Mus musculus

76 known processes

Hps1

Hermansky-Pudlak syndrome 1 homolog (human)

(Aliases: Hps,MGC102063,BB405864,6030422N11Rik,ep)

Hps1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
pigment accumulation GO:0043476 1 0.999
pigment granule localization GO:0051875 13 0.997
coagulation GO:0050817 78 0.997
pigmentation GO:0043473 71 0.996
establishment of melanosome localization GO:0032401 11 0.996
melanocyte differentiation GO:0030318 25 0.996
melanosome organization GO:0032438 8 0.994
pigment cell differentiation GO:0050931 27 0.992
hemostasis GO:0007599 78 0.980
developmental pigmentation GO:0048066 40 0.977
secretory granule organization GO:0033363 20 0.971
lytic vacuole organization GO:0080171 21 0.971
lysosome organization GO:0007040 21 0.966
cellular pigmentation GO:0033059 20 0.960
neuroepithelial cell differentiation GO:0060563 37 0.959
blood coagulation GO:0007596 76 0.958
melanosome transport GO:0032402 11 0.936
pigment granule organization GO:0048753 9 0.923
pigment granule transport GO:0051904 12 0.916
vesicle organization GO:0016050 60 0.895
melanosome localization GO:0032400 12 0.865
establishment of vesicle localization GO:0051650 81 0.861
vesicle localization GO:0051648 86 0.856
microtubule based movement GO:0007018 84 0.791
regulation of body fluid levels GO:0050878 162 0.716
vacuole organization GO:0007033 38 0.697
microtubule based transport GO:0010970 50 0.659
cytoskeleton dependent intracellular transport GO:0030705 50 0.652
anterograde axon cargo transport GO:0008089 20 0.567
establishment of organelle localization GO:0051656 122 0.536
secretion of lysosomal enzymes GO:0033299 6 0.514
antigen processing and presentation of lipid antigen via mhc class ib GO:0048003 3 0.512
establishment of synaptic vesicle localization GO:0097480 57 0.444
establishment of pigment granule localization GO:0051905 12 0.330
wound healing GO:0042060 157 0.321
pigment biosynthetic process GO:0046148 26 0.317
phenol containing compound biosynthetic process GO:0046189 21 0.313
cytoplasmic transport GO:0016482 234 0.267
organelle localization GO:0051640 179 0.257
regulation of pigment cell differentiation GO:0050932 7 0.239
anterograde synaptic vesicle transport GO:0048490 15 0.231
pigment metabolic process GO:0042440 32 0.201
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.162
positive regulation of secretion by cell GO:1903532 114 0.155
cellular ion homeostasis GO:0006873 165 0.131
natural killer cell degranulation GO:0043320 3 0.129
synaptic vesicle transport GO:0048489 57 0.114
neutrophil mediated immunity GO:0002446 19 0.106
regulation of cell activation GO:0050865 289 0.104
organic hydroxy compound metabolic process GO:1901615 203 0.102
natural killer cell activation involved in immune response GO:0002323 10 0.099
cation homeostasis GO:0055080 212 0.090
cellular homeostasis GO:0019725 240 0.088
organic hydroxy compound biosynthetic process GO:1901617 77 0.086
short chain fatty acid metabolic process GO:0046459 6 0.086
defense response to bacterium GO:0042742 119 0.082
leukocyte differentiation GO:0002521 342 0.082
regulation of secretion by cell GO:1903530 249 0.076
phagosome maturation GO:0090382 4 0.075
fatty acid metabolic process GO:0006631 121 0.074
leukocyte mediated immunity GO:0002443 174 0.072
defense response to gram positive bacterium GO:0050830 50 0.071
synaptic vesicle localization GO:0097479 59 0.070
immune effector process GO:0002252 321 0.069
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.066
protein targeting GO:0006605 143 0.065
axon cargo transport GO:0008088 33 0.063
interspecies interaction between organisms GO:0044419 83 0.062
reactive oxygen species biosynthetic process GO:1903409 8 0.062
regulation of lymphocyte activation GO:0051249 240 0.059
nucleoside metabolic process GO:0009116 246 0.058
microtubule based process GO:0007017 236 0.057
protein secretion GO:0009306 111 0.056
protein localization to vacuole GO:0072665 4 0.055
positive regulation of cell activation GO:0050867 158 0.055
innate immune response GO:0045087 157 0.054
protein targeting to vacuole GO:0006623 3 0.053
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.053
melanin metabolic process GO:0006582 12 0.053
phagocytosis GO:0006909 66 0.051
phospholipid transfer to membrane GO:0006649 2 0.051
positive regulation of lymphocyte activation GO:0051251 140 0.048
platelet aggregation GO:0070527 20 0.048
adaptive immune response GO:0002250 155 0.047
cation transmembrane transport GO:0098655 266 0.047
cell chemotaxis GO:0060326 81 0.047
cellular lipid metabolic process GO:0044255 323 0.047
positive regulation of nervous system development GO:0051962 221 0.046
secondary metabolic process GO:0019748 18 0.044
protein modification by small protein conjugation or removal GO:0070647 207 0.044
cellular chemical homeostasis GO:0055082 215 0.044
positive regulation of exocytosis GO:0045921 20 0.043
fertilization GO:0009566 127 0.043
alpha beta t cell differentiation GO:0046632 69 0.043
nucleotide metabolic process GO:0009117 332 0.043
lipid localization GO:0010876 126 0.042
macromolecule catabolic process GO:0009057 281 0.042
purine nucleoside triphosphate metabolic process GO:0009144 226 0.042
establishment of protein localization to vacuole GO:0072666 4 0.041
production of molecular mediator of immune response GO:0002440 103 0.041
membrane organization GO:0061024 245 0.040
lipid homeostasis GO:0055088 63 0.040
nucleobase containing small molecule metabolic process GO:0055086 352 0.040
b cell activation GO:0042113 161 0.040
response to inorganic substance GO:0010035 96 0.040
natural killer cell activation GO:0030101 44 0.040
defense response to other organism GO:0098542 197 0.039
negative regulation of immune system process GO:0002683 209 0.039
cell killing GO:0001906 67 0.038
alpha amino acid metabolic process GO:1901605 59 0.038
regulation of endocytosis GO:0030100 69 0.037
synaptic transmission GO:0007268 329 0.036
melanin biosynthetic process GO:0042438 10 0.035
reactive oxygen species metabolic process GO:0072593 84 0.035
actin cytoskeleton organization GO:0030036 220 0.035
cell proliferation in forebrain GO:0021846 30 0.034
regulation of intracellular ph GO:0051453 11 0.034
alpha beta t cell activation GO:0046631 91 0.034
skeletal system morphogenesis GO:0048705 203 0.034
secondary metabolite biosynthetic process GO:0044550 11 0.033
lymphocyte differentiation GO:0030098 242 0.033
response to transforming growth factor beta GO:0071559 88 0.032
regulation of ion transport GO:0043269 215 0.032
cell activation involved in immune response GO:0002263 126 0.032
cell type specific apoptotic process GO:0097285 268 0.031
phospholipid metabolic process GO:0006644 87 0.031
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.031
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.031
body morphogenesis GO:0010171 45 0.031
regulation of developmental pigmentation GO:0048070 14 0.030
platelet activation GO:0030168 40 0.030
dna metabolic process GO:0006259 303 0.029
spermatogenesis GO:0007283 284 0.028
transmembrane transport GO:0055085 412 0.028
ribonucleotide metabolic process GO:0009259 291 0.028
organic cyclic compound catabolic process GO:1901361 295 0.028
lymphocyte mediated immunity GO:0002449 139 0.028
regulation of secretion GO:0051046 274 0.028
positive regulation of secretion GO:0051047 130 0.027
regulation of vascular smooth muscle contraction GO:0003056 1 0.027
mesodermal cell migration GO:0008078 4 0.027
regulation of interleukin 8 production GO:0032677 3 0.027
regulation of cell adhesion GO:0030155 154 0.027
cellular macromolecule catabolic process GO:0044265 206 0.027
endomembrane system organization GO:0010256 147 0.027
cellular response to dna damage stimulus GO:0006974 207 0.027
nitrogen compound transport GO:0071705 271 0.027
ketone body metabolic process GO:1902224 3 0.027
cell adhesion GO:0007155 329 0.027
immune response regulating signaling pathway GO:0002764 125 0.027
lipid storage GO:0019915 36 0.027
lymphocyte homeostasis GO:0002260 64 0.026
neuromuscular process GO:0050905 99 0.026
interleukin 8 production GO:0032637 4 0.026
regulation of cellular ph GO:0030641 12 0.025
cytokine production GO:0001816 319 0.025
ion transmembrane transport GO:0034220 361 0.025
embryonic skeletal system development GO:0048706 120 0.025
protein catabolic process GO:0030163 221 0.025
calcium ion homeostasis GO:0055074 127 0.024
multicellular organismal homeostasis GO:0048871 164 0.024
cofactor transport GO:0051181 4 0.024
purine containing compound metabolic process GO:0072521 311 0.024
trachea cartilage morphogenesis GO:0060535 4 0.024
male gamete generation GO:0048232 285 0.023
aromatic compound catabolic process GO:0019439 286 0.023
defense response to protozoan GO:0042832 25 0.023
regulation of ph GO:0006885 26 0.022
leukocyte migration GO:0050900 124 0.022
dna repair GO:0006281 107 0.022
stem cell development GO:0048864 219 0.022
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.022
nucleoside phosphate metabolic process GO:0006753 338 0.022
regulation of asymmetric cell division GO:0009786 4 0.022
defecation GO:0030421 1 0.021
ectodermal cell differentiation GO:0010668 3 0.021
cholesterol metabolic process GO:0008203 56 0.021
regulation of organelle organization GO:0033043 289 0.021
cellular response to acid chemical GO:0071229 68 0.021
compound eye development GO:0048749 1 0.020
regulation of reactive oxygen species metabolic process GO:2000377 40 0.020
cellular protein catabolic process GO:0044257 155 0.020
purine nucleoside catabolic process GO:0006152 205 0.020
cellular response to oxidative stress GO:0034599 76 0.020
extrinsic apoptotic signaling pathway GO:0097191 126 0.020
homeostasis of number of cells GO:0048872 210 0.020
divalent inorganic cation homeostasis GO:0072507 138 0.020
regulation of interleukin 6 production GO:0032675 55 0.020
regulation of cytoskeleton organization GO:0051493 122 0.020
genetic imprinting GO:0071514 27 0.020
regulation of cellular response to stress GO:0080135 159 0.019
skeletal system development GO:0001501 356 0.019
purine nucleotide metabolic process GO:0006163 302 0.019
regulation of lymphocyte differentiation GO:0045619 107 0.019
inorganic cation transmembrane transport GO:0098662 207 0.019
gastrulation GO:0007369 116 0.019
chromatin modification GO:0016568 187 0.019
spinal cord development GO:0021510 81 0.019
regulation of membrane protein ectodomain proteolysis GO:0051043 3 0.019
digestive system development GO:0055123 200 0.019
cellular amine metabolic process GO:0044106 44 0.019
pharynx development GO:0060465 1 0.019
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.019
blastocyst development GO:0001824 80 0.019
single organism cell adhesion GO:0098602 156 0.018
purine ribonucleoside metabolic process GO:0046128 241 0.018
maintenance of location GO:0051235 89 0.018
carbohydrate homeostasis GO:0033500 128 0.018
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 4 0.018
nucleoside catabolic process GO:0009164 206 0.018
lateral inhibition GO:0046331 1 0.018
organelle assembly GO:0070925 177 0.018
regulation of multi organism process GO:0043900 111 0.018
glycosyl compound metabolic process GO:1901657 246 0.018
signal transduction in absence of ligand GO:0038034 55 0.018
early endosome to late endosome transport GO:0045022 2 0.018
glycosyl compound catabolic process GO:1901658 206 0.018
protein processing GO:0016485 163 0.018
adult behavior GO:0030534 135 0.017
negative regulation of protein metabolic process GO:0051248 282 0.017
heterocycle catabolic process GO:0046700 280 0.017
stem cell proliferation GO:0072089 117 0.017
tissue remodeling GO:0048771 102 0.017
apoptotic signaling pathway GO:0097190 306 0.017
membrane lipid metabolic process GO:0006643 53 0.017
positive regulation of transcription by glucose GO:0046016 3 0.017
hormone secretion GO:0046879 128 0.017
t cell activation GO:0042110 289 0.017
negative regulation of cell activation GO:0050866 111 0.017
response to protozoan GO:0001562 28 0.017
stem cell differentiation GO:0048863 268 0.016
nucleoside phosphate catabolic process GO:1901292 222 0.016
reverse cholesterol transport GO:0043691 6 0.016
transition metal ion transport GO:0000041 38 0.016
positive regulation of phagocytosis GO:0050766 26 0.016
small molecule biosynthetic process GO:0044283 132 0.016
oocyte construction GO:0007308 2 0.016
intestinal epithelial structure maintenance GO:0060729 4 0.016
organonitrogen compound catabolic process GO:1901565 264 0.016
protein maturation GO:0051604 176 0.016
cellular response to biotic stimulus GO:0071216 92 0.016
positive regulation of cellular amine metabolic process GO:0033240 5 0.016
response to lipopolysaccharide GO:0032496 128 0.016
pallium development GO:0021543 120 0.016
regulation of protein catabolic process GO:0042176 108 0.016
activation of immune response GO:0002253 138 0.016
nuclear division GO:0000280 158 0.015
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.015
dna recombination GO:0006310 92 0.015
immunoglobulin production GO:0002377 73 0.015
regulation of cytokine production GO:0001817 266 0.015
response to molecule of bacterial origin GO:0002237 143 0.015
regulation of neurotransmitter levels GO:0001505 87 0.015
anion transport GO:0006820 177 0.015
nucleoside triphosphate metabolic process GO:0009141 230 0.015
purine containing compound catabolic process GO:0072523 213 0.015
megakaryocyte differentiation GO:0030219 26 0.015
negative regulation of cytokine production GO:0001818 84 0.015
regulation of defense response GO:0031347 233 0.015
positive regulation of proteolysis GO:0045862 85 0.015
exocytosis GO:0006887 121 0.014
cellular nitrogen compound catabolic process GO:0044270 280 0.014
t cell differentiation GO:0030217 174 0.014
regulation of leukocyte mediated immunity GO:0002703 104 0.014
regulation of vesicle mediated transport GO:0060627 139 0.014
positive regulation of mapk cascade GO:0043410 170 0.014
negative regulation of cellular catabolic process GO:0031330 47 0.014
organic anion transport GO:0015711 137 0.014
positive regulation of phagocytosis engulfment GO:0060100 3 0.014
inorganic ion transmembrane transport GO:0098660 234 0.014
peptide transport GO:0015833 133 0.014
organonitrogen compound biosynthetic process GO:1901566 192 0.014
cognition GO:0050890 149 0.014
ear development GO:0043583 200 0.014
response to organonitrogen compound GO:0010243 246 0.014
forebrain development GO:0030900 302 0.014
purine ribonucleotide catabolic process GO:0009154 208 0.014
negative regulation of glycoprotein metabolic process GO:1903019 3 0.014
positive regulation of protein catabolic process GO:0045732 60 0.014
development of primary sexual characteristics GO:0045137 143 0.014
regulation of cysteine type endopeptidase activity GO:2000116 65 0.014
ribonucleoside metabolic process GO:0009119 245 0.013
ameboidal type cell migration GO:0001667 128 0.013
ossification GO:0001503 216 0.013
positive regulation of b cell activation GO:0050871 49 0.013
carbohydrate derivative catabolic process GO:1901136 231 0.013
intracellular protein transport GO:0006886 204 0.013
endocytosis GO:0006897 168 0.013
thick ascending limb development GO:0072023 2 0.013
glucose homeostasis GO:0042593 128 0.013
regulation of cell projection organization GO:0031344 206 0.013
cellular divalent inorganic cation homeostasis GO:0072503 127 0.013
muscle cell differentiation GO:0042692 261 0.013
neural tube closure GO:0001843 90 0.013
reactive nitrogen species metabolic process GO:2001057 0 0.013
regulation of production of molecular mediator of immune response GO:0002700 65 0.013
peptide secretion GO:0002790 114 0.013
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.013
regulation of leukocyte differentiation GO:1902105 159 0.013
stem cell maintenance GO:0019827 130 0.013
negative regulation of intracellular signal transduction GO:1902532 167 0.013
placenta development GO:0001890 140 0.013
negative regulation of lymphocyte activation GO:0051250 91 0.013
epithelium migration GO:0090132 63 0.013
cellular amino acid metabolic process GO:0006520 103 0.013
leukocyte activation involved in immune response GO:0002366 126 0.013
t cell mediated cytotoxicity GO:0001913 26 0.013
tissue migration GO:0090130 68 0.013
homotypic cell cell adhesion GO:0034109 28 0.013
dendrite development GO:0016358 115 0.013
wnt signaling pathway GO:0016055 188 0.013
amine metabolic process GO:0009308 45 0.013
anatomical structure homeostasis GO:0060249 145 0.013
exosomal secretion GO:1990182 1 0.013
morphogenesis of embryonic epithelium GO:0016331 159 0.013
forebrain ventricular zone progenitor cell division GO:0021869 6 0.012
catecholamine metabolic process GO:0006584 30 0.012
natural killer cell mediated cytotoxicity GO:0042267 29 0.012
modification dependent protein catabolic process GO:0019941 133 0.012
protein targeting to lysosome GO:0006622 2 0.012
alcohol metabolic process GO:0006066 116 0.012
gonad development GO:0008406 141 0.012
response to peptide GO:1901652 136 0.012
negative regulation of cell development GO:0010721 169 0.012
peptide hormone secretion GO:0030072 109 0.012
response to superoxide GO:0000303 16 0.012
hematopoietic progenitor cell differentiation GO:0002244 143 0.012
head morphogenesis GO:0060323 34 0.012
midgut development GO:0007494 4 0.012
neurotransmitter secretion GO:0007269 62 0.012
neuromuscular process controlling balance GO:0050885 59 0.012
carbohydrate derivative biosynthetic process GO:1901137 183 0.012
regulation of anion transport GO:0044070 27 0.012
equilibrioception GO:0050957 3 0.012
single fertilization GO:0007338 82 0.012
sphingolipid metabolic process GO:0006665 45 0.012
somatic stem cell division GO:0048103 19 0.012
response to oxidative stress GO:0006979 123 0.012
actomyosin structure organization GO:0031032 56 0.012
positive regulation of protein modification process GO:0031401 299 0.012
regulation of exocytosis GO:0017157 61 0.012
calcium ion dependent exocytosis GO:0017156 35 0.012
single organismal cell cell adhesion GO:0016337 131 0.012
regulation of excitatory postsynaptic membrane potential GO:0060079 41 0.012
oocyte anterior posterior axis specification GO:0007314 2 0.012
cellular response to abiotic stimulus GO:0071214 56 0.012
forebrain generation of neurons GO:0021872 63 0.012
protein localization to membrane GO:0072657 108 0.012
cell division GO:0051301 120 0.012
mesenchymal cell development GO:0014031 93 0.012
positive regulation of cytokine production GO:0001819 174 0.011
regulation of leukocyte apoptotic process GO:2000106 56 0.011
sterol transport GO:0015918 38 0.011
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.011
cellular response to lipid GO:0071396 145 0.011
neuron apoptotic process GO:0051402 142 0.011
regulation of proteolysis GO:0030162 164 0.011
regulation of cellular amino acid metabolic process GO:0006521 5 0.011
defense response to gram negative bacterium GO:0050829 28 0.011
regulation of actin filament based process GO:0032970 99 0.011
protein ubiquitination GO:0016567 171 0.011
regulation of hormone levels GO:0010817 211 0.011
positive regulation of cytokine secretion GO:0050715 41 0.011
regulation of peptide hormone secretion GO:0090276 75 0.011
regulation of gamma aminobutyric acid secretion GO:0014052 2 0.011
morphogenesis of a branching structure GO:0001763 203 0.011
response to temperature stimulus GO:0009266 55 0.011
calcium ion transport GO:0006816 159 0.011
regulation of cellular protein catabolic process GO:1903362 61 0.011
response to acid chemical GO:0001101 111 0.011
regulation of bone resorption GO:0045124 24 0.011
ribonucleotide catabolic process GO:0009261 208 0.011
antigen processing and presentation GO:0019882 47 0.011
chemotaxis GO:0006935 247 0.011
forebrain neuroblast division GO:0021873 9 0.011
regulation of embryonic development GO:0045995 71 0.011
leukocyte chemotaxis GO:0030595 69 0.011
phagolysosome assembly GO:0001845 3 0.011
regulation of establishment of protein localization GO:0070201 181 0.011
interleukin 13 secretion GO:0072611 2 0.011
ribose phosphate metabolic process GO:0019693 291 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
positive regulation of gamma aminobutyric acid secretion GO:0014054 2 0.011
negative regulation of hydrolase activity GO:0051346 71 0.010
organophosphate biosynthetic process GO:0090407 122 0.010
negative regulation of synaptic vesicle transport GO:1902804 3 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.010
regulation of protein transport GO:0051223 163 0.010
aromatic amino acid family metabolic process GO:0009072 9 0.010
positive regulation of immune effector process GO:0002699 107 0.010
cilium morphogenesis GO:0060271 102 0.010
neural precursor cell proliferation GO:0061351 121 0.010
glutamate receptor signaling pathway GO:0007215 35 0.010
negative regulation of cellular component organization GO:0051129 194 0.010
innate immune response in mucosa GO:0002227 3 0.010
lymphocyte activation involved in immune response GO:0002285 93 0.010
regulation of alpha beta t cell differentiation GO:0046637 35 0.010
tyrosine metabolic process GO:0006570 4 0.010

Hps1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.065
nervous system disease DOID:863 0 0.065
disease of metabolism DOID:0014667 0 0.040
inherited metabolic disorder DOID:655 0 0.040
sensory system disease DOID:0050155 0 0.028
eye and adnexa disease DOID:1492 0 0.028
eye disease DOID:5614 0 0.028
immune system disease DOID:2914 0 0.021
retinal disease DOID:5679 0 0.019
central nervous system disease DOID:331 0 0.016
neurodegenerative disease DOID:1289 0 0.016
retinal degeneration DOID:8466 0 0.016
musculoskeletal system disease DOID:17 0 0.016
connective tissue disease DOID:65 0 0.016
bone disease DOID:0080001 0 0.011