Mus musculus

31 known processes

Dot1l

DOT1-like, histone H3 methyltransferase (S. cerevisiae)

(Aliases: KMT4,Dot1,AW907654,mDot1,A630076O07)

Dot1l biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
covalent chromatin modification GO:0016569 163 0.150
actin cytoskeleton organization GO:0030036 220 0.110
striated muscle myosin thick filament assembly GO:0071688 1 0.102
myosin filament assembly GO:0031034 2 0.099
atrial ventricular junction remodeling GO:0003294 2 0.098
peripheral nervous system neuron axonogenesis GO:0048936 3 0.095
chromatin organization GO:0006325 206 0.079
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.071
dna metabolic process GO:0006259 303 0.067
negative regulation of cellular protein metabolic process GO:0032269 247 0.066
negative regulation of cell proliferation GO:0008285 296 0.062
av node cell to bundle of his cell communication GO:0086067 2 0.058
negative regulation of protein metabolic process GO:0051248 282 0.057
histone modification GO:0016570 159 0.056
leukocyte differentiation GO:0002521 342 0.056
axonogenesis GO:0007409 274 0.053
negative regulation of protein modification process GO:0031400 163 0.050
sa node cell to atrial cardiac muscle cell signalling GO:0086018 4 0.048
regulation of protein kinase activity GO:0045859 232 0.047
mitotic cell cycle GO:0000278 195 0.047
cellular ketone metabolic process GO:0042180 84 0.047
regulation of cellular amine metabolic process GO:0033238 20 0.047
peptidyl amino acid modification GO:0018193 336 0.046
Human
muscle tissue development GO:0060537 308 0.044
striated muscle tissue development GO:0014706 293 0.042
regulation of cell cycle GO:0051726 281 0.042
ras protein signal transduction GO:0007265 77 0.039
embryonic placenta development GO:0001892 98 0.039
amine metabolic process GO:0009308 45 0.038
central nervous system neuron differentiation GO:0021953 162 0.038
cell cycle switching mitotic to meiotic cell cycle GO:0051728 1 0.038
ion transmembrane transport GO:0034220 361 0.037
organelle assembly GO:0070925 177 0.037
epithelial cell development GO:0002064 159 0.036
regionalization GO:0003002 337 0.035
regulation of cellular amino acid metabolic process GO:0006521 5 0.035
male gamete generation GO:0048232 285 0.034
embryonic organ morphogenesis GO:0048562 276 0.034
oocyte axis specification GO:0007309 2 0.034
mrna splicing via spliceosome GO:0000398 43 0.034
transmembrane transport GO:0055085 412 0.033
regulation of transferase activity GO:0051338 263 0.033
telencephalon development GO:0021537 186 0.033
muscle cell differentiation GO:0042692 261 0.033
mrna processing GO:0006397 63 0.032
positive regulation of cellular amine metabolic process GO:0033240 5 0.032
chemotaxis GO:0006935 247 0.032
gonad development GO:0008406 141 0.031
respiratory system development GO:0060541 190 0.031
negative regulation of molecular function GO:0044092 258 0.031
organonitrogen compound catabolic process GO:1901565 264 0.030
spinal cord development GO:0021510 81 0.030
myosin filament organization GO:0031033 3 0.029
mrna metabolic process GO:0016071 84 0.029
regulation of androgen receptor signaling pathway GO:0060765 3 0.029
muscle cell development GO:0055001 133 0.029
cellular amino acid metabolic process GO:0006520 103 0.029
microtubule based process GO:0007017 236 0.028
nitrogen compound transport GO:0071705 271 0.028
organic cyclic compound catabolic process GO:1901361 295 0.028
compound eye development GO:0048749 1 0.028
retina development in camera type eye GO:0060041 119 0.028
cation transport GO:0006812 399 0.028
sensory organ morphogenesis GO:0090596 242 0.027
negative regulation of cellular amine metabolic process GO:0033239 1 0.027
germ cell development GO:0007281 185 0.027
small gtpase mediated signal transduction GO:0007264 97 0.027
ventral spinal cord development GO:0021517 48 0.027
cellular chemical homeostasis GO:0055082 215 0.027
milk ejection GO:0060156 1 0.026
stem cell development GO:0048864 219 0.026
neuron projection guidance GO:0097485 141 0.026
meiotic cell cycle GO:0051321 122 0.026
cardiac chamber development GO:0003205 108 0.026
actin filament based movement GO:0030048 23 0.026
cellular component assembly involved in morphogenesis GO:0010927 139 0.025
branching morphogenesis of an epithelial tube GO:0048754 159 0.025
cardiac muscle cell contraction GO:0086003 7 0.025
foramen ovale closure GO:0035922 1 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
camera type eye development GO:0043010 266 0.024
cellular nitrogen compound catabolic process GO:0044270 280 0.024
lymphocyte differentiation GO:0030098 242 0.024
negative regulation of b cell receptor signaling pathway GO:0050859 4 0.024
spermatogenesis GO:0007283 284 0.024
cellular amine metabolic process GO:0044106 44 0.024
protein acylation GO:0043543 64 0.024
gene silencing GO:0016458 38 0.024
regulation of cell activation GO:0050865 289 0.023
dephosphorylation GO:0016311 129 0.023
regulation of membrane potential GO:0042391 192 0.023
regulation of renin secretion into blood stream GO:1900133 4 0.023
bundle of his development GO:0003166 4 0.023
zygotic determination of anterior posterior axis embryo GO:0007354 3 0.023
regulation of cellular ketone metabolic process GO:0010565 66 0.023
spermatid differentiation GO:0048515 115 0.023
cell adhesion GO:0007155 329 0.023
heterocycle catabolic process GO:0046700 280 0.023
rna processing GO:0006396 105 0.022
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.022
regulation of cell cycle process GO:0010564 160 0.022
epithelial tube morphogenesis GO:0060562 303 0.022
regulation of striated muscle cell differentiation GO:0051153 81 0.022
nucleoside phosphate metabolic process GO:0006753 338 0.022
triglyceride metabolic process GO:0006641 51 0.022
germline cell cycle switching mitotic to meiotic cell cycle GO:0051729 1 0.022
cellular lipid metabolic process GO:0044255 323 0.022
glycerolipid metabolic process GO:0046486 122 0.022
multicellular organismal signaling GO:0035637 91 0.022
multicellular organism growth GO:0035264 161 0.021
cell communication by electrical coupling involved in cardiac conduction GO:0086064 2 0.021
cardiac muscle tissue development GO:0048738 130 0.021
myeloid cell differentiation GO:0030099 233 0.021
ameboidal type cell migration GO:0001667 128 0.021
cellular ion homeostasis GO:0006873 165 0.021
endodermal cell fate specification GO:0001714 4 0.021
synapse organization GO:0050808 125 0.020
regulation of cellular catabolic process GO:0031329 242 0.020
macromolecule catabolic process GO:0009057 281 0.020
oocyte construction GO:0007308 2 0.020
sequestering of calcium ion GO:0051208 18 0.020
septum primum development GO:0003284 4 0.020
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.020
dendrite development GO:0016358 115 0.020
positive regulation of cell development GO:0010720 237 0.020
organophosphate catabolic process GO:0046434 232 0.020
negative regulation of lymphocyte activation GO:0051250 91 0.020
development of primary sexual characteristics GO:0045137 143 0.019
rna interference GO:0016246 2 0.019
organonitrogen compound biosynthetic process GO:1901566 192 0.019
transmission of nerve impulse GO:0019226 76 0.019
positive regulation of cell adhesion GO:0045785 80 0.019
regulation of tight junction assembly GO:2000810 2 0.019
positive regulation of transferase activity GO:0051347 167 0.019
protein methylation GO:0006479 81 0.019
microtubule cytoskeleton organization GO:0000226 157 0.019
response to organonitrogen compound GO:0010243 246 0.019
placenta development GO:0001890 140 0.019
membrane organization GO:0061024 245 0.019
sensory perception GO:0007600 245 0.019
regulation of cytokine production GO:0001817 266 0.018
purine ribonucleotide metabolic process GO:0009150 290 0.018
skeletal system morphogenesis GO:0048705 203 0.018
blastocyst formation GO:0001825 33 0.018
blastocyst development GO:0001824 80 0.018
actin filament organization GO:0007015 113 0.018
mesodermal cell migration GO:0008078 4 0.018
telencephalon cell migration GO:0022029 55 0.018
protein complex disassembly GO:0043241 40 0.018
dna recombination GO:0006310 92 0.018
regulation of secretion GO:0051046 274 0.018
organic anion transport GO:0015711 137 0.018
olfactory learning GO:0008355 2 0.018
negative regulation of transferase activity GO:0051348 85 0.018
establishment of organelle localization GO:0051656 122 0.018
skeletal muscle organ development GO:0060538 163 0.018
negative regulation of phosphate metabolic process GO:0045936 184 0.017
cation homeostasis GO:0055080 212 0.017
endocytosis GO:0006897 168 0.017
cation transmembrane transport GO:0098655 266 0.017
positive regulation of growth GO:0045927 104 0.017
regulation of lymphocyte activation GO:0051249 240 0.017
positive regulation of nervous system development GO:0051962 221 0.017
myofibril assembly GO:0030239 34 0.017
internal protein amino acid acetylation GO:0006475 42 0.017
cellular homeostasis GO:0019725 240 0.017
digestive tract development GO:0048565 190 0.017
regulation of organelle organization GO:0033043 289 0.017
morphogenesis of a branching structure GO:0001763 203 0.017
neutral lipid metabolic process GO:0006638 57 0.017
peripheral nervous system development GO:0007422 53 0.017
regulation of kinase activity GO:0043549 249 0.017
aromatic compound catabolic process GO:0019439 286 0.017
protein modification by small protein conjugation GO:0032446 187 0.016
stem cell differentiation GO:0048863 268 0.016
negative regulation of mitotic cell cycle GO:0045930 58 0.016
heart morphogenesis GO:0003007 178 0.016
chromatin modification GO:0016568 187 0.016
rna splicing via transesterification reactions GO:0000375 43 0.016
mapk cascade GO:0000165 281 0.016
purine nucleoside metabolic process GO:0042278 241 0.016
regulation of mitotic cell cycle GO:0007346 126 0.016
neuroblast differentiation GO:0014016 2 0.016
protein catabolic process GO:0030163 221 0.016
gonad morphogenesis GO:0035262 1 0.016
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.016
regulation of mapk cascade GO:0043408 248 0.016
protein alkylation GO:0008213 81 0.016
nucleobase containing small molecule metabolic process GO:0055086 352 0.016
histone acetylation GO:0016573 41 0.016
cytokine production GO:0001816 319 0.016
inorganic ion transmembrane transport GO:0098660 234 0.015
inorganic cation transmembrane transport GO:0098662 207 0.015
oxidation reduction process GO:0055114 342 0.015
regulation of cellular response to stress GO:0080135 159 0.015
regulation of intracellular transport GO:0032386 159 0.015
ensheathment of neurons GO:0007272 76 0.015
gland development GO:0048732 330 0.015
sequestering of metal ion GO:0051238 19 0.015
spermatid development GO:0007286 108 0.015
canonical wnt signaling pathway GO:0060070 130 0.015
spinal cord motor neuron differentiation GO:0021522 35 0.015
cell differentiation in spinal cord GO:0021515 53 0.015
regulation of membrane depolarization GO:0003254 11 0.015
genitalia development GO:0048806 37 0.015
ribonucleoside catabolic process GO:0042454 206 0.015
regulation of cardiac chamber morphogenesis GO:1901219 2 0.015
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.015
wnt signaling pathway GO:0016055 188 0.015
ribonucleotide metabolic process GO:0009259 291 0.015
purine nucleotide metabolic process GO:0006163 302 0.015
negative regulation of phosphorus metabolic process GO:0010563 184 0.015
anatomical structure homeostasis GO:0060249 145 0.015
cell communication by chemical coupling GO:0010643 2 0.015
developmental maturation GO:0021700 193 0.015
cellular divalent inorganic cation homeostasis GO:0072503 127 0.015
cellular response to organonitrogen compound GO:0071417 145 0.014
regulation of organ growth GO:0046620 61 0.014
spleen development GO:0048536 39 0.014
peptide transport GO:0015833 133 0.014
striated muscle cell development GO:0055002 125 0.014
sensory system development GO:0048880 3 0.014
gene silencing by rna GO:0031047 19 0.014
nucleoside metabolic process GO:0009116 246 0.014
synaptic transmission GO:0007268 329 0.014
regulation of cell adhesion GO:0030155 154 0.014
regulation of hormone levels GO:0010817 211 0.014
protein depolymerization GO:0051261 34 0.014
regulation of protein localization GO:0032880 231 0.014
rhythmic process GO:0048511 174 0.014
negative regulation of t cell activation GO:0050868 65 0.014
protein ubiquitination GO:0016567 171 0.014
regulation of ras protein signal transduction GO:0046578 114 0.014
negative regulation of phosphorylation GO:0042326 166 0.014
posttranscriptional regulation of gene expression GO:0010608 155 0.014
regulation of receptor activity GO:0010469 41 0.014
locomotory behavior GO:0007626 195 0.014
neuroblast fate commitment GO:0014017 1 0.014
protein localization to membrane GO:0072657 108 0.014
positive regulation of creb transcription factor activity GO:0032793 4 0.014
endomembrane system organization GO:0010256 147 0.014
regulation of heart growth GO:0060420 31 0.014
response to molecule of bacterial origin GO:0002237 143 0.014
cellular protein complex assembly GO:0043623 116 0.013
rho protein signal transduction GO:0007266 32 0.013
appendage morphogenesis GO:0035107 149 0.013
skeletal system development GO:0001501 356 0.013
regulation of membrane depolarization during cardiac muscle cell action potential GO:1900825 1 0.013
regulation of feeding behavior GO:0060259 3 0.013
negative regulation of apoptotic signaling pathway GO:2001234 104 0.013
peptidyl lysine modification GO:0018205 77 0.013
Human
regulation of chromosome organization GO:0033044 83 0.013
divalent inorganic cation transport GO:0072511 178 0.013
mitotic cell cycle process GO:1903047 159 0.013
cellular metal ion homeostasis GO:0006875 151 0.013
protein modification by small protein conjugation or removal GO:0070647 207 0.013
proteasomal protein catabolic process GO:0010498 98 0.013
gliogenesis GO:0042063 141 0.013
regulation of purine nucleotide catabolic process GO:0033121 122 0.013
lung development GO:0030324 164 0.013
cytoplasmic transport GO:0016482 234 0.013
positive regulation of gtpase activity GO:0043547 85 0.013
peptidyl lysine acetylation GO:0018394 45 0.013
regulation of defense response GO:0031347 233 0.013
positive regulation of cilium movement GO:0003353 1 0.013
positive regulation of dna templated transcription elongation GO:0032786 2 0.013
metencephalon development GO:0022037 89 0.013
protein targeting GO:0006605 143 0.013
embryonic epithelial tube formation GO:0001838 130 0.013
intracellular protein transport GO:0006886 204 0.013
nucleoside triphosphate catabolic process GO:0009143 205 0.013
anion transport GO:0006820 177 0.013
primary neural tube formation GO:0014020 95 0.013
organ growth GO:0035265 117 0.013
positive regulation of nucleotide catabolic process GO:0030813 88 0.012
organelle localization GO:0051640 179 0.012
nuclear transport GO:0051169 139 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
internal peptidyl lysine acetylation GO:0018393 42 0.012
negative regulation of kinase activity GO:0033673 81 0.012
negative regulation of leukocyte proliferation GO:0070664 46 0.012
negative regulation of intracellular signal transduction GO:1902532 167 0.012
purine containing compound metabolic process GO:0072521 311 0.012
amide transport GO:0042886 138 0.012
negative regulation of immune system process GO:0002683 209 0.012
regulation of anatomical structure size GO:0090066 178 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.012
modification dependent protein catabolic process GO:0019941 133 0.012
ribonucleoside triphosphate metabolic process GO:0009199 220 0.012
regulation of ion transport GO:0043269 215 0.012
cellular protein catabolic process GO:0044257 155 0.012
response to peptide hormone GO:0043434 127 0.012
molting cycle GO:0042303 90 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.012
pallium development GO:0021543 120 0.012
purine nucleoside catabolic process GO:0006152 205 0.012
axon guidance GO:0007411 141 0.012
single organism cell adhesion GO:0098602 156 0.012
regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 2 0.012
actomyosin structure organization GO:0031032 56 0.012
lateral inhibition GO:0046331 1 0.012
positive regulation of neuron differentiation GO:0045666 141 0.012
ribonucleoside metabolic process GO:0009119 245 0.012
hematopoietic progenitor cell differentiation GO:0002244 143 0.012
macromolecular complex disassembly GO:0032984 43 0.012
regulation of lymphocyte proliferation GO:0050670 117 0.012
regulation of t cell activation GO:0050863 170 0.012
sa node cell action potential GO:0086015 4 0.012
neural tube closure GO:0001843 90 0.012
regulation of lymphocyte mediated immunity GO:0002706 84 0.012
positive regulation of defense response GO:0031349 124 0.012
glucose homeostasis GO:0042593 128 0.012
platelet derived growth factor receptor signaling pathway GO:0048008 32 0.011
sensory perception of mechanical stimulus GO:0050954 107 0.011
negative regulation of leukocyte differentiation GO:1902106 51 0.011
cardiac septum development GO:0003279 59 0.011
negative regulation of heart growth GO:0061117 7 0.011
regulation of secretion by cell GO:1903530 249 0.011
gene silencing by mirna GO:0035195 10 0.011
forebrain development GO:0030900 302 0.011
purine nucleoside triphosphate metabolic process GO:0009144 226 0.011
regulation of establishment of protein localization GO:0070201 181 0.011
positive regulation of vasoconstriction GO:0045907 4 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
stem cell maintenance GO:0019827 130 0.011
t cell activation GO:0042110 289 0.011
carbohydrate metabolic process GO:0005975 230 0.011
regulation of lymphocyte differentiation GO:0045619 107 0.011
ventricular cardiac muscle cell action potential GO:0086005 4 0.011
cellular response to dna damage stimulus GO:0006974 207 0.011
female gamete generation GO:0007292 74 0.011
posttranscriptional gene silencing GO:0016441 10 0.011
actin mediated cell contraction GO:0070252 15 0.011
rna splicing GO:0008380 54 0.011
myelination GO:0042552 74 0.011
regulation of purine nucleotide metabolic process GO:1900542 169 0.011
lens development in camera type eye GO:0002088 62 0.011
purine ribonucleoside metabolic process GO:0046128 241 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.011
regulation of protein serine threonine kinase activity GO:0071900 157 0.011
cell growth GO:0016049 130 0.011
directional locomotion GO:0033058 3 0.011
purine containing compound catabolic process GO:0072523 213 0.011
actin polymerization or depolymerization GO:0008154 54 0.011
cellular response to lipid GO:0071396 145 0.011
regulation of meiotic cell cycle GO:0051445 34 0.011
p38mapk cascade GO:0038066 4 0.011
regulation of behavioral fear response GO:2000822 2 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.011
guanosine containing compound catabolic process GO:1901069 144 0.011
response to lipopolysaccharide GO:0032496 128 0.011
lymphocyte mediated immunity GO:0002449 139 0.011
cell activation involved in immune response GO:0002263 126 0.011
regulation of protein transport GO:0051223 163 0.011
kidney development GO:0001822 213 0.011
regulation of ion transmembrane transport GO:0034765 119 0.011
negative regulation of protein phosphorylation GO:0001933 126 0.011
positive regulation of cellular catabolic process GO:0031331 148 0.011
regulation of leukocyte mediated immunity GO:0002703 104 0.011
immunoglobulin production GO:0002377 73 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.010
translation GO:0006412 93 0.010
developmental cell growth GO:0048588 84 0.010
establishment of blood nerve barrier GO:0008065 3 0.010
cerebral cortex development GO:0021987 86 0.010
purine nucleoside triphosphate catabolic process GO:0009146 203 0.010
localization within membrane GO:0051668 4 0.010
peptide secretion GO:0002790 114 0.010
cellular protein complex disassembly GO:0043624 36 0.010
regulation of ion homeostasis GO:2000021 64 0.010
rac protein signal transduction GO:0016601 13 0.010
positive regulation of immune effector process GO:0002699 107 0.010
protein secretion GO:0009306 111 0.010
action potential GO:0001508 78 0.010
protein localization to nucleus GO:0034504 121 0.010
ribose phosphate metabolic process GO:0019693 291 0.010
regulation of rna splicing GO:0043484 37 0.010
cell cycle g1 s phase transition GO:0044843 57 0.010
regulation of adaptive immune response GO:0002819 90 0.010
epithelial tube formation GO:0072175 130 0.010

Dot1l disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.030
nervous system disease DOID:863 0 0.030
musculoskeletal system disease DOID:17 0 0.028
muscular disease DOID:0080000 0 0.027
muscle tissue disease DOID:66 0 0.027
bone development disease DOID:0080006 0 0.022
bone disease DOID:0080001 0 0.022
connective tissue disease DOID:65 0 0.022
myopathy DOID:423 0 0.020
muscular dystrophy DOID:9884 0 0.020
immune system disease DOID:2914 0 0.019
heart disease DOID:114 0 0.017
cardiovascular system disease DOID:1287 0 0.017
hematopoietic system disease DOID:74 0 0.015
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
immune system cancer DOID:0060083 0 0.013
hematologic cancer DOID:2531 0 0.013
organ system cancer DOID:0050686 0 0.013
cardiomyopathy DOID:0050700 0 0.013
intrinsic cardiomyopathy DOID:0060036 0 0.013
dysostosis DOID:1934 0 0.012
central nervous system disease DOID:331 0 0.010