Mus musculus

445 known processes

Sirt1

sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)

(Aliases: SIR2L1,Sir2alpha,AA673258,Sir2,Sir2a,MGC150273)

Sirt1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 207 0.953
rhythmic process GO:0048511 174 0.951
positive regulation of apoptotic process GO:0043065 217 0.946
covalent chromatin modification GO:0016569 163 0.943
hexose metabolic process GO:0019318 98 0.935
protein localization to organelle GO:0033365 185 0.930
Human
chromatin organization GO:0006325 206 0.929
histone modification GO:0016570 159 0.925
regulation of intracellular steroid hormone receptor signaling pathway GO:0033143 18 0.910
Human
regulation of cell cycle GO:0051726 281 0.895
Human
chromatin modification GO:0016568 187 0.893
regulation of fatty acid oxidation GO:0046320 10 0.886
response to radiation GO:0009314 165 0.886
gluconeogenesis GO:0006094 39 0.876
myeloid cell differentiation GO:0030099 233 0.875
apoptotic signaling pathway GO:0097190 306 0.874
gland development GO:0048732 330 0.865
protein modification by small protein conjugation GO:0032446 187 0.859
Human
positive regulation of apoptotic signaling pathway GO:2001235 95 0.837
monosaccharide metabolic process GO:0005996 106 0.830
modification dependent macromolecule catabolic process GO:0043632 133 0.826
Human
signal transduction by p53 class mediator GO:0072331 51 0.817
negative regulation of molecular function GO:0044092 258 0.810
Human
positive regulation of fatty acid oxidation GO:0046321 4 0.804
negative regulation of transferase activity GO:0051348 85 0.793
Human
regulation of gluconeogenesis GO:0006111 30 0.792
dna metabolic process GO:0006259 303 0.786
regulation of fatty acid metabolic process GO:0019217 28 0.776
negative regulation of protein modification process GO:0031400 163 0.776
Human
regulation of cell cycle process GO:0010564 160 0.765
cellular carbohydrate metabolic process GO:0044262 119 0.750
negative regulation of cell proliferation GO:0008285 296 0.729
cellular ketone metabolic process GO:0042180 84 0.714
multicellular organism growth GO:0035264 161 0.705
cellular response to radiation GO:0071478 28 0.700
response to hypoxia GO:0001666 58 0.685
Human
histone acetylation GO:0016573 41 0.676
Worm Fly
branching morphogenesis of an epithelial tube GO:0048754 159 0.657
regulation of response to dna damage stimulus GO:2001020 34 0.655
modification dependent protein catabolic process GO:0019941 133 0.654
Human
cell cycle checkpoint GO:0000075 47 0.651
positive regulation of programmed cell death GO:0043068 218 0.647
fibroblast proliferation GO:0048144 35 0.643
negative regulation of cell cycle GO:0045786 123 0.620
response to light stimulus GO:0009416 135 0.617
regulation of lipid metabolic process GO:0019216 118 0.615
intracellular receptor signaling pathway GO:0030522 74 0.613
cell type specific apoptotic process GO:0097285 268 0.609
male gamete generation GO:0048232 285 0.609
generation of precursor metabolites and energy GO:0006091 103 0.607
intrinsic apoptotic signaling pathway GO:0097193 132 0.603
erythrocyte differentiation GO:0030218 88 0.599
negative regulation of phosphorus metabolic process GO:0010563 184 0.595
regulation of cell cycle checkpoint GO:1901976 9 0.584
hexose biosynthetic process GO:0019319 39 0.578
maintenance of location GO:0051235 89 0.569
striated muscle tissue development GO:0014706 293 0.568
organelle fission GO:0048285 170 0.568
oxidation reduction process GO:0055114 342 0.568
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.566
cellular protein catabolic process GO:0044257 155 0.566
Human
response to decreased oxygen levels GO:0036293 59 0.557
Human
b cell activation GO:0042113 161 0.557
circadian rhythm GO:0007623 114 0.557
regulation of carbohydrate metabolic process GO:0006109 75 0.557
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.553
Human
cellular calcium ion homeostasis GO:0006874 119 0.552
cellular response to peptide hormone stimulus GO:0071375 92 0.550
Human
regulation of circadian rhythm GO:0042752 58 0.540
carbohydrate biosynthetic process GO:0016051 74 0.529
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.525
Human
response to extracellular stimulus GO:0009991 127 0.518
response to organonitrogen compound GO:0010243 246 0.511
lipid storage GO:0019915 36 0.506
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.489
carbohydrate metabolic process GO:0005975 230 0.484
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.474
Human
negative regulation of protein metabolic process GO:0051248 282 0.473
Human
cellular lipid metabolic process GO:0044255 323 0.458
steroid metabolic process GO:0008202 119 0.435
negative regulation of phosphate metabolic process GO:0045936 184 0.431
regulation of cell cycle phase transition GO:1901987 77 0.429
response to peptide hormone GO:0043434 127 0.417
monocarboxylic acid metabolic process GO:0032787 191 0.406
regulation of hormone levels GO:0010817 211 0.404
peptidyl amino acid modification GO:0018193 336 0.403
Human Worm Fly
protein modification by small protein conjugation or removal GO:0070647 207 0.398
Human
protein deacetylation GO:0006476 32 0.395
monosaccharide biosynthetic process GO:0046364 44 0.388
negative regulation of dna replication GO:0008156 4 0.383
negative regulation of cell cycle phase transition GO:1901988 48 0.379
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.379
Human
mitotic cell cycle GO:0000278 195 0.378
Human
regulation of dna damage checkpoint GO:2000001 3 0.377
lipid modification GO:0030258 65 0.374
response to organic cyclic compound GO:0014070 198 0.374
Human
protein localization to nucleus GO:0034504 121 0.369
Human
dna damage checkpoint GO:0000077 26 0.369
protein ubiquitination GO:0016567 171 0.366
Human
regulation of myeloid cell differentiation GO:0045637 96 0.362
regulation of peptidase activity GO:0052547 96 0.359
Human
muscle cell differentiation GO:0042692 261 0.352
maternal process involved in female pregnancy GO:0060135 32 0.352
negative regulation of cellular protein metabolic process GO:0032269 247 0.350
Human
development of primary sexual characteristics GO:0045137 143 0.346
spermatogenesis GO:0007283 284 0.340
skeletal muscle cell differentiation GO:0035914 66 0.337
male meiosis GO:0007140 37 0.335
macromolecule catabolic process GO:0009057 281 0.320
Human
myeloid leukocyte differentiation GO:0002573 119 0.319
response to nutrient levels GO:0031667 109 0.318
regulation of leukocyte differentiation GO:1902105 159 0.317
positive regulation of endopeptidase activity GO:0010950 43 0.317
Human
regulation of cellular ketone metabolic process GO:0010565 66 0.316
positive regulation of gluconeogenesis GO:0045722 11 0.312
regulation of mitotic cell cycle phase transition GO:1901990 73 0.309
sensory perception GO:0007600 245 0.309
circadian sleep wake cycle GO:0042745 5 0.305
negative regulation of neuron death GO:1901215 98 0.305
regulation of chromosome organization GO:0033044 83 0.302
Human Fly
lipid oxidation GO:0034440 29 0.300
negative regulation of intracellular signal transduction GO:1902532 167 0.293
protein processing GO:0016485 163 0.287
homeostasis of number of cells GO:0048872 210 0.285
regulation of cellular amine metabolic process GO:0033238 20 0.284
negative regulation of phosphorylation GO:0042326 166 0.280
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.277
positive regulation of lipid metabolic process GO:0045834 40 0.273
regulation of glucose metabolic process GO:0010906 60 0.269
regulation of secretion by cell GO:1903530 249 0.269
regulation of carbohydrate biosynthetic process GO:0043255 40 0.267
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.266
response to temperature stimulus GO:0009266 55 0.266
protein catabolic process GO:0030163 221 0.265
Human
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.262
regulation of lipid catabolic process GO:0050994 15 0.251
epithelial cell proliferation GO:0050673 174 0.251
regulation of organelle organization GO:0033043 289 0.250
Human Fly
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.250
regulation of ion transport GO:0043269 215 0.247
establishment of protein localization to organelle GO:0072594 118 0.244
Human
dna integrity checkpoint GO:0031570 28 0.239
leukocyte differentiation GO:0002521 342 0.237
lymphocyte differentiation GO:0030098 242 0.237
epithelial cell development GO:0002064 159 0.234
regulation of fibroblast proliferation GO:0048145 34 0.231
muscle tissue development GO:0060537 308 0.227
regulation of myeloid leukocyte differentiation GO:0002761 58 0.226
ossification GO:0001503 216 0.225
eye photoreceptor cell differentiation GO:0001754 41 0.223
negative regulation of mitotic cell cycle GO:0045930 58 0.221
cation transport GO:0006812 399 0.218
internal protein amino acid acetylation GO:0006475 42 0.215
Worm Fly
fat cell differentiation GO:0045444 160 0.213
respiratory tube development GO:0030323 167 0.212
glucose homeostasis GO:0042593 128 0.211
cell growth GO:0016049 130 0.211
Human
purine nucleoside biosynthetic process GO:0042451 19 0.209
t cell differentiation GO:0030217 174 0.208
anatomical structure homeostasis GO:0060249 145 0.198
regulation of cysteine type endopeptidase activity GO:2000116 65 0.198
Human
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.197
Human
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.197
Human
cellular response to inorganic substance GO:0071241 37 0.197
protein maturation GO:0051604 176 0.196
positive regulation of proteolysis GO:0045862 85 0.195
Human
skeletal muscle organ development GO:0060538 163 0.195
nucleoside monophosphate metabolic process GO:0009123 85 0.195
response to peptide GO:1901652 136 0.191
placenta development GO:0001890 140 0.190
gene silencing GO:0016458 38 0.190
Human Fly
negative regulation of cellular response to insulin stimulus GO:1900077 16 0.190
amine metabolic process GO:0009308 45 0.189
fatty acid oxidation GO:0019395 28 0.186
protein autophosphorylation GO:0046777 61 0.185
cellular response to abiotic stimulus GO:0071214 56 0.185
positive regulation of carbohydrate metabolic process GO:0045913 30 0.181
nuclear division GO:0000280 158 0.181
regulation of apoptotic signaling pathway GO:2001233 197 0.180
positive regulation of cell death GO:0010942 224 0.180
somite development GO:0061053 81 0.180
mrna processing GO:0006397 63 0.177
circadian regulation of gene expression GO:0032922 48 0.177
peptide transport GO:0015833 133 0.176
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.174
Human
t cell activation GO:0042110 289 0.172
negative regulation of proteolysis GO:0045861 74 0.171
carbohydrate derivative biosynthetic process GO:1901137 183 0.171
gonad development GO:0008406 141 0.171
multicellular organismal homeostasis GO:0048871 164 0.170
positive regulation of protein modification process GO:0031401 299 0.168
regulation of transferase activity GO:0051338 263 0.167
cellular chemical homeostasis GO:0055082 215 0.166
cellular homeostasis GO:0019725 240 0.164
cellular amine metabolic process GO:0044106 44 0.163
regulation of cellular response to stress GO:0080135 159 0.161
intracellular protein transport GO:0006886 204 0.161
Human
blastocyst development GO:0001824 80 0.160
response to glucagon GO:0033762 3 0.157
cellular response to lipid GO:0071396 145 0.157
Human
protein acylation GO:0043543 64 0.156
Human Worm Fly
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.156
Human
leukocyte apoptotic process GO:0071887 71 0.155
regulation of nitrogen cycle metabolic process GO:1903314 1 0.155
cellular amino acid metabolic process GO:0006520 103 0.155
autophagy GO:0006914 45 0.152
nuclear transport GO:0051169 139 0.152
Human
meiotic cell cycle GO:0051321 122 0.149
response to starvation GO:0042594 65 0.149
glucose metabolic process GO:0006006 92 0.146
regulation of secretion GO:0051046 274 0.146
positive regulation of cellular amine metabolic process GO:0033240 5 0.145
response to inorganic substance GO:0010035 96 0.144
Human
neuron apoptotic process GO:0051402 142 0.144
response to uv GO:0009411 44 0.143
osteoclast differentiation GO:0030316 62 0.142
purine nucleotide metabolic process GO:0006163 302 0.142
organ growth GO:0035265 117 0.140
cellular ion homeostasis GO:0006873 165 0.137
glycosyl compound metabolic process GO:1901657 246 0.137
positive regulation of glucose metabolic process GO:0010907 21 0.137
extrinsic apoptotic signaling pathway GO:0097191 126 0.135
ubiquitin dependent protein catabolic process GO:0006511 129 0.135
Human
regulation of steroid biosynthetic process GO:0050810 26 0.135
response to alkaloid GO:0043279 34 0.134
positive regulation of cellular carbohydrate metabolic process GO:0010676 29 0.132
mitotic cell cycle process GO:1903047 159 0.130
regulation of protein kinase activity GO:0045859 232 0.130
positive regulation of growth GO:0045927 104 0.127
organonitrogen compound biosynthetic process GO:1901566 192 0.127
multi multicellular organism process GO:0044706 109 0.125
ribonucleoprotein complex subunit organization GO:0071826 28 0.125
ion transmembrane transport GO:0034220 361 0.124
regulation of cellular catabolic process GO:0031329 242 0.123
embryonic placenta development GO:0001892 98 0.123
regulation of lipid biosynthetic process GO:0046890 54 0.123
lactation GO:0007595 25 0.123
molting cycle GO:0042303 90 0.121
regulation of glucocorticoid secretion GO:2000849 5 0.121
mitotic cell cycle checkpoint GO:0007093 31 0.120
neuron death GO:0070997 154 0.120
regulation of cellular amino acid metabolic process GO:0006521 5 0.119
meiotic nuclear division GO:0007126 115 0.119
cellular response to acid chemical GO:0071229 68 0.118
cellular magnesium ion homeostasis GO:0010961 3 0.117
jak stat cascade GO:0007259 42 0.117
positive regulation of fatty acid metabolic process GO:0045923 8 0.116
response to oxidative stress GO:0006979 123 0.115
Human
cellular response to oxidative stress GO:0034599 76 0.115
Human
myotube differentiation GO:0014902 105 0.115
organic anion transport GO:0015711 137 0.114
blood circulation GO:0008015 195 0.114
internal peptidyl lysine acetylation GO:0018393 42 0.114
Worm Fly
positive regulation of fibroblast proliferation GO:0048146 20 0.113
proteasomal protein catabolic process GO:0010498 98 0.112
Human
lipid biosynthetic process GO:0008610 179 0.112
morphogenesis of a branching structure GO:0001763 203 0.112
single organism nuclear import GO:1902593 95 0.112
Human
cholesterol storage GO:0010878 4 0.111
male meiosis i GO:0007141 16 0.109
negative regulation of cell size GO:0045792 3 0.109
regulation of mesenchymal cell proliferation GO:0010464 37 0.109
purine containing compound biosynthetic process GO:0072522 70 0.107
regulation of epithelial cell proliferation GO:0050678 141 0.107
regulation of defense response GO:0031347 233 0.106
protein targeting GO:0006605 143 0.106
Human
eye photoreceptor cell development GO:0042462 31 0.105
developmental maturation GO:0021700 193 0.104
negative regulation of protein processing GO:0010955 79 0.104
positive regulation of cellular respiration GO:1901857 3 0.103
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.103
spliceosomal complex disassembly GO:0000390 1 0.102
regulation of protein catabolic process GO:0042176 108 0.101
cholesterol homeostasis GO:0042632 44 0.101
negative regulation of lipid metabolic process GO:0045833 30 0.100
amide transport GO:0042886 138 0.099
cell aging GO:0007569 35 0.099
Human
positive regulation of cell cycle GO:0045787 92 0.098
monocarboxylic acid transport GO:0015718 44 0.097
response to tumor necrosis factor GO:0034612 26 0.097
Human
peptidyl lysine modification GO:0018205 77 0.096
Human Worm Fly
posttranscriptional regulation of gene expression GO:0010608 155 0.095
endocrine system development GO:0035270 98 0.095
organic acid transport GO:0015849 101 0.094
female gamete generation GO:0007292 74 0.094
cellular response to hormone stimulus GO:0032870 150 0.093
Human
regulation of hormone secretion GO:0046883 88 0.093
cellular response to nutrient levels GO:0031669 64 0.091
nucleoside phosphate metabolic process GO:0006753 338 0.090
dna biosynthetic process GO:0071897 22 0.089
cell maturation GO:0048469 127 0.089
response to oxygen levels GO:0070482 62 0.088
Human
regulation of homeostatic process GO:0032844 182 0.088
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.087
purine containing compound metabolic process GO:0072521 311 0.087
positive regulation of phagocytosis engulfment GO:0060100 3 0.086
ribonucleoside monophosphate metabolic process GO:0009161 80 0.086
negative regulation of kinase activity GO:0033673 81 0.086
Human
positive regulation of cell development GO:0010720 237 0.086
energy derivation by oxidation of organic compounds GO:0015980 77 0.085
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.085
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 25 0.084
response to estrogen GO:0043627 24 0.084
regulation of vasculature development GO:1901342 88 0.084
regulation of hydrolase activity GO:0051336 246 0.083
Human
regulation of kinase activity GO:0043549 249 0.083
digestion GO:0007586 40 0.083
positive regulation of transferase activity GO:0051347 167 0.083
negative regulation of neuron apoptotic process GO:0043524 92 0.083
cellular macromolecule catabolic process GO:0044265 206 0.082
Human
regulation of feeding behavior GO:0060259 3 0.082
Fly
protein sumoylation GO:0016925 14 0.081
regulation of cellular response to insulin stimulus GO:1900076 30 0.081
Human
regulation of fat cell differentiation GO:0045598 81 0.081
purine nucleoside monophosphate metabolic process GO:0009126 81 0.080
cell adhesion GO:0007155 329 0.080
cytoplasmic transport GO:0016482 234 0.079
Human
regulation of cell activation GO:0050865 289 0.079
chromatin silencing GO:0006342 15 0.079
Human Fly
forebrain development GO:0030900 302 0.079
hormone secretion GO:0046879 128 0.078
lung development GO:0030324 164 0.078
bone morphogenesis GO:0060349 78 0.078
lipid localization GO:0010876 126 0.078
negative regulation of circadian rhythm GO:0042754 8 0.077
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.077
regulation of protein stability GO:0031647 52 0.076
cellular response to decreased oxygen levels GO:0036294 18 0.076
Human
response to acid chemical GO:0001101 111 0.075
positive regulation of kinase activity GO:0033674 155 0.075
protein import into nucleus GO:0006606 95 0.075
Human
divalent inorganic cation transport GO:0072511 178 0.074
cellular metal ion homeostasis GO:0006875 151 0.074
regulation of intracellular transport GO:0032386 159 0.073
Human
regionalization GO:0003002 337 0.073
regulation of telomerase activity GO:0051972 1 0.073
epithelial tube morphogenesis GO:0060562 303 0.073
myeloid cell homeostasis GO:0002262 114 0.072
positive regulation of defense response GO:0031349 124 0.072
mapk cascade GO:0000165 281 0.071
nitrogen compound transport GO:0071705 271 0.070
positive regulation of peptidase activity GO:0010952 49 0.070
Human
response to cold GO:0009409 19 0.070
g1 s transition of mitotic cell cycle GO:0000082 57 0.069
purine ribonucleotide metabolic process GO:0009150 290 0.069
cellular response to light stimulus GO:0071482 19 0.069
purine nucleotide biosynthetic process GO:0006164 65 0.069
axis elongation GO:0003401 30 0.068
atp metabolic process GO:0046034 75 0.068
circulatory system process GO:0003013 197 0.068
response to amino acid GO:0043200 37 0.067
ear development GO:0043583 200 0.067
negative regulation of protein maturation GO:1903318 79 0.066
response to drug GO:0042493 75 0.066
regulation of mitotic cell cycle GO:0007346 126 0.066
Human
cell division GO:0051301 120 0.066
neural precursor cell proliferation GO:0061351 121 0.065
regulation of leukocyte apoptotic process GO:2000106 56 0.065
protein import GO:0017038 101 0.065
Human
macroautophagy GO:0016236 21 0.065
organ regeneration GO:0031100 2 0.065
regulation of cell migration GO:0030334 219 0.065
nucleoside metabolic process GO:0009116 246 0.064
regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0000083 3 0.064
organophosphate biosynthetic process GO:0090407 122 0.064
regulation of calcium ion transport into cytosol GO:0010522 31 0.063
axonogenesis GO:0007409 274 0.063
vitamin d biosynthetic process GO:0042368 3 0.063
n terminal protein amino acid modification GO:0031365 6 0.062
fatty acid metabolic process GO:0006631 121 0.062
response to ionizing radiation GO:0010212 42 0.062
calcium ion transport into cytosol GO:0060402 48 0.062
regulation of transmembrane transport GO:0034762 128 0.060
regulation of nuclear division GO:0051783 56 0.060
galactose metabolic process GO:0006012 4 0.060
regulation of protein processing GO:0070613 96 0.060
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.058
Human
multicellular organismal aging GO:0010259 24 0.058
Worm Fly
l glutamate uptake involved in synaptic transmission GO:0051935 3 0.058
positive regulation of endothelial cell proliferation GO:0001938 17 0.058
prostate gland morphogenesis GO:0060512 32 0.058
regulation of cell division GO:0051302 76 0.057
positive regulation of mitotic cell cycle GO:0045931 41 0.057
calcium ion transport GO:0006816 159 0.057
negative regulation of cell cycle process GO:0010948 69 0.057
activation of cysteine type endopeptidase activity GO:0097202 27 0.056
negative regulation of tor signaling GO:0032007 13 0.056
nucleocytoplasmic transport GO:0006913 139 0.056
Human
regulation of neuron apoptotic process GO:0043523 122 0.056
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.056
Human
androgen receptor signaling pathway GO:0030521 8 0.056
Human
posttranscriptional gene silencing GO:0016441 10 0.055
regulation of proteolysis GO:0030162 164 0.055
Human
germline stem cell asymmetric division GO:0098728 2 0.055
regulation of lymphocyte activation GO:0051249 240 0.055
regulation of ion transmembrane transport GO:0034765 119 0.054
histone h3 deacetylation GO:0070932 8 0.054
positive regulation of organelle organization GO:0010638 128 0.053
Human
fatty acid transport GO:0015908 28 0.053
response to testosterone GO:0033574 3 0.053
Human
positive regulation of intracellular protein transport GO:0090316 42 0.053
tissue homeostasis GO:0001894 115 0.052
carbohydrate homeostasis GO:0033500 128 0.051
negative regulation of epithelial cell proliferation GO:0050680 64 0.051
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.051
blood vessel morphogenesis GO:0048514 285 0.051
Human
b cell apoptotic process GO:0001783 19 0.051
purine ribonucleoside biosynthetic process GO:0046129 19 0.050
positive regulation of hormone secretion GO:0046887 38 0.050
regulation of lymphocyte proliferation GO:0050670 117 0.050
learning or memory GO:0007611 148 0.050
cell cycle g1 s phase transition GO:0044843 57 0.049
negative regulation of endopeptidase activity GO:0010951 44 0.049
skeletal system development GO:0001501 356 0.049
ribonucleotide metabolic process GO:0009259 291 0.049
locomotory behavior GO:0007626 195 0.048
macromolecule deacylation GO:0098732 37 0.048
pigment metabolic process GO:0042440 32 0.048
positive regulation of protein modification by small protein conjugation or removal GO:1903322 30 0.048
intestinal epithelial structure maintenance GO:0060729 4 0.048
negative regulation of fibroblast proliferation GO:0048147 14 0.048
nucleobase containing small molecule metabolic process GO:0055086 352 0.048
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoter GO:0072364 7 0.047
cation homeostasis GO:0055080 212 0.047
regulation of tor signaling GO:0032006 17 0.047
regulation of gliogenesis GO:0014013 50 0.047
purine ribonucleoside catabolic process GO:0046130 205 0.047
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.046
regulation of response to wounding GO:1903034 189 0.045
regulation of cell motility GO:2000145 236 0.045
nuclear import GO:0051170 95 0.045
Human
glandular epithelial cell differentiation GO:0002067 38 0.045
appendage development GO:0048736 166 0.045
cellular nitrogen compound catabolic process GO:0044270 280 0.045
Human
morphogenesis of a branching epithelium GO:0061138 193 0.045
photoreceptor cell differentiation GO:0046530 52 0.045
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.045
regulation of protein import into nucleus translocation GO:0033158 2 0.044
Human
regulation of neuron death GO:1901214 134 0.044
rna splicing GO:0008380 54 0.044
glucocorticoid secretion GO:0035933 6 0.044
regulation of protein transport GO:0051223 163 0.044
Human
nucleus organization GO:0006997 45 0.044
negative regulation of cellular amine metabolic process GO:0033239 1 0.044
purine nucleoside metabolic process GO:0042278 241 0.044
negative regulation of immune system process GO:0002683 209 0.044
nucleotide metabolic process GO:0009117 332 0.043
synaptic transmission GO:0007268 329 0.043
regulation of chromatin modification GO:1903308 57 0.043
Human Fly
ribonucleoside biosynthetic process GO:0042455 21 0.043
regulation of peptide secretion GO:0002791 77 0.043
regulation of striated muscle cell differentiation GO:0051153 81 0.042
insulin secretion GO:0030073 89 0.042
sequestering of calcium ion GO:0051208 18 0.042
transmembrane transport GO:0055085 412 0.042
rna processing GO:0006396 105 0.041
stem cell proliferation GO:0072089 117 0.041
regulation of cell cycle g1 s phase transition GO:1902806 35 0.041
adenylate cyclase activating g protein coupled receptor signaling pathway GO:0007189 30 0.041
telomere maintenance GO:0000723 19 0.041
cellular response to insulin stimulus GO:0032869 78 0.041
Human
genitalia development GO:0048806 37 0.041
mrna metabolic process GO:0016071 84 0.041
positive regulation of dephosphorylation GO:0035306 6 0.041
aortic valve morphogenesis GO:0003180 4 0.040
carboxylic acid transport GO:0046942 100 0.040
cellular divalent inorganic cation homeostasis GO:0072503 127 0.040
wnt signaling pathway GO:0016055 188 0.040
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.040
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.040
regulation of canonical wnt signaling pathway GO:0060828 82 0.040
regulation of blood circulation GO:1903522 93 0.040
negative regulation of homeostatic process GO:0032845 71 0.040
positive regulation of epithelial cell proliferation GO:0050679 68 0.040
dephosphorylation GO:0016311 129 0.040
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.040
Human
peptidyl lysine acetylation GO:0018394 45 0.040
Human Worm Fly
purine ribonucleotide biosynthetic process GO:0009152 59 0.040
bmp signaling pathway GO:0030509 93 0.040
purine ribonucleoside metabolic process GO:0046128 241 0.040

Sirt1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.781
disease of cellular proliferation DOID:14566 0 0.781
organ system cancer DOID:0050686 0 0.781
large intestine cancer DOID:5672 0 0.202
colon cancer DOID:219 0 0.202
gastrointestinal system cancer DOID:3119 0 0.202
intestinal cancer DOID:10155 0 0.202
colorectal cancer DOID:9256 0 0.202
disease of metabolism DOID:0014667 0 0.165
nutrition disease DOID:374 0 0.165
acquired metabolic disease DOID:0060158 0 0.165
diabetes mellitus DOID:9351 0 0.118
type 2 diabetes mellitus DOID:9352 0 0.118
carbohydrate metabolism disease DOID:0050013 0 0.118
glucose metabolism disease DOID:4194 0 0.118
thoracic cancer DOID:5093 0 0.041