Mus musculus

90 known processes

Chuk

conserved helix-loop-helix ubiquitous kinase

(Aliases: IKK1,AI256658,Fbx24,MGC25325,IKBKA,Ikka,Fbxo24,NFKBIKA,Chuk1)

Chuk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
serine phosphorylation of stat protein GO:0042501 3 1.000
dendritic cell proliferation GO:0044565 2 0.999
Mouse
regulation of antibacterial peptide production GO:0002786 1 0.994
Fly
interferon beta biosynthetic process GO:0045350 4 0.992
Mouse
i kappab phosphorylation GO:0007252 6 0.989
Mouse
regulation of interferon beta biosynthetic process GO:0045357 4 0.984
Mouse
activation of nf kappab inducing kinase activity GO:0007250 4 0.929
activation of innate immune response GO:0002218 56 0.929
Mouse
positive regulation of ion transmembrane transporter activity GO:0032414 15 0.921
Mouse
homeostasis of number of cells GO:0048872 210 0.912
Mouse
myeloid cell differentiation GO:0030099 233 0.903
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.891
Fly
regulation of cellular component biogenesis GO:0044087 181 0.891
positive regulation of interferon beta production GO:0032728 8 0.887
Mouse
response to endoplasmic reticulum stress GO:0034976 53 0.874
negative regulation of ripoptosome assembly involved in necroptotic process GO:1902443 3 0.872
skeletal system development GO:0001501 356 0.851
epithelial cell proliferation GO:0050673 174 0.846
positive regulation of innate immune response GO:0045089 80 0.830
Mouse
axonogenesis GO:0007409 274 0.806
mammary gland lobule development GO:0061377 22 0.793
myeloid leukocyte differentiation GO:0002573 119 0.792
regulation of ion transmembrane transport GO:0034765 119 0.764
Mouse
interferon beta production GO:0032608 16 0.747
Mouse
organonitrogen compound biosynthetic process GO:1901566 192 0.743
Fly
regionalization GO:0003002 337 0.743
Zebrafish
positive regulation of interferon beta biosynthetic process GO:0045359 3 0.693
Mouse
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.684
Fly
odontogenesis of dentin containing tooth GO:0042475 66 0.663
regulation of defense response GO:0031347 233 0.644
Mouse Fly
mammary gland alveolus development GO:0060749 22 0.627
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.616
regulation of body fluid levels GO:0050878 162 0.608
i kappab kinase nf kappab signaling GO:0007249 85 0.606
regulation of innate immune response GO:0045088 91 0.585
Mouse Fly
gland development GO:0048732 330 0.564
gastrulation GO:0007369 116 0.555
Zebrafish
osteoclast differentiation GO:0030316 62 0.549
antibacterial peptide production GO:0002778 2 0.537
Fly
embryonic skeletal system development GO:0048706 120 0.527
developmental maturation GO:0021700 193 0.518
morphogenesis of embryonic epithelium GO:0016331 159 0.496
type i interferon biosynthetic process GO:0045351 9 0.486
Mouse
negative regulation of cellular amine metabolic process GO:0033239 1 0.458
positive regulation of cytokine production GO:0001819 174 0.450
Mouse
regulation of establishment of protein localization GO:0070201 181 0.444
cellular protein catabolic process GO:0044257 155 0.440
negative regulation of dna replication GO:0008156 4 0.432
defense response to other organism GO:0098542 197 0.426
Mouse Fly
macromolecule catabolic process GO:0009057 281 0.412
Fly
negative regulation of molecular function GO:0044092 258 0.409
embryonic epithelial tube formation GO:0001838 130 0.399
regulation of cation channel activity GO:2001257 22 0.393
Mouse
embryonic limb morphogenesis GO:0030326 126 0.388
respiratory tube development GO:0030323 167 0.386
positive regulation of ion transmembrane transport GO:0034767 24 0.384
Mouse
modification dependent macromolecule catabolic process GO:0043632 133 0.377
striated muscle contraction GO:0006941 45 0.370
purine ribonucleoside metabolic process GO:0046128 241 0.369
regulation of kinase activity GO:0043549 249 0.364
angiogenesis GO:0001525 201 0.349
protein catabolic process GO:0030163 221 0.348
Fly
positive regulation of apoptotic process GO:0043065 217 0.346
regulation of cellular amino acid metabolic process GO:0006521 5 0.343
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.341
circulatory system process GO:0003013 197 0.329
regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway GO:1902235 11 0.326
regulation of neuron differentiation GO:0045664 281 0.324
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.321
Fly
embryonic skeletal system morphogenesis GO:0048704 91 0.314
negative regulation of growth GO:0045926 99 0.307
regulation of neuron projection development GO:0010975 169 0.301
intracellular protein transport GO:0006886 204 0.300
type i interferon production GO:0032606 29 0.293
Mouse
peptide metabolic process GO:0006518 46 0.291
Fly
purine containing compound metabolic process GO:0072521 311 0.290
mammary gland epithelium development GO:0061180 65 0.287
antimicrobial peptide production GO:0002775 2 0.283
Fly
ion transmembrane transport GO:0034220 361 0.282
Mouse
synaptic vesicle localization GO:0097479 59 0.279
appendage morphogenesis GO:0035107 149 0.275
regulation of protein kinase activity GO:0045859 232 0.275
organonitrogen compound catabolic process GO:1901565 264 0.273
leukocyte differentiation GO:0002521 342 0.272
skin development GO:0043588 220 0.271
regulation of cytokine biosynthetic process GO:0042035 59 0.270
Mouse
purine ribonucleotide metabolic process GO:0009150 290 0.268
positive regulation of proteolysis GO:0045862 85 0.265
b cell homeostasis GO:0001782 34 0.262
Mouse
positive regulation of sodium ion transport GO:0010765 13 0.261
Mouse
regulation of organ morphogenesis GO:2000027 144 0.259
positive regulation of antimicrobial humoral response GO:0002760 2 0.255
Fly
cellular homeostasis GO:0019725 240 0.252
glycosyl compound metabolic process GO:1901657 246 0.252
blood circulation GO:0008015 195 0.250
embryonic organ morphogenesis GO:0048562 276 0.250
lactation GO:0007595 25 0.248
positive regulation of defense response to bacterium GO:1900426 1 0.247
Fly
protein targeting GO:0006605 143 0.243
chemotaxis GO:0006935 247 0.239
asymmetric neuroblast division GO:0055059 1 0.236
activation of immune response GO:0002253 138 0.235
Mouse
aromatic compound catabolic process GO:0019439 286 0.235
regulation of metal ion transport GO:0010959 106 0.234
Mouse
neuron projection guidance GO:0097485 141 0.229
purine nucleotide metabolic process GO:0006163 302 0.228
peptidyl amino acid modification GO:0018193 336 0.226
Fly
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.226
epithelial tube morphogenesis GO:0060562 303 0.225
morphogenesis of an epithelial sheet GO:0002011 27 0.224
positive regulation of cellular catabolic process GO:0031331 148 0.221
peptidyl serine modification GO:0018209 83 0.218
Fly
negative regulation of protein phosphorylation GO:0001933 126 0.214
positive regulation of cytokine biosynthetic process GO:0042108 40 0.213
Mouse
genetic imprinting GO:0071514 27 0.210
protein modification by small protein conjugation or removal GO:0070647 207 0.208
lipid localization GO:0010876 126 0.206
neuron apoptotic process GO:0051402 142 0.205
muscle contraction GO:0006936 101 0.205
regulation of cytokine production GO:0001817 266 0.204
Mouse
negative regulation of necroptotic process GO:0060546 9 0.204
positive regulation of secretion GO:0051047 130 0.203
wnt signaling pathway GO:0016055 188 0.202
ossification GO:0001503 216 0.202
regulation of cellular ketone metabolic process GO:0010565 66 0.193
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.192
carbohydrate derivative catabolic process GO:1901136 231 0.191
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.191
protein modification by small protein conjugation GO:0032446 187 0.190
regulation of cell projection organization GO:0031344 206 0.189
primary neural tube formation GO:0014020 95 0.187
respiratory system development GO:0060541 190 0.186
dna metabolic process GO:0006259 303 0.186
negative regulation of cell proliferation GO:0008285 296 0.184
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.183
negative regulation of apoptotic signaling pathway GO:2001234 104 0.183
cellular ketone metabolic process GO:0042180 84 0.182
cellular nitrogen compound catabolic process GO:0044270 280 0.181
mammary gland epithelial cell proliferation GO:0033598 24 0.180
negative regulation of protein modification process GO:0031400 163 0.179
synaptic transmission GO:0007268 329 0.178
regulation of cell cycle GO:0051726 281 0.176
cellularization GO:0007349 1 0.176
transmembrane transport GO:0055085 412 0.173
Mouse
appendage development GO:0048736 166 0.171
regulation of reactive oxygen species metabolic process GO:2000377 40 0.170
neurotransmitter secretion GO:0007269 62 0.169
neuron death GO:0070997 154 0.166
regulation of neurotransmitter levels GO:0001505 87 0.165
epithelial tube formation GO:0072175 130 0.165
actin cytoskeleton organization GO:0030036 220 0.163
regulation of cell motility GO:2000145 236 0.162
lung development GO:0030324 164 0.162
body fluid secretion GO:0007589 53 0.160
purine ribonucleotide catabolic process GO:0009154 208 0.159
cellular amine metabolic process GO:0044106 44 0.157
skeletal system morphogenesis GO:0048705 203 0.156
apoptotic signaling pathway GO:0097190 306 0.153
cytokine metabolic process GO:0042107 71 0.152
Mouse
cellular metal ion homeostasis GO:0006875 151 0.152
response to nutrient levels GO:0031667 109 0.151
nitrogen compound transport GO:0071705 271 0.151
mitochondrion organization GO:0007005 134 0.151
muscle cell proliferation GO:0033002 52 0.147
regulation of cellular component size GO:0032535 121 0.147
dendrite development GO:0016358 115 0.144
cellular macromolecule catabolic process GO:0044265 206 0.143
response to oxidative stress GO:0006979 123 0.141
nucleoside phosphate metabolic process GO:0006753 338 0.139
carbon catabolite regulation of transcription GO:0045990 4 0.138
cytokine production GO:0001816 319 0.138
Mouse
action potential GO:0001508 78 0.138
organelle localization GO:0051640 179 0.136
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.136
neuronal action potential GO:0019228 54 0.136
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.136
regulation of cellular amine metabolic process GO:0033238 20 0.135
organophosphate catabolic process GO:0046434 232 0.134
ripoptosome assembly involved in necroptotic process GO:1901026 6 0.133
positive regulation of kinase activity GO:0033674 155 0.133
single organism cell adhesion GO:0098602 156 0.133
regulation of anatomical structure size GO:0090066 178 0.133
regulation of protein serine threonine kinase activity GO:0071900 157 0.132
positive regulation of ion transport GO:0043270 65 0.131
Mouse
regulation of defense response to bacterium GO:1900424 3 0.130
Fly
regulation of membrane potential GO:0042391 192 0.130
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.129
positive regulation of defense response GO:0031349 124 0.129
Mouse Fly
embryonic appendage morphogenesis GO:0035113 126 0.127
organic cyclic compound catabolic process GO:1901361 295 0.126
ribonucleotide metabolic process GO:0009259 291 0.125
regulation of organelle organization GO:0033043 289 0.125
bone development GO:0060348 120 0.125
odontogenesis GO:0042476 78 0.124
blood vessel morphogenesis GO:0048514 285 0.124
negative regulation of epithelial cell proliferation GO:0050680 64 0.124
limb morphogenesis GO:0035108 149 0.124
immune effector process GO:0002252 321 0.123
Fly
positive regulation of transferase activity GO:0051347 167 0.122
organic anion transport GO:0015711 137 0.121
synapse organization GO:0050808 125 0.120
establishment or maintenance of cell polarity GO:0007163 86 0.120
hair follicle development GO:0001942 85 0.119
ubiquitin dependent protein catabolic process GO:0006511 129 0.119
neural tube formation GO:0001841 108 0.119
regulation of cell size GO:0008361 72 0.119
male gamete generation GO:0048232 285 0.118
cell division GO:0051301 120 0.118
synaptic vesicle transport GO:0048489 57 0.117
eye photoreceptor cell development GO:0042462 31 0.115
cytokine biosynthetic process GO:0042089 68 0.114
Mouse
negative regulation of cell cycle GO:0045786 123 0.114
mitotic cell cycle GO:0000278 195 0.112
positive regulation of osteoclast differentiation GO:0045672 15 0.110
extrinsic apoptotic signaling pathway GO:0097191 126 0.110
forebrain development GO:0030900 302 0.110
programmed necrotic cell death GO:0097300 28 0.106
reactive oxygen species metabolic process GO:0072593 84 0.106
protein localization to organelle GO:0033365 185 0.105
calcium ion homeostasis GO:0055074 127 0.105
nucleobase containing small molecule metabolic process GO:0055086 352 0.104
positive regulation of interferon alpha production GO:0032727 4 0.103
regulation of transporter activity GO:0032409 57 0.103
Mouse
positive regulation of cell migration GO:0030335 109 0.102
amine metabolic process GO:0009308 45 0.102
metal ion homeostasis GO:0055065 189 0.097
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.097
positive regulation of growth GO:0045927 104 0.097
nucleoside triphosphate metabolic process GO:0009141 230 0.097
negative regulation of protein metabolic process GO:0051248 282 0.093
epidermis development GO:0008544 187 0.093
regulation of protein complex assembly GO:0043254 83 0.092
t cell activation GO:0042110 289 0.092
regulation of secretion GO:0051046 274 0.090
organelle assembly GO:0070925 177 0.089
germ cell development GO:0007281 185 0.089
tube formation GO:0035148 140 0.089
axon guidance GO:0007411 141 0.088
spermatogenesis GO:0007283 284 0.088
positive regulation of type i interferon production GO:0032481 14 0.088
Mouse
purine nucleoside metabolic process GO:0042278 241 0.087
cation homeostasis GO:0055080 212 0.087
positive regulation of rac protein signal transduction GO:0035022 1 0.086
cellular amino acid metabolic process GO:0006520 103 0.086
histone acetylation GO:0016573 41 0.085
heterocycle catabolic process GO:0046700 280 0.085
neural tube closure GO:0001843 90 0.085
cation transport GO:0006812 399 0.085
Mouse
establishment of organelle localization GO:0051656 122 0.084
synapse assembly GO:0007416 56 0.084
activation of mapkk activity GO:0000186 15 0.083
regulation of fat cell differentiation GO:0045598 81 0.083
cell substrate adhesion GO:0031589 130 0.083
establishment or maintenance of apical basal cell polarity GO:0035088 21 0.082
cell fate determination GO:0001709 32 0.082
immune response activating signal transduction GO:0002757 116 0.082
regulation of secretion by cell GO:1903530 249 0.081
leukocyte homeostasis GO:0001776 79 0.081
Mouse
regulation of transferase activity GO:0051338 263 0.081
cellular response to dna damage stimulus GO:0006974 207 0.081
platelet derived growth factor receptor alpha signaling pathway GO:0035790 3 0.080
gliogenesis GO:0042063 141 0.080
antibacterial peptide biosynthetic process GO:0002780 2 0.080
Fly
regulation of epithelial cell proliferation GO:0050678 141 0.079
response to organic cyclic compound GO:0014070 198 0.078
intracellular cholesterol transport GO:0032367 3 0.078
cellular amide metabolic process GO:0043603 58 0.077
Fly
oocyte axis specification GO:0007309 2 0.077
epithelial cell development GO:0002064 159 0.077
negative regulation of cell cycle phase transition GO:1901988 48 0.077
microtubule based process GO:0007017 236 0.077
purine ribonucleoside catabolic process GO:0046130 205 0.077
establishment of protein localization to organelle GO:0072594 118 0.076
response to growth factor GO:0070848 198 0.076
modification dependent protein catabolic process GO:0019941 133 0.076
autophagy GO:0006914 45 0.076
posttranscriptional regulation of gene expression GO:0010608 155 0.075
peptidyl tyrosine phosphorylation GO:0018108 143 0.075
defense response to gram positive bacterium GO:0050830 50 0.075
Mouse
limb development GO:0060173 166 0.075
positive regulation of hydrolase activity GO:0051345 148 0.074
regulation of ion transport GO:0043269 215 0.074
Mouse
lung alveolus development GO:0048286 45 0.074
cellular response to extracellular stimulus GO:0031668 81 0.074
regulation of map kinase activity GO:0043405 120 0.073
regulation of type i interferon production GO:0032479 22 0.073
Mouse
cellular chemical homeostasis GO:0055082 215 0.072
single organismal cell cell adhesion GO:0016337 131 0.072
antimicrobial peptide biosynthetic process GO:0002777 2 0.072
Fly
regulation of neuron death GO:1901214 134 0.072
positive regulation of cell cycle GO:0045787 92 0.072
hair cycle GO:0042633 90 0.072
regulation of autophagy GO:0010506 30 0.071
multicellular organismal homeostasis GO:0048871 164 0.071
response to metal ion GO:0010038 47 0.070
negative regulation of response to endoplasmic reticulum stress GO:1903573 8 0.070
regulation of transmembrane transport GO:0034762 128 0.069
Mouse
female gamete generation GO:0007292 74 0.069
innate immune response GO:0045087 157 0.068
Mouse Fly
regulation of ion transmembrane transporter activity GO:0032412 54 0.068
Mouse
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 0.068
negative regulation of phosphate metabolic process GO:0045936 184 0.067
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.067
morphogenesis of a branching epithelium GO:0061138 193 0.066
regulation of keratinocyte differentiation GO:0045616 11 0.066
myeloid leukocyte activation GO:0002274 83 0.066
endomembrane system organization GO:0010256 147 0.065
regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000148 1 0.065
molting cycle GO:0042303 90 0.065
exocytosis GO:0006887 121 0.065
cell type specific apoptotic process GO:0097285 268 0.064
leukocyte proliferation GO:0070661 172 0.064
Mouse
endodermal cell fate specification GO:0001714 4 0.064
transmission of nerve impulse GO:0019226 76 0.064
muscle cell development GO:0055001 133 0.063
regulation of ossification GO:0030278 112 0.063
cellular response to cytokine stimulus GO:0071345 189 0.062
Human
ribose phosphate metabolic process GO:0019693 291 0.062
regulation of cellular catabolic process GO:0031329 242 0.062
positive regulation of protein kinase activity GO:0045860 144 0.062
positive regulation of cell death GO:0010942 224 0.061
tube closure GO:0060606 91 0.061
response to extracellular stimulus GO:0009991 127 0.061
regulation of endodermal cell fate specification GO:0042663 2 0.061
oocyte anterior posterior axis specification GO:0007314 2 0.060
embryonic digit morphogenesis GO:0042733 56 0.060
response to inorganic substance GO:0010035 96 0.060
foregut regionalization GO:0060423 3 0.060
regulation of myeloid leukocyte differentiation GO:0002761 58 0.060
muscle tissue development GO:0060537 308 0.059
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.059
regulation of proteolysis GO:0030162 164 0.059
central nervous system neuron differentiation GO:0021953 162 0.059
positive regulation of ossification GO:0045778 47 0.059
stem cell proliferation GO:0072089 117 0.059
embryonic hemopoiesis GO:0035162 23 0.058
negative regulation of kinase activity GO:0033673 81 0.058
response to sterol GO:0036314 4 0.057
organelle fission GO:0048285 170 0.057
regulation of neuron apoptotic process GO:0043523 122 0.057
neurotransmitter transport GO:0006836 76 0.057
multicellular organism growth GO:0035264 161 0.056
ribonucleoside metabolic process GO:0009119 245 0.056
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.056
neural tube development GO:0021915 160 0.056
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.056
endodermal cell fate commitment GO:0001711 12 0.055
regulation of mitotic cell cycle phase transition GO:1901990 73 0.055
keratinocyte differentiation GO:0030216 48 0.055
camera type eye photoreceptor cell differentiation GO:0060219 15 0.054
cell maturation GO:0048469 127 0.054
ribonucleoside monophosphate metabolic process GO:0009161 80 0.054
regulation of ripoptosome assembly involved in necroptotic process GO:1902442 3 0.054
negative regulation of cell motility GO:2000146 61 0.054
attachment of spindle microtubules to kinetochore GO:0008608 4 0.053
small molecule catabolic process GO:0044282 71 0.053
regulation of system process GO:0044057 200 0.053
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.052
compound eye development GO:0048749 1 0.052
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.052
regulation of cellular response to growth factor stimulus GO:0090287 82 0.052
digestive system development GO:0055123 200 0.052
Zebrafish
regulation of neuronal synaptic plasticity GO:0048168 30 0.052
purine nucleoside triphosphate catabolic process GO:0009146 203 0.051
oxidation reduction process GO:0055114 342 0.051
canonical wnt signaling pathway GO:0060070 130 0.051
hemostasis GO:0007599 78 0.051
positive regulation of cell development GO:0010720 237 0.051
oocyte differentiation GO:0009994 35 0.050
nucleobase containing compound transport GO:0015931 27 0.050
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.050
negative regulation of phosphorylation GO:0042326 166 0.050
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.049
g protein coupled receptor signaling pathway GO:0007186 243 0.049
regulation of camp biosynthetic process GO:0030817 25 0.049
positive regulation of programmed cell death GO:0043068 218 0.048
activation of jnkk activity GO:0007256 3 0.048
response to acid chemical GO:0001101 111 0.048
cellular protein complex assembly GO:0043623 116 0.048
purine nucleotide catabolic process GO:0006195 211 0.048
cardiac chamber development GO:0003205 108 0.048
response to fatty acid GO:0070542 8 0.048
lipid storage GO:0019915 36 0.047
nucleotide metabolic process GO:0009117 332 0.047
peptidyl lysine modification GO:0018205 77 0.047
regulation of cell migration GO:0030334 219 0.047
cellular divalent inorganic cation homeostasis GO:0072503 127 0.047
regulation of epithelial cell migration GO:0010632 35 0.047
photoreceptor cell differentiation GO:0046530 52 0.047
positive regulation of transporter activity GO:0032411 17 0.046
Mouse
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.046
establishment of synaptic vesicle localization GO:0097480 57 0.046
negative regulation of lymphocyte activation GO:0051250 91 0.046
chondrocyte differentiation GO:0002062 72 0.046
proteasomal protein catabolic process GO:0010498 98 0.046
regulation of purine nucleotide metabolic process GO:1900542 169 0.046
internal protein amino acid acetylation GO:0006475 42 0.046
heparan sulfate proteoglycan metabolic process GO:0030201 10 0.046
peptidyl serine phosphorylation GO:0018105 74 0.045
Fly
segmentation GO:0035282 93 0.045
Zebrafish
oogenesis GO:0048477 56 0.045
keratinocyte proliferation GO:0043616 21 0.045
cellular transition metal ion homeostasis GO:0046916 32 0.045
regulation of antimicrobial peptide production GO:0002784 1 0.044
Fly
organophosphate biosynthetic process GO:0090407 122 0.044
mitochondrial transport GO:0006839 36 0.044
dna templated transcription initiation GO:0006352 13 0.044
regulation of ras gtpase activity GO:0032318 88 0.044
regulation of mapk cascade GO:0043408 248 0.044
spermatid differentiation GO:0048515 115 0.044
nucleotide biosynthetic process GO:0009165 78 0.044
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.044
regulation of cellular protein catabolic process GO:1903362 61 0.043
regulation of protein secretion GO:0050708 82 0.043
ribonucleoside triphosphate metabolic process GO:0009199 220 0.042
pattern recognition receptor signaling pathway GO:0002221 47 0.042
regulation of canonical wnt signaling pathway GO:0060828 82 0.042
regulation of protein catabolic process GO:0042176 108 0.042
regulation of epidermis development GO:0045682 33 0.042
embryonic placenta development GO:0001892 98 0.042
multicellular organismal signaling GO:0035637 91 0.041
renal system development GO:0072001 225 0.041
humoral immune response GO:0006959 57 0.041
Fly
cellular ion homeostasis GO:0006873 165 0.041
urogenital system development GO:0001655 261 0.041
intracellular lipid transport GO:0032365 3 0.040
response to radiation GO:0009314 165 0.040
positive regulation of nervous system development GO:0051962 221 0.040
eye photoreceptor cell differentiation GO:0001754 41 0.040
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.040
regulation of protein transport GO:0051223 163 0.040
regulation of endocytosis GO:0030100 69 0.040
regulation of nucleocytoplasmic transport GO:0046822 73 0.040
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.039
innate immune response activating signal transduction GO:0002758 50 0.039
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.039
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.039
lymphocyte proliferation GO:0046651 164 0.038
Mouse
regulation of cytoskeleton organization GO:0051493 122 0.038
jak stat cascade GO:0007259 42 0.038
pallium development GO:0021543 120 0.038
cardiac muscle tissue development GO:0048738 130 0.037
digestive tract development GO:0048565 190 0.037
Zebrafish
response to organonitrogen compound GO:0010243 246 0.037
asymmetric cell division GO:0008356 8 0.037
lymphocyte activation involved in immune response GO:0002285 93 0.037
mesenchyme development GO:0060485 152 0.037
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.037
regulation of hydrolase activity GO:0051336 246 0.037
formation of radial glial scaffolds GO:0021943 4 0.037
anion transport GO:0006820 177 0.037
morphogenesis of a polarized epithelium GO:0001738 37 0.037
nucleoside monophosphate catabolic process GO:0009125 59 0.037
somatic stem cell maintenance GO:0035019 47 0.037
divalent inorganic cation homeostasis GO:0072507 138 0.037
response to tumor necrosis factor GO:0034612 26 0.036
Human
positive regulation of leukocyte differentiation GO:1902107 86 0.036
intracellular sterol transport GO:0032366 3 0.036
purine nucleoside monophosphate catabolic process GO:0009128 58 0.036
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.036
asymmetric stem cell division GO:0098722 3 0.036
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.036
mapk cascade GO:0000165 281 0.035
positive regulation of peptidase activity GO:0010952 49 0.035
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.035
establishment of tissue polarity GO:0007164 28 0.035
receptor mediated endocytosis GO:0006898 51 0.035
tissue homeostasis GO:0001894 115 0.035
positive regulation of protein localization to nucleus GO:1900182 30 0.035
negative regulation of epidermal growth factor activated receptor activity GO:0007175 3 0.034
ribonucleoside catabolic process GO:0042454 206 0.034
organic hydroxy compound metabolic process GO:1901615 203 0.034
germ line stem cell division GO:0042078 2 0.034
oocyte construction GO:0007308 2 0.034
multi multicellular organism process GO:0044706 109 0.034
regulation of neurotransmitter secretion GO:0046928 29 0.033
visual perception GO:0007601 52 0.033
regulation of neurotransmitter transport GO:0051588 35 0.033
peptidyl lysine acetylation GO:0018394 45 0.033
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.033
establishment or maintenance of bipolar cell polarity GO:0061245 21 0.033

Chuk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.397
cancer DOID:162 0 0.155
organ system cancer DOID:0050686 0 0.155
disease of anatomical entity DOID:7 0 0.100
integumentary system disease DOID:16 0 0.100
large intestine cancer DOID:5672 0 0.079
colon cancer DOID:219 0 0.079
gastrointestinal system cancer DOID:3119 0 0.079
intestinal cancer DOID:10155 0 0.079
colorectal cancer DOID:9256 0 0.079
disease of metabolism DOID:0014667 0 0.069
urinary system cancer DOID:3996 0 0.069
skin disease DOID:37 0 0.066
inherited metabolic disorder DOID:655 0 0.041