Mus musculus

162 known processes

Rapgef4

Rap guanine nucleotide exchange factor (GEF) 4

(Aliases: KIAA4040,6330581N18Rik,5730402K07Rik,mKIAA4040,Epac-2,Epac2,1300003D15Rik,EPAC 2)

Rapgef4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of membrane potential GO:0042391 192 0.477
ion transmembrane transport GO:0034220 361 0.413
nitrogen compound transport GO:0071705 271 0.369
synaptic transmission GO:0007268 329 0.323
Rat
peptide secretion GO:0002790 114 0.292
second messenger mediated signaling GO:0019932 73 0.243
locomotory behavior GO:0007626 195 0.201
neuronal action potential GO:0019228 54 0.192
exocytosis GO:0006887 121 0.191
insulin secretion GO:0030073 89 0.179
mapk cascade GO:0000165 281 0.171
Mouse
hormone secretion GO:0046879 128 0.171
action potential GO:0001508 78 0.170
regulation of hormone levels GO:0010817 211 0.162
peptide hormone secretion GO:0030072 109 0.160
membrane depolarization GO:0051899 64 0.158
amide transport GO:0042886 138 0.153
long term synaptic potentiation GO:0060291 25 0.150
peptide transport GO:0015833 133 0.148
transmembrane transport GO:0055085 412 0.143
defecation GO:0030421 1 0.131
learning or memory GO:0007611 148 0.129
cation homeostasis GO:0055080 212 0.127
nucleobase containing small molecule metabolic process GO:0055086 352 0.126
muscle tissue development GO:0060537 308 0.126
positive regulation of growth GO:0045927 104 0.122
organelle localization GO:0051640 179 0.122
synaptic vesicle priming GO:0016082 8 0.120
cellular metal ion homeostasis GO:0006875 151 0.119
cellular homeostasis GO:0019725 240 0.115
transmission of nerve impulse GO:0019226 76 0.110
ensheathment of neurons GO:0007272 76 0.109
regulation of system process GO:0044057 200 0.109
inorganic cation transmembrane transport GO:0098662 207 0.106
regulation of homeostatic process GO:0032844 182 0.106
multicellular organismal signaling GO:0035637 91 0.101
regulation of secretion GO:0051046 274 0.101
ribonucleoside metabolic process GO:0009119 245 0.100
purine ribonucleotide metabolic process GO:0009150 290 0.099
cell adhesion GO:0007155 329 0.099
regulation of cellular ketone metabolic process GO:0010565 66 0.099
multicellular organism growth GO:0035264 161 0.099
regulation of ion transport GO:0043269 215 0.099
purine nucleoside metabolic process GO:0042278 241 0.097
inorganic ion transmembrane transport GO:0098660 234 0.097
regulation of anatomical structure size GO:0090066 178 0.096
cellular amino acid metabolic process GO:0006520 103 0.095
cation transmembrane transport GO:0098655 266 0.095
regulation of protein kinase activity GO:0045859 232 0.092
Mouse
muscle system process GO:0003012 141 0.090
divalent metal ion transport GO:0070838 172 0.089
ribonucleotide metabolic process GO:0009259 291 0.088
nucleoside triphosphate metabolic process GO:0009141 230 0.088
regulation of secretion by cell GO:1903530 249 0.085
nucleoside metabolic process GO:0009116 246 0.082
cognition GO:0050890 149 0.082
divalent inorganic cation homeostasis GO:0072507 138 0.080
establishment of organelle localization GO:0051656 122 0.079
blood circulation GO:0008015 195 0.078
muscle cell differentiation GO:0042692 261 0.078
calcium ion dependent exocytosis of neurotransmitter GO:0048791 7 0.076
blood vessel morphogenesis GO:0048514 285 0.076
Mouse
respiratory system development GO:0060541 190 0.076
carbohydrate metabolic process GO:0005975 230 0.076
vesicle localization GO:0051648 86 0.075
neurotransmitter transport GO:0006836 76 0.075
cellular protein complex assembly GO:0043623 116 0.074
calcium ion dependent exocytosis GO:0017156 35 0.073
axon ensheathment GO:0008366 76 0.073
cellular chemical homeostasis GO:0055082 215 0.073
protein localization to membrane GO:0072657 108 0.071
positive regulation of membrane potential GO:0045838 15 0.071
regulation of synaptic plasticity GO:0048167 87 0.069
regulation of cellular amine metabolic process GO:0033238 20 0.069
nucleotide metabolic process GO:0009117 332 0.069
cation transport GO:0006812 399 0.068
purine ribonucleoside metabolic process GO:0046128 241 0.068
regulation of feeding behavior GO:0060259 3 0.068
regulation of mapk cascade GO:0043408 248 0.067
Mouse
gliogenesis GO:0042063 141 0.067
striated muscle cell development GO:0055002 125 0.067
striated muscle tissue development GO:0014706 293 0.067
positive regulation of hydrolase activity GO:0051345 148 0.067
regulation of kinase activity GO:0043549 249 0.066
Mouse
nucleoside phosphate metabolic process GO:0006753 338 0.066
synaptic vesicle localization GO:0097479 59 0.065
metal ion homeostasis GO:0055065 189 0.064
circulatory system process GO:0003013 197 0.064
cellular nitrogen compound catabolic process GO:0044270 280 0.062
organonitrogen compound catabolic process GO:1901565 264 0.062
purine nucleotide metabolic process GO:0006163 302 0.061
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.061
glial cell differentiation GO:0010001 131 0.060
regionalization GO:0003002 337 0.060
regulation of postsynaptic membrane potential GO:0060078 48 0.060
purine containing compound metabolic process GO:0072521 311 0.060
adult behavior GO:0030534 135 0.059
leukocyte differentiation GO:0002521 342 0.059
regulation of cellular catabolic process GO:0031329 242 0.059
regulation of ion transmembrane transport GO:0034765 119 0.059
regulation of transmembrane transport GO:0034762 128 0.058
calcium ion homeostasis GO:0055074 127 0.058
chemotaxis GO:0006935 247 0.058
monocarboxylic acid metabolic process GO:0032787 191 0.058
calcium ion transmembrane transport GO:0070588 85 0.057
renal system development GO:0072001 225 0.057
g protein coupled receptor signaling pathway GO:0007186 243 0.056
Mouse
heterocycle catabolic process GO:0046700 280 0.056
glycosyl compound metabolic process GO:1901657 246 0.056
ear development GO:0043583 200 0.056
maintenance of location GO:0051235 89 0.056
myelination GO:0042552 74 0.056
ribose phosphate metabolic process GO:0019693 291 0.056
establishment of synaptic vesicle localization GO:0097480 57 0.055
telencephalon development GO:0021537 186 0.055
establishment of vesicle localization GO:0051650 81 0.055
small gtpase mediated signal transduction GO:0007264 97 0.054
regulation of purine nucleotide catabolic process GO:0033121 122 0.054
glycosyl compound catabolic process GO:1901658 206 0.054
divalent inorganic cation transport GO:0072511 178 0.053
lipid biosynthetic process GO:0008610 179 0.053
synaptic vesicle transport GO:0048489 57 0.053
cellular lipid metabolic process GO:0044255 323 0.052
regulation of cellular amino acid metabolic process GO:0006521 5 0.051
cellular divalent inorganic cation homeostasis GO:0072503 127 0.051
purine containing compound catabolic process GO:0072523 213 0.050
neurotransmitter secretion GO:0007269 62 0.050
cellular calcium ion homeostasis GO:0006874 119 0.050
ribonucleoside triphosphate metabolic process GO:0009199 220 0.049
amine metabolic process GO:0009308 45 0.049
developmental maturation GO:0021700 193 0.049
regulation of muscle system process GO:0090257 80 0.049
male gamete generation GO:0048232 285 0.049
cellular amine metabolic process GO:0044106 44 0.049
regulation of neuron differentiation GO:0045664 281 0.049
Mouse Rat
cellular ion homeostasis GO:0006873 165 0.048
muscle contraction GO:0006936 101 0.048
nucleoside catabolic process GO:0009164 206 0.048
regulation of voltage gated calcium channel activity GO:1901385 4 0.048
gtp metabolic process GO:0046039 144 0.047
regulation of neurotransmitter levels GO:0001505 87 0.047
regulation of excitatory postsynaptic membrane potential GO:0060079 41 0.047
positive regulation of secretion by cell GO:1903532 114 0.047
axonogenesis GO:0007409 274 0.047
regulation of transferase activity GO:0051338 263 0.047
Mouse
purine nucleoside triphosphate catabolic process GO:0009146 203 0.047
response to organonitrogen compound GO:0010243 246 0.047
Mouse
regulation of cell cycle GO:0051726 281 0.047
organ growth GO:0035265 117 0.047
negative regulation of protein metabolic process GO:0051248 282 0.047
positive regulation of cellular catabolic process GO:0031331 148 0.046
cellular ketone metabolic process GO:0042180 84 0.046
apoptotic signaling pathway GO:0097190 306 0.046
rhythmic process GO:0048511 174 0.046
positive regulation of secretion GO:0051047 130 0.046
positive regulation of kinase activity GO:0033674 155 0.046
Mouse
positive regulation of nervous system development GO:0051962 221 0.046
Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.046
learning GO:0007612 98 0.045
sequestering of calcium ion GO:0051208 18 0.045
regulation of exocytosis GO:0017157 61 0.045
regulation of metal ion transport GO:0010959 106 0.045
ribonucleotide catabolic process GO:0009261 208 0.045
regulation of purine nucleotide metabolic process GO:1900542 169 0.045
calcium ion transport GO:0006816 159 0.044
organic acid transport GO:0015849 101 0.044
microtubule based process GO:0007017 236 0.044
positive regulation of apoptotic process GO:0043065 217 0.044
Mouse
sequestering of metal ion GO:0051238 19 0.044
protein polymerization GO:0051258 57 0.043
regulation of ion transmembrane transporter activity GO:0032412 54 0.043
aromatic compound catabolic process GO:0019439 286 0.043
ossification GO:0001503 216 0.043
response to extracellular stimulus GO:0009991 127 0.043
regulation of nucleotide metabolic process GO:0006140 169 0.042
neuron migration GO:0001764 122 0.042
Mouse
ribonucleoside catabolic process GO:0042454 206 0.042
multi multicellular organism process GO:0044706 109 0.042
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.042
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.042
positive regulation of cellular amine metabolic process GO:0033240 5 0.042
male genitalia morphogenesis GO:0048808 4 0.042
glycerolipid metabolic process GO:0046486 122 0.042
organonitrogen compound biosynthetic process GO:1901566 192 0.041
positive regulation of programmed cell death GO:0043068 218 0.041
Mouse
sodium ion transport GO:0006814 73 0.040
purine ribonucleotide catabolic process GO:0009154 208 0.040
heart morphogenesis GO:0003007 178 0.040
neuromuscular process GO:0050905 99 0.040
kidney development GO:0001822 213 0.040
fatty acid metabolic process GO:0006631 121 0.040
organic anion transport GO:0015711 137 0.040
regulation of ion homeostasis GO:2000021 64 0.040
muscle adaptation GO:0043500 39 0.040
epithelial tube morphogenesis GO:0060562 303 0.040
regulation of cellular component biogenesis GO:0044087 181 0.039
tissue remodeling GO:0048771 102 0.039
positive regulation of mapk cascade GO:0043410 170 0.039
Mouse
respiratory tube development GO:0030323 167 0.038
stem cell development GO:0048864 219 0.038
stem cell differentiation GO:0048863 268 0.038
regulation of leukocyte differentiation GO:1902105 159 0.037
neuron death GO:0070997 154 0.037
regulation of synaptic transmission glutamatergic GO:0051966 19 0.037
carboxylic acid transport GO:0046942 100 0.037
hexose metabolic process GO:0019318 98 0.037
cellular carbohydrate metabolic process GO:0044262 119 0.037
positive regulation of protein phosphorylation GO:0001934 242 0.037
Mouse
urogenital system development GO:0001655 261 0.036
lymphocyte differentiation GO:0030098 242 0.036
protein localization to organelle GO:0033365 185 0.036
muscle cell development GO:0055001 133 0.036
asymmetric stem cell division GO:0098722 3 0.036
cellular response to growth factor stimulus GO:0071363 197 0.036
germ cell development GO:0007281 185 0.036
digestive system development GO:0055123 200 0.036
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.036
Mouse
vascular process in circulatory system GO:0003018 62 0.036
asymmetric neuroblast division GO:0055059 1 0.036
regulation of protein localization GO:0032880 231 0.036
organic hydroxy compound metabolic process GO:1901615 203 0.036
Mouse
sensory perception GO:0007600 245 0.035
cytokine production GO:0001816 319 0.035
positive regulation of ion transport GO:0043270 65 0.035
protein maturation GO:0051604 176 0.035
alcohol metabolic process GO:0006066 116 0.034
regulation of vesicle mediated transport GO:0060627 139 0.033
steroid metabolic process GO:0008202 119 0.033
purine ribonucleoside catabolic process GO:0046130 205 0.033
carbohydrate derivative catabolic process GO:1901136 231 0.033
regulation of ossification GO:0030278 112 0.032
homeostasis of number of cells GO:0048872 210 0.032
stem cell maintenance GO:0019827 130 0.032
peptidyl amino acid modification GO:0018193 336 0.032
organophosphate catabolic process GO:0046434 232 0.032
synaptic transmission glutamatergic GO:0035249 36 0.032
regulation of neuron projection development GO:0010975 169 0.032
Mouse Rat
positive regulation of nucleotide metabolic process GO:0045981 114 0.032
membrane hyperpolarization GO:0060081 21 0.032
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.032
plasma membrane organization GO:0007009 90 0.032
angiogenesis GO:0001525 201 0.032
response to growth factor GO:0070848 198 0.032
cell type specific apoptotic process GO:0097285 268 0.032
Mouse
skeletal system development GO:0001501 356 0.031
regulation of receptor activity GO:0010469 41 0.031
nucleoside monophosphate metabolic process GO:0009123 85 0.031
oxidation reduction process GO:0055114 342 0.031
anatomical structure homeostasis GO:0060249 145 0.031
camera type eye development GO:0043010 266 0.031
regulation of lymphocyte activation GO:0051249 240 0.031
spermatogenesis GO:0007283 284 0.031
mating GO:0007618 27 0.031
regulation of cell motility GO:2000145 236 0.030
Mouse Rat
mitochondrion transport along microtubule GO:0047497 3 0.030
peptidyl serine phosphorylation GO:0018105 74 0.030
gland development GO:0048732 330 0.030
microtubule cytoskeleton organization GO:0000226 157 0.030
lung development GO:0030324 164 0.030
organic cyclic compound catabolic process GO:1901361 295 0.030
neuron apoptotic process GO:0051402 142 0.030
regulation of multi organism process GO:0043900 111 0.030
regulation of neuronal synaptic plasticity GO:0048168 30 0.030
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.030
fat cell differentiation GO:0045444 160 0.030
memory GO:0007613 58 0.029
actin filament polymerization GO:0030041 44 0.029
multi organism reproductive behavior GO:0044705 29 0.029
negative regulation of phosphorus metabolic process GO:0010563 184 0.029
regulation of defense response GO:0031347 233 0.029
regulation of protein serine threonine kinase activity GO:0071900 157 0.029
Mouse
nucleotide catabolic process GO:0009166 217 0.029
regulation of hormone secretion GO:0046883 88 0.029
regulation of cell activation GO:0050865 289 0.029
regulation of t cell activation GO:0050863 170 0.029
macromolecule catabolic process GO:0009057 281 0.028
lipid modification GO:0030258 65 0.028
regulation of cell projection organization GO:0031344 206 0.028
Mouse Rat
response to nutrient levels GO:0031667 109 0.027
regulation of long term neuronal synaptic plasticity GO:0048169 19 0.027
cofactor metabolic process GO:0051186 80 0.027
positive regulation of protein modification process GO:0031401 299 0.027
Mouse
gtp catabolic process GO:0006184 143 0.027
forebrain development GO:0030900 302 0.027
Mouse
cytoplasmic transport GO:0016482 234 0.027
neuromuscular process controlling balance GO:0050885 59 0.027
regulation of cytoskeleton organization GO:0051493 122 0.027
negative regulation of molecular function GO:0044092 258 0.026
determination of left right symmetry GO:0007368 80 0.026
regulation of lymphocyte differentiation GO:0045619 107 0.026
positive regulation of organ growth GO:0046622 29 0.026
hindbrain development GO:0030902 128 0.026
positive regulation of ion transmembrane transporter activity GO:0032414 15 0.026
mating behavior GO:0007617 20 0.026
negative regulation of cell proliferation GO:0008285 296 0.026
Mouse
digestive tract morphogenesis GO:0048546 147 0.026
multi organism behavior GO:0051705 62 0.026
glycerophospholipid metabolic process GO:0006650 71 0.026
endomembrane system organization GO:0010256 147 0.026
actin cytoskeleton organization GO:0030036 220 0.026
carbohydrate derivative biosynthetic process GO:1901137 183 0.026
anion transport GO:0006820 177 0.026
purine nucleoside triphosphate metabolic process GO:0009144 226 0.026
endocytosis GO:0006897 168 0.026
activation of mapk activity GO:0000187 59 0.026
developmental cell growth GO:0048588 84 0.025
regulation of response to wounding GO:1903034 189 0.025
reactive nitrogen species metabolic process GO:2001057 0 0.025
regulation of blood vessel size GO:0050880 56 0.025
membrane organization GO:0061024 245 0.025
cellular component assembly involved in morphogenesis GO:0010927 139 0.025
negative regulation of cellular amine metabolic process GO:0033239 1 0.025
synapse organization GO:0050808 125 0.025
positive regulation of ras gtpase activity GO:0032320 65 0.025
negative regulation of intracellular signal transduction GO:1902532 167 0.025
mitochondrion organization GO:0007005 134 0.025
regulation of cytokine production GO:0001817 266 0.025
t cell activation GO:0042110 289 0.025
positive regulation of cellular component biogenesis GO:0044089 94 0.025
positive regulation of cell death GO:0010942 224 0.025
Mouse
nucleoside triphosphate catabolic process GO:0009143 205 0.025
amino acid transport GO:0006865 61 0.024
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.024
heart contraction GO:0060047 93 0.024
negative regulation of neuron apoptotic process GO:0043524 92 0.024
cell fate commitment GO:0045165 210 0.024
regulation of cell cycle process GO:0010564 160 0.024
lipid localization GO:0010876 126 0.024
positive regulation of sodium ion transport GO:0010765 13 0.024
neuron projection extension GO:1990138 64 0.024
regulation of neurotransmitter secretion GO:0046928 29 0.024
regulation of circadian rhythm GO:0042752 58 0.024
nuclear division GO:0000280 158 0.024
epithelial cell proliferation GO:0050673 174 0.024
regulation of organelle organization GO:0033043 289 0.024
positive regulation of cell cycle GO:0045787 92 0.024
purine nucleoside catabolic process GO:0006152 205 0.024
reproductive behavior GO:0019098 32 0.024
peptidyl serine modification GO:0018209 83 0.024
mitotic cell cycle GO:0000278 195 0.024
regulation of peptide secretion GO:0002791 77 0.024
intracellular mrna localization GO:0008298 4 0.024
small molecule biosynthetic process GO:0044283 132 0.024
inflammatory response GO:0006954 244 0.024
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.024
response to inorganic substance GO:0010035 96 0.024
heart process GO:0003015 94 0.024
negative regulation of cellular component organization GO:0051129 194 0.024
Mouse
endothelial cell proliferation GO:0001935 27 0.023
synaptic vesicle exocytosis GO:0016079 26 0.023
positive regulation of cell migration GO:0030335 109 0.023
Mouse Rat
negative regulation of cellular protein metabolic process GO:0032269 247 0.023
regulation of establishment of protein localization GO:0070201 181 0.023
mitotic cell cycle process GO:1903047 159 0.023
glucose metabolic process GO:0006006 92 0.023
male anatomical structure morphogenesis GO:0090598 4 0.023
camp mediated signaling GO:0019933 15 0.023
regulation of organ growth GO:0046620 61 0.023
nucleocytoplasmic transport GO:0006913 139 0.023
nucleoside phosphate catabolic process GO:1901292 222 0.023
male sex differentiation GO:0046661 109 0.023
regulation of peptide transport GO:0090087 91 0.023
microtubule based movement GO:0007018 84 0.023
negative regulation of neuron death GO:1901215 98 0.023
regulation of inflammatory response GO:0050727 147 0.023
nuclear import GO:0051170 95 0.023
ras protein signal transduction GO:0007265 77 0.023
regulation of proteolysis GO:0030162 164 0.022
protein targeting GO:0006605 143 0.022
guanosine containing compound catabolic process GO:1901069 144 0.022
regulation of cell adhesion GO:0030155 154 0.022
regulation of sodium ion transport GO:0002028 29 0.022
regulation of cell size GO:0008361 72 0.022
positive regulation of neuron differentiation GO:0045666 141 0.022
response to organic cyclic compound GO:0014070 198 0.022
Mouse
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.022
sensory perception of light stimulus GO:0050953 54 0.022
axon guidance GO:0007411 141 0.022
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.022
regulation of apoptotic signaling pathway GO:2001233 197 0.022
mechanoreceptor differentiation GO:0042490 67 0.022
associative learning GO:0008306 61 0.022
circadian rhythm GO:0007623 114 0.022
cell cell signaling involved in lung development GO:0060495 1 0.022
regulation of cellular response to stress GO:0080135 159 0.022
positive regulation of excitatory postsynaptic membrane potential GO:2000463 14 0.022
positive regulation of map kinase activity GO:0043406 84 0.022
purine nucleotide catabolic process GO:0006195 211 0.022
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.021
regulation of transporter activity GO:0032409 57 0.021
excretion GO:0007588 22 0.021
protein processing GO:0016485 163 0.021
positive regulation of gtpase activity GO:0043547 85 0.021
regulation of epithelial cell proliferation GO:0050678 141 0.021
placenta development GO:0001890 140 0.021
nuclear transport GO:0051169 139 0.021
regulation of neuron apoptotic process GO:0043523 122 0.021
establishment of protein localization to organelle GO:0072594 118 0.021
cartilage development GO:0051216 140 0.021
regulation of reproductive process GO:2000241 66 0.021
regulation of cellular component size GO:0032535 121 0.021
sensory organ morphogenesis GO:0090596 242 0.021
positive regulation of cell motility GO:2000147 116 0.021
Mouse Rat
ribonucleoside triphosphate catabolic process GO:0009203 199 0.021
dna repair GO:0006281 107 0.021
cellular macromolecule catabolic process GO:0044265 206 0.021
response to radiation GO:0009314 165 0.021
positive regulation of gtp catabolic process GO:0033126 85 0.021
regulation of mitotic cell cycle GO:0007346 126 0.021
regulation of circadian sleep wake cycle GO:0042749 3 0.021
actin polymerization or depolymerization GO:0008154 54 0.020
sensory system development GO:0048880 3 0.020
regulation of fat cell differentiation GO:0045598 81 0.020
purine nucleoside monophosphate metabolic process GO:0009126 81 0.020
cardiac muscle tissue development GO:0048738 130 0.020
response to amino acid GO:0043200 37 0.020
regulation of nucleoside metabolic process GO:0009118 130 0.020
regulation of cell migration GO:0030334 219 0.020
Mouse Rat
regulation of carbohydrate metabolic process GO:0006109 75 0.020
cyclic nucleotide mediated signaling GO:0019935 18 0.020
response to oxygen levels GO:0070482 62 0.020
intracellular protein transport GO:0006886 204 0.020
regulation of heart growth GO:0060420 31 0.020
developmental growth involved in morphogenesis GO:0060560 138 0.020
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.020
synaptic transmission cholinergic GO:0007271 7 0.019
endocrine system development GO:0035270 98 0.019
pallium development GO:0021543 120 0.019
striated muscle contraction GO:0006941 45 0.019
smoothened signaling pathway GO:0007224 105 0.019
protein kinase b signaling GO:0043491 74 0.019
regulation of calcium ion transport GO:0051924 69 0.019
positive regulation of nucleotide catabolic process GO:0030813 88 0.019
olfactory learning GO:0008355 2 0.019
t cell differentiation in thymus GO:0033077 77 0.019
dna metabolic process GO:0006259 303 0.019
cellular response to acid chemical GO:0071229 68 0.019
cellular response to dna damage stimulus GO:0006974 207 0.019
potassium ion transmembrane transport GO:0071805 43 0.019
activation of immune response GO:0002253 138 0.019
protein catabolic process GO:0030163 221 0.019
heart growth GO:0060419 45 0.019
fat cell proliferation GO:0070341 4 0.019
regulation of high voltage gated calcium channel activity GO:1901841 2 0.019
striated muscle myosin thick filament assembly GO:0071688 1 0.019
monosaccharide metabolic process GO:0005996 106 0.019
regulation of muscle tissue development GO:1901861 97 0.019
regulation of muscle contraction GO:0006937 49 0.018
posttranscriptional regulation of gene expression GO:0010608 155 0.018
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.018
negative regulation of neuron differentiation GO:0045665 101 0.018
Mouse
rhodopsin mediated signaling pathway GO:0016056 4 0.018
pancreas development GO:0031016 57 0.018
negative regulation of immune system process GO:0002683 209 0.018
regulation of erk1 and erk2 cascade GO:0070372 71 0.018
Mouse
wound healing GO:0042060 157 0.018
adult locomotory behavior GO:0008344 91 0.018
response to lipopolysaccharide GO:0032496 128 0.018
leukocyte migration GO:0050900 124 0.018
stem cell proliferation GO:0072089 117 0.018
regulation of blood pressure GO:0008217 93 0.018
kidney epithelium development GO:0072073 121 0.018
multicellular organismal homeostasis GO:0048871 164 0.018
alpha amino acid metabolic process GO:1901605 59 0.018
immune response regulating signaling pathway GO:0002764 125 0.018
positive regulation of protein kinase activity GO:0045860 144 0.018
Mouse
operant conditioning GO:0035106 2 0.018
cell growth GO:0016049 130 0.018
erk1 and erk2 cascade GO:0070371 77 0.018
Mouse
protein import into nucleus GO:0006606 95 0.018
regulation of intracellular transport GO:0032386 159 0.017
ribonucleoside monophosphate catabolic process GO:0009158 57 0.017
lipoprotein metabolic process GO:0042157 43 0.017
wnt signaling pathway GO:0016055 188 0.017
regulation of gtp catabolic process GO:0033124 113 0.017
hematopoietic progenitor cell differentiation GO:0002244 143 0.017
atp metabolic process GO:0046034 75 0.017
response to peptide hormone GO:0043434 127 0.017
organelle fission GO:0048285 170 0.017
ribonucleoside monophosphate metabolic process GO:0009161 80 0.017
positive regulation of cell activation GO:0050867 158 0.017
single organism cell adhesion GO:0098602 156 0.017
embryonic genitalia morphogenesis GO:0030538 4 0.017
cardiac muscle hypertrophy GO:0003300 23 0.017
oocyte construction GO:0007308 2 0.017
negative regulation of phosphorylation GO:0042326 166 0.017
negative regulation of homeostatic process GO:0032845 71 0.017
skin development GO:0043588 220 0.017

Rapgef4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.086
nervous system disease DOID:863 0 0.086
sensory system disease DOID:0050155 0 0.058
eye and adnexa disease DOID:1492 0 0.058
eye disease DOID:5614 0 0.058
central nervous system disease DOID:331 0 0.038
disease of metabolism DOID:0014667 0 0.029