Mus musculus

33 known processes

Hps4

Hermansky-Pudlak syndrome 4 homolog (human)

(Aliases: BLOC-3,le,mKIAA1667,AU040608,C130020P05Rik,2010205O06Rik)

Hps4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
pigment accumulation GO:0043476 1 1.000
microtubule based movement GO:0007018 84 0.874
microtubule based transport GO:0010970 50 0.694
pigment cell differentiation GO:0050931 27 0.635
anterograde synaptic vesicle transport GO:0048490 15 0.613
developmental pigmentation GO:0048066 40 0.603
anterograde axon cargo transport GO:0008089 20 0.532
antigen processing and presentation of lipid antigen via mhc class ib GO:0048003 3 0.461
axon cargo transport GO:0008088 33 0.447
cytoskeleton dependent intracellular transport GO:0030705 50 0.446
synaptic vesicle localization GO:0097479 59 0.407
vesicle localization GO:0051648 86 0.389
synaptic transmission GO:0007268 329 0.380
pigmentation GO:0043473 71 0.362
microtubule based process GO:0007017 236 0.361
antigen processing and presentation exogenous lipid antigen via mhc class ib GO:0048007 3 0.350
antigen processing and presentation via mhc class ib GO:0002475 8 0.305
melanosome organization GO:0032438 8 0.272
synaptic vesicle transport GO:0048489 57 0.271
protein localization to organelle GO:0033365 185 0.267
gene silencing by rna GO:0031047 19 0.256
establishment of organelle localization GO:0051656 122 0.251
vesicle organization GO:0016050 60 0.235
regulation of cell activation GO:0050865 289 0.234
establishment of synaptic vesicle localization GO:0097480 57 0.228
positive regulation of lymphocyte activation GO:0051251 140 0.227
eye pigmentation GO:0048069 3 0.225
regulation of lymphocyte activation GO:0051249 240 0.215
positive regulation of cell activation GO:0050867 158 0.209
synaptic vesicle membrane organization GO:0048499 1 0.207
lymphocyte differentiation GO:0030098 242 0.199
pigment granule organization GO:0048753 9 0.199
establishment of melanosome localization GO:0032401 11 0.179
organelle localization GO:0051640 179 0.177
lysosome organization GO:0007040 21 0.174
regulation of t cell activation GO:0050863 170 0.168
establishment of vesicle localization GO:0051650 81 0.168
secretion of lysosomal enzymes GO:0033299 6 0.167
regulation of alpha beta t cell differentiation GO:0046637 35 0.159
regulation of natural killer cell activation GO:0032814 22 0.157
positive regulation of alpha beta t cell activation GO:0046635 39 0.155
melanosome transport GO:0032402 11 0.144
pigment granule localization GO:0051875 13 0.125
regulation of alpha beta t cell activation GO:0046634 53 0.112
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.111
zinc ion homeostasis GO:0055069 10 0.111
cellular zinc ion homeostasis GO:0006882 9 0.103
regulation of lymphocyte differentiation GO:0045619 107 0.102
cellular pigmentation GO:0033059 20 0.101
pigment biosynthetic process GO:0046148 26 0.099
nk t cell differentiation GO:0001865 8 0.091
antigen processing and presentation GO:0019882 47 0.089
alpha beta t cell differentiation GO:0046632 69 0.088
antigen processing and presentation of exogenous antigen GO:0019884 26 0.086
cation homeostasis GO:0055080 212 0.086
cellular ion homeostasis GO:0006873 165 0.082
secondary metabolite biosynthetic process GO:0044550 11 0.078
lytic vacuole organization GO:0080171 21 0.078
maintenance of location GO:0051235 89 0.078
positive regulation of lymphocyte differentiation GO:0045621 61 0.074
positive regulation of leukocyte differentiation GO:1902107 86 0.073
transition metal ion homeostasis GO:0055076 54 0.070
alpha beta t cell activation GO:0046631 91 0.066
regulation of t cell differentiation GO:0045580 83 0.065
negative regulation of gene silencing GO:0060969 2 0.064
metal ion homeostasis GO:0055065 189 0.063
secretory granule organization GO:0033363 20 0.063
intracellular protein transport GO:0006886 204 0.062
endocytosis GO:0006897 168 0.062
cellular transition metal ion homeostasis GO:0046916 32 0.062
cytoplasmic transport GO:0016482 234 0.060
t cell activation GO:0042110 289 0.060
cellular homeostasis GO:0019725 240 0.055
cellular chemical homeostasis GO:0055082 215 0.055
leukocyte differentiation GO:0002521 342 0.055
modification dependent macromolecule catabolic process GO:0043632 133 0.054
positive regulation of t cell activation GO:0050870 101 0.054
vacuole organization GO:0007033 38 0.053
establishment of protein localization to vacuole GO:0072666 4 0.051
positive regulation of t cell differentiation GO:0045582 52 0.050
protein targeting GO:0006605 143 0.049
gene silencing GO:0016458 38 0.048
pigment granule transport GO:0051904 12 0.047
regulation of ion homeostasis GO:2000021 64 0.046
membrane organization GO:0061024 245 0.045
developmental maturation GO:0021700 193 0.045
sequestering of metal ion GO:0051238 19 0.045
endomembrane system organization GO:0010256 147 0.044
cellular macromolecule catabolic process GO:0044265 206 0.043
positive regulation of natural killer cell activation GO:0032816 15 0.042
regulation of leukocyte differentiation GO:1902105 159 0.042
camera type eye development GO:0043010 266 0.042
exocytosis GO:0006887 121 0.042
cellular nitrogen compound catabolic process GO:0044270 280 0.042
nucleotide metabolic process GO:0009117 332 0.041
body morphogenesis GO:0010171 45 0.039
dna repair GO:0006281 107 0.039
ear development GO:0043583 200 0.038
nucleobase containing small molecule metabolic process GO:0055086 352 0.037
protein targeting to vacuole GO:0006623 3 0.036
cellular metal ion homeostasis GO:0006875 151 0.036
embryonic organ morphogenesis GO:0048562 276 0.035
dna metabolic process GO:0006259 303 0.035
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.034
macromolecule catabolic process GO:0009057 281 0.034
cellular protein catabolic process GO:0044257 155 0.033
regulation of homeostatic process GO:0032844 182 0.032
ear morphogenesis GO:0042471 118 0.032
t cell differentiation GO:0030217 174 0.032
cell division GO:0051301 120 0.032
protein localization to vacuole GO:0072665 4 0.031
mitotic cytokinesis GO:0000281 4 0.031
nitrogen compound transport GO:0071705 271 0.031
sensory organ morphogenesis GO:0090596 242 0.030
chromatin modification GO:0016568 187 0.030
small gtpase mediated signal transduction GO:0007264 97 0.030
immune effector process GO:0002252 321 0.030
negative regulation of protein metabolic process GO:0051248 282 0.030
pigment metabolic process GO:0042440 32 0.029
purine nucleotide metabolic process GO:0006163 302 0.028
regulation of cellular catabolic process GO:0031329 242 0.028
amine metabolic process GO:0009308 45 0.028
protein secretion GO:0009306 111 0.028
establishment of protein localization to organelle GO:0072594 118 0.028
nucleoside phosphate catabolic process GO:1901292 222 0.028
secondary metabolic process GO:0019748 18 0.027
coagulation GO:0050817 78 0.027
carbohydrate derivative biosynthetic process GO:1901137 183 0.027
regulation of body fluid levels GO:0050878 162 0.026
negative regulation of nlrp3 inflammasome complex assembly GO:1900226 2 0.026
negative regulation of gene silencing by rna GO:0060967 1 0.026
purine nucleoside triphosphate metabolic process GO:0009144 226 0.026
heterocycle catabolic process GO:0046700 280 0.026
melanosome localization GO:0032400 12 0.026
glycosyl compound catabolic process GO:1901658 206 0.025
ribonucleoside catabolic process GO:0042454 206 0.025
transmembrane transport GO:0055085 412 0.025
retina development in camera type eye GO:0060041 119 0.025
proteasomal protein catabolic process GO:0010498 98 0.024
cellular divalent inorganic cation homeostasis GO:0072503 127 0.024
gpi anchor metabolic process GO:0006505 7 0.023
cellular response to dna damage stimulus GO:0006974 207 0.023
regulation of cellular amino acid metabolic process GO:0006521 5 0.023
ribonucleotide metabolic process GO:0009259 291 0.022
protein catabolic process GO:0030163 221 0.022
nucleoside catabolic process GO:0009164 206 0.022
positive regulation of cellular amine metabolic process GO:0033240 5 0.022
protein modification by small protein conjugation GO:0032446 187 0.022
positive regulation of protein catabolic process GO:0045732 60 0.022
purine nucleoside metabolic process GO:0042278 241 0.021
regulation of organelle organization GO:0033043 289 0.021
regulation of proteolysis GO:0030162 164 0.020
inclusion body assembly GO:0070841 3 0.020
regulation of mitotic cell cycle GO:0007346 126 0.020
neuronal action potential GO:0019228 54 0.020
innate immune response GO:0045087 157 0.020
regulation of cytoskeleton organization GO:0051493 122 0.020
regulation of cellular ketone metabolic process GO:0010565 66 0.019
male gamete generation GO:0048232 285 0.019
cytokine production GO:0001816 319 0.019
regulation of protein catabolic process GO:0042176 108 0.019
cell adhesion GO:0007155 329 0.019
protein modification by small protein conjugation or removal GO:0070647 207 0.019
spermatogenesis GO:0007283 284 0.019
aromatic compound catabolic process GO:0019439 286 0.019
ribose phosphate metabolic process GO:0019693 291 0.019
lymphocyte mediated immunity GO:0002449 139 0.019
cilium morphogenesis GO:0060271 102 0.019
protein targeting to lysosome GO:0006622 2 0.018
protein localization to membrane GO:0072657 108 0.018
neuromuscular process GO:0050905 99 0.018
notch receptor processing GO:0007220 4 0.018
nucleoside triphosphate catabolic process GO:0009143 205 0.018
phospholipid metabolic process GO:0006644 87 0.018
organic cyclic compound catabolic process GO:1901361 295 0.018
actin cytoskeleton organization GO:0030036 220 0.018
fertilization GO:0009566 127 0.018
protein localization to nucleus GO:0034504 121 0.018
cellular ketone metabolic process GO:0042180 84 0.018
cellular amine metabolic process GO:0044106 44 0.017
posttranscriptional regulation of gene expression GO:0010608 155 0.017
lipid localization GO:0010876 126 0.017
modification dependent protein catabolic process GO:0019941 133 0.017
interleukin 8 production GO:0032637 4 0.017
purine nucleotide catabolic process GO:0006195 211 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.017
negative regulation of cellular component organization GO:0051129 194 0.017
cellular lipid metabolic process GO:0044255 323 0.017
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.017
reactive oxygen species metabolic process GO:0072593 84 0.016
cell type specific apoptotic process GO:0097285 268 0.016
reactive oxygen species biosynthetic process GO:1903409 8 0.016
heart morphogenesis GO:0003007 178 0.016
epithelial tube formation GO:0072175 130 0.016
homeostasis of number of cells GO:0048872 210 0.016
protein processing GO:0016485 163 0.016
nucleoside metabolic process GO:0009116 246 0.015
multicellular organismal signaling GO:0035637 91 0.015
natural killer cell activation GO:0030101 44 0.015
nucleoside phosphate metabolic process GO:0006753 338 0.015
carbohydrate metabolic process GO:0005975 230 0.015
mitotic cell cycle process GO:1903047 159 0.015
positive regulation of binding GO:0051099 49 0.015
negative regulation of cellular protein metabolic process GO:0032269 247 0.015
appendage development GO:0048736 166 0.015
telencephalon development GO:0021537 186 0.015
regulation of reactive oxygen species metabolic process GO:2000377 40 0.015
wound healing GO:0042060 157 0.014
regulation of mapk cascade GO:0043408 248 0.014
positive regulation of programmed cell death GO:0043068 218 0.014
regulation of actin nucleation GO:0051125 4 0.014
organophosphate catabolic process GO:0046434 232 0.014
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.014
regulation of hydrolase activity GO:0051336 246 0.014
purine containing compound catabolic process GO:0072523 213 0.014
digestive tract development GO:0048565 190 0.014
pallium development GO:0021543 120 0.014
regulation of cellular amine metabolic process GO:0033238 20 0.014
adaptive immune response GO:0002250 155 0.014
single fertilization GO:0007338 82 0.014
cation transmembrane transport GO:0098655 266 0.014
purine containing compound metabolic process GO:0072521 311 0.014
response to acid chemical GO:0001101 111 0.014
viral gene expression GO:0019080 3 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.014
purine ribonucleotide catabolic process GO:0009154 208 0.014
mapk cascade GO:0000165 281 0.014
dna replication GO:0006260 52 0.014
negative regulation of immune system process GO:0002683 209 0.014
protein maturation GO:0051604 176 0.014
activation of immune response GO:0002253 138 0.014
regulation of membrane potential GO:0042391 192 0.013
positive regulation of actin nucleation GO:0051127 3 0.013
negative regulation of intracellular signal transduction GO:1902532 167 0.013
ribonucleoside metabolic process GO:0009119 245 0.013
lipid storage GO:0019915 36 0.013
b cell activation GO:0042113 161 0.013
positive regulation of proteolysis GO:0045862 85 0.013
ribonucleotide catabolic process GO:0009261 208 0.013
organelle assembly GO:0070925 177 0.013
regulation of cytokine production GO:0001817 266 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.013
cell activation involved in immune response GO:0002263 126 0.013
inorganic ion transmembrane transport GO:0098660 234 0.013
rna processing GO:0006396 105 0.013
tube closure GO:0060606 91 0.013
transcription from rna polymerase iii promoter GO:0006383 3 0.013
nucleoside triphosphate metabolic process GO:0009141 230 0.013
regulation of binding GO:0051098 111 0.012
adult behavior GO:0030534 135 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.012
regulation of interleukin 8 production GO:0032677 3 0.012
action potential GO:0001508 78 0.012
inorganic cation transmembrane transport GO:0098662 207 0.012
immune response regulating signaling pathway GO:0002764 125 0.012
peptidyl amino acid modification GO:0018193 336 0.012
regulation of cell motility GO:2000145 236 0.012
purine nucleoside catabolic process GO:0006152 205 0.012
defense response to bacterium GO:0042742 119 0.012
muscle tissue development GO:0060537 308 0.012
negative regulation of viral transcription GO:0032897 3 0.012
negative regulation of phosphorus metabolic process GO:0010563 184 0.012
urogenital system development GO:0001655 261 0.012
production of molecular mediator of immune response GO:0002440 103 0.012
neural tube closure GO:0001843 90 0.012
regulation of cell cycle GO:0051726 281 0.012
oocyte construction GO:0007308 2 0.012
primary neural tube formation GO:0014020 95 0.012
neuroepithelial cell differentiation GO:0060563 37 0.012
positive regulation of interleukin 8 production GO:0032757 2 0.012
apoptotic signaling pathway GO:0097190 306 0.012
regulation of cellular response to stress GO:0080135 159 0.012
compound eye development GO:0048749 1 0.012
spermatid differentiation GO:0048515 115 0.012
anatomical structure homeostasis GO:0060249 145 0.012
hemostasis GO:0007599 78 0.012
negative regulation of phosphate metabolic process GO:0045936 184 0.012
positive regulation of mapk cascade GO:0043410 170 0.012
purine ribonucleoside metabolic process GO:0046128 241 0.012
response to light stimulus GO:0009416 135 0.012
germ cell development GO:0007281 185 0.011
morphogenesis of embryonic epithelium GO:0016331 159 0.011
nucleoside monophosphate metabolic process GO:0009123 85 0.011
positive regulation of nucleoside metabolic process GO:0045979 91 0.011
transmission of nerve impulse GO:0019226 76 0.011
histone deubiquitination GO:0016578 2 0.011
nucleotide catabolic process GO:0009166 217 0.011
ribonucleoside triphosphate metabolic process GO:0009199 220 0.011
negative regulation of cell development GO:0010721 169 0.011
organophosphate biosynthetic process GO:0090407 122 0.011
forebrain development GO:0030900 302 0.011
peptidyl tyrosine phosphorylation GO:0018108 143 0.011
segmentation GO:0035282 93 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.011
norepinephrine transport GO:0015874 2 0.011
cellular protein complex assembly GO:0043623 116 0.011
skeletal system development GO:0001501 356 0.011
glycosyl compound metabolic process GO:1901657 246 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
male meiosis i GO:0007141 16 0.011
defense response to other organism GO:0098542 197 0.011
cellular response to acid chemical GO:0071229 68 0.011
negative regulation of cell cycle GO:0045786 123 0.010
telomere maintenance in response to dna damage GO:0043247 4 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.010
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.010
cellular amino acid metabolic process GO:0006520 103 0.010
regulation of protein complex assembly GO:0043254 83 0.010
tube formation GO:0035148 140 0.010
lipid homeostasis GO:0055088 63 0.010
cilium assembly GO:0042384 81 0.010
membrane lipid metabolic process GO:0006643 53 0.010
sequestering of calcium ion GO:0051208 18 0.010
purine ribonucleotide metabolic process GO:0009150 290 0.010
neural tube formation GO:0001841 108 0.010
oxidation reduction process GO:0055114 342 0.010
regulation of defense response GO:0031347 233 0.010
carbohydrate derivative catabolic process GO:1901136 231 0.010
chromosome segregation GO:0007059 48 0.010
phospholipid biosynthetic process GO:0008654 36 0.010
response to retinoic acid GO:0032526 56 0.010
hematopoietic progenitor cell differentiation GO:0002244 143 0.010
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.010
mrna metabolic process GO:0016071 84 0.010
regulation of nlrp3 inflammasome complex assembly GO:1900225 4 0.010

Hps4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.038
nervous system disease DOID:863 0 0.038
central nervous system disease DOID:331 0 0.016
neuropathy DOID:870 0 0.014
neurodegenerative disease DOID:1289 0 0.011
sensory system disease DOID:0050155 0 0.010