Mus musculus

98 known processes

Eif2a

eukaryotic translation initiation factor 2A

(Aliases: D3Ertd194e,MGC105246,D030048D22)

Eif2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic cyclic compound catabolic process GO:1901361 295 0.111
gonad development GO:0008406 141 0.074
aromatic compound catabolic process GO:0019439 286 0.072
peptidyl amino acid modification GO:0018193 336 0.069
regulation of cell cycle GO:0051726 281 0.066
cellular macromolecule catabolic process GO:0044265 206 0.063
heterocycle catabolic process GO:0046700 280 0.059
chromatin modification GO:0016568 187 0.056
stem cell development GO:0048864 219 0.054
cellular protein catabolic process GO:0044257 155 0.049
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.049
microtubule based process GO:0007017 236 0.049
protein maturation GO:0051604 176 0.047
regulation of cellular ketone metabolic process GO:0010565 66 0.044
regulation of cellular amino acid metabolic process GO:0006521 5 0.044
cellular ketone metabolic process GO:0042180 84 0.041
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.039
nucleotide metabolic process GO:0009117 332 0.039
apoptotic signaling pathway GO:0097190 306 0.039
cellular nitrogen compound catabolic process GO:0044270 280 0.038
endomembrane system organization GO:0010256 147 0.038
amine metabolic process GO:0009308 45 0.038
macromolecule catabolic process GO:0009057 281 0.035
cellular amine metabolic process GO:0044106 44 0.035
lymphocyte differentiation GO:0030098 242 0.034
cellular amino acid metabolic process GO:0006520 103 0.030
lateral inhibition GO:0046331 1 0.029
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.029
peptidyl tyrosine modification GO:0018212 145 0.029
regulation of cellular amine metabolic process GO:0033238 20 0.028
histone modification GO:0016570 159 0.028
protein modification by small protein conjugation or removal GO:0070647 207 0.027
positive regulation of cellular amine metabolic process GO:0033240 5 0.027
circadian regulation of gene expression GO:0032922 48 0.026
negative regulation of cellular protein metabolic process GO:0032269 247 0.026
positive regulation of cell development GO:0010720 237 0.025
negative regulation of lymphocyte activation GO:0051250 91 0.025
organophosphate catabolic process GO:0046434 232 0.025
modification dependent macromolecule catabolic process GO:0043632 133 0.024
protein processing GO:0016485 163 0.023
cell division GO:0051301 120 0.023
translational initiation GO:0006413 24 0.023
cellular response to growth factor stimulus GO:0071363 197 0.023
nucleoside phosphate catabolic process GO:1901292 222 0.023
regulation of lymphocyte differentiation GO:0045619 107 0.023
inflammatory response GO:0006954 244 0.023
protein modification by small protein conjugation GO:0032446 187 0.022
small gtpase mediated signal transduction GO:0007264 97 0.022
multicellular organism growth GO:0035264 161 0.022
organonitrogen compound catabolic process GO:1901565 264 0.022
endocytosis GO:0006897 168 0.022
negative regulation of cell activation GO:0050866 111 0.022
covalent chromatin modification GO:0016569 163 0.021
regulation of cellular response to growth factor stimulus GO:0090287 82 0.021
chromosome segregation GO:0007059 48 0.021
male gamete generation GO:0048232 285 0.021
negative regulation of protein metabolic process GO:0051248 282 0.021
leukocyte differentiation GO:0002521 342 0.021
negative regulation of immune system process GO:0002683 209 0.020
multi organism reproductive behavior GO:0044705 29 0.020
mitotic cell cycle GO:0000278 195 0.020
regulation of defense response GO:0031347 233 0.020
nucleoside triphosphate catabolic process GO:0009143 205 0.020
meiotic cell cycle process GO:1903046 77 0.020
maintenance of location GO:0051235 89 0.020
regulation of protein kinase activity GO:0045859 232 0.020
multi multicellular organism process GO:0044706 109 0.019
positive regulation of protein modification process GO:0031401 299 0.019
ribonucleoside triphosphate catabolic process GO:0009203 199 0.019
b cell activation GO:0042113 161 0.019
cell fate commitment GO:0045165 210 0.018
purine nucleoside triphosphate metabolic process GO:0009144 226 0.018
regulation of cell activation GO:0050865 289 0.018
hematopoietic progenitor cell differentiation GO:0002244 143 0.018
purine nucleotide metabolic process GO:0006163 302 0.018
response to growth factor GO:0070848 198 0.018
protein ubiquitination GO:0016567 171 0.018
purine ribonucleotide catabolic process GO:0009154 208 0.018
microtubule cytoskeleton organization GO:0000226 157 0.018
regulation of proteolysis GO:0030162 164 0.018
striated muscle tissue development GO:0014706 293 0.018
negative regulation of apoptotic signaling pathway GO:2001234 104 0.018
regulation of apoptotic signaling pathway GO:2001233 197 0.018
nuclear division GO:0000280 158 0.017
chromatin organization GO:0006325 206 0.017
regulation of lymphocyte activation GO:0051249 240 0.017
regulation of mapk cascade GO:0043408 248 0.016
regulation of leukocyte differentiation GO:1902105 159 0.016
positive regulation of dna templated transcription elongation GO:0032786 2 0.016
negative regulation of molecular function GO:0044092 258 0.016
cytoplasmic transport GO:0016482 234 0.016
nucleocytoplasmic transport GO:0006913 139 0.016
positive regulation of nervous system development GO:0051962 221 0.016
negative regulation of protein maturation GO:1903318 79 0.016
ribonucleotide catabolic process GO:0009261 208 0.016
cognition GO:0050890 149 0.016
negative regulation of protein modification process GO:0031400 163 0.015
negative regulation of protein processing GO:0010955 79 0.015
regulation of inflammatory response GO:0050727 147 0.015
dendrite development GO:0016358 115 0.015
germ cell development GO:0007281 185 0.015
t cell differentiation in thymus GO:0033077 77 0.015
modification dependent protein catabolic process GO:0019941 133 0.015
peptidyl tyrosine phosphorylation GO:0018108 143 0.015
leukocyte mediated immunity GO:0002443 174 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.015
nucleoside triphosphate metabolic process GO:0009141 230 0.014
t cell activation GO:0042110 289 0.014
trna processing GO:0008033 11 0.014
nucleoside phosphate metabolic process GO:0006753 338 0.014
transmission of nerve impulse GO:0019226 76 0.014
nucleobase containing small molecule metabolic process GO:0055086 352 0.014
development of primary sexual characteristics GO:0045137 143 0.013
purine nucleoside catabolic process GO:0006152 205 0.013
spermatogenesis GO:0007283 284 0.013
establishment of organelle localization GO:0051656 122 0.013
negative regulation of synaptic transmission glutamatergic GO:0051967 4 0.013
meiotic nuclear division GO:0007126 115 0.013
negative regulation of intracellular signal transduction GO:1902532 167 0.013
ras protein signal transduction GO:0007265 77 0.013
negative regulation of proteolysis GO:0045861 74 0.013
metaphase plate congression GO:0051310 2 0.013
meiotic chromosome segregation GO:0045132 19 0.013
ribonucleoside triphosphate metabolic process GO:0009199 220 0.013
organelle fission GO:0048285 170 0.013
atp catabolic process GO:0006200 55 0.013
carbohydrate metabolic process GO:0005975 230 0.013
regulation of cellular protein catabolic process GO:1903362 61 0.013
regulation of protein processing GO:0070613 96 0.013
learning or memory GO:0007611 148 0.012
negative regulation of mesenchymal cell proliferation GO:0072201 3 0.012
stem cell maintenance GO:0019827 130 0.012
cellular response to dna damage stimulus GO:0006974 207 0.012
regulation of mitotic cell cycle GO:0007346 126 0.012
regulation of protein maturation GO:1903317 96 0.012
positive regulation of protein kinase activity GO:0045860 144 0.012
chemotaxis GO:0006935 247 0.012
t cell differentiation GO:0030217 174 0.012
ribonucleoside metabolic process GO:0009119 245 0.012
protein secretion GO:0009306 111 0.012
membrane organization GO:0061024 245 0.012
organelle assembly GO:0070925 177 0.012
multi organism behavior GO:0051705 62 0.012
regulation of cellular response to stress GO:0080135 159 0.012
carbohydrate derivative catabolic process GO:1901136 231 0.012
regulation of kinase activity GO:0043549 249 0.012
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 1 0.012
positive regulation of cell death GO:0010942 224 0.011
ribose phosphate metabolic process GO:0019693 291 0.011
purine ribonucleotide metabolic process GO:0009150 290 0.011
positive regulation of hydrolase activity GO:0051345 148 0.011
translation GO:0006412 93 0.011
negative regulation of dna replication GO:0008156 4 0.011
positive regulation of programmed cell death GO:0043068 218 0.011
cellular response to hormone stimulus GO:0032870 150 0.011
regulation of protein localization GO:0032880 231 0.011
purine containing compound metabolic process GO:0072521 311 0.011
nucleotide catabolic process GO:0009166 217 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.011
erk1 and erk2 cascade GO:0070371 77 0.011
negative regulation of cellular response to insulin stimulus GO:1900077 16 0.010
regulation of vesicle mediated transport GO:0060627 139 0.010
energy reserve metabolic process GO:0006112 39 0.010
immune effector process GO:0002252 321 0.010
b cell differentiation GO:0030183 78 0.010
cytokine mediated signaling pathway GO:0019221 115 0.010
male gonad development GO:0008584 88 0.010
purine nucleotide catabolic process GO:0006195 211 0.010
purine ribonucleoside catabolic process GO:0046130 205 0.010
glycosyl compound metabolic process GO:1901657 246 0.010
male sex differentiation GO:0046661 109 0.010
cellular response to cytokine stimulus GO:0071345 189 0.010
development of primary male sexual characteristics GO:0046546 88 0.010
ribonucleotide metabolic process GO:0009259 291 0.010

Eif2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 0 0.102
muscular disease DOID:0080000 0 0.102
disease of anatomical entity DOID:7 0 0.102
muscle tissue disease DOID:66 0 0.039
myopathy DOID:423 0 0.039
nervous system disease DOID:863 0 0.031
muscular dystrophy DOID:9884 0 0.016
neurodegenerative disease DOID:1289 0 0.012
central nervous system disease DOID:331 0 0.012