna packaging GO:0006323 30 0.015
negative regulation of lymphocyte activation GO:0051250 91 0.015
cellular response to abiotic stimulus GO:0071214 56 0.015
cytokine production GO:0001816 319 0.015
lipid localization GO:0010876 126 0.014
positive regulation of cellular catabolic process GO:0031331 148 0.014
organonitrogen compound catabolic process GO:1901565 264 0.014
leukocyte apoptotic process GO:0071887 71 0.014
regulation of lipid storage GO:0010883 20 0.014
maintenance of location GO:0051235 89 0.014
positive regulation of cell death GO:0010942 224 0.014
positive regulation of homeostatic process GO:0032846 64 0.014
positive regulation of nervous system development GO:0051962 221 0.014
male meiosis GO:0007140 37 0.014
cellular nitrogen compound catabolic process GO:0044270 280 0.014
negative regulation of molecular function GO:0044092 258 0.014
bone development GO:0060348 120 0.014
developmental maturation GO:0021700 193 0.014
nuclear membrane organization GO:0071763 4 0.014
regulation of hydrolase activity GO:0051336 246 0.014
positive regulation of programmed cell death GO:0043068 218 0.014
oocyte anterior posterior axis specification GO:0007314 2 0.013
cation transport GO:0006812 399 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.013
t cell activation GO:0042110 289 0.013
hematopoietic progenitor cell differentiation GO:0002244 143 0.013
multi multicellular organism process GO:0044706 109 0.013
muscle cell differentiation GO:0042692 261 0.013
centrosome separation GO:0051299 4 0.013
nucleobase containing small molecule metabolic process GO:0055086 352 0.013
inorganic cation transmembrane transport GO:0098662 207 0.013
protein modification by small protein conjugation or removal GO:0070647 207 0.013
rhythmic process GO:0048511 174 0.012
negative regulation of cell activation GO:0050866 111 0.012
carbohydrate derivative biosynthetic process GO:1901137 183 0.012
histone modification GO:0016570 159 0.012
regulation of leukocyte proliferation GO:0070663 121 0.012
nucleotide catabolic process GO:0009166 217 0.012
nucleobase containing compound transport GO:0015931 27 0.012
regulation of transferase activity GO:0051338 263 0.012
lymphocyte differentiation GO:0030098 242 0.012
positive regulation of mitotic cell cycle GO:0045931 41 0.012
action potential GO:0001508 78 0.012
wound healing GO:0042060 157 0.012
locomotory behavior GO:0007626 195 0.012
oocyte development GO:0048599 33 0.012
lipid storage GO:0019915 36 0.012
regulation of engulfment of apoptotic cell GO:1901074 2 0.012
transmembrane transport GO:0055085 412 0.012
protein import into nucleus GO:0006606 95 0.012
developmental growth involved in morphogenesis GO:0060560 138 0.012
membrane organization GO:0061024 245 0.012
cation homeostasis GO:0055080 212 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.011
response to uv GO:0009411 44 0.011
cellular protein catabolic process GO:0044257 155 0.011
organic anion transport GO:0015711 137 0.011
response to inorganic substance GO:0010035 96 0.011
cell matrix adhesion GO:0007160 68 0.011
signal transduction by p53 class mediator GO:0072331 51 0.011
positive regulation of protein phosphorylation GO:0001934 242 0.011
protein processing GO:0016485 163 0.011
ribosomal small subunit biogenesis GO:0042274 4 0.011
meiosis i GO:0007127 60 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.011
nucleoside triphosphate metabolic process GO:0009141 230 0.011
regulation of response to wounding GO:1903034 189 0.011
methylation GO:0032259 134 0.011
female gamete generation GO:0007292 74 0.011
protein oligomerization GO:0051259 67 0.011
protein autophosphorylation GO:0046777 61 0.010
purine nucleotide metabolic process GO:0006163 302 0.010
genitalia development GO:0048806 37 0.010
protein polyubiquitination GO:0000209 33 0.010
rna 5 end processing GO:0000966 1 0.010
male sex differentiation GO:0046661 109 0.010
purine ribonucleotide catabolic process GO:0009154 208 0.010
anatomical structure homeostasis GO:0060249 145 0.010
regulation of inflammatory response GO:0050727 147 0.010
negative regulation of cellular amine metabolic process GO:0033239 1 0.010
regulation of rna splicing GO:0043484 37 0.010
cell substrate adhesion GO:0031589 130 0.010
negative regulation of neuron differentiation GO:0045665 101 0.010
neural tube development GO:0021915 160 0.010
neuronal action potential GO:0019228 54 0.010
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000462 1 0.010
cellular response to organic cyclic compound GO:0071407 87 0.010
regulation of cytoskeleton organization GO:0051493 122 0.010
negative regulation of proteolysis GO:0045861 74 0.010
single organism nuclear import GO:1902593 95 0.010

Xrn2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.061
nervous system disease DOID:863 0 0.061
sensory system disease DOID:0050155 0 0.021
eye and adnexa disease DOID:1492 0 0.021
eye disease DOID:5614 0 0.021
central nervous system disease DOID:331 0 0.018
neurodegenerative disease DOID:1289 0 0.016
retinal disease DOID:5679 0 0.016
retinal degeneration DOID:8466 0 0.014
nephritis DOID:10952 0 0.010
kidney disease DOID:557 0 0.010
urinary system disease DOID:18 0 0.010