Mus musculus

30 known processes

Map4k4

mitogen-activated protein kinase kinase kinase kinase 4

(Aliases: Nik,AW046177,9430080K19Rik,HGK,AU045934,AU043147)

Map4k4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
actin cytoskeleton organization GO:0030036 220 0.551
gtp catabolic process GO:0006184 143 0.408
regulation of cellular amine metabolic process GO:0033238 20 0.368
amine metabolic process GO:0009308 45 0.353
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.351
aromatic compound catabolic process GO:0019439 286 0.340
cellular ketone metabolic process GO:0042180 84 0.324
cellular amino acid metabolic process GO:0006520 103 0.322
regulation of cell migration GO:0030334 219 0.310
regulation of cellular amino acid metabolic process GO:0006521 5 0.293
nucleoside metabolic process GO:0009116 246 0.290
purine ribonucleotide metabolic process GO:0009150 290 0.283
ras protein signal transduction GO:0007265 77 0.243
Fly
regulation of cellular ketone metabolic process GO:0010565 66 0.239
transmembrane transport GO:0055085 412 0.220
ribonucleoside metabolic process GO:0009119 245 0.219
cellular amine metabolic process GO:0044106 44 0.219
negative regulation of cellular amine metabolic process GO:0033239 1 0.207
purine nucleotide catabolic process GO:0006195 211 0.196
nucleotide metabolic process GO:0009117 332 0.188
nucleobase containing small molecule metabolic process GO:0055086 352 0.187
purine ribonucleoside catabolic process GO:0046130 205 0.178
ribonucleotide catabolic process GO:0009261 208 0.178
mapk cascade GO:0000165 281 0.175
Human Mouse Fly
organonitrogen compound catabolic process GO:1901565 264 0.171
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.169
small gtpase mediated signal transduction GO:0007264 97 0.161
Fly
purine containing compound metabolic process GO:0072521 311 0.159
axonogenesis GO:0007409 274 0.158
Worm Fly
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.156
t cell activation GO:0042110 289 0.155
Mouse
purine nucleoside metabolic process GO:0042278 241 0.154
ribonucleoside triphosphate catabolic process GO:0009203 199 0.153
purine nucleotide metabolic process GO:0006163 302 0.152
digestive tract development GO:0048565 190 0.151
chemotaxis GO:0006935 247 0.144
Worm Fly
gastrulation GO:0007369 116 0.143
positive regulation of gtp catabolic process GO:0033126 85 0.142
regulation of purine nucleotide metabolic process GO:1900542 169 0.139
ribonucleotide metabolic process GO:0009259 291 0.139
digestive system development GO:0055123 200 0.137
nucleoside phosphate metabolic process GO:0006753 338 0.131
neuron projection guidance GO:0097485 141 0.131
Worm Fly
gtp metabolic process GO:0046039 144 0.127
multicellular organism growth GO:0035264 161 0.126
regulation of cell motility GO:2000145 236 0.126
actin filament organization GO:0007015 113 0.126
positive regulation of nucleotide metabolic process GO:0045981 114 0.125
negative regulation of cellular component organization GO:0051129 194 0.125
camera type eye development GO:0043010 266 0.124
purine containing compound catabolic process GO:0072523 213 0.124
i kappab kinase nf kappab signaling GO:0007249 85 0.124
nucleoside triphosphate catabolic process GO:0009143 205 0.121
mitotic cell cycle process GO:1903047 159 0.121
organelle fission GO:0048285 170 0.121
cellular nitrogen compound catabolic process GO:0044270 280 0.116
negative regulation of phosphate metabolic process GO:0045936 184 0.115
nucleoside triphosphate metabolic process GO:0009141 230 0.114
regulation of apoptotic signaling pathway GO:2001233 197 0.109
response to organonitrogen compound GO:0010243 246 0.107
negative regulation of protein phosphorylation GO:0001933 126 0.106
synapse organization GO:0050808 125 0.106
maintenance of location GO:0051235 89 0.105
Worm
rho protein signal transduction GO:0007266 32 0.102
membrane organization GO:0061024 245 0.098
leukocyte differentiation GO:0002521 342 0.097
Mouse
nucleoside phosphate catabolic process GO:1901292 222 0.097
stem cell differentiation GO:0048863 268 0.096
regulation of cellular response to stress GO:0080135 159 0.096
Human Mouse
regulation of mapk cascade GO:0043408 248 0.095
Human Mouse
cation transport GO:0006812 399 0.092
wound healing GO:0042060 157 0.092
glycosyl compound catabolic process GO:1901658 206 0.092
t cell differentiation GO:0030217 174 0.091
Mouse
t cell differentiation in thymus GO:0033077 77 0.091
Mouse
ribose phosphate metabolic process GO:0019693 291 0.091
negative regulation of protein metabolic process GO:0051248 282 0.090
purine nucleoside triphosphate catabolic process GO:0009146 203 0.090
purine nucleoside catabolic process GO:0006152 205 0.090
dephosphorylation GO:0016311 129 0.088
heterocycle catabolic process GO:0046700 280 0.088
lymphocyte differentiation GO:0030098 242 0.087
Mouse
regulation of response to wounding GO:1903034 189 0.087
nucleotide catabolic process GO:0009166 217 0.086
cellular homeostasis GO:0019725 240 0.086
cell adhesion GO:0007155 329 0.086
regulation of cell projection assembly GO:0060491 38 0.085
purine ribonucleotide catabolic process GO:0009154 208 0.084
organic cyclic compound catabolic process GO:1901361 295 0.084
ion transmembrane transport GO:0034220 361 0.084
renal system development GO:0072001 225 0.083
purine nucleoside triphosphate metabolic process GO:0009144 226 0.081
negative regulation of molecular function GO:0044092 258 0.081
cellular response to insulin stimulus GO:0032869 78 0.081
regulation of organelle organization GO:0033043 289 0.080
blood vessel morphogenesis GO:0048514 285 0.079
regulation of lymphocyte activation GO:0051249 240 0.077
regulation of transferase activity GO:0051338 263 0.077
Mouse
inflammatory response GO:0006954 244 0.076
regulation of cellular catabolic process GO:0031329 242 0.074
ribonucleoside triphosphate metabolic process GO:0009199 220 0.074
regulation of hydrolase activity GO:0051336 246 0.073
sequestering of calcium ion GO:0051208 18 0.073
cellular response to hormone stimulus GO:0032870 150 0.072
sensory organ morphogenesis GO:0090596 242 0.072
cytoplasmic transport GO:0016482 234 0.072
negative regulation of intracellular signal transduction GO:1902532 167 0.072
Fly
negative regulation of cellular protein metabolic process GO:0032269 247 0.071
protein localization to membrane GO:0072657 108 0.070
retina development in camera type eye GO:0060041 119 0.070
digestive tract morphogenesis GO:0048546 147 0.070
mitotic cell cycle GO:0000278 195 0.070
striated muscle cell development GO:0055002 125 0.069
regulation of insulin receptor signaling pathway GO:0046626 21 0.068
lateral inhibition GO:0046331 1 0.068
ribonucleoside catabolic process GO:0042454 206 0.068
muscle fiber development GO:0048747 76 0.065
single organismal cell cell adhesion GO:0016337 131 0.065
divalent metal ion transport GO:0070838 172 0.064
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.064
epithelial tube morphogenesis GO:0060562 303 0.064
negative regulation of cell migration GO:0030336 59 0.064
organelle assembly GO:0070925 177 0.063
regulation of homeostatic process GO:0032844 182 0.063
peptidyl amino acid modification GO:0018193 336 0.063
nucleoside catabolic process GO:0009164 206 0.063
regulation of protein kinase activity GO:0045859 232 0.062
Mouse
muscle cell differentiation GO:0042692 261 0.061
cell fate commitment GO:0045165 210 0.060
lymphocyte proliferation GO:0046651 164 0.059
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.059
activation of immune response GO:0002253 138 0.059
leukocyte proliferation GO:0070661 172 0.058
cell junction organization GO:0034330 77 0.058
cell type specific apoptotic process GO:0097285 268 0.058
guanosine containing compound catabolic process GO:1901069 144 0.057
regulation of nucleotide metabolic process GO:0006140 169 0.057
purine ribonucleoside metabolic process GO:0046128 241 0.057
muscle cell development GO:0055001 133 0.057
actin polymerization or depolymerization GO:0008154 54 0.056
regulation of protein localization GO:0032880 231 0.056
stem cell development GO:0048864 219 0.055
sequestering of metal ion GO:0051238 19 0.055
negative regulation of phosphorus metabolic process GO:0010563 184 0.055
regulation of camp metabolic process GO:0030814 30 0.055
negative regulation of phosphorylation GO:0042326 166 0.055
homeostasis of number of cells GO:0048872 210 0.054
activation of adenylate cyclase activity GO:0007190 4 0.053
regulation of cell projection organization GO:0031344 206 0.053
cellular response to organonitrogen compound GO:0071417 145 0.053
establishment of organelle localization GO:0051656 122 0.053
Fly
guanosine containing compound metabolic process GO:1901068 144 0.053
regulation of ras gtpase activity GO:0032318 88 0.053
nuclear division GO:0000280 158 0.053
muscle tissue development GO:0060537 308 0.052
negative regulation of protein modification process GO:0031400 163 0.052
carbohydrate derivative catabolic process GO:1901136 231 0.052
regulation of cell adhesion GO:0030155 154 0.052
glycosyl compound metabolic process GO:1901657 246 0.051
positive regulation of programmed cell death GO:0043068 218 0.051
positive regulation of nucleoside metabolic process GO:0045979 91 0.050
synaptic transmission GO:0007268 329 0.050
regulation of intracellular transport GO:0032386 159 0.050
myeloid cell differentiation GO:0030099 233 0.050
cellular lipid metabolic process GO:0044255 323 0.050
positive regulation of apoptotic signaling pathway GO:2001235 95 0.050
negative regulation of cell motility GO:2000146 61 0.049
regulation of inflammatory response GO:0050727 147 0.049
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.048
urogenital system development GO:0001655 261 0.048
response to oxidative stress GO:0006979 123 0.047
positive regulation of cell migration GO:0030335 109 0.047
wnt signaling pathway GO:0016055 188 0.047
positive regulation of cell motility GO:2000147 116 0.046
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.046
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.046
ameboidal type cell migration GO:0001667 128 0.046
regulation of mammary gland epithelial cell proliferation GO:0033599 12 0.046
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.045
divalent inorganic cation transport GO:0072511 178 0.045
regulation of vesicle mediated transport GO:0060627 139 0.044
single organism cell adhesion GO:0098602 156 0.044
t cell proliferation GO:0042098 120 0.044
regulation of neuron projection development GO:0010975 169 0.044
regulation of cell activation GO:0050865 289 0.043
cellular protein complex assembly GO:0043623 116 0.043
kidney development GO:0001822 213 0.043
epithelial tube formation GO:0072175 130 0.043
dendrite development GO:0016358 115 0.043
regulation of neuron differentiation GO:0045664 281 0.043
gland development GO:0048732 330 0.043
organophosphate catabolic process GO:0046434 232 0.042
regulation of rho gtpase activity GO:0032319 58 0.042
regulation of protein transport GO:0051223 163 0.041
regulation of t cell proliferation GO:0042129 92 0.041
regulation of leukocyte differentiation GO:1902105 159 0.041
forebrain development GO:0030900 302 0.041
positive regulation of nervous system development GO:0051962 221 0.040
regulation of establishment of protein localization GO:0070201 181 0.040
organelle localization GO:0051640 179 0.039
Fly
regulation of t cell activation GO:0050863 170 0.039
regulation of cell shape GO:0008360 39 0.039
Fly
alpha beta t cell activation GO:0046631 91 0.039
axon guidance GO:0007411 141 0.039
Worm Fly
response to peptide hormone GO:0043434 127 0.038
positive regulation of cell development GO:0010720 237 0.038
thymic t cell selection GO:0045061 22 0.038
Mouse
bmp signaling pathway GO:0030509 93 0.038
apoptotic signaling pathway GO:0097190 306 0.038
limb development GO:0060173 166 0.037
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.037
response to light stimulus GO:0009416 135 0.037
negative regulation of transferase activity GO:0051348 85 0.037
canonical wnt signaling pathway GO:0060070 130 0.036
response to insulin GO:0032868 100 0.036
cation transmembrane transport GO:0098655 266 0.036
actin cytoskeleton reorganization GO:0031532 21 0.036
cell growth GO:0016049 130 0.036
Worm
mitotic nuclear division GO:0007067 48 0.036
nephron development GO:0072006 109 0.036
regulation of nucleoside metabolic process GO:0009118 130 0.035
cellular response to peptide hormone stimulus GO:0071375 92 0.035
nitrogen compound transport GO:0071705 271 0.035
development of primary sexual characteristics GO:0045137 143 0.035
Worm
nuclear transport GO:0051169 139 0.035
macromolecule catabolic process GO:0009057 281 0.035
regulation of ras protein signal transduction GO:0046578 114 0.035
Fly
methylation GO:0032259 134 0.035
regulation of muscle tissue development GO:1901861 97 0.035
organic hydroxy compound transport GO:0015850 93 0.035
developmental growth involved in morphogenesis GO:0060560 138 0.035
Worm
morphogenesis of a branching epithelium GO:0061138 193 0.035
cell cell junction organization GO:0045216 72 0.034
calcium ion transport GO:0006816 159 0.034
immune effector process GO:0002252 321 0.034
regulation of metal ion transport GO:0010959 106 0.034
positive regulation of hydrolase activity GO:0051345 148 0.034
regulation of cellular component biogenesis GO:0044087 181 0.034
anion transport GO:0006820 177 0.034
cellular divalent inorganic cation homeostasis GO:0072503 127 0.034
regulation of purine nucleotide catabolic process GO:0033121 122 0.033
cyclic nucleotide metabolic process GO:0009187 59 0.033
fat cell differentiation GO:0045444 160 0.033
compound eye development GO:0048749 1 0.033
regulation of secretion by cell GO:1903530 249 0.033
positive regulation of intracellular transport GO:0032388 70 0.032
cellular protein catabolic process GO:0044257 155 0.032
blastocyst development GO:0001824 80 0.032
myeloid cell homeostasis GO:0002262 114 0.032
positive regulation of cellular catabolic process GO:0031331 148 0.032
cellular response to peptide GO:1901653 92 0.032
gonad morphogenesis GO:0035262 1 0.032
stem cell fate specification GO:0048866 3 0.032
carbohydrate derivative biosynthetic process GO:1901137 183 0.031
regulation of wnt signaling pathway GO:0030111 123 0.031
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.031
angiogenesis GO:0001525 201 0.031
negative regulation of bmp signaling pathway GO:0030514 35 0.031
positive regulation of cell projection organization GO:0031346 95 0.031
cellular ion homeostasis GO:0006873 165 0.030
purine nucleotide biosynthetic process GO:0006164 65 0.030
release of sequestered calcium ion into cytosol GO:0051209 42 0.030
regulation of rho protein signal transduction GO:0035023 71 0.030
response to inorganic substance GO:0010035 96 0.030
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.030
negative regulation of cell proliferation GO:0008285 296 0.030
Mouse
positive regulation of cellular component biogenesis GO:0044089 94 0.030
adaptive immune response GO:0002250 155 0.030
exocytosis GO:0006887 121 0.029
cation homeostasis GO:0055080 212 0.029
peptidyl lysine modification GO:0018205 77 0.029
actin filament polymerization GO:0030041 44 0.029
phagocytosis GO:0006909 66 0.029
respiratory tube development GO:0030323 167 0.029
negative regulation of synapse assembly GO:0051964 3 0.029
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.029
cellular response to growth factor stimulus GO:0071363 197 0.029
cellular metal ion homeostasis GO:0006875 151 0.029
positive regulation of mapk cascade GO:0043410 170 0.029
Mouse
response to transforming growth factor beta GO:0071559 88 0.029
positive regulation of cellular amine metabolic process GO:0033240 5 0.029
response to growth factor GO:0070848 198 0.028
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.028
positive regulation of cell activation GO:0050867 158 0.028
epithelial cell migration GO:0010631 63 0.028
activation of mapkkk activity GO:0000185 1 0.028
cellular response to cytokine stimulus GO:0071345 189 0.028
regulation of gtp catabolic process GO:0033124 113 0.028
antigen receptor mediated signaling pathway GO:0050851 64 0.027
endocytosis GO:0006897 168 0.027
Worm
cellular chemical homeostasis GO:0055082 215 0.027
nucleocytoplasmic transport GO:0006913 139 0.027
negative regulation of growth GO:0045926 99 0.027
positive regulation of rho gtpase activity GO:0032321 41 0.027
positive regulation of t cell proliferation GO:0042102 52 0.027
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.027
response to lipopolysaccharide GO:0032496 128 0.026
positive regulation of cell death GO:0010942 224 0.026
regulation of leukocyte proliferation GO:0070663 121 0.026
inorganic cation transmembrane transport GO:0098662 207 0.026
chromosome segregation GO:0007059 48 0.026
positive regulation of mesoderm development GO:2000382 2 0.026
striated muscle tissue development GO:0014706 293 0.026
interleukin 2 mediated signaling pathway GO:0038110 2 0.026
developmental maturation GO:0021700 193 0.026
response to extracellular stimulus GO:0009991 127 0.025
regulation of cardiac cell fate specification GO:2000043 1 0.025
regulation of hormone levels GO:0010817 211 0.025
cellular macromolecule catabolic process GO:0044265 206 0.025
morphogenesis of embryonic epithelium GO:0016331 159 0.025
Fly
cellular response to dna damage stimulus GO:0006974 207 0.025
dna metabolic process GO:0006259 303 0.025
cytosolic calcium ion homeostasis GO:0051480 70 0.025
negative regulation of mapk cascade GO:0043409 65 0.025
regulation of cellular response to growth factor stimulus GO:0090287 82 0.025
intracellular protein transport GO:0006886 204 0.025
microtubule based process GO:0007017 236 0.024
leukocyte activation involved in immune response GO:0002366 126 0.024
positive regulation of protein modification process GO:0031401 299 0.024
Mouse
positive regulation of nucleotide catabolic process GO:0030813 88 0.024
camp metabolic process GO:0046058 40 0.024
calcium ion transport into cytosol GO:0060402 48 0.024
tube formation GO:0035148 140 0.024
epithelial cell morphogenesis GO:0003382 41 0.024
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.024
erythrocyte differentiation GO:0030218 88 0.024
regulation of cytoplasmic transport GO:1903649 112 0.024
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.024
negative regulation of kinase activity GO:0033673 81 0.024
gonad development GO:0008406 141 0.024
Worm
embryonic organ morphogenesis GO:0048562 276 0.024
inorganic ion transmembrane transport GO:0098660 234 0.024
positive regulation of transferase activity GO:0051347 167 0.024
Mouse
immune response activating signal transduction GO:0002757 116 0.023
positive regulation of gtpase activity GO:0043547 85 0.023
regulation of kinase activity GO:0043549 249 0.023
Mouse
regulation of cytokine production GO:0001817 266 0.023
positive regulation of lymphocyte activation GO:0051251 140 0.023
chromatin modification GO:0016568 187 0.023
regulation of ion homeostasis GO:2000021 64 0.023
mrna metabolic process GO:0016071 84 0.023
g protein coupled receptor signaling pathway GO:0007186 243 0.023
adult behavior GO:0030534 135 0.023
cell division GO:0051301 120 0.023
neuron migration GO:0001764 122 0.023
negative regulation of response to wounding GO:1903035 77 0.023
cell maturation GO:0048469 127 0.023
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.023
cellular response to oxidative stress GO:0034599 76 0.022
carbohydrate transport GO:0008643 62 0.022
peptidyl tyrosine phosphorylation GO:0018108 143 0.022
response to acid chemical GO:0001101 111 0.022
carbohydrate metabolic process GO:0005975 230 0.022
epithelial cell development GO:0002064 159 0.022
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.022
positive regulation of ras gtpase activity GO:0032320 65 0.022
oocyte anterior posterior axis specification GO:0007314 2 0.022
protein modification by small protein conjugation or removal GO:0070647 207 0.022
negative regulation of nervous system development GO:0051961 156 0.022
response to peptide GO:1901652 136 0.022
cerebral cortex development GO:0021987 86 0.022
ear morphogenesis GO:0042471 118 0.022
cell substrate junction assembly GO:0007044 24 0.022
monosaccharide transport GO:0015749 58 0.022
cell junction assembly GO:0034329 52 0.021
negative regulation of homeostatic process GO:0032845 71 0.021
negative regulation of inflammatory response GO:0050728 61 0.021
ossification GO:0001503 216 0.021
cell substrate adhesion GO:0031589 130 0.021
action potential GO:0001508 78 0.021
response to oxygen levels GO:0070482 62 0.021
microtubule cytoskeleton organization GO:0000226 157 0.021
neuron projection extension GO:1990138 64 0.021
Worm
divalent inorganic cation homeostasis GO:0072507 138 0.021
cytokine mediated signaling pathway GO:0019221 115 0.021
regulation of actin filament polymerization GO:0030833 38 0.021
peptidyl tyrosine modification GO:0018212 145 0.021
protein localization to nucleus GO:0034504 121 0.021
sphingolipid metabolic process GO:0006665 45 0.021
protein processing GO:0016485 163 0.021
mesenchyme development GO:0060485 152 0.021
negative regulation of cellular response to insulin stimulus GO:1900077 16 0.020
organonitrogen compound biosynthetic process GO:1901566 192 0.020
peptidyl threonine phosphorylation GO:0018107 31 0.020
g1 s transition of mitotic cell cycle GO:0000082 57 0.020
protein catabolic process GO:0030163 221 0.020
positive regulation of t cell activation GO:0050870 101 0.020
spermatogenesis GO:0007283 284 0.020
neural tube development GO:0021915 160 0.020
positive regulation of neuron differentiation GO:0045666 141 0.020
regulation of defense response GO:0031347 233 0.020
germ cell development GO:0007281 185 0.020
positive regulation of transcription by galactose GO:0000411 1 0.020
inner ear morphogenesis GO:0042472 101 0.020
organic hydroxy compound metabolic process GO:1901615 203 0.020
epithelial cell proliferation GO:0050673 174 0.020
positive t cell selection GO:0043368 23 0.020
regulation of canonical wnt signaling pathway GO:0060828 82 0.020
positive regulation of secretion GO:0051047 130 0.020
calcium ion homeostasis GO:0055074 127 0.020
skeletal muscle organ development GO:0060538 163 0.019
mesodermal cell migration GO:0008078 4 0.019
regulation of cyclic nucleotide metabolic process GO:0030799 40 0.019
mesenchymal cell differentiation GO:0048762 107 0.019
photoreceptor cell differentiation GO:0046530 52 0.019
Fly
meiotic cell cycle GO:0051321 122 0.019
nephron epithelium development GO:0072009 92 0.019
apical constriction GO:0003383 4 0.019
kidney morphogenesis GO:0060993 83 0.019
regulation of nucleotide catabolic process GO:0030811 122 0.019
endoderm development GO:0007492 45 0.019
regulation of protein localization to nucleus GO:1900180 60 0.019
mitochondrion organization GO:0007005 134 0.019
heart process GO:0003015 94 0.019
regulation of cytoskeleton organization GO:0051493 122 0.019
posttranscriptional regulation of gene expression GO:0010608 155 0.019
regulation of membrane potential GO:0042391 192 0.019
protein import into nucleus GO:0006606 95 0.019
protein localization to organelle GO:0033365 185 0.019
positive regulation of cyclic nucleotide metabolic process GO:0030801 24 0.019
branching morphogenesis of an epithelial tube GO:0048754 159 0.019
cartilage development GO:0051216 140 0.019
skin development GO:0043588 220 0.019
regulation of response to dna damage stimulus GO:2001020 34 0.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.019
negative regulation of defense response GO:0031348 77 0.019
regulation of calcium ion transport GO:0051924 69 0.019
zygotic determination of anterior posterior axis embryo GO:0007354 3 0.019
alpha beta t cell differentiation GO:0046632 69 0.019
lateral line system development GO:0048925 1 0.019
ribose phosphate biosynthetic process GO:0046390 59 0.019
cell activation involved in immune response GO:0002263 126 0.019
positive regulation of apoptotic process GO:0043065 217 0.019
positive regulation of leukocyte proliferation GO:0070665 73 0.019
regulation of mrna processing GO:0050684 41 0.019
meiotic nuclear division GO:0007126 115 0.019
regulation of system process GO:0044057 200 0.019
cell cycle comprising mitosis without cytokinesis GO:0033301 1 0.019
regulation of map kinase activity GO:0043405 120 0.018
Mouse
tube closure GO:0060606 91 0.018
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.018
rna processing GO:0006396 105 0.018
engulfment of apoptotic cell GO:0043652 3 0.018
t cell selection GO:0045058 34 0.018
Mouse
osteoclast differentiation GO:0030316 62 0.018
embryonic epithelial tube formation GO:0001838 130 0.018
positive regulation of leukocyte differentiation GO:1902107 86 0.018
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.018
response to radiation GO:0009314 165 0.018
response to organic cyclic compound GO:0014070 198 0.018
positive regulation of binding GO:0051099 49 0.018
sensory system development GO:0048880 3 0.018
peptidyl serine modification GO:0018209 83 0.018
oxidation reduction process GO:0055114 342 0.018
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.018
regulation of anatomical structure size GO:0090066 178 0.018
regulation of leukocyte mediated immunity GO:0002703 104 0.018
regulation of t cell differentiation GO:0045580 83 0.018
lipid biosynthetic process GO:0008610 179 0.018
regulation of secretion GO:0051046 274 0.018
myeloid leukocyte differentiation GO:0002573 119 0.018
purine ribonucleotide biosynthetic process GO:0009152 59 0.018
negative regulation of apoptotic signaling pathway GO:2001234 104 0.018
morphogenesis of a branching structure GO:0001763 203 0.018
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.018
protein autophosphorylation GO:0046777 61 0.018
filopodium assembly GO:0046847 19 0.018
lung development GO:0030324 164 0.018
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.017
response to reactive oxygen species GO:0000302 56 0.017
immune response regulating signaling pathway GO:0002764 125 0.017
ubiquitin dependent protein catabolic process GO:0006511 129 0.017
skeletal system development GO:0001501 356 0.017
neuron maturation GO:0042551 29 0.017
organophosphate biosynthetic process GO:0090407 122 0.017
skeletal system morphogenesis GO:0048705 203 0.017
chromatin organization GO:0006325 206 0.017
single organism nuclear import GO:1902593 95 0.017
establishment of planar polarity GO:0001736 28 0.017
carbon catabolite regulation of transcription GO:0045990 4 0.017
positive regulation of neuron projection development GO:0010976 79 0.017
regulation of adaptive immune response GO:0002819 90 0.017
lymphocyte mediated immunity GO:0002449 139 0.017
cellular carbohydrate metabolic process GO:0044262 119 0.017
defense response to other organism GO:0098542 197 0.017
regulation of lymphocyte proliferation GO:0050670 117 0.017
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.017
peptidyl serine phosphorylation GO:0018105 74 0.017
regulation of bmp signaling pathway GO:0030510 60 0.017
regulation of lymphocyte differentiation GO:0045619 107 0.017
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.017
positive regulation of cytoplasmic transport GO:1903651 40 0.017
cellular response to molecule of bacterial origin GO:0071219 83 0.017
regulation of epithelial cell proliferation GO:0050678 141 0.017
regulation of cellular component size GO:0032535 121 0.017
localization within membrane GO:0051668 4 0.016

Map4k4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.031
disease of anatomical entity DOID:7 0 0.017
nervous system disease DOID:863 0 0.017