Mus musculus

63 known processes

Thoc2

THO complex 2

(Aliases: Gm1139,D130005M13Rik,Gm1793,6330441O12Rik,Tho2)

Thoc2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin organization GO:0006325 206 0.361
histone h3 k9 trimethylation GO:0036124 6 0.274
heterochromatin organization GO:0070828 4 0.232
histone methylation GO:0016571 71 0.191
organonitrogen compound catabolic process GO:1901565 264 0.162
rna interference GO:0016246 2 0.162
rna splicing GO:0008380 54 0.158
dna replication independent nucleosome assembly GO:0006336 1 0.152
purine nucleoside triphosphate metabolic process GO:0009144 226 0.150
positive regulation of chromosome organization GO:2001252 33 0.144
organic cyclic compound catabolic process GO:1901361 295 0.138
heterocycle catabolic process GO:0046700 280 0.136
glycosyl compound catabolic process GO:1901658 206 0.136
chromatin modification GO:0016568 187 0.136
purine ribonucleotide catabolic process GO:0009154 208 0.133
purine nucleoside catabolic process GO:0006152 205 0.122
ribose phosphate metabolic process GO:0019693 291 0.116
nucleotide metabolic process GO:0009117 332 0.112
cellular nitrogen compound catabolic process GO:0044270 280 0.106
nucleobase containing small molecule metabolic process GO:0055086 352 0.105
organophosphate catabolic process GO:0046434 232 0.101
purine ribonucleoside catabolic process GO:0046130 205 0.099
methylation GO:0032259 134 0.099
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.098
purine nucleoside triphosphate catabolic process GO:0009146 203 0.098
regulation of mrna processing GO:0050684 41 0.098
positive regulation of organelle organization GO:0010638 128 0.097
alternative mrna splicing via spliceosome GO:0000380 12 0.097
purine ribonucleotide metabolic process GO:0009150 290 0.097
epithelial cell development GO:0002064 159 0.097
regulation of rna splicing GO:0043484 37 0.095
regulation of transcription by chromatin organization GO:0034401 0 0.090
purine nucleotide metabolic process GO:0006163 302 0.089
nucleoside triphosphate catabolic process GO:0009143 205 0.088
ribonucleoside catabolic process GO:0042454 206 0.085
histone h3 k9 methylation GO:0051567 17 0.085
purine containing compound metabolic process GO:0072521 311 0.085
purine containing compound catabolic process GO:0072523 213 0.083
nucleotide catabolic process GO:0009166 217 0.083
sensory perception of mechanical stimulus GO:0050954 107 0.080
glycosyl compound metabolic process GO:1901657 246 0.075
nucleoside metabolic process GO:0009116 246 0.075
purine ribonucleoside metabolic process GO:0046128 241 0.074
meiotic cell cycle GO:0051321 122 0.074
positive regulation of mapk cascade GO:0043410 170 0.073
gene silencing GO:0016458 38 0.073
positive regulation of cellular amine metabolic process GO:0033240 5 0.073
regulation of cell cycle process GO:0010564 160 0.071
ribonucleotide catabolic process GO:0009261 208 0.071
histone lysine methylation GO:0034968 50 0.070
posttranscriptional regulation of gene expression GO:0010608 155 0.069
osteoclast fusion GO:0072675 3 0.069
endocytosis GO:0006897 168 0.068
cellular response to dna damage stimulus GO:0006974 207 0.068
dna conformation change GO:0071103 37 0.068
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.067
synaptic transmission GO:0007268 329 0.067
nucleoside phosphate metabolic process GO:0006753 338 0.067
aromatic compound catabolic process GO:0019439 286 0.066
nucleoside phosphate catabolic process GO:1901292 222 0.066
intracellular mrna localization GO:0008298 4 0.064
chromosome organization involved in meiosis GO:0070192 39 0.063
regulation of alternative mrna splicing via spliceosome GO:0000381 8 0.062
carbohydrate derivative catabolic process GO:1901136 231 0.062
nucleoside triphosphate metabolic process GO:0009141 230 0.062
mrna metabolic process GO:0016071 84 0.059
gene silencing by rna GO:0031047 19 0.059
chromatin assembly GO:0031497 13 0.058
regulation of organelle organization GO:0033043 289 0.058
ribonucleoside monophosphate metabolic process GO:0009161 80 0.057
ribonucleoside monophosphate catabolic process GO:0009158 57 0.056
mapk cascade GO:0000165 281 0.055
sensory perception GO:0007600 245 0.054
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.054
purine nucleoside metabolic process GO:0042278 241 0.054
histone modification GO:0016570 159 0.053
development of primary sexual characteristics GO:0045137 143 0.052
regulation of cellular ketone metabolic process GO:0010565 66 0.052
regulation of system process GO:0044057 200 0.051
dna packaging GO:0006323 30 0.051
ribonucleotide metabolic process GO:0009259 291 0.050
chromatin assembly or disassembly GO:0006333 16 0.050
atp catabolic process GO:0006200 55 0.050
regulation of meiotic cell cycle GO:0051445 34 0.050
posttranscriptional gene silencing GO:0016441 10 0.049
positive regulation of chromatin modification GO:1903310 28 0.049
regulation of cell cycle GO:0051726 281 0.048
positive regulation of histone modification GO:0031058 28 0.047
ras protein signal transduction GO:0007265 77 0.047
regulation of mapk cascade GO:0043408 248 0.046
nucleoside monophosphate catabolic process GO:0009125 59 0.046
macromolecule methylation GO:0043414 120 0.046
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.045
cell type specific apoptotic process GO:0097285 268 0.044
nucleoside catabolic process GO:0009164 206 0.043
positive regulation of necrotic cell death GO:0010940 1 0.042
mitotic sister chromatid cohesion GO:0007064 1 0.040
uterus morphogenesis GO:0061038 2 0.039
apoptotic signaling pathway GO:0097190 306 0.038
spermatogenesis GO:0007283 284 0.038
mitotic cell cycle GO:0000278 195 0.037
gonad development GO:0008406 141 0.037
purine nucleotide catabolic process GO:0006195 211 0.037
posttranscriptional gene silencing by rna GO:0035194 10 0.036
atp metabolic process GO:0046034 75 0.036
oogenesis GO:0048477 56 0.036
dna metabolic process GO:0006259 303 0.035
regulation of chromosome organization GO:0033044 83 0.035
cellular amino acid metabolic process GO:0006520 103 0.035
ribonucleoside triphosphate metabolic process GO:0009199 220 0.035
positive regulation of cell cycle process GO:0090068 61 0.035
positive regulation of protein modification process GO:0031401 299 0.035
positive regulation of cell cycle GO:0045787 92 0.034
protein methylation GO:0006479 81 0.034
neural tube development GO:0021915 160 0.033
chromatin silencing GO:0006342 15 0.033
lateral inhibition GO:0046331 1 0.033
mrna processing GO:0006397 63 0.032
regulation of mrna splicing via spliceosome GO:0048024 32 0.032
meiotic nuclear division GO:0007126 115 0.032
cellular response to lipid GO:0071396 145 0.032
multinuclear osteoclast differentiation GO:0072674 4 0.032
sensory perception of sound GO:0007605 97 0.031
negative regulation of intracellular signal transduction GO:1902532 167 0.031
nucleoside monophosphate metabolic process GO:0009123 85 0.030
heterochromatin organization involved in chromatin silencing GO:0070868 1 0.029
regulation of hydrolase activity GO:0051336 246 0.029
protein deacetylation GO:0006476 32 0.028
regulation of cell division GO:0051302 76 0.028
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.028
protein localization to organelle GO:0033365 185 0.028
ribonucleoside triphosphate catabolic process GO:0009203 199 0.027
positive regulation of histone h3 k9 methylation GO:0051574 4 0.027
purine nucleoside monophosphate metabolic process GO:0009126 81 0.026
protein dna complex subunit organization GO:0071824 28 0.026
histone h4 k20 methylation GO:0034770 8 0.026
cellular ketone metabolic process GO:0042180 84 0.025
rna processing GO:0006396 105 0.025
learning or memory GO:0007611 148 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
gtp catabolic process GO:0006184 143 0.025
mitochondrion organization GO:0007005 134 0.025
purine nucleoside monophosphate catabolic process GO:0009128 58 0.024
rna splicing via transesterification reactions GO:0000375 43 0.024
negative regulation of molecular function GO:0044092 258 0.024
regulation of protein localization GO:0032880 231 0.024
sertoli cell development GO:0060009 15 0.024
muscle contraction GO:0006936 101 0.024
cation homeostasis GO:0055080 212 0.023
synapse organization GO:0050808 125 0.023
chromatin remodeling GO:0006338 32 0.023
negative regulation of phosphorylation GO:0042326 166 0.023
small gtpase mediated signal transduction GO:0007264 97 0.023
macromolecule deacylation GO:0098732 37 0.023
mitotic nuclear division GO:0007067 48 0.023
regulation of cellular amine metabolic process GO:0033238 20 0.022
compound eye development GO:0048749 1 0.022
extrinsic apoptotic signaling pathway GO:0097191 126 0.021
ribonucleoside metabolic process GO:0009119 245 0.021
mrna splicing via spliceosome GO:0000398 43 0.021
regulation of cellular response to stress GO:0080135 159 0.021
covalent chromatin modification GO:0016569 163 0.021
response to extracellular stimulus GO:0009991 127 0.020
regulation of mrna stability GO:0043488 23 0.020
membrane organization GO:0061024 245 0.020
cellular homeostasis GO:0019725 240 0.020
nuclear division GO:0000280 158 0.020
meiotic cell cycle process GO:1903046 77 0.020
cell cycle checkpoint GO:0000075 47 0.019
meiosis i GO:0007127 60 0.019
forebrain development GO:0030900 302 0.019
regulation of mrna metabolic process GO:1903311 43 0.019
chromatin silencing at rdna GO:0000183 3 0.019
receptor mediated endocytosis GO:0006898 51 0.019
protein deacylation GO:0035601 36 0.019
interkinetic nuclear migration GO:0022027 8 0.019
innate immune response GO:0045087 157 0.019
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.018
oocyte axis specification GO:0007309 2 0.018
positive regulation of homeostatic process GO:0032846 64 0.018
positive regulation of apoptotic process GO:0043065 217 0.018
negative regulation of nervous system development GO:0051961 156 0.018
establishment of vesicle localization GO:0051650 81 0.018
microtubule cytoskeleton organization GO:0000226 157 0.018
microtubule based process GO:0007017 236 0.018
cellular ion homeostasis GO:0006873 165 0.018
neural precursor cell proliferation GO:0061351 121 0.017
germ cell development GO:0007281 185 0.017
regulation of protein maturation GO:1903317 96 0.017
cognition GO:0050890 149 0.017
ribonucleoprotein complex subunit organization GO:0071826 28 0.017
dna methylation involved in gamete generation GO:0043046 15 0.017
negative regulation of phosphate metabolic process GO:0045936 184 0.017
axonogenesis GO:0007409 274 0.016
negative regulation of protein metabolic process GO:0051248 282 0.016
androgen biosynthetic process GO:0006702 4 0.016
regulation of ras protein signal transduction GO:0046578 114 0.016
positive regulation of potassium ion transport GO:0043268 3 0.016
dendrite development GO:0016358 115 0.016
calcium ion transport GO:0006816 159 0.016
trna wobble uridine modification GO:0002098 2 0.016
female gamete generation GO:0007292 74 0.016
oxidation reduction process GO:0055114 342 0.015
leukocyte migration GO:0050900 124 0.015
stem cell differentiation GO:0048863 268 0.015
organelle localization GO:0051640 179 0.015
cellular metal ion homeostasis GO:0006875 151 0.015
establishment or maintenance of polarity of embryonic epithelium GO:0016332 1 0.015
rhythmic process GO:0048511 174 0.015
regulation of nuclear division GO:0051783 56 0.015
organic hydroxy compound metabolic process GO:1901615 203 0.014
regulation of cell motility GO:2000145 236 0.014
divalent inorganic cation homeostasis GO:0072507 138 0.014
sister chromatid segregation GO:0000819 20 0.014
protein localization to nucleus GO:0034504 121 0.014
chloride transport GO:0006821 32 0.014
cellular chemical homeostasis GO:0055082 215 0.014
amine metabolic process GO:0009308 45 0.014
cellular respiration GO:0045333 38 0.014
locomotory behavior GO:0007626 195 0.014
organelle fission GO:0048285 170 0.014
muscle system process GO:0003012 141 0.013
nucleocytoplasmic transport GO:0006913 139 0.013
phagocytosis GO:0006909 66 0.013
external genitalia morphogenesis GO:0035261 1 0.013
histone deacetylation GO:0016575 26 0.013
nucleosome positioning GO:0016584 4 0.013
jnk cascade GO:0007254 72 0.013
positive regulation of cell death GO:0010942 224 0.013
negative regulation of apoptotic signaling pathway GO:2001234 104 0.013
male gonad development GO:0008584 88 0.013
positive regulation of histone methylation GO:0031062 16 0.013
circulatory system process GO:0003013 197 0.013
genitalia development GO:0048806 37 0.012
nuclear transport GO:0051169 139 0.012
stress activated mapk cascade GO:0051403 80 0.012
cation transport GO:0006812 399 0.012
skeletal system development GO:0001501 356 0.012
positive regulation of mitotic cell cycle GO:0045931 41 0.012
regulation of chromatin modification GO:1903308 57 0.012
histone h3 k4 trimethylation GO:0080182 5 0.012
digestive tract development GO:0048565 190 0.012
regulation of ion transport GO:0043269 215 0.012
bone development GO:0060348 120 0.012
sensory organ morphogenesis GO:0090596 242 0.012
regulation of cellular component biogenesis GO:0044087 181 0.012
organelle assembly GO:0070925 177 0.012
mitotic cell cycle process GO:1903047 159 0.012
regulation of protein complex assembly GO:0043254 83 0.011
hepaticobiliary system development GO:0061008 67 0.011
development of primary male sexual characteristics GO:0046546 88 0.011
dna alkylation GO:0006305 43 0.011
regulation of embryonic development GO:0045995 71 0.011
neurohypophysis development GO:0021985 2 0.011
negative regulation of immune system process GO:0002683 209 0.011
epithelial tube morphogenesis GO:0060562 303 0.011
cellular response to radiation GO:0071478 28 0.011
synaptic vesicle transport GO:0048489 57 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.011
regulation of cell migration GO:0030334 219 0.011
regulation of planar cell polarity pathway involved in axis elongation GO:2000040 3 0.011
neuron apoptotic process GO:0051402 142 0.011
positive regulation of cell division GO:0051781 31 0.011
protein processing GO:0016485 163 0.011
rna catabolic process GO:0006401 29 0.011
fat cell differentiation GO:0045444 160 0.011
male gamete generation GO:0048232 285 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.011
response to alcohol GO:0097305 48 0.011
blood circulation GO:0008015 195 0.011
meiotic sister chromatid segregation GO:0045144 6 0.011
regulation of kinase activity GO:0043549 249 0.010
developmental maturation GO:0021700 193 0.010
peptidyl lysine methylation GO:0018022 29 0.010
erk1 and erk2 cascade GO:0070371 77 0.010
response to organic cyclic compound GO:0014070 198 0.010
synaptic vesicle localization GO:0097479 59 0.010
negative regulation of blood vessel morphogenesis GO:2000181 25 0.010

Thoc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
osteochondrodysplasia DOID:2256 0 0.024
bone development disease DOID:0080006 0 0.024
bone disease DOID:0080001 0 0.024
disease of anatomical entity DOID:7 0 0.024
musculoskeletal system disease DOID:17 0 0.024
connective tissue disease DOID:65 0 0.024
long qt syndrome DOID:2843 0 0.017
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015