Mus musculus

0 known processes

Apex2

apurinic/apyrimidinic endonuclease 2

(Aliases: ape2,C430040P13Rik)

Apex2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 103 0.068
dna metabolic process GO:0006259 303 0.066
cellular ketone metabolic process GO:0042180 84 0.049
cellular amine metabolic process GO:0044106 44 0.049
regulation of cellular amino acid metabolic process GO:0006521 5 0.049
amine metabolic process GO:0009308 45 0.048
regulation of cellular ketone metabolic process GO:0010565 66 0.044
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.043
cellular response to dna damage stimulus GO:0006974 207 0.042
regulation of cellular amine metabolic process GO:0033238 20 0.040
regulation of cell cycle GO:0051726 281 0.040
regulation of organelle organization GO:0033043 289 0.038
ras protein signal transduction GO:0007265 77 0.038
macromolecule catabolic process GO:0009057 281 0.036
small gtpase mediated signal transduction GO:0007264 97 0.035
heterocycle catabolic process GO:0046700 280 0.034
apoptotic signaling pathway GO:0097190 306 0.034
response to organonitrogen compound GO:0010243 246 0.033
cation transport GO:0006812 399 0.033
nucleoside phosphate metabolic process GO:0006753 338 0.033
positive regulation of cellular amine metabolic process GO:0033240 5 0.032
nucleotide metabolic process GO:0009117 332 0.031
peptidyl amino acid modification GO:0018193 336 0.031
leukocyte differentiation GO:0002521 342 0.030
positive regulation of cell death GO:0010942 224 0.030
transmembrane transport GO:0055085 412 0.029
immune effector process GO:0002252 321 0.029
nucleobase containing small molecule metabolic process GO:0055086 352 0.027
regulation of apoptotic signaling pathway GO:2001233 197 0.027
regulation of cellular catabolic process GO:0031329 242 0.027
positive regulation of protein modification process GO:0031401 299 0.027
regulation of cell cycle process GO:0010564 160 0.026
regulation of transferase activity GO:0051338 263 0.026
cellular nitrogen compound catabolic process GO:0044270 280 0.026
positive regulation of apoptotic process GO:0043065 217 0.026
ribose phosphate metabolic process GO:0019693 291 0.026
response to lipopolysaccharide GO:0032496 128 0.026
positive regulation of programmed cell death GO:0043068 218 0.026
response to molecule of bacterial origin GO:0002237 143 0.026
ribonucleoside metabolic process GO:0009119 245 0.026
nuclear division GO:0000280 158 0.025
male gamete generation GO:0048232 285 0.025
cellular homeostasis GO:0019725 240 0.025
organic cyclic compound catabolic process GO:1901361 295 0.025
purine ribonucleotide metabolic process GO:0009150 290 0.025
aromatic compound catabolic process GO:0019439 286 0.025
purine nucleotide metabolic process GO:0006163 302 0.024
camera type eye development GO:0043010 266 0.024
cytoplasmic transport GO:0016482 234 0.024
sensory perception GO:0007600 245 0.024
cytokine production GO:0001816 319 0.024
nitrogen compound transport GO:0071705 271 0.024
regulation of cell activation GO:0050865 289 0.024
ribonucleotide metabolic process GO:0009259 291 0.024
oxidation reduction process GO:0055114 342 0.024
purine containing compound metabolic process GO:0072521 311 0.023
mitotic cell cycle GO:0000278 195 0.023
organelle fission GO:0048285 170 0.023
regulation of hydrolase activity GO:0051336 246 0.023
organonitrogen compound biosynthetic process GO:1901566 192 0.023
cellular lipid metabolic process GO:0044255 323 0.023
muscle tissue development GO:0060537 308 0.023
regulation of membrane potential GO:0042391 192 0.022
rna processing GO:0006396 105 0.022
organonitrogen compound catabolic process GO:1901565 264 0.022
regulation of lymphocyte activation GO:0051249 240 0.022
mapk cascade GO:0000165 281 0.022
negative regulation of cellular amine metabolic process GO:0033239 1 0.022
cellular macromolecule catabolic process GO:0044265 206 0.022
cellular chemical homeostasis GO:0055082 215 0.022
myeloid cell differentiation GO:0030099 233 0.022
nucleoside triphosphate metabolic process GO:0009141 230 0.022
mitotic cell cycle process GO:1903047 159 0.022
lymphocyte differentiation GO:0030098 242 0.022
ion transmembrane transport GO:0034220 361 0.021
striated muscle tissue development GO:0014706 293 0.021
organelle assembly GO:0070925 177 0.021
negative regulation of cellular protein metabolic process GO:0032269 247 0.021
spermatogenesis GO:0007283 284 0.021
posttranscriptional regulation of gene expression GO:0010608 155 0.021
regulation of mapk cascade GO:0043408 248 0.021
skeletal system development GO:0001501 356 0.021
response to oxygen levels GO:0070482 62 0.020
regulation of cytokine production GO:0001817 266 0.020
protein modification by small protein conjugation or removal GO:0070647 207 0.020
microtubule based process GO:0007017 236 0.020
nucleoside metabolic process GO:0009116 246 0.020
positive regulation of protein phosphorylation GO:0001934 242 0.020
meiotic nuclear division GO:0007126 115 0.020
membrane organization GO:0061024 245 0.020
homeostasis of number of cells GO:0048872 210 0.020
regulation of proteolysis GO:0030162 164 0.020
negative regulation of protein metabolic process GO:0051248 282 0.020
negative regulation of cell cycle GO:0045786 123 0.020
regulation of anatomical structure size GO:0090066 178 0.020
purine nucleoside metabolic process GO:0042278 241 0.020
meiotic cell cycle GO:0051321 122 0.020
germ cell development GO:0007281 185 0.020
circulatory system process GO:0003013 197 0.019
cation transmembrane transport GO:0098655 266 0.019
b cell activation GO:0042113 161 0.019
cell adhesion GO:0007155 329 0.019
histone modification GO:0016570 159 0.019
glycosyl compound metabolic process GO:1901657 246 0.019
protein ubiquitination GO:0016567 171 0.019
ribonucleoside triphosphate metabolic process GO:0009199 220 0.019
t cell activation GO:0042110 289 0.019
wnt signaling pathway GO:0016055 188 0.019
gland development GO:0048732 330 0.019
purine ribonucleoside metabolic process GO:0046128 241 0.018
cation homeostasis GO:0055080 212 0.018
negative regulation of cellular component organization GO:0051129 194 0.018
reactive oxygen species metabolic process GO:0072593 84 0.018
cellular response to biotic stimulus GO:0071216 92 0.018
inflammatory response GO:0006954 244 0.018
cellular response to molecule of bacterial origin GO:0071219 83 0.018
protein modification by small protein conjugation GO:0032446 187 0.018
positive regulation of hydrolase activity GO:0051345 148 0.018
blood vessel morphogenesis GO:0048514 285 0.018
purine nucleoside triphosphate metabolic process GO:0009144 226 0.018
purine ribonucleotide catabolic process GO:0009154 208 0.018
forebrain development GO:0030900 302 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.018
carbohydrate derivative catabolic process GO:1901136 231 0.018
regulation of secretion GO:0051046 274 0.018
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.018
protein catabolic process GO:0030163 221 0.018
rho protein signal transduction GO:0007266 32 0.017
cellular response to lipid GO:0071396 145 0.017
cell type specific apoptotic process GO:0097285 268 0.017
regulation of neuron differentiation GO:0045664 281 0.017
nucleotide catabolic process GO:0009166 217 0.017
regulation of mitotic cell cycle GO:0007346 126 0.017
purine containing compound catabolic process GO:0072523 213 0.017
cellular protein complex assembly GO:0043623 116 0.017
negative regulation of cell proliferation GO:0008285 296 0.017
fertilization GO:0009566 127 0.017
regulation of cytoskeleton organization GO:0051493 122 0.017
regulation of kinase activity GO:0043549 249 0.017
compound eye development GO:0048749 1 0.017
divalent metal ion transport GO:0070838 172 0.017
positive regulation of cellular catabolic process GO:0031331 148 0.017
regulation of defense response GO:0031347 233 0.017
purine nucleotide catabolic process GO:0006195 211 0.017
cellular response to organonitrogen compound GO:0071417 145 0.017
dna repair GO:0006281 107 0.016
muscle cell differentiation GO:0042692 261 0.016
cell cycle g1 s phase transition GO:0044843 57 0.016
protein processing GO:0016485 163 0.016
digestive system development GO:0055123 200 0.016
negative regulation of protein modification process GO:0031400 163 0.016
mitochondrion organization GO:0007005 134 0.016
protein maturation GO:0051604 176 0.016
cellular response to hormone stimulus GO:0032870 150 0.016
purine ribonucleoside catabolic process GO:0046130 205 0.016
regulation of secretion by cell GO:1903530 249 0.016
carbohydrate metabolic process GO:0005975 230 0.016
lymphocyte proliferation GO:0046651 164 0.016
covalent chromatin modification GO:0016569 163 0.016
chromatin organization GO:0006325 206 0.016
locomotory behavior GO:0007626 195 0.016
nucleoside catabolic process GO:0009164 206 0.016
anion transport GO:0006820 177 0.016
response to oxidative stress GO:0006979 123 0.016
purine nucleoside catabolic process GO:0006152 205 0.016
response to inorganic substance GO:0010035 96 0.016
maintenance of location GO:0051235 89 0.016
mrna metabolic process GO:0016071 84 0.016
response to acid chemical GO:0001101 111 0.016
cellular response to cytokine stimulus GO:0071345 189 0.016
organic anion transport GO:0015711 137 0.016
regulation of protein localization GO:0032880 231 0.016
embryonic organ morphogenesis GO:0048562 276 0.016
divalent inorganic cation transport GO:0072511 178 0.016
inorganic cation transmembrane transport GO:0098662 207 0.015
blood circulation GO:0008015 195 0.015
regulation of protein kinase activity GO:0045859 232 0.015
positive regulation of organelle organization GO:0010638 128 0.015
small molecule biosynthetic process GO:0044283 132 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.015
positive regulation of cell development GO:0010720 237 0.015
nuclear transport GO:0051169 139 0.015
organophosphate catabolic process GO:0046434 232 0.015
g protein coupled receptor signaling pathway GO:0007186 243 0.015
ribonucleotide catabolic process GO:0009261 208 0.015
nucleocytoplasmic transport GO:0006913 139 0.015
g1 s transition of mitotic cell cycle GO:0000082 57 0.015
cellular protein catabolic process GO:0044257 155 0.015
microtubule cytoskeleton organization GO:0000226 157 0.015
inorganic ion transmembrane transport GO:0098660 234 0.015
negative regulation of phosphate metabolic process GO:0045936 184 0.015
nucleoside phosphate catabolic process GO:1901292 222 0.015
retina development in camera type eye GO:0060041 119 0.015
nucleoside triphosphate catabolic process GO:0009143 205 0.015
negative regulation of immune system process GO:0002683 209 0.015
cellular ion homeostasis GO:0006873 165 0.015
ribonucleoside triphosphate catabolic process GO:0009203 199 0.015
oocyte construction GO:0007308 2 0.015
intracellular protein transport GO:0006886 204 0.015
lipid biosynthetic process GO:0008610 179 0.015
response to organic cyclic compound GO:0014070 198 0.015
leukocyte mediated immunity GO:0002443 174 0.014
cellular component assembly involved in morphogenesis GO:0010927 139 0.014
response to radiation GO:0009314 165 0.014
epithelial cell development GO:0002064 159 0.014
mitotic g1 dna damage checkpoint GO:0031571 4 0.014
developmental maturation GO:0021700 193 0.014
regulation of purine nucleotide metabolic process GO:1900542 169 0.014
modification dependent protein catabolic process GO:0019941 133 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.014
regulation of cell migration GO:0030334 219 0.014
leukocyte proliferation GO:0070661 172 0.014
angiogenesis GO:0001525 201 0.014
regulation of homeostatic process GO:0032844 182 0.014
negative regulation of phosphorylation GO:0042326 166 0.014
regulation of establishment of protein localization GO:0070201 181 0.014
positive regulation of cell activation GO:0050867 158 0.014
purine nucleoside triphosphate catabolic process GO:0009146 203 0.014
regulation of ion transport GO:0043269 215 0.014
regulation of cellular response to stress GO:0080135 159 0.014
chromatin modification GO:0016568 187 0.014
regulation of reactive oxygen species metabolic process GO:2000377 40 0.014
regulation of cellular component biogenesis GO:0044087 181 0.014
calcium ion transport GO:0006816 159 0.014
multicellular organism growth GO:0035264 161 0.014
negative regulation of molecular function GO:0044092 258 0.014
carbohydrate derivative biosynthetic process GO:1901137 183 0.014
organelle localization GO:0051640 179 0.014
cellular response to lipopolysaccharide GO:0071222 77 0.014
innate immune response GO:0045087 157 0.014
regulation of response to wounding GO:1903034 189 0.014
skeletal muscle organ development GO:0060538 163 0.013
rhythmic process GO:0048511 174 0.013
anatomical structure homeostasis GO:0060249 145 0.013
lymphocyte mediated immunity GO:0002449 139 0.013
cellular metal ion homeostasis GO:0006875 151 0.013
skeletal system morphogenesis GO:0048705 203 0.013
regulation of leukocyte proliferation GO:0070663 121 0.013
regulation of body fluid levels GO:0050878 162 0.013
protein polymerization GO:0051258 57 0.013
guanosine containing compound metabolic process GO:1901068 144 0.013
central nervous system neuron differentiation GO:0021953 162 0.013
regulation of leukocyte differentiation GO:1902105 159 0.013
regulation of hormone levels GO:0010817 211 0.013
metal ion homeostasis GO:0055065 189 0.013
regulation of nucleotide metabolic process GO:0006140 169 0.013
ossification GO:0001503 216 0.013
ribonucleoside catabolic process GO:0042454 206 0.013
negative regulation of intracellular signal transduction GO:1902532 167 0.013
positive regulation of mapk cascade GO:0043410 170 0.013
regulation of mitotic cell cycle phase transition GO:1901990 73 0.013
positive regulation of transferase activity GO:0051347 167 0.013
positive regulation of cell cycle process GO:0090068 61 0.013
single organism cell adhesion GO:0098602 156 0.013
regulation of ras protein signal transduction GO:0046578 114 0.013
actin cytoskeleton organization GO:0030036 220 0.013
modification dependent macromolecule catabolic process GO:0043632 133 0.013
guanosine containing compound catabolic process GO:1901069 144 0.013
synaptic transmission GO:0007268 329 0.013
transmission of nerve impulse GO:0019226 76 0.013
regulation of actin filament based process GO:0032970 99 0.013
positive regulation of lymphocyte activation GO:0051251 140 0.012
multicellular organismal signaling GO:0035637 91 0.012
lateral inhibition GO:0046331 1 0.012
action potential GO:0001508 78 0.012
negative regulation of apoptotic signaling pathway GO:2001234 104 0.012
cell activation involved in immune response GO:0002263 126 0.012
sequestering of metal ion GO:0051238 19 0.012
sensory organ morphogenesis GO:0090596 242 0.012
peptidyl tyrosine modification GO:0018212 145 0.012
regulation of cell projection organization GO:0031344 206 0.012
regulation of system process GO:0044057 200 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.012
regulation of protein serine threonine kinase activity GO:0071900 157 0.012
endomembrane system organization GO:0010256 147 0.012
digestive tract development GO:0048565 190 0.012
multicellular organismal homeostasis GO:0048871 164 0.012
regulation of cell motility GO:2000145 236 0.012
positive regulation of nucleotide metabolic process GO:0045981 114 0.012
ubiquitin dependent protein catabolic process GO:0006511 129 0.012
multi multicellular organism process GO:0044706 109 0.012
regulation of cellular component size GO:0032535 121 0.012
monocarboxylic acid metabolic process GO:0032787 191 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.012
cell growth GO:0016049 130 0.012
glycosyl compound catabolic process GO:1901658 206 0.012
regulation of nucleotide catabolic process GO:0030811 122 0.012
regulation of purine nucleotide catabolic process GO:0033121 122 0.012
oocyte axis specification GO:0007309 2 0.012
carbohydrate homeostasis GO:0033500 128 0.011
fat cell differentiation GO:0045444 160 0.011
gtp catabolic process GO:0006184 143 0.011
regulation of t cell activation GO:0050863 170 0.011
organic hydroxy compound metabolic process GO:1901615 203 0.011
epithelial tube morphogenesis GO:0060562 303 0.011
organic acid biosynthetic process GO:0016053 86 0.011
respiratory tube development GO:0030323 167 0.011
stem cell differentiation GO:0048863 268 0.011
positive regulation of cell cycle GO:0045787 92 0.011
extrinsic apoptotic signaling pathway GO:0097191 126 0.011
organophosphate biosynthetic process GO:0090407 122 0.011
sequestering of calcium ion GO:0051208 18 0.011
regulation of lymphocyte proliferation GO:0050670 117 0.011
stress activated mapk cascade GO:0051403 80 0.011
connective tissue development GO:0061448 179 0.011
regulation of peptidase activity GO:0052547 96 0.011
extracellular matrix organization GO:0030198 147 0.011
negative regulation of cell cycle process GO:0010948 69 0.011
regulation of inflammatory response GO:0050727 147 0.011
regulation of endopeptidase activity GO:0052548 89 0.011
positive regulation of secretion GO:0051047 130 0.011
learning or memory GO:0007611 148 0.011
adult behavior GO:0030534 135 0.011
carboxylic acid biosynthetic process GO:0046394 86 0.011
renal system development GO:0072001 225 0.011
hematopoietic progenitor cell differentiation GO:0002244 143 0.011
regulation of nucleoside metabolic process GO:0009118 130 0.011
wound healing GO:0042060 157 0.011
t cell differentiation GO:0030217 174 0.011
adaptive immune response GO:0002250 155 0.011
positive regulation of nervous system development GO:0051962 221 0.011
regulation of metal ion transport GO:0010959 106 0.011
positive regulation of proteolysis GO:0045862 85 0.011
rna splicing GO:0008380 54 0.011
dna endoreduplication GO:0042023 4 0.011
glucose homeostasis GO:0042593 128 0.011
carboxylic acid transport GO:0046942 100 0.011
signal transduction by p53 class mediator GO:0072331 51 0.011
negative regulation of protein phosphorylation GO:0001933 126 0.011
placenta development GO:0001890 140 0.011
respiratory system development GO:0060541 190 0.011
positive regulation of protein kinase activity GO:0045860 144 0.011
protein localization to organelle GO:0033365 185 0.011
negative regulation of nervous system development GO:0051961 156 0.011
exocytosis GO:0006887 121 0.011
inter male aggressive behavior GO:0002121 3 0.011
reactive nitrogen species metabolic process GO:2001057 0 0.011
regionalization GO:0003002 337 0.011
myeloid cell homeostasis GO:0002262 114 0.010
heart morphogenesis GO:0003007 178 0.010
cellular carbohydrate metabolic process GO:0044262 119 0.010
peptide transport GO:0015833 133 0.010
gtp metabolic process GO:0046039 144 0.010
regulation of ossification GO:0030278 112 0.010
proteasomal protein catabolic process GO:0010498 98 0.010
peptidyl tyrosine phosphorylation GO:0018108 143 0.010
dephosphorylation GO:0016311 129 0.010
macromolecule methylation GO:0043414 120 0.010
cellular response to growth factor stimulus GO:0071363 197 0.010
response to growth factor GO:0070848 198 0.010
urogenital system development GO:0001655 261 0.010
cognition GO:0050890 149 0.010
methylation GO:0032259 134 0.010
response to peptide hormone GO:0043434 127 0.010
chemotaxis GO:0006935 247 0.010
neural tube development GO:0021915 160 0.010
regulation of intracellular transport GO:0032386 159 0.010
regulation of transmembrane transport GO:0034762 128 0.010
regulation of muscle tissue development GO:1901861 97 0.010
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.010
extracellular structure organization GO:0043062 148 0.010
myosin filament assembly GO:0031034 2 0.010
response to extracellular stimulus GO:0009991 127 0.010
regulation of cell adhesion GO:0030155 154 0.010
endocytosis GO:0006897 168 0.010
axonogenesis GO:0007409 274 0.010
tissue remodeling GO:0048771 102 0.010
response to peptide GO:1901652 136 0.010
amide transport GO:0042886 138 0.010
rna splicing via transesterification reactions GO:0000375 43 0.010
cofactor metabolic process GO:0051186 80 0.010
regulation of stress activated mapk cascade GO:0032872 69 0.010
skin development GO:0043588 220 0.010
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.010
cellular response to acid chemical GO:0071229 68 0.010
telencephalon development GO:0021537 186 0.010

Apex2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.027
disease of anatomical entity DOID:7 0 0.027
nervous system disease DOID:863 0 0.027
central nervous system disease DOID:331 0 0.021
sensory system disease DOID:0050155 0 0.017
hematopoietic system disease DOID:74 0 0.014
eye and adnexa disease DOID:1492 0 0.014
eye disease DOID:5614 0 0.014
musculoskeletal system disease DOID:17 0 0.012
anemia DOID:2355 0 0.011
disease of metabolism DOID:0014667 0 0.011
inherited metabolic disorder DOID:655 0 0.011
neurodegenerative disease DOID:1289 0 0.011
retinal disease DOID:5679 0 0.010
retinal degeneration DOID:8466 0 0.010