Mus musculus

0 known processes

Thoc4

THO complex 4

(Aliases: REF1,Refbp1,ALY)

Thoc4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of nucleotide catabolic process GO:0030812 9 0.716
Yeast
rna splicing via transesterification reactions GO:0000375 43 0.590
negative regulation of purine nucleotide catabolic process GO:0033122 9 0.541
Yeast
nucleic acid transport GO:0050657 18 0.536
Human Yeast Mouse
mitotic cell cycle process GO:1903047 159 0.508
mrna metabolic process GO:0016071 84 0.439
positive regulation of dna templated transcription elongation GO:0032786 2 0.391
Human
establishment of rna localization GO:0051236 18 0.361
Human Yeast Mouse
rna transport GO:0050658 18 0.353
Human Yeast Mouse
mrna processing GO:0006397 63 0.343
regulation of mitotic cell cycle GO:0007346 126 0.338
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.337
rna processing GO:0006396 105 0.316
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.310
rna localization GO:0006403 23 0.280
Human Yeast Mouse
mitotic cell cycle GO:0000278 195 0.278
negative regulation of purine nucleotide metabolic process GO:1900543 16 0.249
Yeast
microtubule based process GO:0007017 236 0.249
mrna splicing via spliceosome GO:0000398 43 0.228
mitotic centrosome separation GO:0007100 4 0.197
negative regulation of dna templated transcription termination GO:0060567 1 0.192
dna repair GO:0006281 107 0.191
Yeast
regulation of rna splicing GO:0043484 37 0.190
regulation of mrna splicing via spliceosome GO:0048024 32 0.181
regulation of mrna metabolic process GO:1903311 43 0.179
regulation of mrna processing GO:0050684 41 0.176
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.169
microtubule cytoskeleton organization GO:0000226 157 0.168
oocyte construction GO:0007308 2 0.160
regulation of hydrolase activity GO:0051336 246 0.158
Yeast
rna splicing GO:0008380 54 0.156
nucleobase containing compound transport GO:0015931 27 0.151
Human Yeast Mouse
nuclear export GO:0051168 34 0.149
Human Yeast Mouse
development of primary sexual characteristics GO:0045137 143 0.147
nucleocytoplasmic transport GO:0006913 139 0.137
Human Yeast Mouse
pole plasm assembly GO:0007315 2 0.137
endocytosis GO:0006897 168 0.135
oocyte anterior posterior axis specification GO:0007314 2 0.126
negative regulation of nucleoside metabolic process GO:0045978 11 0.125
Yeast
cellular nitrogen compound catabolic process GO:0044270 280 0.125
Yeast
negative regulation of atpase activity GO:0032780 2 0.120
Yeast
transcription coupled nucleotide excision repair GO:0006283 2 0.114
Yeast
organelle fission GO:0048285 170 0.113
aromatic compound catabolic process GO:0019439 286 0.110
Yeast
nuclear transport GO:0051169 139 0.109
Human Yeast Mouse
negative regulation of phosphate metabolic process GO:0045936 184 0.105
Yeast
nuclear division GO:0000280 158 0.102
purine nucleotide catabolic process GO:0006195 211 0.101
Yeast
regulation of protein complex disassembly GO:0043244 28 0.098
negative regulation of molecular function GO:0044092 258 0.094
Yeast
regulation of cell cycle process GO:0010564 160 0.091
intracellular mrna localization GO:0008298 4 0.089
regulation of purine nucleotide catabolic process GO:0033121 122 0.088
Yeast
spermatogenesis GO:0007283 284 0.087
negative regulation of cellular component organization GO:0051129 194 0.086
negative regulation of nucleotide metabolic process GO:0045980 16 0.086
Yeast
oocyte axis specification GO:0007309 2 0.086
dephosphorylation GO:0016311 129 0.080
posttranscriptional regulation of gene expression GO:0010608 155 0.080
heterocycle catabolic process GO:0046700 280 0.076
Yeast
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.071
purine nucleoside metabolic process GO:0042278 241 0.068
Yeast
organic cyclic compound catabolic process GO:1901361 295 0.065
Yeast
centrosome separation GO:0051299 4 0.064
negative regulation of hydrolase activity GO:0051346 71 0.063
Yeast
dna metabolic process GO:0006259 303 0.063
Human Yeast
alternative mrna splicing via spliceosome GO:0000380 12 0.061
positive regulation of cell cycle GO:0045787 92 0.060
regulation of cellular catabolic process GO:0031329 242 0.059
Yeast
regionalization GO:0003002 337 0.058
cellular response to dna damage stimulus GO:0006974 207 0.058
Human Yeast
regulation of cell cycle GO:0051726 281 0.058
nitrogen compound transport GO:0071705 271 0.057
Human Yeast Mouse
ribose phosphate metabolic process GO:0019693 291 0.057
Yeast
nucleoside catabolic process GO:0009164 206 0.055
Yeast
poly a mrna export from nucleus GO:0016973 4 0.054
Mouse
segmentation GO:0035282 93 0.054
nucleoside triphosphate metabolic process GO:0009141 230 0.052
Yeast
ribonucleotide metabolic process GO:0009259 291 0.050
Yeast
regulation of cellular component biogenesis GO:0044087 181 0.050
mrna export from nucleus GO:0006406 11 0.048
Human Yeast Mouse
negative regulation of atp metabolic process GO:1903579 4 0.048
Yeast
regulation of organelle organization GO:0033043 289 0.047
regulation of nucleotide catabolic process GO:0030811 122 0.047
Yeast
striated muscle contraction GO:0006941 45 0.047
organophosphate catabolic process GO:0046434 232 0.047
Yeast
cellular macromolecule catabolic process GO:0044265 206 0.046
nucleoside phosphate metabolic process GO:0006753 338 0.046
Yeast
regulation of nucleotide metabolic process GO:0006140 169 0.046
Yeast
oxidation reduction process GO:0055114 342 0.046
regulation of nucleoside metabolic process GO:0009118 130 0.045
Yeast
regulation of cell cycle phase transition GO:1901987 77 0.044
purine ribonucleoside metabolic process GO:0046128 241 0.044
Yeast
response to organic cyclic compound GO:0014070 198 0.043
protein complex disassembly GO:0043241 40 0.041
positive regulation of cytoskeleton organization GO:0051495 49 0.041
cell division GO:0051301 120 0.041
positive regulation of protein modification process GO:0031401 299 0.041
germ cell development GO:0007281 185 0.040
mitotic nuclear division GO:0007067 48 0.039
regulation of translation GO:0006417 71 0.039
negative regulation of cellular protein metabolic process GO:0032269 247 0.038
nucleoside metabolic process GO:0009116 246 0.038
Yeast
cellular amine metabolic process GO:0044106 44 0.038
regulation of cell division GO:0051302 76 0.038
amine metabolic process GO:0009308 45 0.037
macromolecule catabolic process GO:0009057 281 0.036
positive regulation of rna splicing GO:0033120 12 0.035
dna templated transcription termination GO:0006353 4 0.035
mrna transport GO:0051028 13 0.035
Human Yeast Mouse
positive regulation of mrna metabolic process GO:1903313 17 0.034
recombinational repair GO:0000725 21 0.034
cell cycle checkpoint GO:0000075 47 0.033
intracellular protein transport GO:0006886 204 0.033
cellular amino acid metabolic process GO:0006520 103 0.032
nucleotide catabolic process GO:0009166 217 0.032
Yeast
negative regulation of translation GO:0017148 22 0.032
regulation of cellular amino acid metabolic process GO:0006521 5 0.032
nucleobase containing small molecule metabolic process GO:0055086 352 0.032
Yeast
purine ribonucleotide metabolic process GO:0009150 290 0.031
Yeast
response to organonitrogen compound GO:0010243 246 0.031
chromatin organization GO:0006325 206 0.030
positive regulation of cell cycle process GO:0090068 61 0.030
regulation of dna templated transcription elongation GO:0032784 10 0.030
Human
cytoplasmic transport GO:0016482 234 0.030
Human Yeast Mouse
chromatin modification GO:0016568 187 0.030
translation GO:0006412 93 0.029
positive regulation of glycogen catabolic process GO:0045819 2 0.029
cellular carbohydrate metabolic process GO:0044262 119 0.029
negative regulation of immune system process GO:0002683 209 0.028
adult behavior GO:0030534 135 0.028
protein import into nucleus GO:0006606 95 0.028
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 1 0.027
rna export from nucleus GO:0006405 15 0.027
Human Yeast Mouse
negative regulation of phagocytosis GO:0050765 4 0.027
positive regulation of organelle organization GO:0010638 128 0.027
polysaccharide metabolic process GO:0005976 39 0.027
purine nucleoside triphosphate metabolic process GO:0009144 226 0.026
Yeast
glucose homeostasis GO:0042593 128 0.026
dna damage checkpoint GO:0000077 26 0.026
mrna catabolic process GO:0006402 22 0.026
nuclear transcribed mrna catabolic process GO:0000956 16 0.026
regulation of cellular response to stress GO:0080135 159 0.026
regulation of dna damage checkpoint GO:2000001 3 0.026
regulation of mitotic cell cycle phase transition GO:1901990 73 0.026
organonitrogen compound catabolic process GO:1901565 264 0.025
Yeast
regulation of homeostatic process GO:0032844 182 0.025
regulation of cellular amine metabolic process GO:0033238 20 0.025
apoptotic signaling pathway GO:0097190 306 0.025
respiratory system development GO:0060541 190 0.025
negative regulation of cell cycle GO:0045786 123 0.025
regulation of atp metabolic process GO:1903578 17 0.024
Yeast
generation of precursor metabolites and energy GO:0006091 103 0.024
receptor mediated endocytosis GO:0006898 51 0.024
negative regulation of protein complex disassembly GO:0043242 22 0.024
regulation of intracellular protein transport GO:0033157 82 0.024
ribonucleoside monophosphate catabolic process GO:0009158 57 0.024
Yeast
hematopoietic progenitor cell differentiation GO:0002244 143 0.024
protein ubiquitination GO:0016567 171 0.023
leukocyte differentiation GO:0002521 342 0.023
male gamete generation GO:0048232 285 0.023
double strand break repair GO:0006302 48 0.023
positive regulation of mitotic cell cycle GO:0045931 41 0.023
regulation of multi organism process GO:0043900 111 0.023
small gtpase mediated signal transduction GO:0007264 97 0.023
ras protein signal transduction GO:0007265 77 0.022
nuclear import GO:0051170 95 0.022
dna templated transcription elongation GO:0006354 13 0.022
Human
single fertilization GO:0007338 82 0.022
negative regulation of myeloid cell differentiation GO:0045638 38 0.022
protein localization to nucleus GO:0034504 121 0.022
muscle contraction GO:0006936 101 0.022
spermatid differentiation GO:0048515 115 0.022
cellular homeostasis GO:0019725 240 0.022
positive regulation of mrna splicing via spliceosome GO:0048026 11 0.022
sensory perception GO:0007600 245 0.021
rna dependent dna replication GO:0006278 3 0.021
multicellular organism growth GO:0035264 161 0.021
regulation of protein localization GO:0032880 231 0.021
gonad development GO:0008406 141 0.021
purine nucleotide metabolic process GO:0006163 302 0.021
Yeast
regulation of establishment of protein localization GO:0070201 181 0.021
nucleoside triphosphate catabolic process GO:0009143 205 0.021
Yeast
histone modification GO:0016570 159 0.021
positive regulation of cellular catabolic process GO:0031331 148 0.021
termination of rna polymerase ii transcription GO:0006369 1 0.020
maternal determination of anterior posterior axis embryo GO:0008358 2 0.020
ribonucleoside triphosphate catabolic process GO:0009203 199 0.020
Yeast
regulation of double strand break repair via nonhomologous end joining GO:2001032 2 0.020
multi multicellular organism process GO:0044706 109 0.020
regulation of lymphocyte activation GO:0051249 240 0.020
regulation of purine nucleotide metabolic process GO:1900542 169 0.020
Yeast
purine nucleoside monophosphate metabolic process GO:0009126 81 0.020
Yeast
regulation of ras protein signal transduction GO:0046578 114 0.020
establishment or maintenance of cell polarity GO:0007163 86 0.020
regulation of alternative mrna splicing via spliceosome GO:0000381 8 0.020
cellular response to cytokine stimulus GO:0071345 189 0.019
regulation of cell cycle checkpoint GO:1901976 9 0.019
regulation of cellular ketone metabolic process GO:0010565 66 0.019
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.018
fertilization GO:0009566 127 0.018
glycosyl compound metabolic process GO:1901657 246 0.018
Yeast
spindle organization GO:0007051 28 0.018
stem cell differentiation GO:0048863 268 0.018
cellular protein complex disassembly GO:0043624 36 0.018
cellular chemical homeostasis GO:0055082 215 0.018
cardiac muscle contraction GO:0060048 32 0.018
atp metabolic process GO:0046034 75 0.018
Yeast
peptidyl amino acid modification GO:0018193 336 0.018
response to lipopolysaccharide GO:0032496 128 0.018
lung development GO:0030324 164 0.018
protein processing GO:0016485 163 0.018
female gamete generation GO:0007292 74 0.018
negative regulation of cell activation GO:0050866 111 0.017
stem cell development GO:0048864 219 0.017
regulation of apoptotic signaling pathway GO:2001233 197 0.017
genitalia development GO:0048806 37 0.017
purine containing compound metabolic process GO:0072521 311 0.017
Yeast
regulation of leukocyte differentiation GO:1902105 159 0.017
protein localization to organelle GO:0033365 185 0.017
nuclear mrna surveillance GO:0071028 1 0.017
glycosyl compound catabolic process GO:1901658 206 0.017
Yeast
digestive system development GO:0055123 200 0.017
positive regulation of translation GO:0045727 19 0.017
actin cytoskeleton organization GO:0030036 220 0.017
methylation GO:0032259 134 0.017
monosaccharide metabolic process GO:0005996 106 0.016
chemotaxis GO:0006935 247 0.016
nucleoside monophosphate catabolic process GO:0009125 59 0.016
Yeast
ion transmembrane transport GO:0034220 361 0.016
striated muscle myosin thick filament assembly GO:0071688 1 0.016
positive regulation of cell cycle phase transition GO:1901989 17 0.016
muscle tissue development GO:0060537 308 0.016
carbohydrate homeostasis GO:0033500 128 0.016
chromatin assembly GO:0031497 13 0.015
atp catabolic process GO:0006200 55 0.015
Yeast
cellular response to carbohydrate stimulus GO:0071322 50 0.015
protein targeting GO:0006605 143 0.015
carbohydrate metabolic process GO:0005975 230 0.015
energy derivation by oxidation of organic compounds GO:0015980 77 0.015
positive regulation of cellular amine metabolic process GO:0033240 5 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.015
Yeast
regulation of cell migration GO:0030334 219 0.015
regulation of vesicle mediated transport GO:0060627 139 0.015
regulation of cytoskeleton organization GO:0051493 122 0.015
hexose metabolic process GO:0019318 98 0.015
positive regulation of dna repair GO:0045739 3 0.015
regulation of double strand break repair via homologous recombination GO:0010569 2 0.014
homeostasis of number of cells GO:0048872 210 0.014
stem cell maintenance GO:0019827 130 0.014
regulation of mrna stability GO:0043488 23 0.014
regulation of lymphocyte differentiation GO:0045619 107 0.014
covalent chromatin modification GO:0016569 163 0.014
organelle assembly GO:0070925 177 0.014
cell type specific apoptotic process GO:0097285 268 0.014
epithelial tube morphogenesis GO:0060562 303 0.014
reactive oxygen species metabolic process GO:0072593 84 0.014
purine nucleoside monophosphate catabolic process GO:0009128 58 0.014
Yeast
ribonucleoside catabolic process GO:0042454 206 0.014
Yeast
glycogen metabolic process GO:0005977 32 0.014
cell cycle g1 s phase transition GO:0044843 57 0.014
camera type eye development GO:0043010 266 0.014
protein maturation GO:0051604 176 0.014
ribonucleoside metabolic process GO:0009119 245 0.014
Yeast
spermatid development GO:0007286 108 0.013
mapk cascade GO:0000165 281 0.013
respiratory tube development GO:0030323 167 0.013
protein modification by small protein conjugation or removal GO:0070647 207 0.013
regulation of intracellular transport GO:0032386 159 0.013
regulation of transferase activity GO:0051338 263 0.013
purine ribonucleoside catabolic process GO:0046130 205 0.013
Yeast
regulation of cell motility GO:2000145 236 0.013
regulation of cell activation GO:0050865 289 0.013
meiotic cell cycle checkpoint GO:0033313 2 0.013
membrane organization GO:0061024 245 0.013
ear development GO:0043583 200 0.013
developmental maturation GO:0021700 193 0.013
striated muscle tissue development GO:0014706 293 0.013
nucleus organization GO:0006997 45 0.013
chromatin assembly or disassembly GO:0006333 16 0.013
compound eye development GO:0048749 1 0.013
cellular glucan metabolic process GO:0006073 32 0.013
double strand break repair via nonhomologous end joining GO:0006303 10 0.013
response to acid chemical GO:0001101 111 0.013
positive regulation of cell division GO:0051781 31 0.013
myeloid cell differentiation GO:0030099 233 0.013
cellular response to hexose stimulus GO:0071331 47 0.013
cell adhesion GO:0007155 329 0.013
cellular polysaccharide metabolic process GO:0044264 38 0.013
regulation of mapk cascade GO:0043408 248 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.012
Yeast
negative regulation of leukocyte differentiation GO:1902106 51 0.012
cellular response to acid chemical GO:0071229 68 0.012
cellular ketone metabolic process GO:0042180 84 0.012
ribonucleoside triphosphate metabolic process GO:0009199 220 0.012
Yeast
ossification GO:0001503 216 0.012
Human
organelle localization GO:0051640 179 0.012
nucleotide metabolic process GO:0009117 332 0.012
Yeast
double strand break repair via homologous recombination GO:0000724 21 0.012
negative regulation of protein metabolic process GO:0051248 282 0.012
placenta development GO:0001890 140 0.012
positive regulation of intracellular transport GO:0032388 70 0.012
skin development GO:0043588 220 0.012
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.012
positive regulation of hydrolase activity GO:0051345 148 0.012
blastoderm segmentation GO:0007350 13 0.012
negative regulation of phosphorus metabolic process GO:0010563 184 0.012
Yeast
single organism nuclear import GO:1902593 95 0.012
chromosome segregation GO:0007059 48 0.012
macromolecular complex disassembly GO:0032984 43 0.012
regulation of chromatin modification GO:1903308 57 0.012
connective tissue development GO:0061448 179 0.012
cellular response to hormone stimulus GO:0032870 150 0.012
regulation of cell cycle g1 s phase transition GO:1902806 35 0.011
modification dependent macromolecule catabolic process GO:0043632 133 0.011
circulatory system process GO:0003013 197 0.011
regulation of embryonic development GO:0045995 71 0.011
regulation of rna stability GO:0043487 26 0.011
extrinsic apoptotic signaling pathway GO:0097191 126 0.011
nucleoside phosphate catabolic process GO:1901292 222 0.011
Yeast
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.011
Yeast
cation transport GO:0006812 399 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
transcription elongation from rna polymerase ii promoter GO:0006368 9 0.011
transmembrane transport GO:0055085 412 0.011
dna integrity checkpoint GO:0031570 28 0.011
regulation of protein import into nucleus GO:0042306 52 0.011
negative regulation of mitotic cell cycle GO:0045930 58 0.011
protein import GO:0017038 101 0.011
mitotic cell cycle checkpoint GO:0007093 31 0.011
b cell activation GO:0042113 161 0.011
regulation of nuclear division GO:0051783 56 0.011
positive regulation of transferase activity GO:0051347 167 0.011
regulation of secretion by cell GO:1903530 249 0.011
muscle cell differentiation GO:0042692 261 0.011
megakaryocyte differentiation GO:0030219 26 0.011
protein dna complex subunit organization GO:0071824 28 0.011
positive regulation of keratinocyte proliferation GO:0010838 4 0.011
regulation of response to dna damage stimulus GO:2001020 34 0.011
positive regulation of mrna processing GO:0050685 16 0.010
positive regulation of cell death GO:0010942 224 0.010
myosin filament assembly GO:0031034 2 0.010
negative regulation of apoptotic cell clearance GO:2000426 1 0.010
maternal process involved in female pregnancy GO:0060135 32 0.010
lymphocyte differentiation GO:0030098 242 0.010
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.010
carbohydrate derivative biosynthetic process GO:1901137 183 0.010
regulation of nucleocytoplasmic transport GO:0046822 73 0.010
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.010

Thoc4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.012
large intestine cancer DOID:5672 0 0.011
colon cancer DOID:219 0 0.011
gastrointestinal system cancer DOID:3119 0 0.011
intestinal cancer DOID:10155 0 0.011
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011
colorectal cancer DOID:9256 0 0.011