Mus musculus

27 known processes

Tpi1

triosephosphate isomerase 1

(Aliases: AI255506,Tpi-1,Tpi)

Tpi1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
pyruvate metabolic process GO:0006090 28 0.999
Fly
glycolytic process GO:0006096 20 0.999
Fly
ribonucleoside monophosphate biosynthetic process GO:0009156 9 0.996
hexose catabolic process GO:0019320 3 0.996
carbohydrate catabolic process GO:0016052 32 0.989
Fly
generation of precursor metabolites and energy GO:0006091 103 0.984
Fly
apoptotic mitochondrial changes GO:0008637 48 0.911
atp metabolic process GO:0046034 75 0.910
ribose phosphate biosynthetic process GO:0046390 59 0.887
monocarboxylic acid metabolic process GO:0032787 191 0.887
Fly
lactate biosynthetic process GO:0019249 4 0.874
hexose metabolic process GO:0019318 98 0.836
carboxylic acid biosynthetic process GO:0046394 86 0.824
monosaccharide metabolic process GO:0005996 106 0.815
carbohydrate metabolic process GO:0005975 230 0.761
purine nucleoside biosynthetic process GO:0042451 19 0.748
nucleoside metabolic process GO:0009116 246 0.684
myosin filament organization GO:0031033 3 0.672
Worm
purine nucleoside monophosphate biosynthetic process GO:0009127 9 0.671
sperm motility GO:0030317 47 0.662
ribonucleoside triphosphate metabolic process GO:0009199 220 0.643
ribonucleoside monophosphate metabolic process GO:0009161 80 0.613
purine ribonucleoside biosynthetic process GO:0046129 19 0.613
purine nucleoside triphosphate metabolic process GO:0009144 226 0.609
pentose phosphate shunt GO:0006098 2 0.606
purine ribonucleotide metabolic process GO:0009150 290 0.606
nucleotide metabolic process GO:0009117 332 0.603
purine nucleotide biosynthetic process GO:0006164 65 0.593
purine ribonucleotide biosynthetic process GO:0009152 59 0.579
oxidation reduction process GO:0055114 342 0.575
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.570
purine containing compound metabolic process GO:0072521 311 0.558
response to hypoxia GO:0001666 58 0.529
nucleoside phosphate metabolic process GO:0006753 338 0.502
purine nucleoside monophosphate metabolic process GO:0009126 81 0.459
carbohydrate derivative biosynthetic process GO:1901137 183 0.446
nucleoside biosynthetic process GO:0009163 21 0.441
nucleoside monophosphate metabolic process GO:0009123 85 0.433
response to decreased oxygen levels GO:0036293 59 0.431
ribonucleoside biosynthetic process GO:0042455 21 0.399
purine nucleoside metabolic process GO:0042278 241 0.390
ribonucleotide metabolic process GO:0009259 291 0.376
nucleoside phosphate biosynthetic process GO:1901293 79 0.376
nadph regeneration GO:0006740 2 0.353
nucleobase containing small molecule metabolic process GO:0055086 352 0.343
nitrogen compound transport GO:0071705 271 0.341
purine ribonucleoside metabolic process GO:0046128 241 0.311
purine nucleoside triphosphate biosynthetic process GO:0009145 7 0.309
nucleoside triphosphate metabolic process GO:0009141 230 0.305
glucose catabolic process GO:0006007 3 0.303
glycosyl compound biosynthetic process GO:1901659 21 0.277
purine containing compound biosynthetic process GO:0072522 70 0.240
purine nucleotide metabolic process GO:0006163 302 0.230
substantia nigra development GO:0021762 2 0.220
neural nucleus development GO:0048857 22 0.219
ribose phosphate metabolic process GO:0019693 291 0.215
energy derivation by oxidation of organic compounds GO:0015980 77 0.215
carbohydrate phosphorylation GO:0046835 15 0.215
organic hydroxy compound biosynthetic process GO:1901617 77 0.211
cellular aldehyde metabolic process GO:0006081 12 0.199
negative regulation of cellular protein metabolic process GO:0032269 247 0.194
cellular response to external stimulus GO:0071496 88 0.187
response to oxygen levels GO:0070482 62 0.173
glucose homeostasis GO:0042593 128 0.170
cellular response to extracellular stimulus GO:0031668 81 0.165
positive regulation of apoptotic process GO:0043065 217 0.150
cellular amino acid metabolic process GO:0006520 103 0.148
response to nicotine GO:0035094 6 0.145
hormone secretion GO:0046879 128 0.142
ribonucleotide biosynthetic process GO:0009260 59 0.142
amide transport GO:0042886 138 0.138
organonitrogen compound biosynthetic process GO:1901566 192 0.133
glycosyl compound metabolic process GO:1901657 246 0.133
mesoderm morphogenesis GO:0048332 64 0.131
cellular homeostasis GO:0019725 240 0.120
Worm
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.114
purine ribonucleoside monophosphate biosynthetic process GO:0009168 9 0.113
insulin secretion GO:0030073 89 0.112
regulation of hormone levels GO:0010817 211 0.112
pigmentation GO:0043473 71 0.106
monosaccharide catabolic process GO:0046365 5 0.099
regulation of peptide secretion GO:0002791 77 0.098
nucleoside monophosphate biosynthetic process GO:0009124 12 0.094
cellular response to dna damage stimulus GO:0006974 207 0.092
somitogenesis GO:0001756 69 0.092
lipid localization GO:0010876 126 0.089
organic hydroxy compound metabolic process GO:1901615 203 0.086
muscle contraction GO:0006936 101 0.085
regulation of cell cycle GO:0051726 281 0.079
formation of primary germ layer GO:0001704 77 0.077
mesoderm formation GO:0001707 62 0.075
regulation of translation GO:0006417 71 0.074
negative regulation of cell cycle phase transition GO:1901988 48 0.073
midbrain development GO:0030901 35 0.072
monocarboxylic acid biosynthetic process GO:0072330 61 0.070
carbohydrate biosynthetic process GO:0016051 74 0.070
positive regulation of hormone secretion GO:0046887 38 0.070
response to organic cyclic compound GO:0014070 198 0.066
ribonucleoside metabolic process GO:0009119 245 0.065
mitotic cell cycle GO:0000278 195 0.065
ribonucleoside triphosphate biosynthetic process GO:0009201 6 0.064
regulation of peptide transport GO:0090087 91 0.063
negative regulation of protein metabolic process GO:0051248 282 0.058
mitotic cell cycle checkpoint GO:0007093 31 0.056
apoptotic signaling pathway GO:0097190 306 0.056
anatomical structure homeostasis GO:0060249 145 0.056
positive regulation of growth GO:0045927 104 0.056
regulation of cellular amino acid metabolic process GO:0006521 5 0.053
regulation of coenzyme metabolic process GO:0051196 4 0.052
regulation of cellular amine metabolic process GO:0033238 20 0.051
alpha amino acid metabolic process GO:1901605 59 0.051
negative regulation of mitotic cell cycle GO:0045930 58 0.050
nucleotide biosynthetic process GO:0009165 78 0.050
regulation of mitotic cell cycle GO:0007346 126 0.050
organophosphate biosynthetic process GO:0090407 122 0.049
response to estrogen GO:0043627 24 0.049
fructose 6 phosphate metabolic process GO:0006002 1 0.048
oxidoreduction coenzyme metabolic process GO:0006733 16 0.048
response to heat GO:0009408 27 0.047
regulation of membrane potential GO:0042391 192 0.047
muscle system process GO:0003012 141 0.046
protein targeting GO:0006605 143 0.046
striated muscle contraction GO:0006941 45 0.046
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.046
positive regulation of peptide secretion GO:0002793 33 0.046
carbohydrate homeostasis GO:0033500 128 0.044
protein catabolic process GO:0030163 221 0.042
positive regulation of programmed cell death GO:0043068 218 0.042
cellular amine metabolic process GO:0044106 44 0.041
regulation of cellular catabolic process GO:0031329 242 0.040
multi multicellular organism process GO:0044706 109 0.040
cellular modified amino acid metabolic process GO:0006575 63 0.040
purine ribonucleoside triphosphate biosynthetic process GO:0009206 6 0.040
gluconeogenesis GO:0006094 39 0.040
maintenance of location GO:0051235 89 0.040
response to oxidative stress GO:0006979 123 0.039
nucleoside triphosphate biosynthetic process GO:0009142 8 0.038
positive regulation of cell death GO:0010942 224 0.038
organic acid biosynthetic process GO:0016053 86 0.038
negative regulation of molecular function GO:0044092 258 0.037
myeloid cell homeostasis GO:0002262 114 0.037
activation of cysteine type endopeptidase activity GO:0097202 27 0.036
monosaccharide biosynthetic process GO:0046364 44 0.036
positive regulation of apoptotic signaling pathway GO:2001235 95 0.036
response to inorganic substance GO:0010035 96 0.035
negative regulation of cell cycle GO:0045786 123 0.035
male gamete generation GO:0048232 285 0.035
reactive oxygen species metabolic process GO:0072593 84 0.034
spermatogenesis GO:0007283 284 0.034
cellular carbohydrate catabolic process GO:0044275 15 0.033
aromatic compound catabolic process GO:0019439 286 0.033
inorganic cation transmembrane transport GO:0098662 207 0.032
response to organonitrogen compound GO:0010243 246 0.031
cellular amide metabolic process GO:0043603 58 0.031
transmembrane transport GO:0055085 412 0.030
regulation of cellular ketone metabolic process GO:0010565 66 0.030
striated muscle myosin thick filament assembly GO:0071688 1 0.030
Worm
amine metabolic process GO:0009308 45 0.030
regulation of glycolytic process GO:0006110 10 0.029
defecation GO:0030421 1 0.029
glucose metabolic process GO:0006006 92 0.029
regulation of protein kinase activity GO:0045859 232 0.029
regulation of apoptotic signaling pathway GO:2001233 197 0.028
regulation of proteolysis GO:0030162 164 0.028
regulation of organelle organization GO:0033043 289 0.028
placenta development GO:0001890 140 0.027
regulation of purine nucleotide metabolic process GO:1900542 169 0.027
cytoplasmic transport GO:0016482 234 0.027
determination of adult lifespan GO:0008340 11 0.027
Worm Fly
negative regulation of peptide secretion GO:0002792 16 0.027
homeostasis of number of cells GO:0048872 210 0.026
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.026
intrinsic apoptotic signaling pathway GO:0097193 132 0.026
heterocycle catabolic process GO:0046700 280 0.025
intracellular protein transport GO:0006886 204 0.024
positive regulation of cellular amine metabolic process GO:0033240 5 0.024
cofactor metabolic process GO:0051186 80 0.024
regulation of nucleotide metabolic process GO:0006140 169 0.024
protein processing GO:0016485 163 0.024
regulation of hydrolase activity GO:0051336 246 0.023
regulation of endopeptidase activity GO:0052548 89 0.023
release of cytochrome c from mitochondria GO:0001836 23 0.023
genitalia development GO:0048806 37 0.023
regulation of release of cytochrome c from mitochondria GO:0090199 11 0.023
myofibril assembly GO:0030239 34 0.023
Worm
muscle cell development GO:0055001 133 0.023
Worm
chromatin organization GO:0006325 206 0.022
neuron neuron synaptic transmission GO:0007270 69 0.022
response to lipopolysaccharide GO:0032496 128 0.022
organonitrogen compound catabolic process GO:1901565 264 0.022
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.022
protein modification by small protein conjugation GO:0032446 187 0.022
small molecule biosynthetic process GO:0044283 132 0.022
sulfur compound metabolic process GO:0006790 100 0.021
regulation of cofactor metabolic process GO:0051193 5 0.021
positive regulation of hydrolase activity GO:0051345 148 0.021
protein ubiquitination GO:0016567 171 0.021
negative regulation of phosphorus metabolic process GO:0010563 184 0.021
neuron apoptotic process GO:0051402 142 0.021
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.021
positive regulation of peptide hormone secretion GO:0090277 31 0.021
ribonucleoside catabolic process GO:0042454 206 0.020
t cell activation GO:0042110 289 0.020
cation transmembrane transport GO:0098655 266 0.020
cation homeostasis GO:0055080 212 0.020
cellular divalent inorganic cation homeostasis GO:0072503 127 0.020
regulation of interleukin 8 production GO:0032677 3 0.020
proton transport GO:0015992 35 0.020
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.020
regulation of neuron apoptotic process GO:0043523 122 0.020
aldehyde catabolic process GO:0046185 4 0.020
mitochondrion organization GO:0007005 134 0.020
regulation of transferase activity GO:0051338 263 0.020
regulation of protein serine threonine kinase activity GO:0071900 157 0.020
regulation of cell cycle phase transition GO:1901987 77 0.020
regulation of protein localization GO:0032880 231 0.019
skin development GO:0043588 220 0.019
regulation of nucleoside metabolic process GO:0009118 130 0.019
gonad development GO:0008406 141 0.019
digestive tract morphogenesis GO:0048546 147 0.018
regulation of lymphocyte activation GO:0051249 240 0.018
cellular lipid metabolic process GO:0044255 323 0.018
neuron death GO:0070997 154 0.018
regionalization GO:0003002 337 0.018
regulation of cell activation GO:0050865 289 0.017
somite development GO:0061053 81 0.017
galactose metabolic process GO:0006012 4 0.017
cation transport GO:0006812 399 0.017
nucleotide sugar metabolic process GO:0009225 4 0.017
regulation of oxidative phosphorylation uncoupler activity GO:2000275 3 0.017
nucleoside phosphate catabolic process GO:1901292 222 0.017
cellular ion homeostasis GO:0006873 165 0.017
nadp metabolic process GO:0006739 6 0.017
dopamine uptake involved in synaptic transmission GO:0051583 4 0.017
regulation of cell shape GO:0008360 39 0.016
energy reserve metabolic process GO:0006112 39 0.016
macromolecule catabolic process GO:0009057 281 0.016
carbohydrate derivative catabolic process GO:1901136 231 0.016
regulation of leukocyte proliferation GO:0070663 121 0.016
positive regulation of nucleoside metabolic process GO:0045979 91 0.016
regulation of cell cycle process GO:0010564 160 0.016
nuclear transport GO:0051169 139 0.016
cell type specific apoptotic process GO:0097285 268 0.016
epithelial cell development GO:0002064 159 0.016
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.016
protein oligomerization GO:0051259 67 0.016
regulation of response to wounding GO:1903034 189 0.015
cellular nitrogen compound catabolic process GO:0044270 280 0.015
regulation of ion transport GO:0043269 215 0.015
inorganic ion transmembrane transport GO:0098660 234 0.015
negative regulation of cell cycle process GO:0010948 69 0.015
metal ion homeostasis GO:0055065 189 0.015
epithelial tube morphogenesis GO:0060562 303 0.015
regulation of chromatin modification GO:1903308 57 0.015
mesoderm development GO:0007498 100 0.015
synaptic transmission GO:0007268 329 0.014
regulation of cytokine production GO:0001817 266 0.014
endomembrane system organization GO:0010256 147 0.014
regulation of cysteine type endopeptidase activity GO:2000116 65 0.014
mitotic cell cycle process GO:1903047 159 0.014
response to steroid hormone GO:0048545 56 0.014
regulation of glucose metabolic process GO:0010906 60 0.014
regulation of secretion GO:0051046 274 0.014
positive regulation of proteolysis GO:0045862 85 0.014
protein maturation GO:0051604 176 0.014
protein modification by small protein conjugation or removal GO:0070647 207 0.014
regulation of nucleocytoplasmic transport GO:0046822 73 0.014
t cell proliferation GO:0042098 120 0.014
lymphocyte proliferation GO:0046651 164 0.014
regulation of secretion by cell GO:1903530 249 0.014
fat cell differentiation GO:0045444 160 0.014
g0 to g1 transition GO:0045023 3 0.014
leukocyte proliferation GO:0070661 172 0.013
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.013
organic hydroxy compound transport GO:0015850 93 0.013
alcohol metabolic process GO:0006066 116 0.013
hydrogen transport GO:0006818 35 0.013
regulation of transmembrane transport GO:0034762 128 0.013
regulation of oxidative phosphorylation GO:0002082 6 0.013
removal of superoxide radicals GO:0019430 12 0.013
cellular respiration GO:0045333 38 0.013
divalent metal ion transport GO:0070838 172 0.013
cellular ketone metabolic process GO:0042180 84 0.013
purine nucleoside triphosphate catabolic process GO:0009146 203 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.013
regulation of binding GO:0051098 111 0.013
modification dependent macromolecule catabolic process GO:0043632 133 0.013
reactive oxygen species biosynthetic process GO:1903409 8 0.013
regulation of chromosome organization GO:0033044 83 0.013
epithelial cell proliferation GO:0050673 174 0.013
cellular carbohydrate metabolic process GO:0044262 119 0.013
positive regulation of protein modification process GO:0031401 299 0.013
peptidyl amino acid modification GO:0018193 336 0.013
wound healing GO:0042060 157 0.013
response to temperature stimulus GO:0009266 55 0.013
protein deacetylation GO:0006476 32 0.013
cellular component assembly involved in morphogenesis GO:0010927 139 0.013
Worm
regulation of transporter activity GO:0032409 57 0.013
fructose metabolic process GO:0006000 1 0.013
response to extracellular stimulus GO:0009991 127 0.012
cell fate commitment GO:0045165 210 0.012
negative regulation of phosphorylation GO:0042326 166 0.012
regulation of peptidase activity GO:0052547 96 0.012
negative regulation of neuron apoptotic process GO:0043524 92 0.012
peptide transport GO:0015833 133 0.012
regulation of t cell activation GO:0050863 170 0.012
compound eye development GO:0048749 1 0.012
peptide hormone secretion GO:0030072 109 0.012
negative regulation of translation GO:0017148 22 0.012
negative regulation of protein modification process GO:0031400 163 0.012
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.012
regulation of androgen receptor signaling pathway GO:0060765 3 0.012
positive regulation of binding GO:0051099 49 0.012
ion transmembrane transport GO:0034220 361 0.011
purine nucleotide catabolic process GO:0006195 211 0.011
positive regulation of kinase activity GO:0033674 155 0.011
positive regulation of protein phosphorylation GO:0001934 242 0.011
regulation of purine nucleotide catabolic process GO:0033121 122 0.011
negative regulation of neuron death GO:1901215 98 0.011
myosin filament assembly GO:0031034 2 0.011
Worm
negative regulation of phosphate metabolic process GO:0045936 184 0.011
protein homotetramerization GO:0051289 12 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.011
positive regulation of transferase activity GO:0051347 167 0.011
negative regulation of oxidative stress induced cell death GO:1903202 9 0.011
regulation of mapk cascade GO:0043408 248 0.011
negative regulation of hydrolase activity GO:0051346 71 0.011
chromatin modification GO:0016568 187 0.011
purine containing compound catabolic process GO:0072523 213 0.011
regulation of generation of precursor metabolites and energy GO:0043467 38 0.011
lateral inhibition GO:0046331 1 0.011
regulation of establishment of protein localization GO:0070201 181 0.011
leukocyte differentiation GO:0002521 342 0.011
peptide secretion GO:0002790 114 0.011
peptidyl proline hydroxylation GO:0019511 3 0.011
alditol metabolic process GO:0019400 5 0.011
mapk cascade GO:0000165 281 0.010
cellular response to cytokine stimulus GO:0071345 189 0.010
tricarboxylic acid metabolic process GO:0072350 5 0.010
organophosphate catabolic process GO:0046434 232 0.010
atp synthesis coupled electron transport GO:0042773 8 0.010
inflammatory response GO:0006954 244 0.010
purine ribonucleoside catabolic process GO:0046130 205 0.010
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.010
regulation of neurotransmitter levels GO:0001505 87 0.010
positive regulation of transmembrane transport GO:0034764 29 0.010
cellular response to organonitrogen compound GO:0071417 145 0.010
asymmetric stem cell division GO:0098722 3 0.010
negative regulation of protein phosphorylation GO:0001933 126 0.010
renal system development GO:0072001 225 0.010
cell cycle checkpoint GO:0000075 47 0.010
histone modification GO:0016570 159 0.010
translation GO:0006412 93 0.010
negative regulation of transferase activity GO:0051348 85 0.010

Tpi1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.822
disease of anatomical entity DOID:7 0 0.822
hemolytic anemia DOID:583 0 0.257
normocytic anemia DOID:720 0 0.257
anemia DOID:2355 0 0.257
hematopoietic system disease DOID:74 0 0.257
central nervous system disease DOID:331 0 0.113
neurodegenerative disease DOID:1289 0 0.113
nervous system disease DOID:863 0 0.113
disease of metabolism DOID:0014667 0 0.020
Human
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
organ system cancer DOID:0050686 0 0.010