Mus musculus

86 known processes

Usp21

ubiquitin specific peptidase 21

(Aliases: ESTM28,Usp23,Usp16,W53272)

Usp21 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin modification GO:0016568 187 0.276
histone methylation GO:0016571 71 0.257
covalent chromatin modification GO:0016569 163 0.198
negative regulation of molecular function GO:0044092 258 0.192
nucleobase containing small molecule metabolic process GO:0055086 352 0.151
histone modification GO:0016570 159 0.112
chromatin organization GO:0006325 206 0.103
skeletal system development GO:0001501 356 0.099
ribonucleoside catabolic process GO:0042454 206 0.086
ribonucleoside triphosphate metabolic process GO:0009199 220 0.081
regulation of cell cycle GO:0051726 281 0.080
macromolecule catabolic process GO:0009057 281 0.077
Yeast Fly
histone lysine methylation GO:0034968 50 0.075
negative regulation of cell proliferation GO:0008285 296 0.074
organic cyclic compound catabolic process GO:1901361 295 0.072
defense response to other organism GO:0098542 197 0.072
Fly
urogenital system development GO:0001655 261 0.072
ribonucleotide metabolic process GO:0009259 291 0.071
protein alkylation GO:0008213 81 0.070
regulation of cellular ketone metabolic process GO:0010565 66 0.068
purine ribonucleotide metabolic process GO:0009150 290 0.067
camera type eye development GO:0043010 266 0.067
methylation GO:0032259 134 0.065
spermatogenesis GO:0007283 284 0.065
heterocycle catabolic process GO:0046700 280 0.065
cellular response to dna damage stimulus GO:0006974 207 0.064
response to organic cyclic compound GO:0014070 198 0.064
cellular macromolecule catabolic process GO:0044265 206 0.063
Yeast Fly
cilium morphogenesis GO:0060271 102 0.062
protein methylation GO:0006479 81 0.061
male gamete generation GO:0048232 285 0.060
organonitrogen compound catabolic process GO:1901565 264 0.060
protein localization to organelle GO:0033365 185 0.059
purine containing compound metabolic process GO:0072521 311 0.057
synaptonemal complex assembly GO:0007130 13 0.057
regulation of binding GO:0051098 111 0.056
peptidyl amino acid modification GO:0018193 336 0.055
synapsis GO:0007129 34 0.055
purine nucleoside triphosphate metabolic process GO:0009144 226 0.055
nucleoside triphosphate metabolic process GO:0009141 230 0.054
regulation of proteolysis GO:0030162 164 0.054
Fly
cytokine production GO:0001816 319 0.053
regulation of cell cycle process GO:0010564 160 0.052
negative regulation of phosphate metabolic process GO:0045936 184 0.052
modification dependent protein catabolic process GO:0019941 133 0.052
Yeast
innate immune response GO:0045087 157 0.051
Fly
nucleotide catabolic process GO:0009166 217 0.051
negative regulation of protein metabolic process GO:0051248 282 0.051
carbohydrate metabolic process GO:0005975 230 0.051
dna alkylation GO:0006305 43 0.050
nucleoside phosphate catabolic process GO:1901292 222 0.050
aromatic compound catabolic process GO:0019439 286 0.049
protein ubiquitination GO:0016567 171 0.048
skeletal system morphogenesis GO:0048705 203 0.048
protein localization to nucleus GO:0034504 121 0.048
intracellular protein transport GO:0006886 204 0.048
carbohydrate derivative catabolic process GO:1901136 231 0.048
glycosyl compound metabolic process GO:1901657 246 0.047
positive regulation of proteolysis GO:0045862 85 0.047
Fly
synaptonemal complex organization GO:0070193 15 0.047
cellular nitrogen compound catabolic process GO:0044270 280 0.046
purine nucleoside triphosphate catabolic process GO:0009146 203 0.046
regulation of protein localization GO:0032880 231 0.046
gland development GO:0048732 330 0.045
purine containing compound catabolic process GO:0072523 213 0.044
protein modification by small protein conjugation or removal GO:0070647 207 0.044
macromolecule methylation GO:0043414 120 0.044
renal system development GO:0072001 225 0.043
nucleoside triphosphate catabolic process GO:0009143 205 0.043
cellular amino acid metabolic process GO:0006520 103 0.043
lens development in camera type eye GO:0002088 62 0.042
nucleoside catabolic process GO:0009164 206 0.041
response to acid chemical GO:0001101 111 0.040
positive regulation of programmed cell death GO:0043068 218 0.039
response to organonitrogen compound GO:0010243 246 0.039
protein import GO:0017038 101 0.039
regulation of hydrolase activity GO:0051336 246 0.039
positive regulation of apoptotic process GO:0043065 217 0.039
negative regulation of intracellular signal transduction GO:1902532 167 0.039
regulation of cytokine production GO:0001817 266 0.038
purine ribonucleoside catabolic process GO:0046130 205 0.038
cellular ketone metabolic process GO:0042180 84 0.038
ribonucleoside triphosphate catabolic process GO:0009203 199 0.037
tube closure GO:0060606 91 0.037
neural tube development GO:0021915 160 0.037
tube formation GO:0035148 140 0.036
ribose phosphate metabolic process GO:0019693 291 0.036
cellular protein catabolic process GO:0044257 155 0.036
Yeast Fly
cellular response to lipid GO:0071396 145 0.035
multi multicellular organism process GO:0044706 109 0.035
homeostasis of number of cells GO:0048872 210 0.035
nucleoside phosphate metabolic process GO:0006753 338 0.034
epithelial tube formation GO:0072175 130 0.034
positive regulation of cell death GO:0010942 224 0.034
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.034
response to molecule of bacterial origin GO:0002237 143 0.034
positive regulation of binding GO:0051099 49 0.034
embryonic appendage morphogenesis GO:0035113 126 0.034
purine nucleoside catabolic process GO:0006152 205 0.033
cilium assembly GO:0042384 81 0.033
guanosine containing compound catabolic process GO:1901069 144 0.033
apoptotic signaling pathway GO:0097190 306 0.033
purine nucleotide metabolic process GO:0006163 302 0.032
positive regulation of hydrolase activity GO:0051345 148 0.032
regulation of apoptotic signaling pathway GO:2001233 197 0.031
gtp catabolic process GO:0006184 143 0.030
primary neural tube formation GO:0014020 95 0.030
protein maturation GO:0051604 176 0.030
nucleoside metabolic process GO:0009116 246 0.030
cellular amine metabolic process GO:0044106 44 0.030
protein targeting GO:0006605 143 0.030
negative regulation of nervous system development GO:0051961 156 0.029
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.029
regulation of protein kinase activity GO:0045859 232 0.029
guanosine containing compound metabolic process GO:1901068 144 0.029
gtp metabolic process GO:0046039 144 0.028
cellular carbohydrate metabolic process GO:0044262 119 0.028
regulation of purine nucleotide metabolic process GO:1900542 169 0.028
histone h4 k16 acetylation GO:0043984 3 0.028
synaptic transmission GO:0007268 329 0.028
mitotic cell cycle process GO:1903047 159 0.027
regulation of antimicrobial humoral response GO:0002759 3 0.027
Fly
purine ribonucleotide catabolic process GO:0009154 208 0.027
posttranscriptional regulation of gene expression GO:0010608 155 0.027
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.026
embryonic epithelial tube formation GO:0001838 130 0.026
negative regulation of cellular protein metabolic process GO:0032269 247 0.026
fat cell differentiation GO:0045444 160 0.026
ubiquitin dependent protein catabolic process GO:0006511 129 0.026
Yeast
dna modification GO:0006304 50 0.026
small gtpase mediated signal transduction GO:0007264 97 0.026
Mouse
kidney development GO:0001822 213 0.025
blood vessel morphogenesis GO:0048514 285 0.025
peptidyl lysine modification GO:0018205 77 0.025
forebrain development GO:0030900 302 0.025
negative regulation of kinase activity GO:0033673 81 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
nuclear division GO:0000280 158 0.025
regulation of transferase activity GO:0051338 263 0.024
midbrain development GO:0030901 35 0.024
negative regulation of protein phosphorylation GO:0001933 126 0.024
immune effector process GO:0002252 321 0.024
Fly
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.023
negative regulation of phosphorus metabolic process GO:0010563 184 0.023
skeletal muscle organ development GO:0060538 163 0.023
axon target recognition GO:0007412 4 0.023
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.023
rhythmic process GO:0048511 174 0.023
regulation of establishment of protein localization GO:0070201 181 0.023
regulation of nucleotide catabolic process GO:0030811 122 0.023
response to radiation GO:0009314 165 0.023
regulation of histone methylation GO:0031060 30 0.023
mitotic cell cycle GO:0000278 195 0.023
learning or memory GO:0007611 148 0.023
organophosphate catabolic process GO:0046434 232 0.023
appendage morphogenesis GO:0035107 149 0.023
protein catabolic process GO:0030163 221 0.022
Yeast Fly
intracellular receptor signaling pathway GO:0030522 74 0.022
ribonucleoside metabolic process GO:0009119 245 0.022
regulation of cellular catabolic process GO:0031329 242 0.022
Fly
response to oxidative stress GO:0006979 123 0.022
response to decreased oxygen levels GO:0036293 59 0.022
stem cell development GO:0048864 219 0.022
neural tube formation GO:0001841 108 0.022
telencephalon development GO:0021537 186 0.022
myeloid cell differentiation GO:0030099 233 0.022
regulation of kinase activity GO:0043549 249 0.022
regulation of purine nucleotide catabolic process GO:0033121 122 0.022
morphogenesis of embryonic epithelium GO:0016331 159 0.022
purine nucleotide catabolic process GO:0006195 211 0.022
negative regulation of cytokine production GO:0001818 84 0.021
regulation of chromosome organization GO:0033044 83 0.021
mitochondrion organization GO:0007005 134 0.021
rho protein signal transduction GO:0007266 32 0.021
ribonucleotide catabolic process GO:0009261 208 0.021
intrinsic apoptotic signaling pathway GO:0097193 132 0.021
histone deubiquitination GO:0016578 2 0.020
purine nucleoside metabolic process GO:0042278 241 0.020
ossification GO:0001503 216 0.020
chromatin remodeling GO:0006338 32 0.020
regulation of cellular amino acid metabolic process GO:0006521 5 0.020
regulation of ossification GO:0030278 112 0.020
protein acylation GO:0043543 64 0.020
cellular component assembly involved in morphogenesis GO:0010927 139 0.020
rna interference GO:0016246 2 0.020
regulation of organelle organization GO:0033043 289 0.020
glycosyl compound catabolic process GO:1901658 206 0.020
response to oxygen levels GO:0070482 62 0.020
meiotic nuclear division GO:0007126 115 0.019
locomotory behavior GO:0007626 195 0.019
multicellular organism growth GO:0035264 161 0.019
regulation of neuron differentiation GO:0045664 281 0.019
negative regulation of cellular amine metabolic process GO:0033239 1 0.019
nuclear import GO:0051170 95 0.019
cellular response to organonitrogen compound GO:0071417 145 0.019
leukocyte homeostasis GO:0001776 79 0.019
regionalization GO:0003002 337 0.019
cognition GO:0050890 149 0.019
regulation of chromatin modification GO:1903308 57 0.019
negative regulation of protein modification process GO:0031400 163 0.019
proteasomal protein catabolic process GO:0010498 98 0.019
Fly
negative regulation of cell development GO:0010721 169 0.018
negative regulation of synapse assembly GO:0051964 3 0.018
ameboidal type cell migration GO:0001667 128 0.018
cellular response to oxidative stress GO:0034599 76 0.018
lymphocyte differentiation GO:0030098 242 0.018
regulation of cellular amine metabolic process GO:0033238 20 0.018
regulation of osteoblast differentiation GO:0045667 67 0.018
response to lipopolysaccharide GO:0032496 128 0.018
dna repair GO:0006281 107 0.018
regulation of protein serine threonine kinase activity GO:0071900 157 0.018
amine metabolic process GO:0009308 45 0.018
regulation of histone modification GO:0031056 56 0.018
regulation of chromatin organization GO:1902275 57 0.018
developmental growth involved in morphogenesis GO:0060560 138 0.018
regulation of multi organism process GO:0043900 111 0.018
Fly
rna processing GO:0006396 105 0.018
negative regulation of phosphorylation GO:0042326 166 0.018
single organism nuclear import GO:1902593 95 0.018
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.018
positive regulation of organelle organization GO:0010638 128 0.017
embryonic organ morphogenesis GO:0048562 276 0.017
palate development GO:0060021 76 0.017
regulation of anatomical structure size GO:0090066 178 0.017
protein homotrimerization GO:0070207 4 0.017
regulation of defense response to bacterium GO:1900424 3 0.017
Fly
regulation of mapk cascade GO:0043408 248 0.017
mammary gland epithelium development GO:0061180 65 0.017
embryonic skeletal system development GO:0048706 120 0.017
striated muscle tissue development GO:0014706 293 0.017
translation GO:0006412 93 0.017
negative regulation of transferase activity GO:0051348 85 0.017
regulation of cellular protein catabolic process GO:1903362 61 0.017
Fly
cellular response to growth factor stimulus GO:0071363 197 0.016
appendage development GO:0048736 166 0.016
peptide secretion GO:0002790 114 0.016
angiogenesis GO:0001525 201 0.016
regulation of cell motility GO:2000145 236 0.016
fertilization GO:0009566 127 0.016
regulation of endopeptidase activity GO:0052548 89 0.016
myeloid leukocyte differentiation GO:0002573 119 0.016
response to insulin GO:0032868 100 0.016
demethylation GO:0070988 23 0.016
tissue homeostasis GO:0001894 115 0.015
microtubule based process GO:0007017 236 0.015
regulation of angiogenesis GO:0045765 81 0.015
regulation of protein binding GO:0043393 60 0.015
epithelial cell proliferation GO:0050673 174 0.015
extrinsic apoptotic signaling pathway GO:0097191 126 0.015
negative regulation of growth GO:0045926 99 0.015
stem cell maintenance GO:0019827 130 0.015
regulation of cysteine type endopeptidase activity GO:2000116 65 0.015
cell cycle checkpoint GO:0000075 47 0.015
nuclear transport GO:0051169 139 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.015
regulation of membrane potential GO:0042391 192 0.015
positive regulation of dna templated transcription elongation GO:0032786 2 0.015
canonical wnt signaling pathway GO:0060070 130 0.015
sensory perception GO:0007600 245 0.015
nucleocytoplasmic transport GO:0006913 139 0.015
microtubule cytoskeleton organization GO:0000226 157 0.014
positive regulation of cellular catabolic process GO:0031331 148 0.014
Fly
cellular response to misfolded protein GO:0071218 5 0.014
pallium development GO:0021543 120 0.014
response to peptide GO:1901652 136 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.014
cellular response to insulin stimulus GO:0032869 78 0.014
positive regulation of protein modification process GO:0031401 299 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.014
Yeast Fly
multicellular organismal homeostasis GO:0048871 164 0.014
regulation of cellular response to stress GO:0080135 159 0.014
dna methylation GO:0006306 43 0.014
negative regulation of dna replication GO:0008156 4 0.014
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.014
regulation of nucleoside metabolic process GO:0009118 130 0.014
regulation of mitotic cell cycle GO:0007346 126 0.014
nucleotide metabolic process GO:0009117 332 0.014
regulation of myeloid cell differentiation GO:0045637 96 0.014
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.014
anatomical structure homeostasis GO:0060249 145 0.014
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.014
transmission of nerve impulse GO:0019226 76 0.014
regulation of ras protein signal transduction GO:0046578 114 0.014
meiosis i GO:0007127 60 0.014
leukocyte differentiation GO:0002521 342 0.014
protein import into nucleus GO:0006606 95 0.013
multicellular organismal response to stress GO:0033555 62 0.013
regulation of stem cell proliferation GO:0072091 78 0.013
limb development GO:0060173 166 0.013
cation homeostasis GO:0055080 212 0.013
rna splicing GO:0008380 54 0.013
muscle cell differentiation GO:0042692 261 0.013
spermatid differentiation GO:0048515 115 0.013
regulation of neural precursor cell proliferation GO:2000177 70 0.013
development of primary sexual characteristics GO:0045137 143 0.013
negative regulation of cell cycle GO:0045786 123 0.013
peptidyl lysine methylation GO:0018022 29 0.013
nitrogen compound transport GO:0071705 271 0.013
hematopoietic progenitor cell differentiation GO:0002244 143 0.013
antimicrobial peptide production GO:0002775 2 0.013
Fly
response to light stimulus GO:0009416 135 0.013
regulation of cytoskeleton organization GO:0051493 122 0.013
dendrite development GO:0016358 115 0.013
regulation of protein kinase b signaling GO:0051896 56 0.013
histone lysine demethylation GO:0070076 13 0.013
neural tube closure GO:0001843 90 0.013
membrane organization GO:0061024 245 0.013
Yeast
regulation of epithelial cell proliferation GO:0050678 141 0.013
positive regulation of protein catabolic process GO:0045732 60 0.013
Fly
protein oligomerization GO:0051259 67 0.013
adult behavior GO:0030534 135 0.013
positive regulation of gtpase activity GO:0043547 85 0.013
placenta development GO:0001890 140 0.013
positive regulation of cellular amine metabolic process GO:0033240 5 0.013
regulation of vasculature development GO:1901342 88 0.013
muscle tissue development GO:0060537 308 0.013
positive regulation of defense response GO:0031349 124 0.013
wnt signaling pathway GO:0016055 188 0.013
single fertilization GO:0007338 82 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.012
Fly
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.012
response to heat GO:0009408 27 0.012
regulation of protein transport GO:0051223 163 0.012
negative regulation of cellular component organization GO:0051129 194 0.012
epithelial tube morphogenesis GO:0060562 303 0.012
negative regulation of immune system process GO:0002683 209 0.012
Fly
cellular response to acid chemical GO:0071229 68 0.012
regulation of nucleotide metabolic process GO:0006140 169 0.012
regulation of cellular component size GO:0032535 121 0.012
regulation of dna replication GO:0006275 17 0.012
Yeast
histone acetylation GO:0016573 41 0.012
response to sterol GO:0036314 4 0.012
cytoplasmic transport GO:0016482 234 0.012
metal ion homeostasis GO:0055065 189 0.012
amide transport GO:0042886 138 0.012
cellular homeostasis GO:0019725 240 0.012
Yeast
synaptic vesicle localization GO:0097479 59 0.012
regulation of asymmetric cell division GO:0009786 4 0.012
positive regulation of peptidase activity GO:0010952 49 0.012
atp metabolic process GO:0046034 75 0.012
positive regulation of protein transport GO:0051222 93 0.012
metencephalon development GO:0022037 89 0.012
purine ribonucleoside metabolic process GO:0046128 241 0.012
glucose homeostasis GO:0042593 128 0.012
response to growth factor GO:0070848 198 0.012
regulation of translation GO:0006417 71 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.012
regulation of hormone levels GO:0010817 211 0.012
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.012
interleukin 8 production GO:0032637 4 0.012
protein processing GO:0016485 163 0.012
response to retinoic acid GO:0032526 56 0.012
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.012
actin polymerization or depolymerization GO:0008154 54 0.012
memory GO:0007613 58 0.011
regulation of intracellular transport GO:0032386 159 0.011
response to hypoxia GO:0001666 58 0.011
stem cell differentiation GO:0048863 268 0.011
attachment of spindle microtubules to kinetochore GO:0008608 4 0.011
regulation of peptidase activity GO:0052547 96 0.011
dna replication GO:0006260 52 0.011
Yeast
cation transport GO:0006812 399 0.011
organophosphate biosynthetic process GO:0090407 122 0.011
cellular response to peptide hormone stimulus GO:0071375 92 0.011
defense response to bacterium GO:0042742 119 0.011
Fly
protein dna complex disassembly GO:0032986 1 0.011
cellular response to organic cyclic compound GO:0071407 87 0.011
germ cell development GO:0007281 185 0.011
regulation of myeloid leukocyte differentiation GO:0002761 58 0.011
mitotic g1 dna damage checkpoint GO:0031571 4 0.011
protein secretion GO:0009306 111 0.011
multicellular organismal signaling GO:0035637 91 0.011
positive regulation of protein phosphorylation GO:0001934 242 0.011
cellular response to cytokine stimulus GO:0071345 189 0.011
glial cell differentiation GO:0010001 131 0.011
cellular amide metabolic process GO:0043603 58 0.011
regulation of protein catabolic process GO:0042176 108 0.011
Fly
carbohydrate homeostasis GO:0033500 128 0.011
establishment of protein localization to organelle GO:0072594 118 0.011
positive regulation of apoptotic signaling pathway GO:2001235 95 0.011
response to temperature stimulus GO:0009266 55 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.011
regulation of response to dna damage stimulus GO:2001020 34 0.011
sequestering of metal ion GO:0051238 19 0.011
regulation of cell projection organization GO:0031344 206 0.011
ras protein signal transduction GO:0007265 77 0.011
Mouse
muscle cell development GO:0055001 133 0.011
regulation of leukocyte differentiation GO:1902105 159 0.010
positive regulation of synaptic plasticity GO:0031915 4 0.010
transcription factor import into nucleus GO:0042991 26 0.010
regulation of protein stability GO:0031647 52 0.010
positive regulation of mapk cascade GO:0043410 170 0.010
response to transforming growth factor beta GO:0071559 88 0.010
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.010
peroxisomal transport GO:0043574 4 0.010
mrna metabolic process GO:0016071 84 0.010
cell type specific apoptotic process GO:0097285 268 0.010
response to topologically incorrect protein GO:0035966 25 0.010
protein modification by small protein conjugation GO:0032446 187 0.010
chemotaxis GO:0006935 247 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.010
spermatid development GO:0007286 108 0.010
neural retina development GO:0003407 41 0.010
negative regulation of multi organism process GO:0043901 68 0.010
Fly
regulation of system process GO:0044057 200 0.010
sensory organ morphogenesis GO:0090596 242 0.010

Usp21 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.020
disease of anatomical entity DOID:7 0 0.020
eye and adnexa disease DOID:1492 0 0.017
retinal disease DOID:5679 0 0.017
eye disease DOID:5614 0 0.017
sensory system disease DOID:0050155 0 0.017
retinal degeneration DOID:8466 0 0.017