Mus musculus

148 known processes

Dock8

dedicator of cytokinesis 8

(Aliases: A130095G14Rik,AI461977,1200017A24Rik,5830472H07Rik)

Dock8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleoside phosphate metabolic process GO:0006753 338 0.156
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.102
regulation of hydrolase activity GO:0051336 246 0.100
purine nucleotide metabolic process GO:0006163 302 0.099
cellular nitrogen compound catabolic process GO:0044270 280 0.092
positive regulation of gtp catabolic process GO:0033126 85 0.089
ribonucleoside triphosphate catabolic process GO:0009203 199 0.087
small gtpase mediated signal transduction GO:0007264 97 0.087
Fly
purine ribonucleoside catabolic process GO:0046130 205 0.084
nucleotide metabolic process GO:0009117 332 0.083
ras protein signal transduction GO:0007265 77 0.083
Fly
purine ribonucleotide metabolic process GO:0009150 290 0.079
purine containing compound catabolic process GO:0072523 213 0.078
purine nucleoside metabolic process GO:0042278 241 0.076
ribonucleotide metabolic process GO:0009259 291 0.075
carbohydrate derivative catabolic process GO:1901136 231 0.074
glycosyl compound metabolic process GO:1901657 246 0.073
regulation of nucleotide metabolic process GO:0006140 169 0.071
immune response regulating signaling pathway GO:0002764 125 0.070
amine metabolic process GO:0009308 45 0.069
rho protein signal transduction GO:0007266 32 0.069
Fly
guanosine containing compound metabolic process GO:1901068 144 0.069
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.068
glycosyl compound catabolic process GO:1901658 206 0.067
nucleoside catabolic process GO:0009164 206 0.066
organonitrogen compound catabolic process GO:1901565 264 0.064
nucleoside phosphate catabolic process GO:1901292 222 0.064
purine nucleotide catabolic process GO:0006195 211 0.063
purine containing compound metabolic process GO:0072521 311 0.061
regulation of cellular catabolic process GO:0031329 242 0.060
immune response activating signal transduction GO:0002757 116 0.060
nucleobase containing small molecule metabolic process GO:0055086 352 0.058
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.056
activation of immune response GO:0002253 138 0.056
ribonucleotide catabolic process GO:0009261 208 0.055
nucleoside triphosphate metabolic process GO:0009141 230 0.055
purine nucleoside triphosphate catabolic process GO:0009146 203 0.055
cellular amino acid metabolic process GO:0006520 103 0.054
purine nucleoside catabolic process GO:0006152 205 0.054
heterocycle catabolic process GO:0046700 280 0.054
ribonucleoside triphosphate metabolic process GO:0009199 220 0.053
cellular ketone metabolic process GO:0042180 84 0.050
regulation of cellular ketone metabolic process GO:0010565 66 0.050
regulation of cellular amino acid metabolic process GO:0006521 5 0.049
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.047
nucleotide catabolic process GO:0009166 217 0.047
aromatic compound catabolic process GO:0019439 286 0.047
nucleoside metabolic process GO:0009116 246 0.046
cellular amine metabolic process GO:0044106 44 0.046
membrane organization GO:0061024 245 0.045
organophosphate catabolic process GO:0046434 232 0.045
purine ribonucleoside metabolic process GO:0046128 241 0.044
t cell activation GO:0042110 289 0.043
Human
regulation of nucleotide catabolic process GO:0030811 122 0.043
positive regulation of cellular catabolic process GO:0031331 148 0.043
ribonucleoside catabolic process GO:0042454 206 0.043
ribose phosphate metabolic process GO:0019693 291 0.043
cation transport GO:0006812 399 0.042
gtp metabolic process GO:0046039 144 0.042
positive regulation of gtpase activity GO:0043547 85 0.042
purine ribonucleotide catabolic process GO:0009154 208 0.041
ribonucleoside metabolic process GO:0009119 245 0.040
cellular lipid metabolic process GO:0044255 323 0.039
divalent inorganic cation transport GO:0072511 178 0.039
nucleoside triphosphate catabolic process GO:0009143 205 0.038
ion transmembrane transport GO:0034220 361 0.037
purine nucleoside triphosphate metabolic process GO:0009144 226 0.037
guanosine containing compound catabolic process GO:1901069 144 0.037
leukocyte differentiation GO:0002521 342 0.036
reactive oxygen species metabolic process GO:0072593 84 0.035
regulation of vesicle mediated transport GO:0060627 139 0.035
positive regulation of hydrolase activity GO:0051345 148 0.035
immune effector process GO:0002252 321 0.035
Fly
organic cyclic compound catabolic process GO:1901361 295 0.034
regulation of cellular amine metabolic process GO:0033238 20 0.034
peptidyl amino acid modification GO:0018193 336 0.033
regulation of purine nucleotide metabolic process GO:1900542 169 0.033
cation transmembrane transport GO:0098655 266 0.033
positive regulation of nucleotide metabolic process GO:0045981 114 0.033
regulation of purine nucleotide catabolic process GO:0033121 122 0.033
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.032
regulation of ras protein signal transduction GO:0046578 114 0.032
Mouse Fly
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.032
negative regulation of protein metabolic process GO:0051248 282 0.032
innate immune response GO:0045087 157 0.032
Fly
synaptic transmission GO:0007268 329 0.032
gtp catabolic process GO:0006184 143 0.031
macromolecule catabolic process GO:0009057 281 0.031
sequestering of calcium ion GO:0051208 18 0.031
actin cytoskeleton organization GO:0030036 220 0.030
protein catabolic process GO:0030163 221 0.030
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.029
divalent metal ion transport GO:0070838 172 0.029
myeloid cell differentiation GO:0030099 233 0.029
regulation of organelle organization GO:0033043 289 0.029
regulation of ras gtpase activity GO:0032318 88 0.028
Mouse Fly
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.028
inorganic ion transmembrane transport GO:0098660 234 0.028
maintenance of location GO:0051235 89 0.027
regulation of gtp catabolic process GO:0033124 113 0.027
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.027
sensory perception GO:0007600 245 0.027
negative regulation of cellular amine metabolic process GO:0033239 1 0.027
cellular calcium ion homeostasis GO:0006874 119 0.026
positive regulation of cellular amine metabolic process GO:0033240 5 0.026
transmembrane transport GO:0055085 412 0.026
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.026
response to molecule of bacterial origin GO:0002237 143 0.025
regulation of cell cycle GO:0051726 281 0.025
cellular ion homeostasis GO:0006873 165 0.024
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.024
cellular homeostasis GO:0019725 240 0.024
regulation of cell motility GO:2000145 236 0.024
regulation of nucleoside metabolic process GO:0009118 130 0.024
positive regulation of protein modification process GO:0031401 299 0.024
inorganic cation transmembrane transport GO:0098662 207 0.023
monocarboxylic acid metabolic process GO:0032787 191 0.023
regulation of cell activation GO:0050865 289 0.023
regulation of cell migration GO:0030334 219 0.023
g protein coupled receptor signaling pathway GO:0007186 243 0.023
positive regulation of ras gtpase activity GO:0032320 65 0.022
Mouse Fly
organelle assembly GO:0070925 177 0.022
multicellular organismal homeostasis GO:0048871 164 0.022
wound healing GO:0042060 157 0.022
cellular response to molecule of bacterial origin GO:0071219 83 0.022
positive regulation of nucleotide catabolic process GO:0030813 88 0.022
cell adhesion GO:0007155 329 0.022
positive regulation of rac gtpase activity GO:0032855 14 0.022
homeostasis of number of cells GO:0048872 210 0.022
antigen receptor mediated signaling pathway GO:0050851 64 0.022
protein modification by small protein conjugation or removal GO:0070647 207 0.022
positive regulation of nucleoside metabolic process GO:0045979 91 0.022
oxidation reduction process GO:0055114 342 0.021
cation homeostasis GO:0055080 212 0.021
sequestering of metal ion GO:0051238 19 0.021
regulation of mapk cascade GO:0043408 248 0.021
organelle localization GO:0051640 179 0.021
Mouse
regulation of lymphocyte activation GO:0051249 240 0.021
reactive nitrogen species metabolic process GO:2001057 0 0.021
activation of innate immune response GO:0002218 56 0.020
positive regulation of cytokine production GO:0001819 174 0.020
regulation of body fluid levels GO:0050878 162 0.020
cytoplasmic transport GO:0016482 234 0.020
regulation of secretion GO:0051046 274 0.020
regulation of cell projection organization GO:0031344 206 0.020
divalent inorganic cation homeostasis GO:0072507 138 0.020
phagocytosis GO:0006909 66 0.019
Fly
regulation of interferon beta biosynthetic process GO:0045357 4 0.019
muscle tissue development GO:0060537 308 0.019
glycoprotein biosynthetic process GO:0009101 89 0.019
anion transport GO:0006820 177 0.019
nuclear division GO:0000280 158 0.019
negative regulation of immune system process GO:0002683 209 0.019
regulation of cytokine production GO:0001817 266 0.019
response to organonitrogen compound GO:0010243 246 0.019
protein modification by small protein conjugation GO:0032446 187 0.019
glycoprotein metabolic process GO:0009100 116 0.019
negative regulation of cellular component organization GO:0051129 194 0.018
endocytosis GO:0006897 168 0.018
Fly
gland development GO:0048732 330 0.018
multicellular organism growth GO:0035264 161 0.018
cellular chemical homeostasis GO:0055082 215 0.018
mapk cascade GO:0000165 281 0.018
negative regulation of cell proliferation GO:0008285 296 0.018
respiratory system development GO:0060541 190 0.018
negative regulation of phosphorylation GO:0042326 166 0.018
single organism cell adhesion GO:0098602 156 0.017
protein ubiquitination GO:0016567 171 0.017
anatomical structure homeostasis GO:0060249 145 0.017
regulation of endocytosis GO:0030100 69 0.017
response to acid chemical GO:0001101 111 0.017
negative regulation of cellular protein metabolic process GO:0032269 247 0.017
regulation of actin nucleation GO:0051125 4 0.017
exocytosis GO:0006887 121 0.017
cognition GO:0050890 149 0.017
chromatin modification GO:0016568 187 0.017
single organismal cell cell adhesion GO:0016337 131 0.017
response to lipopolysaccharide GO:0032496 128 0.017
tissue homeostasis GO:0001894 115 0.017
axonogenesis GO:0007409 274 0.017
kidney development GO:0001822 213 0.017
cellular component assembly involved in morphogenesis GO:0010927 139 0.017
regulation of cytoskeleton organization GO:0051493 122 0.017
compound eye development GO:0048749 1 0.016
cell substrate adhesion GO:0031589 130 0.016
negative regulation of intracellular signal transduction GO:1902532 167 0.016
actin filament organization GO:0007015 113 0.016
reactive oxygen species biosynthetic process GO:1903409 8 0.016
interferon beta biosynthetic process GO:0045350 4 0.016
regulation of rho protein signal transduction GO:0035023 71 0.016
Mouse Fly
regulation of reactive oxygen species metabolic process GO:2000377 40 0.016
renal system development GO:0072001 225 0.016
positive regulation of protein phosphorylation GO:0001934 242 0.016
regulation of membrane potential GO:0042391 192 0.016
blood vessel morphogenesis GO:0048514 285 0.016
regulation of transferase activity GO:0051338 263 0.016
regulation of actin filament based process GO:0032970 99 0.016
regulation of secretion by cell GO:1903530 249 0.016
telencephalon development GO:0021537 186 0.016
neural precursor cell proliferation GO:0061351 121 0.016
Mouse
skeletal muscle organ development GO:0060538 163 0.016
organophosphate biosynthetic process GO:0090407 122 0.016
regionalization GO:0003002 337 0.016
monocyte extravasation GO:0035696 2 0.016
learning or memory GO:0007611 148 0.016
endomembrane system organization GO:0010256 147 0.016
lipid localization GO:0010876 126 0.016
regulation of ion transport GO:0043269 215 0.015
organonitrogen compound biosynthetic process GO:1901566 192 0.015
carbohydrate derivative biosynthetic process GO:1901137 183 0.015
calcium ion homeostasis GO:0055074 127 0.015
establishment of organelle localization GO:0051656 122 0.015
cell activation involved in immune response GO:0002263 126 0.015
digestive system development GO:0055123 200 0.015
cytokine production GO:0001816 319 0.015
regulation of kinase activity GO:0043549 249 0.015
negative regulation of molecular function GO:0044092 258 0.015
regulation of innate immune response GO:0045088 91 0.015
cellular response to lipid GO:0071396 145 0.015
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.015
regulation of anatomical structure size GO:0090066 178 0.015
protein maturation GO:0051604 176 0.015
myeloid leukocyte differentiation GO:0002573 119 0.015
carbohydrate metabolic process GO:0005975 230 0.015
male gamete generation GO:0048232 285 0.015
modification dependent protein catabolic process GO:0019941 133 0.015
forebrain development GO:0030900 302 0.015
Mouse
nitrogen compound transport GO:0071705 271 0.015
mitotic cell cycle GO:0000278 195 0.015
organelle fission GO:0048285 170 0.015
regulation of actin cytoskeleton organization GO:0032956 84 0.015
positive regulation of cell death GO:0010942 224 0.015
negative regulation of synapse assembly GO:0051964 3 0.015
ubiquitin dependent protein catabolic process GO:0006511 129 0.015
b cell activation GO:0042113 161 0.014
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.014
regulation of defense response GO:0031347 233 0.014
lung development GO:0030324 164 0.014
negative regulation of homeostatic process GO:0032845 71 0.014
chemotaxis GO:0006935 247 0.014
regulation of cellular component biogenesis GO:0044087 181 0.014
cell division GO:0051301 120 0.014
positive regulation of transferase activity GO:0051347 167 0.014
lymphocyte proliferation GO:0046651 164 0.014
Human
microtubule based process GO:0007017 236 0.014
lymphocyte differentiation GO:0030098 242 0.014
regulation of myeloid cell differentiation GO:0045637 96 0.014
regulation of establishment of protein localization GO:0070201 181 0.014
establishment of vesicle localization GO:0051650 81 0.014
retrograde transport endosome to golgi GO:0042147 2 0.014
calcium ion transport GO:0006816 159 0.014
germ cell development GO:0007281 185 0.014
t cell receptor signaling pathway GO:0050852 46 0.014
inflammatory response GO:0006954 244 0.014
placenta development GO:0001890 140 0.014
positive regulation of secretion by cell GO:1903532 114 0.014
epithelial cell proliferation GO:0050673 174 0.014
cellular macromolecule catabolic process GO:0044265 206 0.014
interleukin 6 production GO:0032635 58 0.014
regulation of apoptotic signaling pathway GO:2001233 197 0.014
cofactor transport GO:0051181 4 0.014
regulation of homeostatic process GO:0032844 182 0.014
gonad development GO:0008406 141 0.014
cellular metal ion homeostasis GO:0006875 151 0.014
dna metabolic process GO:0006259 303 0.014
glycerolipid metabolic process GO:0046486 122 0.014
regulation of phospholipase c activity GO:1900274 3 0.013
alcohol metabolic process GO:0006066 116 0.013
protein processing GO:0016485 163 0.013
response to growth factor GO:0070848 198 0.013
cellular protein complex assembly GO:0043623 116 0.013
positive regulation of interferon alpha production GO:0032727 4 0.013
cell type specific apoptotic process GO:0097285 268 0.013
urogenital system development GO:0001655 261 0.013
spermatogenesis GO:0007283 284 0.013
ameboidal type cell migration GO:0001667 128 0.013
coagulation GO:0050817 78 0.013
defecation GO:0030421 1 0.013
metal ion homeostasis GO:0055065 189 0.013
macromolecule glycosylation GO:0043413 55 0.013
cellular response to lipopolysaccharide GO:0071222 77 0.013
response to starvation GO:0042594 65 0.013
lateral inhibition GO:0046331 1 0.013
carbohydrate homeostasis GO:0033500 128 0.013
modification dependent macromolecule catabolic process GO:0043632 133 0.013
positive regulation of cell development GO:0010720 237 0.013
regulation of neuron differentiation GO:0045664 281 0.013
positive regulation of apoptotic process GO:0043065 217 0.013
ossification GO:0001503 216 0.013
negative regulation of cell development GO:0010721 169 0.013
alpha beta t cell activation GO:0046631 91 0.013
regulation of cellular component size GO:0032535 121 0.013
positive regulation of defense response GO:0031349 124 0.013
lipid transport GO:0006869 98 0.013
cellular response to biotic stimulus GO:0071216 92 0.013
regulation of protein complex assembly GO:0043254 83 0.013
cellular protein catabolic process GO:0044257 155 0.013
organic hydroxy compound metabolic process GO:1901615 203 0.013
Fly
positive regulation of mapk cascade GO:0043410 170 0.013
apoptotic signaling pathway GO:0097190 306 0.013
regulation of cytoplasmic transport GO:1903649 112 0.012
toll like receptor signaling pathway GO:0002224 38 0.012
leukocyte proliferation GO:0070661 172 0.012
Human
peptidyl tyrosine phosphorylation GO:0018108 143 0.012
cell growth GO:0016049 130 0.012
regulation of neuron projection development GO:0010975 169 0.012
negative regulation of protein phosphorylation GO:0001933 126 0.012
cytosolic calcium ion transport GO:0060401 48 0.012
engulfment of apoptotic cell GO:0043652 3 0.012
positive regulation of nervous system development GO:0051962 221 0.012
calcium ion transmembrane transport GO:0070588 85 0.012
protein localization to membrane GO:0072657 108 0.012
regulation of phagocytosis GO:0050764 33 0.012
regulation of wnt signaling pathway GO:0030111 123 0.012
protein localization to organelle GO:0033365 185 0.012
positive regulation of innate immune response GO:0045089 80 0.012
muscle cell differentiation GO:0042692 261 0.012
glycosylation GO:0070085 62 0.012
protein autophosphorylation GO:0046777 61 0.012
multicellular organismal signaling GO:0035637 91 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
glucose homeostasis GO:0042593 128 0.012
nuclear transport GO:0051169 139 0.012
heart morphogenesis GO:0003007 178 0.012
positive regulation of organelle organization GO:0010638 128 0.012
morphogenesis of a branching structure GO:0001763 203 0.012
negative regulation of growth GO:0045926 99 0.012
intracellular protein transport GO:0006886 204 0.012
meiotic cell cycle GO:0051321 122 0.012
blood coagulation GO:0007596 76 0.012
respiratory tube development GO:0030323 167 0.012
mitotic cytokinesis GO:0000281 4 0.012
mesodermal cell migration GO:0008078 4 0.012
posttranscriptional regulation of gene expression GO:0010608 155 0.012
cellular response to organonitrogen compound GO:0071417 145 0.012
purine nucleoside monophosphate metabolic process GO:0009126 81 0.012
response to organic cyclic compound GO:0014070 198 0.012
hemostasis GO:0007599 78 0.012
nucleotide sugar metabolic process GO:0009225 4 0.012
negative regulation of b cell receptor signaling pathway GO:0050859 4 0.012
regulation of mitotic cell cycle GO:0007346 126 0.012
stem cell maintenance GO:0019827 130 0.012
negative regulation of phosphorus metabolic process GO:0010563 184 0.012
regulation of t cell activation GO:0050863 170 0.012
microtubule cytoskeleton organization GO:0000226 157 0.011
fatty acid metabolic process GO:0006631 121 0.011
morphogenesis of a branching epithelium GO:0061138 193 0.011
rab protein signal transduction GO:0032482 1 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.011
dna repair GO:0006281 107 0.011
neuron apoptotic process GO:0051402 142 0.011
phospholipid metabolic process GO:0006644 87 0.011
nucleoside monophosphate metabolic process GO:0009123 85 0.011
erythrocyte differentiation GO:0030218 88 0.011
sensory organ morphogenesis GO:0090596 242 0.011
leukocyte mediated immunity GO:0002443 174 0.011
regulation of system process GO:0044057 200 0.011
protein localization to nucleus GO:0034504 121 0.011
t cell differentiation GO:0030217 174 0.011
development of primary sexual characteristics GO:0045137 143 0.011
stem cell development GO:0048864 219 0.011
regulation of proteolysis GO:0030162 164 0.011
positive regulation of immune effector process GO:0002699 107 0.011
b 1 b cell differentiation GO:0001923 3 0.011
negative regulation of nik nf kappab signaling GO:1901223 2 0.011
positive regulation of rho gtpase activity GO:0032321 41 0.011
Mouse Fly
regulation of protein catabolic process GO:0042176 108 0.011
positive regulation of t cell activation GO:0050870 101 0.011
regulation of leukocyte differentiation GO:1902105 159 0.011
cellularization GO:0007349 1 0.011
regulation of ion homeostasis GO:2000021 64 0.011
vesicle localization GO:0051648 86 0.011
negative regulation of nervous system development GO:0051961 156 0.011
ribonucleoside monophosphate metabolic process GO:0009161 80 0.011
regulation of cell cycle process GO:0010564 160 0.011
glycerophospholipid metabolic process GO:0006650 71 0.011
myeloid leukocyte activation GO:0002274 83 0.011
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.011
regulation of coagulation GO:0050818 31 0.011
stem cell differentiation GO:0048863 268 0.011
regulation of cell adhesion GO:0030155 154 0.010
cellular divalent inorganic cation homeostasis GO:0072503 127 0.010
activation of rac gtpase activity GO:0032863 2 0.010
chromatin organization GO:0006325 206 0.010
striated muscle tissue development GO:0014706 293 0.010
actin filament polymerization GO:0030041 44 0.010
mitochondrion organization GO:0007005 134 0.010
protein polymerization GO:0051258 57 0.010
hematopoietic progenitor cell differentiation GO:0002244 143 0.010
Mouse
nucleocytoplasmic transport GO:0006913 139 0.010
positive regulation of actin nucleation GO:0051127 3 0.010
cellular response to extracellular stimulus GO:0031668 81 0.010
toll like receptor 7 signaling pathway GO:0034154 4 0.010
negative regulation of phagocytosis GO:0050765 4 0.010
negative regulation of toll like receptor 2 signaling pathway GO:0034136 3 0.010
peptidyl tyrosine modification GO:0018212 145 0.010
myosin filament assembly GO:0031034 2 0.010
negative regulation of neuron death GO:1901215 98 0.010
organic hydroxy compound transport GO:0015850 93 0.010
axon guidance GO:0007411 141 0.010
regulation of protein transport GO:0051223 163 0.010
regulation of lymphocyte proliferation GO:0050670 117 0.010
regulation of transmembrane transport GO:0034762 128 0.010
cellular response to dna damage stimulus GO:0006974 207 0.010
methylation GO:0032259 134 0.010
myotube differentiation GO:0014902 105 0.010
skeletal system development GO:0001501 356 0.010

Dock8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.026
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.026
central nervous system disease DOID:331 0 0.023
inherited metabolic disorder DOID:655 0 0.020
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
organ system cancer DOID:0050686 0 0.018
immune system disease DOID:2914 0 0.018
sensory system disease DOID:0050155 0 0.015
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011