Mus musculus

23 known processes

Nfkbib

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

(Aliases: IkB,IKB-beta,MGC36057,IkBb,IKappaBbeta)

Nfkbib biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 103 0.141
response to organonitrogen compound GO:0010243 246 0.102
Mouse
leukocyte differentiation GO:0002521 342 0.093
Mouse
cellular amine metabolic process GO:0044106 44 0.084
lymphocyte differentiation GO:0030098 242 0.079
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.076
positive regulation of cellular amine metabolic process GO:0033240 5 0.075
protein catabolic process GO:0030163 221 0.070
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.067
Mouse
protein modification by small protein conjugation GO:0032446 187 0.066
negative regulation of protein metabolic process GO:0051248 282 0.065
Mouse
immune effector process GO:0002252 321 0.064
Mouse Fly
apoptotic signaling pathway GO:0097190 306 0.061
negative regulation of molecular function GO:0044092 258 0.060
response to peptide GO:1901652 136 0.059
Mouse
t cell activation GO:0042110 289 0.059
Mouse
t cell differentiation GO:0030217 174 0.059
Mouse
response to peptide hormone GO:0043434 127 0.058
regulation of cellular amine metabolic process GO:0033238 20 0.058
negative regulation of intracellular signal transduction GO:1902532 167 0.054
Rat
regulation of antimicrobial humoral response GO:0002759 3 0.054
Fly
antimicrobial peptide production GO:0002775 2 0.053
Fly
innate immune response GO:0045087 157 0.051
Mouse
response to molecule of bacterial origin GO:0002237 143 0.051
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.050
regulation of cellular ketone metabolic process GO:0010565 66 0.050
amine metabolic process GO:0009308 45 0.048
modification dependent macromolecule catabolic process GO:0043632 133 0.048
regulation of lymphocyte differentiation GO:0045619 107 0.046
peptidyl amino acid modification GO:0018193 336 0.045
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.045
cellular amide metabolic process GO:0043603 58 0.043
Fly
cellular response to peptide hormone stimulus GO:0071375 92 0.042
myeloid leukocyte differentiation GO:0002573 119 0.042
regulation of neuron death GO:1901214 134 0.041
camera type eye development GO:0043010 266 0.041
positive regulation of apoptotic process GO:0043065 217 0.041
cellular response to hormone stimulus GO:0032870 150 0.040
peptide metabolic process GO:0006518 46 0.040
Fly
chromatin organization GO:0006325 206 0.039
cytokine production GO:0001816 319 0.038
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.038
cellular ketone metabolic process GO:0042180 84 0.038
gland development GO:0048732 330 0.037
mapk cascade GO:0000165 281 0.036
positive regulation of protein modification process GO:0031401 299 0.036
protein ubiquitination GO:0016567 171 0.035
protein targeting GO:0006605 143 0.035
Mouse Rat
small gtpase mediated signal transduction GO:0007264 97 0.035
germinal center formation GO:0002467 16 0.035
Mouse
organonitrogen compound biosynthetic process GO:1901566 192 0.034
Fly
sensory organ morphogenesis GO:0090596 242 0.034
t cell differentiation in thymus GO:0033077 77 0.034
response to lipopolysaccharide GO:0032496 128 0.034
purine ribonucleotide metabolic process GO:0009150 290 0.034
cellular response to lipopolysaccharide GO:0071222 77 0.033
macromolecule catabolic process GO:0009057 281 0.033
response to inorganic substance GO:0010035 96 0.033
regulation of leukocyte differentiation GO:1902105 159 0.032
positive regulation of programmed cell death GO:0043068 218 0.032
chromatin modification GO:0016568 187 0.032
positive regulation of antimicrobial peptide production GO:0002225 1 0.032
Fly
negative regulation of phosphorus metabolic process GO:0010563 184 0.031
regulation of cytokine production GO:0001817 266 0.031
Mouse
regulation of defense response to bacterium GO:1900424 3 0.031
gonad development GO:0008406 141 0.030
positive regulation of cell death GO:0010942 224 0.030
cellular response to organonitrogen compound GO:0071417 145 0.030
protein modification by small protein conjugation or removal GO:0070647 207 0.030
regulation of transferase activity GO:0051338 263 0.030
protein localization to membrane GO:0072657 108 0.030
heterocycle catabolic process GO:0046700 280 0.030
regulation of lymphocyte activation GO:0051249 240 0.029
regionalization GO:0003002 337 0.029
Fly
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.029
Fly
cellular response to dna damage stimulus GO:0006974 207 0.029
Fly
covalent chromatin modification GO:0016569 163 0.029
regulation of antimicrobial peptide production GO:0002784 1 0.027
Fly
cellular response to cytokine stimulus GO:0071345 189 0.027
regulation of defense response GO:0031347 233 0.027
Mouse Fly
molting cycle GO:0042303 90 0.027
cellular response to peptide GO:1901653 92 0.027
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.027
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.027
Fly
regulation of cell cycle GO:0051726 281 0.027
purine containing compound metabolic process GO:0072521 311 0.027
glycosyl compound metabolic process GO:1901657 246 0.027
myeloid cell differentiation GO:0030099 233 0.026
Mouse
spermatogenesis GO:0007283 284 0.026
neuron death GO:0070997 154 0.026
histone modification GO:0016570 159 0.026
response to oxidative stress GO:0006979 123 0.026
positive regulation of defense response GO:0031349 124 0.026
Mouse Fly
response to radiation GO:0009314 165 0.026
glycosyl compound catabolic process GO:1901658 206 0.026
modification dependent protein catabolic process GO:0019941 133 0.025
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.025
negative regulation of neuron death GO:1901215 98 0.025
regulation of inflammatory response GO:0050727 147 0.025
purine nucleotide metabolic process GO:0006163 302 0.025
regulation of t cell differentiation GO:0045580 83 0.024
rhythmic process GO:0048511 174 0.024
response to organic cyclic compound GO:0014070 198 0.024
Mouse
cytokine metabolic process GO:0042107 71 0.024
Mouse
regulation of kinase activity GO:0043549 249 0.024
purine nucleotide catabolic process GO:0006195 211 0.023
negative regulation of protein modification process GO:0031400 163 0.023
ribonucleoside triphosphate metabolic process GO:0009199 220 0.023
regulation of innate immune response GO:0045088 91 0.023
Mouse
striated muscle tissue development GO:0014706 293 0.023
regulation of protein kinase activity GO:0045859 232 0.023
protein localization to organelle GO:0033365 185 0.023
Mouse Rat
development of primary sexual characteristics GO:0045137 143 0.023
g protein coupled receptor signaling pathway GO:0007186 243 0.023
negative regulation of phosphorylation GO:0042326 166 0.023
multicellular organismal signaling GO:0035637 91 0.022
regulation of mapk cascade GO:0043408 248 0.022
negative regulation of cellular protein metabolic process GO:0032269 247 0.022
cellular macromolecule catabolic process GO:0044265 206 0.022
negative regulation of immune system process GO:0002683 209 0.022
Mouse
skin development GO:0043588 220 0.021
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.021
germ cell development GO:0007281 185 0.021
Fly
alpha beta t cell differentiation GO:0046632 69 0.021
Mouse
ras protein signal transduction GO:0007265 77 0.021
regulation of ion transport GO:0043269 215 0.020
regulation of multi organism process GO:0043900 111 0.020
Fly
connective tissue development GO:0061448 179 0.020
reactive oxygen species metabolic process GO:0072593 84 0.020
lung development GO:0030324 164 0.020
spermatid differentiation GO:0048515 115 0.020
intracellular receptor signaling pathway GO:0030522 74 0.020
Mouse
membrane organization GO:0061024 245 0.020
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.020
cellular response to biotic stimulus GO:0071216 92 0.019
rna processing GO:0006396 105 0.019
cellular protein catabolic process GO:0044257 155 0.019
maintenance of location GO:0051235 89 0.019
Rat
regulation of cell activation GO:0050865 289 0.019
intracellular protein transport GO:0006886 204 0.019
Mouse Rat
epithelial cell development GO:0002064 159 0.019
Fly
meiotic nuclear division GO:0007126 115 0.019
negative regulation of phosphate metabolic process GO:0045936 184 0.019
regulation of membrane potential GO:0042391 192 0.019
epidermis development GO:0008544 187 0.019
cellular chemical homeostasis GO:0055082 215 0.018
blood circulation GO:0008015 195 0.018
locomotory behavior GO:0007626 195 0.018
mrna metabolic process GO:0016071 84 0.018
cellular response to lipid GO:0071396 145 0.018
purine nucleoside triphosphate catabolic process GO:0009146 203 0.018
peptidyl serine modification GO:0018209 83 0.018
nuclear transport GO:0051169 139 0.018
Mouse Rat
adaptive immune response GO:0002250 155 0.018
Mouse
sequestering of calcium ion GO:0051208 18 0.018
embryonic organ morphogenesis GO:0048562 276 0.018
ribonucleoside metabolic process GO:0009119 245 0.018
nucleoside triphosphate metabolic process GO:0009141 230 0.018
purine nucleoside metabolic process GO:0042278 241 0.018
response to acid chemical GO:0001101 111 0.018
establishment of protein localization to organelle GO:0072594 118 0.018
Mouse Rat
production of molecular mediator of immune response GO:0002440 103 0.018
Fly
cell type specific apoptotic process GO:0097285 268 0.018
antigen processing and presentation GO:0019882 47 0.017
carbohydrate derivative biosynthetic process GO:1901137 183 0.017
regulation of organelle organization GO:0033043 289 0.017
purine ribonucleoside metabolic process GO:0046128 241 0.017
carbohydrate metabolic process GO:0005975 230 0.017
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.017
cellular response to molecule of bacterial origin GO:0071219 83 0.017
positive regulation of kinase activity GO:0033674 155 0.017
regulation of binding GO:0051098 111 0.017
male sex differentiation GO:0046661 109 0.017
regulation of hormone levels GO:0010817 211 0.017
synaptic transmission GO:0007268 329 0.017
negative regulation of apoptotic signaling pathway GO:2001234 104 0.017
female gonad development GO:0008585 71 0.017
ribose phosphate metabolic process GO:0019693 291 0.017
nucleoside triphosphate catabolic process GO:0009143 205 0.016
male gamete generation GO:0048232 285 0.016
glycoprotein metabolic process GO:0009100 116 0.016
defense response to bacterium GO:0042742 119 0.016
Mouse
post embryonic retina morphogenesis in camera type eye GO:0060060 3 0.016
hair cycle GO:0042633 90 0.016
embryonic placenta development GO:0001892 98 0.016
aromatic compound catabolic process GO:0019439 286 0.016
cation transport GO:0006812 399 0.016
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.016
muscle tissue development GO:0060537 308 0.016
neuron apoptotic process GO:0051402 142 0.016
development of primary male sexual characteristics GO:0046546 88 0.016
posttranscriptional regulation of gene expression GO:0010608 155 0.016
cellular response to organic cyclic compound GO:0071407 87 0.016
purine containing compound catabolic process GO:0072523 213 0.016
lymphocyte activation involved in immune response GO:0002285 93 0.016
Mouse
compound eye development GO:0048749 1 0.016
cellular nitrogen compound catabolic process GO:0044270 280 0.016
positive regulation of protein kinase activity GO:0045860 144 0.016
activation of innate immune response GO:0002218 56 0.016
Mouse
inflammatory response GO:0006954 244 0.015
negative regulation of cellular amine metabolic process GO:0033239 1 0.015
spleen development GO:0048536 39 0.015
Mouse
positive regulation of cytokine production GO:0001819 174 0.015
Mouse
development of primary female sexual characteristics GO:0046545 73 0.015
rna interference GO:0016246 2 0.015
nitrogen compound transport GO:0071705 271 0.015
Rat
protein import GO:0017038 101 0.015
Mouse Rat
divalent inorganic cation transport GO:0072511 178 0.015
negative regulation of response to wounding GO:1903035 77 0.015
regulation of t cell activation GO:0050863 170 0.015
ovarian follicle development GO:0001541 40 0.015
retina development in camera type eye GO:0060041 119 0.015
activation of immune response GO:0002253 138 0.015
Mouse
cell adhesion GO:0007155 329 0.015
tumor necrosis factor production GO:0032640 50 0.015
Mouse
cytokine biosynthetic process GO:0042089 68 0.015
Mouse
organelle fission GO:0048285 170 0.015
mrna splicing via spliceosome GO:0000398 43 0.015
cellular homeostasis GO:0019725 240 0.015
ear development GO:0043583 200 0.015
positive regulation of antimicrobial humoral response GO:0002760 2 0.015
Fly
lens development in camera type eye GO:0002088 62 0.015
respiratory tube development GO:0030323 167 0.015
reactive oxygen species biosynthetic process GO:1903409 8 0.015
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.015
Mouse
regulation of mitotic cell cycle GO:0007346 126 0.015
regulation of response to wounding GO:1903034 189 0.015
nucleotide metabolic process GO:0009117 332 0.015
regulation of protein targeting GO:1903533 61 0.015
Rat
positive regulation of hydrolase activity GO:0051345 148 0.015
ribonucleotide metabolic process GO:0009259 291 0.014
regulation of intracellular protein transport GO:0033157 82 0.014
Rat
regulation of peptide transport GO:0090087 91 0.014
Rat
positive regulation of mirna metabolic process GO:2000630 1 0.014
female sex differentiation GO:0046660 84 0.014
cellular protein complex assembly GO:0043623 116 0.014
interferon gamma production GO:0032609 67 0.014
Mouse
regulation of apoptotic signaling pathway GO:2001233 197 0.014
regulation of cytoplasmic transport GO:1903649 112 0.014
Rat
regulation of neuron apoptotic process GO:0043523 122 0.014
regulation of purine nucleotide metabolic process GO:1900542 169 0.014
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.014
Mouse
regulation of protein catabolic process GO:0042176 108 0.014
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 6 0.014
Mouse
male gonad development GO:0008584 88 0.014
nucleobase containing small molecule metabolic process GO:0055086 352 0.014
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.014
peptidyl serine phosphorylation GO:0018105 74 0.014
positive regulation of innate immune response GO:0045089 80 0.014
Mouse
regulation of secretion by cell GO:1903530 249 0.014
ossification GO:0001503 216 0.014
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.013
Mouse
regulation of establishment of protein localization GO:0070201 181 0.013
Rat
regulation of transmembrane transport GO:0034762 128 0.013
positive regulation of growth hormone receptor signaling pathway GO:0060399 3 0.013
organic cyclic compound catabolic process GO:1901361 295 0.013
placenta development GO:0001890 140 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.013
regulation of protein serine threonine kinase activity GO:0071900 157 0.013
endomembrane system organization GO:0010256 147 0.013
organic hydroxy compound metabolic process GO:1901615 203 0.013
positive regulation of proteolysis GO:0045862 85 0.013
organonitrogen compound catabolic process GO:1901565 264 0.013
stem cell differentiation GO:0048863 268 0.013
i kappab kinase nf kappab signaling GO:0007249 85 0.013
Rat
antibacterial peptide production GO:0002778 2 0.013
developmental maturation GO:0021700 193 0.013
response to copper ion GO:0046688 3 0.013
regulation of cell migration GO:0030334 219 0.013
regulation of protein transport GO:0051223 163 0.013
Rat
regulation of defense response to fungus GO:1900150 1 0.013
Fly
regulation of anatomical structure size GO:0090066 178 0.013
hair follicle development GO:0001942 85 0.013
rna splicing GO:0008380 54 0.013
response to light stimulus GO:0009416 135 0.013
protein polyubiquitination GO:0000209 33 0.013
nuclear import GO:0051170 95 0.013
Mouse Rat
hepaticobiliary system development GO:0061008 67 0.013
notch signaling pathway GO:0007219 71 0.012
Mouse
regulation of intracellular transport GO:0032386 159 0.012
Rat
regulation of antibacterial peptide production GO:0002786 1 0.012
multicellular organism growth GO:0035264 161 0.012
cell growth GO:0016049 130 0.012
regulation of striated muscle cell differentiation GO:0051153 81 0.012
extracellular structure organization GO:0043062 148 0.012
Mouse
negative regulation of defense response GO:0031348 77 0.012
cellular metal ion homeostasis GO:0006875 151 0.012
transmembrane transport GO:0055085 412 0.012
peptidyl tyrosine phosphorylation GO:0018108 143 0.012
nucleoside phosphate metabolic process GO:0006753 338 0.012
positive regulation of transferase activity GO:0051347 167 0.012
positive regulation of cellular catabolic process GO:0031331 148 0.012
antibacterial peptide biosynthetic process GO:0002780 2 0.012
negative regulation of neuron apoptotic process GO:0043524 92 0.012
dna metabolic process GO:0006259 303 0.012
cell maturation GO:0048469 127 0.012
mrna processing GO:0006397 63 0.012
protein maturation GO:0051604 176 0.012
myeloid cell homeostasis GO:0002262 114 0.012
purine ribonucleoside catabolic process GO:0046130 205 0.012
steroid metabolic process GO:0008202 119 0.012
purine ribonucleotide catabolic process GO:0009154 208 0.012
regulation of mrna metabolic process GO:1903311 43 0.012
circadian rhythm GO:0007623 114 0.012
defense response to other organism GO:0098542 197 0.012
Mouse Fly
cellular lipid metabolic process GO:0044255 323 0.012
myeloid leukocyte activation GO:0002274 83 0.012
b cell activation GO:0042113 161 0.012
Mouse
positive regulation of mapk cascade GO:0043410 170 0.012
divalent metal ion transport GO:0070838 172 0.012
nucleoside phosphate catabolic process GO:1901292 222 0.012
regulation of cytokine biosynthetic process GO:0042035 59 0.011
Mouse
cellular carbohydrate metabolic process GO:0044262 119 0.011
skeletal system morphogenesis GO:0048705 203 0.011
muscle cell differentiation GO:0042692 261 0.011
protein polymerization GO:0051258 57 0.011
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.011
Fly
regulation of metal ion transport GO:0010959 106 0.011
positive regulation of cytokine biosynthetic process GO:0042108 40 0.011
Mouse
response to growth factor GO:0070848 198 0.011
carbohydrate biosynthetic process GO:0016051 74 0.011
extracellular matrix organization GO:0030198 147 0.011
Mouse
innate immune response activating signal transduction GO:0002758 50 0.011
Mouse
purine nucleoside triphosphate metabolic process GO:0009144 226 0.011
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.011
regulation of mirna metabolic process GO:2000628 4 0.011
regulation of reactive oxygen species metabolic process GO:2000377 40 0.011
ovulation cycle GO:0042698 59 0.011
nucleoside catabolic process GO:0009164 206 0.011
circadian regulation of gene expression GO:0032922 48 0.011
negative regulation of protein phosphorylation GO:0001933 126 0.011
glucose homeostasis GO:0042593 128 0.011
nucleoside monophosphate metabolic process GO:0009123 85 0.011
ion transmembrane transport GO:0034220 361 0.011
extrinsic apoptotic signaling pathway GO:0097191 126 0.011
skeletal system development GO:0001501 356 0.011
adult behavior GO:0030534 135 0.011
nik nf kappab signaling GO:0038061 14 0.011
positive regulation of growth GO:0045927 104 0.011
mitotic cell cycle GO:0000278 195 0.011
nucleocytoplasmic transport GO:0006913 139 0.011
Mouse Rat
response to interleukin 6 GO:0070741 10 0.011
negative regulation of cell proliferation GO:0008285 296 0.011
humoral immune response GO:0006959 57 0.010
Mouse Fly
vitamin d biosynthetic process GO:0042368 3 0.010
microtubule based process GO:0007017 236 0.010
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 3 0.010
oxidation reduction process GO:0055114 342 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.010
liver development GO:0001889 66 0.010
wnt signaling pathway GO:0016055 188 0.010
metal ion homeostasis GO:0055065 189 0.010
myosin filament organization GO:0031033 3 0.010
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.010
Mouse
b cell differentiation GO:0030183 78 0.010
Mouse
response to reactive oxygen species GO:0000302 56 0.010
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.010
Mouse
response to oxygen levels GO:0070482 62 0.010
glycoprotein biosynthetic process GO:0009101 89 0.010
carbohydrate derivative catabolic process GO:1901136 231 0.010
regulation of interferon gamma production GO:0032649 57 0.010
Mouse
microtubule cytoskeleton organization GO:0000226 157 0.010
homeostasis of number of cells GO:0048872 210 0.010
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.010
Mouse
respiratory system development GO:0060541 190 0.010

Nfkbib disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
nervous system disease DOID:863 0 0.016
immune system disease DOID:2914 0 0.015
hematopoietic system disease DOID:74 0 0.015
disease of metabolism DOID:0014667 0 0.014