Mus musculus

226 known processes

Gpx1

glutathione peroxidase 1

(Aliases: AI195024,GPx-1,AL033363,CGPx,Gpx,GSHPx-1)

Gpx1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular hyperosmotic salinity response GO:0071475 0 1.000
cellular response to salt stress GO:0071472 1 0.535
response to hydroperoxide GO:0033194 6 0.308
oxidation reduction process GO:0055114 342 0.295
cellular lipid metabolic process GO:0044255 323 0.267
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.227
response to acid chemical GO:0001101 111 0.223
cellular hyperosmotic response GO:0071474 0 0.220
response to organonitrogen compound GO:0010243 246 0.213
cellular response to lipid GO:0071396 145 0.201
cellular amino acid metabolic process GO:0006520 103 0.185
reactive oxygen species metabolic process GO:0072593 84 0.178
cellular modified amino acid metabolic process GO:0006575 63 0.132
cellular response to acid chemical GO:0071229 68 0.128
regulation of cellular ketone metabolic process GO:0010565 66 0.121
response to organic cyclic compound GO:0014070 198 0.117
positive regulation of cell death GO:0010942 224 0.110
protein oxidation GO:0018158 2 0.109
cellular response to amino acid stimulus GO:0071230 29 0.100
hydrogen peroxide catabolic process GO:0042744 5 0.089
response to steroid hormone GO:0048545 56 0.083
negative regulation of apoptotic signaling pathway GO:2001234 104 0.083
response to symbiont GO:0009608 2 0.081
cellular ketone metabolic process GO:0042180 84 0.078
negative regulation of response to oxidative stress GO:1902883 10 0.078
regulation of cellular amino acid metabolic process GO:0006521 5 0.071
response to molecule of fungal origin GO:0002238 4 0.069
regulation of cellular response to stress GO:0080135 159 0.069
regulation of apoptotic signaling pathway GO:2001233 197 0.067
inflammatory response GO:0006954 244 0.063
amine metabolic process GO:0009308 45 0.063
ameboidal type cell migration GO:0001667 128 0.062
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.061
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.060
cell type specific apoptotic process GO:0097285 268 0.058
cellular response to osmotic stress GO:0071470 7 0.057
organic cyclic compound catabolic process GO:1901361 295 0.057
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.057
cellular macromolecule catabolic process GO:0044265 206 0.056
cellular response to oxidative stress GO:0034599 76 0.054
neutral lipid metabolic process GO:0006638 57 0.054
tissue migration GO:0090130 68 0.054
purine containing compound metabolic process GO:0072521 311 0.053
regulation of cellular amine metabolic process GO:0033238 20 0.052
myotube cell development GO:0014904 60 0.052
striated muscle tissue development GO:0014706 293 0.052
muscle cell development GO:0055001 133 0.051
interaction with symbiont GO:0051702 14 0.050
epithelial cell migration GO:0010631 63 0.049
cellular amine metabolic process GO:0044106 44 0.049
inflammatory response to antigenic stimulus GO:0002437 30 0.049
positive regulation of protein phosphorylation GO:0001934 242 0.048
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.048
cellular chemical homeostasis GO:0055082 215 0.047
glutathione metabolic process GO:0006749 16 0.047
regulation of cellular response to oxidative stress GO:1900407 19 0.047
multicellular organismal homeostasis GO:0048871 164 0.046
cellular response to estrogen stimulus GO:0071391 12 0.045
positive regulation of protein modification process GO:0031401 299 0.045
skeletal muscle organ development GO:0060538 163 0.045
hyperosmotic response GO:0006972 4 0.045
circulatory system process GO:0003013 197 0.045
regulation of response to oxidative stress GO:1902882 19 0.045
blood vessel endothelial cell migration GO:0043534 23 0.044
neuron death GO:0070997 154 0.044
response to oxidative stress GO:0006979 123 0.044
cellular homeostasis GO:0019725 240 0.044
pigment metabolic process GO:0042440 32 0.043
immune effector process GO:0002252 321 0.043
sensory perception of sound GO:0007605 97 0.043
positive regulation of programmed cell death GO:0043068 218 0.042
blood vessel morphogenesis GO:0048514 285 0.042
response to reactive oxygen species GO:0000302 56 0.041
regulation of proteolysis GO:0030162 164 0.041
vasodilation GO:0042311 28 0.041
positive regulation of apoptotic process GO:0043065 217 0.040
pigment biosynthetic process GO:0046148 26 0.040
acylglycerol metabolic process GO:0006639 55 0.039
apoptotic signaling pathway GO:0097190 306 0.039
interspecies interaction between organisms GO:0044419 83 0.039
response to molecule of bacterial origin GO:0002237 143 0.038
regulation of hydrolase activity GO:0051336 246 0.037
response to ionizing radiation GO:0010212 42 0.037
skeletal muscle fiber development GO:0048741 58 0.036
sterol metabolic process GO:0016125 58 0.036
skeletal muscle tissue regeneration GO:0043403 20 0.035
heterocycle catabolic process GO:0046700 280 0.035
regulation of response to wounding GO:1903034 189 0.035
negative regulation of oxidative stress induced cell death GO:1903202 9 0.034
gland development GO:0048732 330 0.034
response to osmotic stress GO:0006970 21 0.034
muscle tissue development GO:0060537 308 0.033
positive regulation of mapk cascade GO:0043410 170 0.033
regulation of protein kinase activity GO:0045859 232 0.033
muscle fiber development GO:0048747 76 0.032
muscle cell differentiation GO:0042692 261 0.032
negative regulation of immune system process GO:0002683 209 0.032
positive regulation of transferase activity GO:0051347 167 0.032
wound healing GO:0042060 157 0.031
innate immune response GO:0045087 157 0.031
negative regulation of cellular response to oxidative stress GO:1900408 10 0.031
angiogenesis GO:0001525 201 0.031
regulation of secretion GO:0051046 274 0.031
epithelial cell development GO:0002064 159 0.031
regulation of mapk cascade GO:0043408 248 0.031
cellular response to steroid hormone stimulus GO:0071383 33 0.031
positive regulation of cellular amine metabolic process GO:0033240 5 0.030
epithelium migration GO:0090132 63 0.030
purine nucleoside metabolic process GO:0042278 241 0.029
nitrogen compound transport GO:0071705 271 0.029
mapk cascade GO:0000165 281 0.029
negative regulation of defense response GO:0031348 77 0.029
protein modification by small protein conjugation or removal GO:0070647 207 0.029
metal ion homeostasis GO:0055065 189 0.028
negative regulation of molecular function GO:0044092 258 0.028
myoblast proliferation GO:0051450 11 0.028
positive regulation of kinase activity GO:0033674 155 0.028
cation transport GO:0006812 399 0.028
carbohydrate homeostasis GO:0033500 128 0.028
protein processing GO:0016485 163 0.028
regulation of kinase activity GO:0043549 249 0.028
regulation of transmembrane transport GO:0034762 128 0.028
regulation of ion transport GO:0043269 215 0.028
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.027
triglyceride metabolic process GO:0006641 51 0.027
endothelial cell development GO:0001885 20 0.027
negative regulation of cellular protein metabolic process GO:0032269 247 0.027
regulation of homeostatic process GO:0032844 182 0.026
response to radiation GO:0009314 165 0.026
regulation of cell adhesion GO:0030155 154 0.026
ion transmembrane transport GO:0034220 361 0.026
striated muscle cell development GO:0055002 125 0.025
sulfur compound metabolic process GO:0006790 100 0.024
single organism cell adhesion GO:0098602 156 0.024
nucleotide metabolic process GO:0009117 332 0.024
intrinsic apoptotic signaling pathway GO:0097193 132 0.024
negative regulation of inflammatory response GO:0050728 61 0.024
male gamete generation GO:0048232 285 0.024
protein kinase b signaling GO:0043491 74 0.024
protein maturation GO:0051604 176 0.024
regulation of transferase activity GO:0051338 263 0.024
cation homeostasis GO:0055080 212 0.024
nucleoside phosphate biosynthetic process GO:1901293 79 0.024
negative regulation of protein metabolic process GO:0051248 282 0.024
protein catabolic process GO:0030163 221 0.024
regulation of tube size GO:0035150 57 0.023
macromolecule catabolic process GO:0009057 281 0.023
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.023
response to inorganic substance GO:0010035 96 0.023
defense response to other organism GO:0098542 197 0.022
regulation of cellular catabolic process GO:0031329 242 0.022
epithelial cell proliferation GO:0050673 174 0.022
fatty acid metabolic process GO:0006631 121 0.022
cellular response to hormone stimulus GO:0032870 150 0.022
monocarboxylic acid metabolic process GO:0032787 191 0.022
regulation of protein localization GO:0032880 231 0.022
regulation of endocytosis GO:0030100 69 0.022
glucose homeostasis GO:0042593 128 0.022
response to mineralocorticoid GO:0051385 1 0.022
peptidyl amino acid modification GO:0018193 336 0.022
nucleobase containing small molecule metabolic process GO:0055086 352 0.022
endothelial cell differentiation GO:0045446 41 0.021
negative regulation of cellular component organization GO:0051129 194 0.021
myeloid cell differentiation GO:0030099 233 0.021
receptor mediated endocytosis of low density lipoprotein particle involved in cholesterol transport GO:0090118 1 0.021
regulation of cell motility GO:2000145 236 0.021
nucleoside phosphate metabolic process GO:0006753 338 0.021
positive regulation of protein kinase activity GO:0045860 144 0.021
regulation of binding GO:0051098 111 0.021
regulation of protein processing GO:0070613 96 0.021
aromatic compound catabolic process GO:0019439 286 0.021
cellular metal ion homeostasis GO:0006875 151 0.020
cellular nitrogen compound catabolic process GO:0044270 280 0.020
organic acid biosynthetic process GO:0016053 86 0.020
anatomical structure homeostasis GO:0060249 145 0.020
ribonucleoside metabolic process GO:0009119 245 0.020
peptidyl tyrosine phosphorylation GO:0018108 143 0.020
sensory perception of mechanical stimulus GO:0050954 107 0.020
cofactor metabolic process GO:0051186 80 0.020
response to amino acid GO:0043200 37 0.020
detection of molecule of bacterial origin GO:0032490 2 0.020
myeloid cell homeostasis GO:0002262 114 0.019
blood circulation GO:0008015 195 0.019
transmembrane transport GO:0055085 412 0.019
regulation of body fluid levels GO:0050878 162 0.019
regulation of cell migration GO:0030334 219 0.019
second messenger mediated signaling GO:0019932 73 0.019
multi multicellular organism process GO:0044706 109 0.019
response to symbiotic bacterium GO:0009609 2 0.019
innate immune response in mucosa GO:0002227 3 0.018
regulation of phospholipase a2 activity GO:0032429 3 0.018
regulation of hormone levels GO:0010817 211 0.018
lateral inhibition GO:0046331 1 0.018
negative regulation of cell proliferation GO:0008285 296 0.018
regulation of peptidase activity GO:0052547 96 0.018
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.018
regulation of defense response GO:0031347 233 0.018
lipid biosynthetic process GO:0008610 179 0.018
steroid metabolic process GO:0008202 119 0.018
negative regulation of proteolysis GO:0045861 74 0.018
negative regulation of sterol transport GO:0032372 4 0.018
cell killing GO:0001906 67 0.018
alcohol metabolic process GO:0006066 116 0.017
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 9 0.017
regulation of presynaptic membrane organization GO:1901629 3 0.017
cellular response to molecule of bacterial origin GO:0071219 83 0.017
cellular response to biotic stimulus GO:0071216 92 0.017
regulation of cytokine production GO:0001817 266 0.017
heart contraction GO:0060047 93 0.017
protein localization to membrane GO:0072657 108 0.017
response to monosaccharide GO:0034284 67 0.017
cellular response to dna damage stimulus GO:0006974 207 0.017
leukocyte mediated immunity GO:0002443 174 0.017
positive regulation of binding GO:0051099 49 0.017
regulation of cell projection organization GO:0031344 206 0.017
negative regulation of neuron differentiation GO:0045665 101 0.017
negative regulation of cholesterol transport GO:0032375 4 0.017
regulation of reactive oxygen species metabolic process GO:2000377 40 0.017
cellular response to cytokine stimulus GO:0071345 189 0.016
membrane organization GO:0061024 245 0.016
modification dependent protein catabolic process GO:0019941 133 0.016
response to endoplasmic reticulum stress GO:0034976 53 0.016
fat cell differentiation GO:0045444 160 0.016
spermatogenesis GO:0007283 284 0.016
regulation of cell activation GO:0050865 289 0.016
coenzyme metabolic process GO:0006732 52 0.016
monosaccharide metabolic process GO:0005996 106 0.016
response to xenobiotic stimulus GO:0009410 13 0.016
leukocyte proliferation GO:0070661 172 0.016
positive regulation of phagocytosis GO:0050766 26 0.016
regulation of secretion by cell GO:1903530 249 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.016
porphyrin containing compound metabolic process GO:0006778 22 0.016
peptide metabolic process GO:0006518 46 0.016
posttranscriptional regulation of gene expression GO:0010608 155 0.016
carboxylic acid biosynthetic process GO:0046394 86 0.016
myotube differentiation GO:0014902 105 0.016
adaptive immune response GO:0002250 155 0.016
regulation of anatomical structure size GO:0090066 178 0.016
nucleosome disassembly GO:0006337 1 0.015
purine nucleoside triphosphate metabolic process GO:0009144 226 0.015
hexose metabolic process GO:0019318 98 0.015
hematopoietic progenitor cell differentiation GO:0002244 143 0.015
cellular response to lipopolysaccharide GO:0071222 77 0.015
organonitrogen compound catabolic process GO:1901565 264 0.015
purine nucleobase biosynthetic process GO:0009113 3 0.015
ribose phosphate metabolic process GO:0019693 291 0.015
cytokine production GO:0001816 319 0.015
cholesterol metabolic process GO:0008203 56 0.015
cofactor catabolic process GO:0051187 6 0.015
ras protein signal transduction GO:0007265 77 0.015
cellular protein complex assembly GO:0043623 116 0.015
morphogenesis of a branching structure GO:0001763 203 0.015
regulation of protein kinase b signaling GO:0051896 56 0.015
signal transduction in absence of ligand GO:0038034 55 0.015
response to hydrogen peroxide GO:0042542 32 0.015
regulation of epithelial cell proliferation GO:0050678 141 0.015
negative regulation of intracellular signal transduction GO:1902532 167 0.015
regulation of intracellular transport GO:0032386 159 0.015
hydrogen peroxide metabolic process GO:0042743 16 0.015
ossification GO:0001503 216 0.015
intracellular protein transport GO:0006886 204 0.014
regulation of ion transmembrane transport GO:0034765 119 0.014
regulation of transporter activity GO:0032409 57 0.014
homeostasis of number of cells GO:0048872 210 0.014
regulation of engulfment of apoptotic cell GO:1901074 2 0.014
regulation of protein transport GO:0051223 163 0.014
protein localization to organelle GO:0033365 185 0.014
leukocyte migration GO:0050900 124 0.014
response to lipopolysaccharide GO:0032496 128 0.014
cytoplasmic transport GO:0016482 234 0.014
regulation of inflammatory response GO:0050727 147 0.014
amide transport GO:0042886 138 0.014
regulation of organelle organization GO:0033043 289 0.014
regulation of ion transmembrane transporter activity GO:0032412 54 0.014
defense response to bacterium GO:0042742 119 0.014
small molecule biosynthetic process GO:0044283 132 0.014
regulation of multi organism process GO:0043900 111 0.014
extrinsic apoptotic signaling pathway GO:0097191 126 0.014
cellular glucose homeostasis GO:0001678 52 0.014
response to oxygen radical GO:0000305 16 0.014
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.014
response to iron ion GO:0010039 4 0.014
lymphocyte mediated immunity GO:0002449 139 0.014
morphogenesis of a branching epithelium GO:0061138 193 0.013
t cell differentiation GO:0030217 174 0.013
tumor necrosis factor production GO:0032640 50 0.013
purine containing compound biosynthetic process GO:0072522 70 0.013
humoral immune response GO:0006959 57 0.013
endothelium development GO:0003158 45 0.013
synaptic transmission GO:0007268 329 0.013
alpha amino acid metabolic process GO:1901605 59 0.013
cellular protein catabolic process GO:0044257 155 0.013
dna repair GO:0006281 107 0.013
nucleoside metabolic process GO:0009116 246 0.013
leukocyte differentiation GO:0002521 342 0.013
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.013
regulation of protein serine threonine kinase activity GO:0071900 157 0.013
purine ribonucleoside biosynthetic process GO:0046129 19 0.013
peptidyl tyrosine modification GO:0018212 145 0.013
purine nucleotide metabolic process GO:0006163 302 0.013
regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000148 1 0.013
regulation of leukocyte mediated immunity GO:0002703 104 0.013
camera type eye development GO:0043010 266 0.013
regulation of protein catabolic process GO:0042176 108 0.013
sensory perception GO:0007600 245 0.013
cellular calcium ion homeostasis GO:0006874 119 0.013
kidney development GO:0001822 213 0.013
pyridine containing compound catabolic process GO:0072526 4 0.013
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.013
lymphocyte proliferation GO:0046651 164 0.012
calcium ion homeostasis GO:0055074 127 0.012
lymphocyte differentiation GO:0030098 242 0.012
hormone metabolic process GO:0042445 86 0.012
regulation of cellular component biogenesis GO:0044087 181 0.012
regulation of endopeptidase activity GO:0052548 89 0.012
regulation of ossification GO:0030278 112 0.012
insulin secretion involved in cellular response to glucose stimulus GO:0035773 36 0.012
organonitrogen compound biosynthetic process GO:1901566 192 0.012
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.012
cellular response to hexose stimulus GO:0071331 47 0.012
epidermis development GO:0008544 187 0.012
glycosyl compound metabolic process GO:1901657 246 0.012
response to testosterone GO:0033574 3 0.012
urogenital system development GO:0001655 261 0.012
actin cytoskeleton organization GO:0030036 220 0.012
regulation of neuron projection development GO:0010975 169 0.012
carbohydrate derivative biosynthetic process GO:1901137 183 0.012
germ cell development GO:0007281 185 0.012
translation GO:0006412 93 0.012
carbohydrate metabolic process GO:0005975 230 0.012
negative regulation of protein maturation GO:1903318 79 0.012
positive regulation of cell activation GO:0050867 158 0.012
monocarboxylic acid biosynthetic process GO:0072330 61 0.012
cognition GO:0050890 149 0.012
regulation of membrane potential GO:0042391 192 0.012
regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000163 1 0.012
gonad development GO:0008406 141 0.012
regulation of establishment of protein localization GO:0070201 181 0.012
response to drug GO:0042493 75 0.012
endocytosis GO:0006897 168 0.012
negative regulation of homeostatic process GO:0032845 71 0.012
regulation of myeloid cell differentiation GO:0045637 96 0.012
organophosphate biosynthetic process GO:0090407 122 0.011
cellular amide metabolic process GO:0043603 58 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
purine nucleobase metabolic process GO:0006144 4 0.011
defense response to gram positive bacterium GO:0050830 50 0.011
purine ribonucleoside metabolic process GO:0046128 241 0.011
regulation of intracellular protein transport GO:0033157 82 0.011
leukocyte mediated cytotoxicity GO:0001909 62 0.011
phagocytosis GO:0006909 66 0.011
carboxylic acid catabolic process GO:0046395 51 0.011
tissue remodeling GO:0048771 102 0.011
negative regulation of peptidase activity GO:0010466 46 0.011
adiponectin activated signaling pathway GO:0033211 4 0.011
protein ubiquitination GO:0016567 171 0.011
angiogenesis involved in wound healing GO:0060055 7 0.011
regulation of fat cell differentiation GO:0045598 81 0.011
nucleocytoplasmic transport GO:0006913 139 0.011
response to superoxide GO:0000303 16 0.011
spermatid differentiation GO:0048515 115 0.011
transition metal ion homeostasis GO:0055076 54 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.011
positive regulation of cell motility GO:2000147 116 0.011
positive regulation of proteolysis GO:0045862 85 0.011
establishment of protein localization to organelle GO:0072594 118 0.011
myeloid leukocyte differentiation GO:0002573 119 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.011
multicellular organismal signaling GO:0035637 91 0.010
cellular response to monosaccharide stimulus GO:0071326 47 0.010
regulation of plasma lipoprotein particle levels GO:0097006 23 0.010
developmental growth involved in morphogenesis GO:0060560 138 0.010
actin filament organization GO:0007015 113 0.010
purine nucleoside biosynthetic process GO:0042451 19 0.010
nuclear import GO:0051170 95 0.010
glial cell differentiation GO:0010001 131 0.010
placenta development GO:0001890 140 0.010
cellular response to arsenic containing substance GO:0071243 4 0.010
chromatin disassembly GO:0031498 1 0.010
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000162 1 0.010
calcium mediated signaling GO:0019722 46 0.010
regulation of lymphocyte mediated immunity GO:0002706 84 0.010
regulation of glutamate receptor signaling pathway GO:1900449 16 0.010
ubiquitin dependent protein catabolic process GO:0006511 129 0.010
skin development GO:0043588 220 0.010
regulation of vesicle mediated transport GO:0060627 139 0.010

Gpx1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.038
nervous system disease DOID:863 0 0.038
immune system disease DOID:2914 0 0.032
disease of metabolism DOID:0014667 0 0.030
inherited metabolic disorder DOID:655 0 0.030
musculoskeletal system disease DOID:17 0 0.023
connective tissue disease DOID:65 0 0.023
primary immunodeficiency disease DOID:612 0 0.013
central nervous system disease DOID:331 0 0.013
sensory system disease DOID:0050155 0 0.012