Mus musculus

0 known processes

Rnf167

ring finger protein 167

(Aliases: 5730408C10Rik,0610010G05Rik,AU019305,RP23-326P7.8,AV328608)

Rnf167 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
macroautophagy GO:0016236 21 0.426
modification dependent protein catabolic process GO:0019941 133 0.346
regulation of neuron differentiation GO:0045664 281 0.276
histone modification GO:0016570 159 0.162
protein modification by small protein conjugation GO:0032446 187 0.155
Human Mouse
negative regulation of cellular component organization GO:0051129 194 0.151
regulation of cellular ketone metabolic process GO:0010565 66 0.142
regulation of mapk cascade GO:0043408 248 0.141
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.138
viral gene expression GO:0019080 3 0.124
cellular response to extracellular stimulus GO:0031668 81 0.121
generation of precursor metabolites and energy GO:0006091 103 0.118
peptidyl amino acid modification GO:0018193 336 0.112
regulation of organelle organization GO:0033043 289 0.110
ubiquitin dependent protein catabolic process GO:0006511 129 0.106
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.106
response to nutrient levels GO:0031667 109 0.106
protein catabolic process GO:0030163 221 0.104
covalent chromatin modification GO:0016569 163 0.093
regulation of intracellular transport GO:0032386 159 0.092
cellular ketone metabolic process GO:0042180 84 0.091
regulation of cellular amino acid metabolic process GO:0006521 5 0.090
protein maturation GO:0051604 176 0.088
actin cytoskeleton organization GO:0030036 220 0.088
response to starvation GO:0042594 65 0.087
cellular carbohydrate metabolic process GO:0044262 119 0.086
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.084
regulation of homeostatic process GO:0032844 182 0.082
regulation of insulin receptor signaling pathway GO:0046626 21 0.082
response to peptide GO:1901652 136 0.081
synapsis GO:0007129 34 0.079
cellular macromolecule catabolic process GO:0044265 206 0.076
renal water transport GO:0003097 6 0.074
cellular response to nutrient levels GO:0031669 64 0.073
establishment of protein localization to membrane GO:0090150 54 0.070
regulation of anatomical structure size GO:0090066 178 0.070
chromatin modification GO:0016568 187 0.070
glucose homeostasis GO:0042593 128 0.070
negative regulation of nervous system development GO:0051961 156 0.069
protein ubiquitination GO:0016567 171 0.066
Human Mouse
macromolecule catabolic process GO:0009057 281 0.065
amine metabolic process GO:0009308 45 0.065
cellular response to insulin stimulus GO:0032869 78 0.065
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.063
glycerolipid metabolic process GO:0046486 122 0.063
regulation of protein targeting GO:1903533 61 0.062
regulation of vacuole organization GO:0044088 4 0.060
cation transport GO:0006812 399 0.059
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.058
negative regulation of neuron differentiation GO:0045665 101 0.058
negative regulation of cellular amine metabolic process GO:0033239 1 0.057
response to organonitrogen compound GO:0010243 246 0.057
regulation of cellular component size GO:0032535 121 0.056
membrane organization GO:0061024 245 0.055
melanosome localization GO:0032400 12 0.055
mitotic cell cycle GO:0000278 195 0.054
negative regulation of neuron projection development GO:0010977 50 0.053
regulation of protein localization GO:0032880 231 0.053
carbohydrate biosynthetic process GO:0016051 74 0.052
response to extracellular stimulus GO:0009991 127 0.051
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.051
negative regulation of organelle organization GO:0010639 90 0.050
dna metabolic process GO:0006259 303 0.050
cellular response to starvation GO:0009267 57 0.049
cellular response to peptide GO:1901653 92 0.049
negative regulation of glycogen biosynthetic process GO:0045719 1 0.047
regulation of proteolysis GO:0030162 164 0.046
chromatin organization GO:0006325 206 0.046
protein processing GO:0016485 163 0.046
retrograde transport endosome to golgi GO:0042147 2 0.046
regulation of cellular component biogenesis GO:0044087 181 0.046
actin filament organization GO:0007015 113 0.044
insulin receptor signaling pathway GO:0008286 49 0.042
regulation of carbohydrate biosynthetic process GO:0043255 40 0.042
positive regulation of programmed cell death GO:0043068 218 0.041
endomembrane system organization GO:0010256 147 0.041
regulation of vesicle mediated transport GO:0060627 139 0.040
cellular response to external stimulus GO:0071496 88 0.040
negative regulation of nlrp3 inflammasome complex assembly GO:1900226 2 0.040
divalent metal ion transport GO:0070838 172 0.040
ras protein signal transduction GO:0007265 77 0.039
regulation of glucose metabolic process GO:0010906 60 0.039
regulation of establishment of protein localization GO:0070201 181 0.039
mitotic cell cycle process GO:1903047 159 0.039
carbohydrate metabolic process GO:0005975 230 0.039
microtubule based process GO:0007017 236 0.038
protein localization to organelle GO:0033365 185 0.038
cellular response to dna damage stimulus GO:0006974 207 0.037
glucose metabolic process GO:0006006 92 0.036
regulation of protein maturation GO:1903317 96 0.036
positive regulation of protein modification process GO:0031401 299 0.036
cellular response to cytokine stimulus GO:0071345 189 0.036
cellular polysaccharide metabolic process GO:0044264 38 0.036
regulation of carbohydrate metabolic process GO:0006109 75 0.036
water transport GO:0006833 12 0.035
regulation of viral transcription GO:0046782 3 0.035
regulation of intracellular protein transport GO:0033157 82 0.035
peptidyl threonine phosphorylation GO:0018107 31 0.035
cellular amine metabolic process GO:0044106 44 0.035
stem cell development GO:0048864 219 0.035
dephosphorylation GO:0016311 129 0.035
negative regulation of cell development GO:0010721 169 0.035
organelle fission GO:0048285 170 0.034
cellular protein catabolic process GO:0044257 155 0.034
cellular glucan metabolic process GO:0006073 32 0.034
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.034
small gtpase mediated signal transduction GO:0007264 97 0.033
monosaccharide metabolic process GO:0005996 106 0.033
peptidyl lysine modification GO:0018205 77 0.033
inositol phosphate catabolic process GO:0071545 4 0.032
positive regulation of protein phosphorylation GO:0001934 242 0.032
modification dependent macromolecule catabolic process GO:0043632 133 0.032
stem cell maintenance GO:0019827 130 0.032
regulation of ion transport GO:0043269 215 0.032
negative regulation of protein transport GO:0051224 46 0.032
protein targeting GO:0006605 143 0.032
protein modification by small protein conjugation or removal GO:0070647 207 0.032
Human Mouse
stem cell differentiation GO:0048863 268 0.031
cellular response to organonitrogen compound GO:0071417 145 0.031
regulation of cell projection organization GO:0031344 206 0.031
proteasomal protein catabolic process GO:0010498 98 0.031
rna processing GO:0006396 105 0.031
glucan metabolic process GO:0044042 32 0.031
spermatogenesis GO:0007283 284 0.030
response to peptide hormone GO:0043434 127 0.030
polysaccharide metabolic process GO:0005976 39 0.030
positive regulation of cellular protein catabolic process GO:1903364 34 0.030
intracellular protein transport GO:0006886 204 0.030
peptidyl threonine modification GO:0018210 31 0.030
negative regulation of stress fiber assembly GO:0051497 4 0.029
regulation of protein targeting to membrane GO:0090313 9 0.029
positive regulation of cell death GO:0010942 224 0.029
apoptotic signaling pathway GO:0097190 306 0.028
positive regulation of intracellular transport GO:0032388 70 0.028
phospholipid metabolic process GO:0006644 87 0.028
cell type specific apoptotic process GO:0097285 268 0.028
regulation of neuron projection development GO:0010975 169 0.028
regulation of protein transport GO:0051223 163 0.028
autophagic vacuole assembly GO:0000045 13 0.028
response to insulin GO:0032868 100 0.027
response to growth factor GO:0070848 198 0.027
regulation of binding GO:0051098 111 0.027
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.027
positive regulation of urine volume GO:0035810 6 0.027
negative regulation of protein modification process GO:0031400 163 0.027
response to organic cyclic compound GO:0014070 198 0.027
protein kinase b signaling GO:0043491 74 0.027
regulation of transferase activity GO:0051338 263 0.027
protein polyubiquitination GO:0000209 33 0.026
Human
multicellular organism growth GO:0035264 161 0.026
response to epidermal growth factor GO:0070849 4 0.026
cytoplasmic transport GO:0016482 234 0.026
divalent inorganic cation transport GO:0072511 178 0.026
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.026
positive regulation of triglyceride lipase activity GO:0061365 3 0.026
regulation of system process GO:0044057 200 0.026
regulation of endocytosis GO:0030100 69 0.026
defense response to other organism GO:0098542 197 0.026
innate immune response GO:0045087 157 0.026
organelle localization GO:0051640 179 0.026
glycogen metabolic process GO:0005977 32 0.025
purine nucleotide metabolic process GO:0006163 302 0.025
regulation of cytoskeleton organization GO:0051493 122 0.025
cellular amino acid metabolic process GO:0006520 103 0.025
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.025
positive regulation of apoptotic process GO:0043065 217 0.025
negative regulation of viral transcription GO:0032897 3 0.025
phosphorylated carbohydrate dephosphorylation GO:0046838 4 0.025
viral transcription GO:0019083 3 0.025
plasma membrane organization GO:0007009 90 0.025
male gamete generation GO:0048232 285 0.025
organelle assembly GO:0070925 177 0.025
negative regulation of cytoskeleton organization GO:0051494 36 0.024
polyol metabolic process GO:0019751 26 0.024
nucleoside phosphate metabolic process GO:0006753 338 0.024
regulation of map kinase activity GO:0043405 120 0.024
nucleoside catabolic process GO:0009164 206 0.024
negative regulation of phosphorylation GO:0042326 166 0.024
Mouse
trna wobble base modification GO:0002097 2 0.023
meiosis i GO:0007127 60 0.023
cellular response to epidermal growth factor stimulus GO:0071364 4 0.023
regulation of protein processing GO:0070613 96 0.023
protein targeting to membrane GO:0006612 20 0.022
protein localization to membrane GO:0072657 108 0.022
peptidyl serine modification GO:0018209 83 0.022
anatomical structure homeostasis GO:0060249 145 0.022
endocytosis GO:0006897 168 0.022
protein methylation GO:0006479 81 0.022
microtubule cytoskeleton organization GO:0000226 157 0.021
regulation of actin cytoskeleton organization GO:0032956 84 0.021
striated muscle tissue development GO:0014706 293 0.021
regulation of actin filament based process GO:0032970 99 0.021
vacuole organization GO:0007033 38 0.021
regulation of cell cycle GO:0051726 281 0.021
Human
single organism nuclear import GO:1902593 95 0.021
central nervous system neuron differentiation GO:0021953 162 0.021
small molecule catabolic process GO:0044282 71 0.021
negative regulation of intracellular signal transduction GO:1902532 167 0.021
Mouse
cellular nitrogen compound catabolic process GO:0044270 280 0.021
negative regulation of cell projection organization GO:0031345 56 0.021
negative regulation of protein phosphorylation GO:0001933 126 0.021
vesicle localization GO:0051648 86 0.021
regulation of protein serine threonine kinase activity GO:0071900 157 0.020
negative regulation of glycogen metabolic process GO:0070874 2 0.020
negative regulation of growth GO:0045926 99 0.020
regulation of cytoplasmic transport GO:1903649 112 0.020
methylation GO:0032259 134 0.020
skeletal system development GO:0001501 356 0.020
erythrocyte differentiation GO:0030218 88 0.020
aromatic compound catabolic process GO:0019439 286 0.019
regulation of cellular response to stress GO:0080135 159 0.019
regulation of kinase activity GO:0043549 249 0.019
macromolecule methylation GO:0043414 120 0.019
nuclear division GO:0000280 158 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.019
regulation of neurotrophin trk receptor signaling pathway GO:0051386 4 0.019
carbohydrate homeostasis GO:0033500 128 0.019
regulation of cellular amine metabolic process GO:0033238 20 0.019
histone lysine methylation GO:0034968 50 0.019
cell adhesion GO:0007155 329 0.019
cognition GO:0050890 149 0.019
regulation of cellular protein catabolic process GO:1903362 61 0.019
tissue homeostasis GO:0001894 115 0.019
regulation of metal ion transport GO:0010959 106 0.018
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.018
negative regulation of multi organism process GO:0043901 68 0.018
negative regulation of cellular carbohydrate metabolic process GO:0010677 19 0.018
attachment of spindle microtubules to kinetochore GO:0008608 4 0.018
regulation of urine volume GO:0035809 6 0.018
regulation of macroautophagy GO:0016241 12 0.018
alcohol metabolic process GO:0006066 116 0.018
regulation of cell size GO:0008361 72 0.018
dna repair GO:0006281 107 0.018
positive regulation of homeostatic process GO:0032846 64 0.018
phagocytosis GO:0006909 66 0.018
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.018
myeloid cell homeostasis GO:0002262 114 0.018
positive regulation of cellular catabolic process GO:0031331 148 0.018
skin development GO:0043588 220 0.018
glycerophospholipid metabolic process GO:0006650 71 0.017
myeloid cell differentiation GO:0030099 233 0.017
axonogenesis GO:0007409 274 0.017
renal water homeostasis GO:0003091 7 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.017
positive regulation of mapk cascade GO:0043410 170 0.017
sequestering of metal ion GO:0051238 19 0.017
lipid modification GO:0030258 65 0.017
cellular protein complex assembly GO:0043623 116 0.017
calcium ion transport GO:0006816 159 0.017
protein autophosphorylation GO:0046777 61 0.017
negative regulation of cellular catabolic process GO:0031330 47 0.017
negative regulation of protein metabolic process GO:0051248 282 0.017
Mouse
negative regulation of phosphate metabolic process GO:0045936 184 0.017
Mouse
positive regulation of macroautophagy GO:0016239 3 0.017
regulation of cellular catabolic process GO:0031329 242 0.017
nucleotide metabolic process GO:0009117 332 0.017
regulation of body fluid levels GO:0050878 162 0.017
nucleoside triphosphate metabolic process GO:0009141 230 0.016
autophagy GO:0006914 45 0.016
negative regulation of cell proliferation GO:0008285 296 0.016
gliogenesis GO:0042063 141 0.016
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.016
regulation of membrane potential GO:0042391 192 0.016
cellular response to growth factor stimulus GO:0071363 197 0.016
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.016
cellular homeostasis GO:0019725 240 0.016
homeostasis of number of cells GO:0048872 210 0.016
regulation of protein kinase activity GO:0045859 232 0.016
adult behavior GO:0030534 135 0.016
chemotaxis GO:0006935 247 0.016
organophosphate catabolic process GO:0046434 232 0.016
regulation of hydrolase activity GO:0051336 246 0.016
regeneration GO:0031099 38 0.016
placenta development GO:0001890 140 0.016
leukocyte differentiation GO:0002521 342 0.016
negative regulation of homeostatic process GO:0032845 71 0.015
negative regulation of synapse assembly GO:0051964 3 0.015
sperm motility GO:0030317 47 0.015
protein polymerization GO:0051258 57 0.015
positive regulation of hydrolase activity GO:0051345 148 0.015
monosaccharide transport GO:0015749 58 0.015
cellular lipid metabolic process GO:0044255 323 0.015
ribonucleotide metabolic process GO:0009259 291 0.015
meiotic nuclear division GO:0007126 115 0.015
regulation of autophagic vacuole assembly GO:2000785 4 0.015
regulation of protein kinase b signaling GO:0051896 56 0.015
mapk cascade GO:0000165 281 0.015
Mouse
establishment of protein localization to plasma membrane GO:0090002 34 0.015
protein localization to plasma membrane GO:0072659 57 0.015
organic hydroxy compound metabolic process GO:1901615 203 0.015
monocarboxylic acid metabolic process GO:0032787 191 0.015
g protein coupled receptor signaling pathway GO:0007186 243 0.015
response to tumor necrosis factor GO:0034612 26 0.015
positive regulation of protein kinase activity GO:0045860 144 0.015
positive regulation of cellular amine metabolic process GO:0033240 5 0.015
protein localization to chromatin GO:0071168 3 0.014
carbohydrate transport GO:0008643 62 0.014
positive regulation of cell adhesion GO:0045785 80 0.014
cerebellum development GO:0021549 77 0.014
regulation of secretion GO:0051046 274 0.014
regulation of peptidyl serine phosphorylation GO:0033135 39 0.014
purine containing compound metabolic process GO:0072521 311 0.014
muscle cell differentiation GO:0042692 261 0.014
regulation of response to drug GO:2001023 2 0.014
regulation of cellular response to insulin stimulus GO:1900076 30 0.014
sensory system development GO:0048880 3 0.014
intra golgi vesicle mediated transport GO:0006891 1 0.014
interaction with symbiont GO:0051702 14 0.014
gtp metabolic process GO:0046039 144 0.014
cell division GO:0051301 120 0.014
neuron death GO:0070997 154 0.014
regulation of cell activation GO:0050865 289 0.014
regulation of nucleocytoplasmic transport GO:0046822 73 0.014
purine ribonucleotide metabolic process GO:0009150 290 0.013
iron sulfur cluster assembly GO:0016226 3 0.013
intrinsic apoptotic signaling pathway GO:0097193 132 0.013
mitotic nuclear division GO:0007067 48 0.013
organophosphate biosynthetic process GO:0090407 122 0.013
protein import GO:0017038 101 0.013
gtp catabolic process GO:0006184 143 0.013
cation homeostasis GO:0055080 212 0.013
myeloid leukocyte differentiation GO:0002573 119 0.013
chromosome organization involved in meiosis GO:0070192 39 0.013
development of primary sexual characteristics GO:0045137 143 0.013
peptidyl serine phosphorylation GO:0018105 74 0.013
gland development GO:0048732 330 0.013
response to molecule of bacterial origin GO:0002237 143 0.013
positive regulation of dna templated transcription elongation GO:0032786 2 0.013
learning or memory GO:0007611 148 0.013
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.013
regulation of glycogen starch synthase activity GO:2000465 5 0.013
maintenance of location GO:0051235 89 0.013
asymmetric stem cell division GO:0098722 3 0.013
inorganic cation transmembrane transport GO:0098662 207 0.013
regulation of myeloid cell differentiation GO:0045637 96 0.013
regulation of reactive oxygen species metabolic process GO:2000377 40 0.013
negative regulation of cellular protein metabolic process GO:0032269 247 0.013
negative regulation of peptidyl serine phosphorylation GO:0033137 10 0.013
histone methylation GO:0016571 71 0.013
schwann cell differentiation GO:0014037 26 0.012
positive regulation of tor signaling GO:0032008 3 0.012
germ line stem cell division GO:0042078 2 0.012
establishment of organelle localization GO:0051656 122 0.012
hexose transport GO:0008645 56 0.012
actin filament bundle assembly GO:0051017 40 0.012
response to inactivity GO:0014854 4 0.012
glycosyl compound metabolic process GO:1901657 246 0.012
lipid biosynthetic process GO:0008610 179 0.012
regulation of autophagy GO:0010506 30 0.012
actin filament polymerization GO:0030041 44 0.012
regulation of glucose transport GO:0010827 32 0.012
cellular metal ion homeostasis GO:0006875 151 0.012
skeletal muscle organ development GO:0060538 163 0.012
negative regulation of protein processing GO:0010955 79 0.012
regulation of generation of precursor metabolites and energy GO:0043467 38 0.012
regulation of mitotic cell cycle GO:0007346 126 0.012
fat cell differentiation GO:0045444 160 0.012
actomyosin structure organization GO:0031032 56 0.012
muscle tissue development GO:0060537 308 0.012
compound eye development GO:0048749 1 0.012
trna wobble uridine modification GO:0002098 2 0.012
phosphatidylinositol metabolic process GO:0046488 45 0.012
regulation of defense response GO:0031347 233 0.012
regulation of engulfment of apoptotic cell GO:1901074 2 0.012
glial cell differentiation GO:0010001 131 0.012
cellular component assembly involved in morphogenesis GO:0010927 139 0.012
nitrogen compound transport GO:0071705 271 0.012
protein import into nucleus GO:0006606 95 0.012
regulation of osteoblast differentiation GO:0045667 67 0.012
protein alkylation GO:0008213 81 0.012
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.012
nucleotide catabolic process GO:0009166 217 0.012
histone acetylation GO:0016573 41 0.011
negative regulation of transferase activity GO:0051348 85 0.011
glycerolipid biosynthetic process GO:0045017 50 0.011
response to muscle inactivity involved in regulation of muscle adaptation GO:0014877 4 0.011
cellular response to hormone stimulus GO:0032870 150 0.011
negative regulation of intracellular protein transport GO:0090317 27 0.011
regulation of cell migration involved in sprouting angiogenesis GO:0090049 4 0.011
regulation of cell adhesion GO:0030155 154 0.011
pyruvate metabolic process GO:0006090 28 0.011
modification by host of symbiont morphology or physiology GO:0051851 12 0.011
negative regulation of cell cycle GO:0045786 123 0.011
Human
meiotic cell cycle process GO:1903046 77 0.011
lateral inhibition GO:0046331 1 0.011
response to oxidative stress GO:0006979 123 0.011
phosphatidic acid biosynthetic process GO:0006654 2 0.011
positive regulation of apoptotic cell clearance GO:2000427 3 0.011
regulation of protein complex assembly GO:0043254 83 0.011
engulfment of apoptotic cell GO:0043652 3 0.011
nucleobase containing small molecule metabolic process GO:0055086 352 0.011
heterocycle catabolic process GO:0046700 280 0.011
cellular response to peptide hormone stimulus GO:0071375 92 0.011
body fluid secretion GO:0007589 53 0.011
guanosine containing compound catabolic process GO:1901069 144 0.011
multicellular organismal water homeostasis GO:0050891 23 0.010
lipid localization GO:0010876 126 0.010
nucleocytoplasmic transport GO:0006913 139 0.010
regulation of cell cycle process GO:0010564 160 0.010
regulation of chromatin organization GO:1902275 57 0.010
purine nucleoside triphosphate metabolic process GO:0009144 226 0.010
purine ribonucleotide catabolic process GO:0009154 208 0.010
nuclear import GO:0051170 95 0.010
negative regulation of protein targeting to membrane GO:0090315 1 0.010
negative regulation of protein kinase b signaling GO:0051898 18 0.010
extrinsic apoptotic signaling pathway GO:0097191 126 0.010
purine nucleoside triphosphate catabolic process GO:0009146 203 0.010
hindbrain morphogenesis GO:0021575 46 0.010
organic acid biosynthetic process GO:0016053 86 0.010
spermatid development GO:0007286 108 0.010
meiotic cell cycle GO:0051321 122 0.010
tube formation GO:0035148 140 0.010
er associated ubiquitin dependent protein catabolic process GO:0030433 10 0.010
establishment of melanosome localization GO:0032401 11 0.010
hematopoietic progenitor cell differentiation GO:0002244 143 0.010
organonitrogen compound catabolic process GO:1901565 264 0.010
neuron apoptotic process GO:0051402 142 0.010

Rnf167 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.014
cardiovascular system disease DOID:1287 0 0.014
immune system disease DOID:2914 0 0.013
hematopoietic system disease DOID:74 0 0.012
nervous system disease DOID:863 0 0.012