Mus musculus

57 known processes

Astl

astacin-like metalloendopeptidase (M12 family)

(Aliases: MGC76457,7420700F21,C87576)

Astl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cytokine production GO:0001816 319 0.103
regulation of cellular amino acid metabolic process GO:0006521 5 0.065
regulation of cytokine production GO:0001817 266 0.064
defense response to bacterium GO:0042742 119 0.064
cellular amino acid metabolic process GO:0006520 103 0.062
inflammatory response GO:0006954 244 0.056
defense response to other organism GO:0098542 197 0.048
regulation of cellular ketone metabolic process GO:0010565 66 0.044
cellular amine metabolic process GO:0044106 44 0.041
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.041
amine metabolic process GO:0009308 45 0.037
cellular ketone metabolic process GO:0042180 84 0.036
lymphocyte differentiation GO:0030098 242 0.035
positive regulation of cytokine production GO:0001819 174 0.035
dna metabolic process GO:0006259 303 0.034
cation homeostasis GO:0055080 212 0.034
leukocyte differentiation GO:0002521 342 0.034
regulation of lymphocyte activation GO:0051249 240 0.033
regulation of secretion by cell GO:1903530 249 0.033
cation transmembrane transport GO:0098655 266 0.032
cation transport GO:0006812 399 0.032
small molecule biosynthetic process GO:0044283 132 0.032
regulation of secretion GO:0051046 274 0.031
organonitrogen compound catabolic process GO:1901565 264 0.031
regulation of establishment of protein localization GO:0070201 181 0.031
cellular protein complex assembly GO:0043623 116 0.031
positive regulation of programmed cell death GO:0043068 218 0.030
regulation of ion transport GO:0043269 215 0.030
regulation of cellular amine metabolic process GO:0033238 20 0.030
cell activation involved in immune response GO:0002263 126 0.030
positive regulation of cellular amine metabolic process GO:0033240 5 0.030
nucleobase containing small molecule metabolic process GO:0055086 352 0.029
interleukin 8 secretion GO:0072606 3 0.029
immune effector process GO:0002252 321 0.029
apoptotic signaling pathway GO:0097190 306 0.028
regulation of defense response GO:0031347 233 0.028
heterocycle catabolic process GO:0046700 280 0.028
t cell activation GO:0042110 289 0.028
reactive oxygen species metabolic process GO:0072593 84 0.027
sensory perception GO:0007600 245 0.027
regulation of cell activation GO:0050865 289 0.027
chemotaxis GO:0006935 247 0.027
leukocyte activation involved in immune response GO:0002366 126 0.027
regulation of membrane potential GO:0042391 192 0.027
negative regulation of intracellular signal transduction GO:1902532 167 0.026
g protein coupled receptor signaling pathway GO:0007186 243 0.026
leukocyte migration GO:0050900 124 0.025
response to molecule of bacterial origin GO:0002237 143 0.025
detection of molecule of bacterial origin GO:0032490 2 0.025
t cell proliferation GO:0042098 120 0.025
developmental growth involved in morphogenesis GO:0060560 138 0.025
regulation of t cell activation GO:0050863 170 0.025
regulation of interleukin 8 production GO:0032677 3 0.024
inorganic cation transmembrane transport GO:0098662 207 0.024
regulation of cell cycle GO:0051726 281 0.024
leukocyte proliferation GO:0070661 172 0.024
purine containing compound metabolic process GO:0072521 311 0.024
gland development GO:0048732 330 0.023
positive regulation of cell death GO:0010942 224 0.023
endocytosis GO:0006897 168 0.023
homeostasis of number of cells GO:0048872 210 0.023
interleukin 8 production GO:0032637 4 0.023
cell growth GO:0016049 130 0.022
lymphocyte proliferation GO:0046651 164 0.022
positive regulation of apoptotic process GO:0043065 217 0.022
regulation of multi organism process GO:0043900 111 0.021
calcitriol biosynthetic process from calciol GO:0036378 3 0.021
response to lipopolysaccharide GO:0032496 128 0.021
purine nucleotide metabolic process GO:0006163 302 0.021
t cell differentiation GO:0030217 174 0.021
negative regulation of immune system process GO:0002683 209 0.021
camera type eye development GO:0043010 266 0.021
cellular nitrogen compound catabolic process GO:0044270 280 0.020
protein ubiquitination GO:0016567 171 0.020
regulation of protein localization GO:0032880 231 0.020
transmembrane transport GO:0055085 412 0.020
regulation of organelle organization GO:0033043 289 0.020
protein catabolic process GO:0030163 221 0.020
striated muscle tissue development GO:0014706 293 0.020
ribonucleotide metabolic process GO:0009259 291 0.019
mitotic cell cycle GO:0000278 195 0.019
nucleotide metabolic process GO:0009117 332 0.019
carbohydrate metabolic process GO:0005975 230 0.019
membrane organization GO:0061024 245 0.019
sulfur compound metabolic process GO:0006790 100 0.019
positive regulation of protein modification process GO:0031401 299 0.019
protein secretion GO:0009306 111 0.019
cell fate commitment GO:0045165 210 0.019
protein modification by small protein conjugation or removal GO:0070647 207 0.019
cell type specific apoptotic process GO:0097285 268 0.018
regulation of cell projection organization GO:0031344 206 0.018
ubiquitin dependent protein catabolic process GO:0006511 129 0.018
fat soluble vitamin biosynthetic process GO:0042362 4 0.018
cellular homeostasis GO:0019725 240 0.018
purine nucleoside triphosphate metabolic process GO:0009144 226 0.018
neural tube development GO:0021915 160 0.018
regulation of t cell proliferation GO:0042129 92 0.018
ribose phosphate metabolic process GO:0019693 291 0.017
nucleoside catabolic process GO:0009164 206 0.017
circulatory system process GO:0003013 197 0.017
negative regulation of growth GO:0045926 99 0.017
cellular response to dna damage stimulus GO:0006974 207 0.017
regulation of cellular catabolic process GO:0031329 242 0.017
forebrain development GO:0030900 302 0.017
divalent inorganic cation transport GO:0072511 178 0.017
defense response to gram positive bacterium GO:0050830 50 0.017
glycoprotein metabolic process GO:0009100 116 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.017
protein modification by small protein conjugation GO:0032446 187 0.016
carbohydrate derivative biosynthetic process GO:1901137 183 0.016
response to inorganic substance GO:0010035 96 0.016
axonogenesis GO:0007409 274 0.016
nucleoside phosphate metabolic process GO:0006753 338 0.016
spinal cord development GO:0021510 81 0.016
gamma delta t cell lineage commitment GO:0002365 1 0.016
positive regulation of immune effector process GO:0002699 107 0.016
aromatic compound catabolic process GO:0019439 286 0.016
ribonucleoside catabolic process GO:0042454 206 0.016
microtubule based process GO:0007017 236 0.016
embryonic organ morphogenesis GO:0048562 276 0.016
organic cyclic compound catabolic process GO:1901361 295 0.016
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.016
defense response to gram negative bacterium GO:0050829 28 0.016
metal ion homeostasis GO:0055065 189 0.016
positive regulation of cell activation GO:0050867 158 0.016
modification dependent protein catabolic process GO:0019941 133 0.016
nucleoside triphosphate metabolic process GO:0009141 230 0.016
nucleoside phosphate catabolic process GO:1901292 222 0.015
production of molecular mediator of immune response GO:0002440 103 0.015
alcohol metabolic process GO:0006066 116 0.015
negative regulation of cell activation GO:0050866 111 0.015
protein oligomerization GO:0051259 67 0.015
nucleoside triphosphate catabolic process GO:0009143 205 0.015
oxidation reduction process GO:0055114 342 0.015
mitotic cell cycle process GO:1903047 159 0.015
ribonucleoside metabolic process GO:0009119 245 0.015
organophosphate catabolic process GO:0046434 232 0.015
germ cell development GO:0007281 185 0.015
ras protein signal transduction GO:0007265 77 0.015
lipid catabolic process GO:0016042 69 0.015
cellular response to cytokine stimulus GO:0071345 189 0.015
glycoprotein biosynthetic process GO:0009101 89 0.015
muscle cell differentiation GO:0042692 261 0.015
regulation of proteolysis GO:0030162 164 0.015
regulation of cell migration GO:0030334 219 0.015
myeloid leukocyte activation GO:0002274 83 0.015
muscle cell development GO:0055001 133 0.015
purine ribonucleotide metabolic process GO:0009150 290 0.015
regulation of interleukin 8 secretion GO:2000482 2 0.015
purine ribonucleoside catabolic process GO:0046130 205 0.015
blood circulation GO:0008015 195 0.014
positive regulation of secretion GO:0051047 130 0.014
regulation of feeding behavior GO:0060259 3 0.014
b cell activation GO:0042113 161 0.014
response to organonitrogen compound GO:0010243 246 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.014
sensory organ morphogenesis GO:0090596 242 0.014
developmental maturation GO:0021700 193 0.014
detection of bacterial lipoprotein GO:0042494 1 0.014
ribonucleotide catabolic process GO:0009261 208 0.014
nucleoside metabolic process GO:0009116 246 0.014
organic hydroxy compound metabolic process GO:1901615 203 0.014
cellular protein catabolic process GO:0044257 155 0.014
negative regulation of interleukin 8 secretion GO:2000483 1 0.014
carboxylic acid biosynthetic process GO:0046394 86 0.014
ion transmembrane transport GO:0034220 361 0.014
small gtpase mediated signal transduction GO:0007264 97 0.014
regulation of neuron differentiation GO:0045664 281 0.014
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.014
regulation of cell growth GO:0001558 91 0.014
purine nucleoside metabolic process GO:0042278 241 0.014
protein maturation GO:0051604 176 0.014
purine nucleoside triphosphate catabolic process GO:0009146 203 0.014
immune response regulating signaling pathway GO:0002764 125 0.014
regulation of cell cycle process GO:0010564 160 0.014
naphthalene metabolic process GO:0018931 1 0.013
negative regulation of cell proliferation GO:0008285 296 0.013
myosin filament assembly GO:0031034 2 0.013
ribonucleoside triphosphate metabolic process GO:0009199 220 0.013
wnt signaling pathway GO:0016055 188 0.013
exocytosis GO:0006887 121 0.013
regulation of neuron projection development GO:0010975 169 0.013
cytokine secretion GO:0050663 72 0.013
cellular response to biotic stimulus GO:0071216 92 0.013
nucleotide catabolic process GO:0009166 217 0.013
posttranscriptional regulation of gene expression GO:0010608 155 0.013
purine ribonucleoside metabolic process GO:0046128 241 0.013
adaptive immune response GO:0002250 155 0.013
regulation of lymphocyte differentiation GO:0045619 107 0.013
immune response activating signal transduction GO:0002757 116 0.013
cellular macromolecule catabolic process GO:0044265 206 0.013
regulation of vesicle mediated transport GO:0060627 139 0.013
oocyte construction GO:0007308 2 0.013
ribonucleoside monophosphate metabolic process GO:0009161 80 0.013
muscle tissue development GO:0060537 308 0.013
regulation of cell motility GO:2000145 236 0.013
lipid biosynthetic process GO:0008610 179 0.012
regulation of protein transport GO:0051223 163 0.012
regulation of leukocyte differentiation GO:1902105 159 0.012
regulation of interleukin 10 secretion GO:2001179 4 0.012
atp catabolic process GO:0006200 55 0.012
regulation of leukocyte proliferation GO:0070663 121 0.012
respiratory system development GO:0060541 190 0.012
cellular lipid metabolic process GO:0044255 323 0.012
purine containing compound catabolic process GO:0072523 213 0.012
modification dependent macromolecule catabolic process GO:0043632 133 0.012
organonitrogen compound biosynthetic process GO:1901566 192 0.012
leukocyte mediated immunity GO:0002443 174 0.012
negative regulation of cellular component organization GO:0051129 194 0.012
regulation of reactive oxygen species metabolic process GO:2000377 40 0.012
regulation of protein secretion GO:0050708 82 0.012
proteoglycan metabolic process GO:0006029 38 0.012
negative regulation of protein metabolic process GO:0051248 282 0.012
plasma membrane organization GO:0007009 90 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
regulation of cell size GO:0008361 72 0.012
positive regulation of defense response GO:0031349 124 0.012
negative regulation of cell development GO:0010721 169 0.012
regulation of lymphocyte proliferation GO:0050670 117 0.012
regulation of blood pressure GO:0008217 93 0.012
ribonucleoside triphosphate catabolic process GO:0009203 199 0.012
regulation of hormone levels GO:0010817 211 0.012
multi multicellular organism process GO:0044706 109 0.012
nuclear division GO:0000280 158 0.012
negative regulation of cytokine production GO:0001818 84 0.012
regulation of cytokine secretion GO:0050707 61 0.012
regulation of leukocyte mediated immunity GO:0002703 104 0.012
cartilage development GO:0051216 140 0.012
glycosyl compound metabolic process GO:1901657 246 0.012
regulation of hydrolase activity GO:0051336 246 0.011
antimicrobial peptide biosynthetic process GO:0002777 2 0.011
macromolecule catabolic process GO:0009057 281 0.011
monocarboxylic acid metabolic process GO:0032787 191 0.011
chromatin organization GO:0006325 206 0.011
interleukin 10 secretion GO:0072608 4 0.011
humoral immune response GO:0006959 57 0.011
regulation of protein maturation GO:1903317 96 0.011
nucleoside monophosphate metabolic process GO:0009123 85 0.011
ribonucleoside monophosphate catabolic process GO:0009158 57 0.011
innate immune response GO:0045087 157 0.011
regulation of protein complex assembly GO:0043254 83 0.011
negative regulation of secretion by cell GO:1903531 54 0.011
response to pain GO:0048265 26 0.011
activation of immune response GO:0002253 138 0.011
purine ribonucleotide catabolic process GO:0009154 208 0.011
calcium ion transport GO:0006816 159 0.011
regulation of anatomical structure size GO:0090066 178 0.011
stem cell differentiation GO:0048863 268 0.011
carbohydrate derivative catabolic process GO:1901136 231 0.011
compound eye development GO:0048749 1 0.011
cell fate specification GO:0001708 72 0.011
regulation of innate immune response GO:0045088 91 0.011
multicellular organismal homeostasis GO:0048871 164 0.011
cellular response to molecule of bacterial origin GO:0071219 83 0.011
regulation of cytoskeleton organization GO:0051493 122 0.011
negative regulation of cellular amine metabolic process GO:0033239 1 0.011
chemokine production GO:0032602 34 0.011
lipid transport GO:0006869 98 0.011
somatotropin secreting cell differentiation GO:0060126 4 0.011
cellular response to lipopolysaccharide GO:0071222 77 0.011
naphthalene containing compound metabolic process GO:0090420 1 0.011
lymphocyte activation involved in immune response GO:0002285 93 0.011
g1 s transition of mitotic cell cycle GO:0000082 57 0.011
regionalization GO:0003002 337 0.011
steroid metabolic process GO:0008202 119 0.011
neuron projection extension GO:1990138 64 0.011
microtubule cytoskeleton organization GO:0000226 157 0.011
peptidyl amino acid modification GO:0018193 336 0.011
negative regulation of secretion GO:0051048 61 0.011
antimicrobial peptide production GO:0002775 2 0.011
skeletal muscle organ development GO:0060538 163 0.011
meiotic cell cycle GO:0051321 122 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.010
regulation of metal ion transport GO:0010959 106 0.010
atp metabolic process GO:0046034 75 0.010
receptor mediated endocytosis GO:0006898 51 0.010
regulation of striated muscle cell differentiation GO:0051153 81 0.010
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.010
cellular response to hormone stimulus GO:0032870 150 0.010
regulation of protein processing GO:0070613 96 0.010
organic hydroxy compound biosynthetic process GO:1901617 77 0.010
lymphocyte mediated immunity GO:0002449 139 0.010
positive regulation of cellular catabolic process GO:0031331 148 0.010
regulation of system process GO:0044057 200 0.010
response to acid chemical GO:0001101 111 0.010
protein localization to membrane GO:0072657 108 0.010
negative regulation of lymphocyte activation GO:0051250 91 0.010
intracellular protein transport GO:0006886 204 0.010
mesodermal cell migration GO:0008078 4 0.010
rho protein signal transduction GO:0007266 32 0.010
positive regulation of lymphocyte activation GO:0051251 140 0.010
organelle fission GO:0048285 170 0.010
regulation of cellular component biogenesis GO:0044087 181 0.010

Astl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.024
nervous system disease DOID:863 0 0.017
disease of anatomical entity DOID:7 0 0.017
inherited metabolic disorder DOID:655 0 0.012
disease of cellular proliferation DOID:14566 0 0.010
gastrointestinal system cancer DOID:3119 0 0.010
cancer DOID:162 0 0.010
organ system cancer DOID:0050686 0 0.010