Mus musculus

199 known processes

Ptch1

patched homolog 1

(Aliases: Ptc1,A230106A15Rik,Ptc,mes,Ptch)

Ptch1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regionalization GO:0003002 337 0.999
branching morphogenesis of an epithelial tube GO:0048754 159 0.996
hindlimb morphogenesis GO:0035137 42 0.992
spinal cord motor neuron differentiation GO:0021522 35 0.982
nodal signaling pathway involved in determination of left right asymmetry GO:0038107 2 0.981
stem cell proliferation GO:0072089 117 0.979
regulation of smoothened signaling pathway GO:0008589 58 0.970
appendage development GO:0048736 166 0.969
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.969
neural tube closure GO:0001843 90 0.969
embryonic skeletal system development GO:0048706 120 0.966
smoothened signaling pathway involved in dorsal ventral neural tube patterning GO:0060831 12 0.965
osteoblast development GO:0002076 17 0.964
neural tube patterning GO:0021532 43 0.963
epithelial tube morphogenesis GO:0060562 303 0.962
negative regulation of cell proliferation GO:0008285 296 0.962
response to sterol GO:0036314 4 0.958
embryonic skeletal system morphogenesis GO:0048704 91 0.957
formation of radial glial scaffolds GO:0021943 4 0.954
skeletal system development GO:0001501 356 0.953
embryonic organ morphogenesis GO:0048562 276 0.948
regulation of astrocyte differentiation GO:0048710 20 0.948
gland development GO:0048732 330 0.941
smoothened signaling pathway GO:0007224 105 0.940
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900164 2 0.934
regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072039 4 0.929
positive regulation of bmp signaling pathway GO:0030513 23 0.927
germ line stem cell division GO:0042078 2 0.926
actin cytoskeleton organization GO:0030036 220 0.921
chondrocyte differentiation GO:0002062 72 0.921
epithelial tube formation GO:0072175 130 0.920
floor plate morphogenesis GO:0033505 3 0.918
nephrogenic mesenchyme morphogenesis GO:0072134 2 0.912
morphogenesis of a branching structure GO:0001763 203 0.912
positive regulation of cell death GO:0010942 224 0.908
neural tube development GO:0021915 160 0.907
endodermal cell fate specification GO:0001714 4 0.905
heart morphogenesis GO:0003007 178 0.904
rhythmic process GO:0048511 174 0.902
angiogenesis GO:0001525 201 0.900
forebrain radial glial cell differentiation GO:0021861 4 0.900
camera type eye development GO:0043010 266 0.894
Zebrafish
stem cell development GO:0048864 219 0.891
stem cell maintenance GO:0019827 130 0.886
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 7 0.886
central nervous system neuron differentiation GO:0021953 162 0.882
somite development GO:0061053 81 0.881
metanephric mesenchyme morphogenesis GO:0072133 4 0.879
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.876
cardiac endothelial cell differentiation GO:0003348 4 0.872
regulation of cardiac muscle tissue development GO:0055024 31 0.870
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 2 0.867
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.866
negative regulation of cell cycle GO:0045786 123 0.862
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 0.857
embryonic skeletal joint morphogenesis GO:0060272 11 0.857
oocyte axis specification GO:0007309 2 0.855
negative regulation of glial cell differentiation GO:0045686 21 0.835
mammary gland epithelium development GO:0061180 65 0.833
negative regulation of protein modification process GO:0031400 163 0.832
regulation of kinase activity GO:0043549 249 0.829
mesonephric tubule development GO:0072164 94 0.825
ureteric bud morphogenesis GO:0060675 62 0.823
negative regulation of cell fate specification GO:0009996 4 0.819
neural tube formation GO:0001841 108 0.818
kidney epithelium development GO:0072073 121 0.809
muscle cell fate specification GO:0042694 1 0.807
telencephalon development GO:0021537 186 0.802
regulation of protein transport GO:0051223 163 0.801
Fly
axial mesodermal cell fate commitment GO:0048322 1 0.800
negative regulation of smoothened signaling pathway GO:0045879 25 0.799
mesenchymal cell apoptotic process involved in nephron morphogenesis GO:1901145 4 0.793
regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000148 1 0.789
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000166 1 0.789
negative regulation of bmp signaling pathway GO:0030514 35 0.788
regulation of mitotic cell cycle GO:0007346 126 0.788
primary neural tube formation GO:0014020 95 0.779
homeostasis of number of cells GO:0048872 210 0.773
neuron projection guidance GO:0097485 141 0.770
Fly
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.769
negative regulation of molecular function GO:0044092 258 0.767
lung development GO:0030324 164 0.766
negative regulation of astrocyte differentiation GO:0048712 10 0.763
cellular response to cholesterol GO:0071397 2 0.763
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.760
mesenchyme development GO:0060485 152 0.754
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.753
embryonic epithelial tube formation GO:0001838 130 0.751
negative regulation of mitotic cell cycle GO:0045930 58 0.741
negative regulation of lymphocyte differentiation GO:0045620 32 0.740
negative regulation of glial cell proliferation GO:0060253 4 0.735
cellular ketone metabolic process GO:0042180 84 0.731
protein localization to nucleus GO:0034504 121 0.725
Fly
regulation of cardiac cell fate specification GO:2000043 1 0.723
pallium development GO:0021543 120 0.720
retinal ganglion cell axon guidance GO:0031290 18 0.715
gastrulation GO:0007369 116 0.713
smoothened signaling pathway involved in ventral spinal cord patterning GO:0021910 7 0.710
positive regulation of apoptotic signaling pathway GO:2001235 95 0.709
ventricular zone neuroblast division GO:0021847 3 0.709
germ cell development GO:0007281 185 0.707
Worm Fly
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.706
inner ear receptor cell differentiation GO:0060113 61 0.704
oocyte differentiation GO:0009994 35 0.698
regulation of cellular amino acid metabolic process GO:0006521 5 0.698
lymphocyte differentiation GO:0030098 242 0.697
negative regulation of protein metabolic process GO:0051248 282 0.694
mesenchymal cell proliferation GO:0010463 44 0.693
cellular response to lipid GO:0071396 145 0.692
regulation of protein targeting GO:1903533 61 0.691
Fly
bone morphogenesis GO:0060349 78 0.689
carbon catabolite activation of transcription GO:0045991 4 0.687
mammary gland morphogenesis GO:0060443 54 0.685
smooth muscle tissue development GO:0048745 22 0.683
trophectodermal cellular morphogenesis GO:0001831 3 0.675
somatic stem cell maintenance GO:0035019 47 0.674
regulation of protein kinase activity GO:0045859 232 0.673
kidney development GO:0001822 213 0.672
nephron morphogenesis GO:0072028 69 0.670
muscle cell differentiation GO:0042692 261 0.667
positive regulation of programmed cell death GO:0043068 218 0.666
regulation of cell migration GO:0030334 219 0.654
Fly
negative regulation of stem cell maintenance GO:1902455 4 0.654
connective tissue development GO:0061448 179 0.654
positive regulation of apoptotic process GO:0043065 217 0.649
respiratory system development GO:0060541 190 0.648
Fly
negative regulation of leukocyte differentiation GO:1902106 51 0.646
negative regulation of prostatic bud formation GO:0060686 4 0.643
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.643
regulation of establishment of protein localization GO:0070201 181 0.636
Fly
establishment or maintenance of neuroblast polarity GO:0045196 1 0.635
leukocyte differentiation GO:0002521 342 0.634
dorsal ventral neural tube patterning GO:0021904 28 0.633
embryonic skeletal joint development GO:0072498 13 0.631
dna metabolic process GO:0006259 303 0.631
regulation of apoptotic signaling pathway GO:2001233 197 0.627
ossification GO:0001503 216 0.625
Zebrafish
neural precursor cell proliferation GO:0061351 121 0.624
leukocyte proliferation GO:0070661 172 0.624
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.618
negative regulation of epithelial cell proliferation GO:0050680 64 0.618
spermatogenesis GO:0007283 284 0.616
regulation of cell cycle GO:0051726 281 0.616
branching involved in ureteric bud morphogenesis GO:0001658 56 0.614
morphogenesis of embryonic epithelium GO:0016331 159 0.612
somitogenesis GO:0001756 69 0.610
negative regulation of kinase activity GO:0033673 81 0.608
regulation of mapk cascade GO:0043408 248 0.607
protein processing GO:0016485 163 0.605
regulation of somitogenesis GO:0014807 6 0.604
regulation of cellular component biogenesis GO:0044087 181 0.603
negative regulation of cell development GO:0010721 169 0.603
skeletal system morphogenesis GO:0048705 203 0.596
astrocyte differentiation GO:0048708 43 0.593
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.589
axonogenesis GO:0007409 274 0.577
Fly
regulation of glial cell differentiation GO:0045685 41 0.573
regulation of cytoskeleton organization GO:0051493 122 0.571
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.571
chondrocyte development GO:0002063 24 0.567
somite specification GO:0001757 4 0.566
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.563
cardiac right atrium morphogenesis GO:0003213 3 0.561
auditory receptor cell fate determination GO:0042668 3 0.559
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.555
morphogenesis of a branching epithelium GO:0061138 193 0.554
transforming growth factor beta receptor signaling pathway involved in primitive streak formation GO:0090010 1 0.548
axis elongation involved in somitogenesis GO:0090245 4 0.548
cellular macromolecule catabolic process GO:0044265 206 0.548
regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000163 1 0.545
regulation of stem cell differentiation GO:2000736 50 0.543
bmp signaling pathway GO:0030509 93 0.541
cellular amine metabolic process GO:0044106 44 0.540
cellular response to organic cyclic compound GO:0071407 87 0.540
sensory perception GO:0007600 245 0.539
axon guidance GO:0007411 141 0.538
Fly
forebrain morphogenesis GO:0048853 17 0.531
cell type specific apoptotic process GO:0097285 268 0.529
negative regulation of protein phosphorylation GO:0001933 126 0.529
positive regulation of epithelial to mesenchymal transition GO:0010718 13 0.527
nuclear transport GO:0051169 139 0.526
Fly
forebrain development GO:0030900 302 0.526
regulation of endodermal cell fate specification GO:0042663 2 0.525
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.522
cerebral cortex radial glia guided migration GO:0021801 17 0.518
protein maturation GO:0051604 176 0.517
male gamete generation GO:0048232 285 0.508
trachea formation GO:0060440 3 0.505
negative regulation of cardiac muscle tissue development GO:0055026 8 0.504
mesenchymal cell development GO:0014031 93 0.502
positive regulation of kinase activity GO:0033674 155 0.501
ovulation cycle GO:0042698 59 0.500
myeloid leukocyte differentiation GO:0002573 119 0.499
negative regulation of growth GO:0045926 99 0.498
roof plate formation GO:0021509 1 0.497
negative regulation of t cell differentiation GO:0045581 23 0.496
epithelial tube branching involved in lung morphogenesis GO:0060441 28 0.496
blood vessel morphogenesis GO:0048514 285 0.489
forebrain generation of neurons GO:0021872 63 0.489
negative regulation of planar cell polarity pathway involved in heart morphogenesis GO:2000160 1 0.488
nuclear import GO:0051170 95 0.488
Fly
positive regulation of cellular amine metabolic process GO:0033240 5 0.488
ureteric bud development GO:0001657 94 0.483
negative regulation of photoreceptor cell differentiation GO:0046533 4 0.482
endothelial cell differentiation GO:0045446 41 0.479
positive regulation of immature t cell proliferation GO:0033091 4 0.479
protein targeting GO:0006605 143 0.476
Fly
regulation of actin cytoskeleton organization GO:0032956 84 0.475
negative regulation of lymphocyte activation GO:0051250 91 0.472
brain morphogenesis GO:0048854 32 0.472
multicellular organism growth GO:0035264 161 0.467
embryonic limb morphogenesis GO:0030326 126 0.465
kidney morphogenesis GO:0060993 83 0.465
negative regulation of phosphorylation GO:0042326 166 0.465
endocardial cell differentiation GO:0060956 4 0.464
positive regulation of neuron death GO:1901216 28 0.463
cellular response to growth factor stimulus GO:0071363 197 0.462
aorta morphogenesis GO:0035909 22 0.460
small gtpase mediated signal transduction GO:0007264 97 0.458
tube closure GO:0060606 91 0.454
renal tubule development GO:0061326 87 0.454
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.448
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.447
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.443
carbon catabolite regulation of transcription GO:0045990 4 0.441
embryonic heart tube morphogenesis GO:0003143 51 0.440
lung morphogenesis GO:0060425 50 0.438
tube formation GO:0035148 140 0.435
negative regulation of neuron differentiation GO:0045665 101 0.431
mesenchymal cell differentiation GO:0048762 107 0.426
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.425
positive regulation of leukocyte differentiation GO:1902107 86 0.422
regulation of smooth muscle cell differentiation GO:0051150 9 0.421
spinal cord ventral commissure morphogenesis GO:0021965 2 0.419
platelet derived growth factor receptor alpha signaling pathway GO:0035790 3 0.419
negative regulation of immature t cell proliferation GO:0033087 3 0.415
respiratory tube development GO:0030323 167 0.415
regulation of organelle organization GO:0033043 289 0.414
regulation of transferase activity GO:0051338 263 0.414
regulation of endodermal cell differentiation GO:1903224 2 0.413
nephron tubule development GO:0072080 84 0.413
muscle tissue development GO:0060537 308 0.411
hippocampus development GO:0021766 52 0.409
regulation of neuron projection development GO:0010975 169 0.409
negative regulation of cellular protein metabolic process GO:0032269 247 0.408
regulation of cell motility GO:2000145 236 0.407
Fly
anterior commissure morphogenesis GO:0021960 6 0.407
epithelial cell proliferation GO:0050673 174 0.406
positive regulation of transcription from rna polymerase ii promoter by glucose GO:0000432 3 0.404
developmental maturation GO:0021700 193 0.404
ubiquitin dependent protein catabolic process GO:0006511 129 0.404
cerebellum development GO:0021549 77 0.404
regulation of canonical wnt signaling pathway GO:0060828 82 0.404
regulation of cellular amine metabolic process GO:0033238 20 0.402
muscle cell development GO:0055001 133 0.400
regulation of protein localization GO:0032880 231 0.397
organelle assembly GO:0070925 177 0.395
positive regulation of hh target transcription factor activity GO:0007228 3 0.395
negative regulation of gliogenesis GO:0014014 23 0.394
regulation of endothelial cell differentiation GO:0045601 10 0.394
regulation of bmp signaling pathway GO:0030510 60 0.394
molting cycle GO:0042303 90 0.390
Mouse Worm
mesenchyme morphogenesis GO:0072132 32 0.390
digestive tract morphogenesis GO:0048546 147 0.389
regulation of neuron differentiation GO:0045664 281 0.388
regulation of intracellular protein transport GO:0033157 82 0.385
Fly
appendage morphogenesis GO:0035107 149 0.383
cell fate commitment GO:0045165 210 0.383
Fly
negative regulation of map kinase activity GO:0043407 34 0.380
carbohydrate homeostasis GO:0033500 128 0.380
stem cell differentiation GO:0048863 268 0.379
Zebrafish
prostate gland morphogenesis GO:0060512 32 0.379
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.379
regulation of leukocyte differentiation GO:1902105 159 0.373
glomerulus morphogenesis GO:0072102 10 0.373
positive regulation of growth GO:0045927 104 0.373
Worm
lateral mesodermal cell differentiation GO:0048371 3 0.372
regulation of tendon cell differentiation GO:2001049 1 0.372
metanephros development GO:0001656 79 0.370
formation of anatomical boundary GO:0048859 6 0.368
cytoplasmic transport GO:0016482 234 0.366
Fly
positive regulation of actin filament bundle assembly GO:0032233 11 0.355
kidney mesenchyme development GO:0072074 14 0.355
regulation of protein import into nucleus GO:0042306 52 0.352
Fly
cell differentiation in spinal cord GO:0021515 53 0.352
glycosyl compound metabolic process GO:1901657 246 0.351
cell proliferation involved in metanephros development GO:0072203 9 0.351
negative regulation of cell activation GO:0050866 111 0.351
regulation of nucleocytoplasmic transport GO:0046822 73 0.348
Fly
signal transduction by p53 class mediator GO:0072331 51 0.345
endodermal cell fate determination GO:0007493 2 0.344
epithelial cell maturation involved in prostate gland development GO:0060743 4 0.342
positive regulation of transferase activity GO:0051347 167 0.340
regulation of cytoplasmic transport GO:1903649 112 0.339
Fly
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.339
regulation of protein stability GO:0031647 52 0.337
notch signaling pathway GO:0007219 71 0.335
urogenital system development GO:0001655 261 0.333
somatic sex determination GO:0018993 2 0.332
regulation of cell projection organization GO:0031344 206 0.332
positive regulation of protein modification process GO:0031401 299 0.331
central nervous system neuron development GO:0021954 67 0.330
neural crest cell migration GO:0001755 32 0.329
diencephalon development GO:0021536 63 0.329
regulation of myoblast differentiation GO:0045661 29 0.327
mesodermal cell fate determination GO:0007500 1 0.324
digestive tract development GO:0048565 190 0.324
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.321
peptidyl tyrosine modification GO:0018212 145 0.320
positive regulation of cartilage development GO:0061036 18 0.320
ras protein signal transduction GO:0007265 77 0.319
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000149 1 0.318
morphogenesis of an epithelial bud GO:0060572 18 0.318
jak stat cascade GO:0007259 42 0.318
cardiac cell development GO:0055006 41 0.317
negative regulation of cellular amine metabolic process GO:0033239 1 0.314
positive regulation of ossification GO:0045778 47 0.311
cell proliferation involved in heart valve morphogenesis GO:0003249 1 0.309
regulation of anatomical structure size GO:0090066 178 0.308
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 4 0.305
cell division GO:0051301 120 0.305
epithelial cell proliferation involved in prostate gland development GO:0060767 11 0.305
retina development in camera type eye GO:0060041 119 0.304
Zebrafish
negative regulation of reproductive process GO:2000242 31 0.304
epithelial to mesenchymal transition GO:0001837 47 0.303
cellular component assembly involved in morphogenesis GO:0010927 139 0.303
inner cell mass cellular morphogenesis GO:0001828 1 0.303
cerebellar granule cell precursor proliferation GO:0021930 10 0.300
morphogenesis of an epithelial fold GO:0060571 28 0.300
regulation of mitotic cell cycle phase transition GO:1901990 73 0.300
protein catabolic process GO:0030163 221 0.297
t cell activation GO:0042110 289 0.297
wnt signaling pathway involved in somitogenesis GO:0090244 4 0.297
sensory organ morphogenesis GO:0090596 242 0.296
Zebrafish Fly
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.295
positive regulation of epithelial cell proliferation GO:0050679 68 0.294
peptidyl tyrosine phosphorylation GO:0018108 143 0.293
single organismal cell cell adhesion GO:0016337 131 0.292
pyramidal neuron migration GO:0021852 1 0.292
glomerulus vasculature morphogenesis GO:0072103 6 0.292
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072040 4 0.290
g1 s transition of mitotic cell cycle GO:0000082 57 0.290
ureter morphogenesis GO:0072197 4 0.289
response to nutrient levels GO:0031667 109 0.289
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.289
protein modification by small protein conjugation or removal GO:0070647 207 0.288
cell migration involved in coronary angiogenesis GO:0060981 1 0.287
forebrain ventricular zone progenitor cell division GO:0021869 6 0.287
nephron development GO:0072006 109 0.284
mesonephros development GO:0001823 97 0.284
regulation of cell cycle process GO:0010564 160 0.279
regulation of dna replication GO:0006275 17 0.279
regulation of smad protein import into nucleus GO:0060390 3 0.278
spinal cord development GO:0021510 81 0.277
ascending aorta morphogenesis GO:0035910 3 0.276
positive regulation of cell migration GO:0030335 109 0.275
lipid homeostasis GO:0055088 63 0.275
Fly
heart field specification GO:0003128 6 0.274
canonical wnt signaling pathway GO:0060070 130 0.272
regulation of vasculature development GO:1901342 88 0.272
positive regulation of neuron apoptotic process GO:0043525 25 0.272
posttranscriptional regulation of gene expression GO:0010608 155 0.270
guanosine containing compound metabolic process GO:1901068 144 0.270
purine nucleoside metabolic process GO:0042278 241 0.269
mammary gland specification GO:0060594 4 0.269
negative regulation of transferase activity GO:0051348 85 0.269
regulation of transcription involved in primary germ layer cell fate commitment GO:0060796 2 0.269
embryonic heart tube anterior posterior pattern specification GO:0035054 3 0.267
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 4 0.267
epidermis development GO:0008544 187 0.266
rho protein signal transduction GO:0007266 32 0.266
meiotic cell cycle GO:0051321 122 0.265
glomerular capillary formation GO:0072104 6 0.265
regulation of neuron death GO:1901214 134 0.263
positive regulation of chondrocyte differentiation GO:0032332 13 0.263
glomerulus vasculature development GO:0072012 14 0.261
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.261
apoptotic signaling pathway GO:0097190 306 0.258
regulation of cellular catabolic process GO:0031329 242 0.258
forebrain neuron differentiation GO:0021879 52 0.257
regulation of hydrolase activity GO:0051336 246 0.257
cloacal septation GO:0060197 2 0.257
ear morphogenesis GO:0042471 118 0.255
regulation of binding GO:0051098 111 0.254
radial glial cell differentiation GO:0060019 6 0.254
limb development GO:0060173 166 0.252
negative regulation of wnt signaling pathway involved in heart development GO:0003308 4 0.252
negative regulation of t cell activation GO:0050868 65 0.252
regulation of ras protein signal transduction GO:0046578 114 0.251
metanephric glomerular mesangium development GO:0072223 3 0.251
negative regulation of dendritic spine development GO:0061000 3 0.250
hypophysis morphogenesis GO:0048850 3 0.249
carbon catabolite regulation of transcription from rna polymerase ii promoter GO:0000429 4 0.248
kidney mesenchyme morphogenesis GO:0072131 4 0.248
pituitary gland development GO:0021983 38 0.248
regulation of t cell differentiation in thymus GO:0033081 24 0.247
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.247
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 2 0.247
organelle fission GO:0048285 170 0.247
cell proliferation in midbrain GO:0033278 2 0.247
chemotaxis GO:0006935 247 0.246
Fly
regulation of alpha beta t cell differentiation GO:0046637 35 0.246
ear development GO:0043583 200 0.245
positive regulation of lens epithelial cell proliferation GO:2001111 1 0.244
cardiocyte differentiation GO:0035051 87 0.244
Zebrafish
positive regulation of nervous system development GO:0051962 221 0.244
hindbrain development GO:0030902 128 0.243
dendrite development GO:0016358 115 0.242
face morphogenesis GO:0060325 29 0.242
mesonephric epithelium development GO:0072163 94 0.242
regulation of cellular response to growth factor stimulus GO:0090287 82 0.241
regulation of t cell differentiation GO:0045580 83 0.241
orbitofrontal cortex development GO:0021769 2 0.241
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.241
organ growth GO:0035265 117 0.240
foregut morphogenesis GO:0007440 12 0.239
heterocycle catabolic process GO:0046700 280 0.239
actomyosin structure organization GO:0031032 56 0.237
response to cholesterol GO:0070723 4 0.237
skin development GO:0043588 220 0.235
regulation of intracellular transport GO:0032386 159 0.235
Fly
digestive system development GO:0055123 200 0.233
midbrain hindbrain boundary morphogenesis GO:0021555 4 0.233
metanephric nephron tubule formation GO:0072289 4 0.233
ribonucleoside catabolic process GO:0042454 206 0.232
cellular response to dna damage stimulus GO:0006974 207 0.232
ribonucleoside metabolic process GO:0009119 245 0.232
rostrocaudal neural tube patterning GO:0021903 12 0.232
nucleoside triphosphate metabolic process GO:0009141 230 0.231
protein import into nucleus GO:0006606 95 0.231
Fly
epithelial cell development GO:0002064 159 0.230
liver development GO:0001889 66 0.227
negative regulation of nervous system development GO:0051961 156 0.226
renal vesicle induction GO:0072034 3 0.226
insulin secretion GO:0030073 89 0.226
regulation of gliogenesis GO:0014013 50 0.226
cellular response to sterol GO:0036315 2 0.224
positive regulation of osteoblast differentiation GO:0045669 34 0.224
regulation of fat cell differentiation GO:0045598 81 0.224
renal system development GO:0072001 225 0.224
regulation of protein localization to nucleus GO:1900180 60 0.223
Fly
modification dependent macromolecule catabolic process GO:0043632 133 0.223
nucleoside metabolic process GO:0009116 246 0.223
regulation of cellular ketone metabolic process GO:0010565 66 0.222
prostate epithelial cord elongation GO:0060523 3 0.222
negative regulation of intracellular signal transduction GO:1902532 167 0.222
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000162 1 0.221
ameboidal type cell migration GO:0001667 128 0.219
Fly
regulation of cardioblast differentiation GO:0051890 3 0.219
b cell activation GO:0042113 161 0.219
purine nucleoside triphosphate catabolic process GO:0009146 203 0.219
regulation of ras gtpase activity GO:0032318 88 0.218
odontogenesis GO:0042476 78 0.218
endothelium development GO:0003158 45 0.215
oocyte construction GO:0007308 2 0.214
spermatid differentiation GO:0048515 115 0.214
prostate gland epithelium morphogenesis GO:0060740 31 0.212
response to light stimulus GO:0009416 135 0.211
cell growth GO:0016049 130 0.210
sensory perception of sound GO:0007605 97 0.210
negative regulation of t cell proliferation GO:0042130 38 0.210
medulla oblongata development GO:0021550 3 0.210
lateral mesoderm morphogenesis GO:0048369 3 0.209
cell cycle checkpoint GO:0000075 47 0.209
regulation of neuron apoptotic process GO:0043523 122 0.209
negative regulation of phosphorus metabolic process GO:0010563 184 0.208
segmentation GO:0035282 93 0.207
forebrain cell migration GO:0021885 58 0.207
embryonic digit morphogenesis GO:0042733 56 0.206
osteoclast differentiation GO:0030316 62 0.206
regulation of t cell proliferation GO:0042129 92 0.205
renal system vasculature development GO:0061437 15 0.204
positive regulation of cell cycle g1 s phase transition GO:1902808 9 0.204
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.204
ribonucleotide metabolic process GO:0009259 291 0.203
lung induction GO:0060492 3 0.203
negative regulation of dendritic spine morphogenesis GO:0061002 3 0.203
positive regulation of proteolysis GO:0045862 85 0.202
positive regulation of protein kinase activity GO:0045860 144 0.202
oogenesis GO:0048477 56 0.201
Worm Fly
embryonic hemopoiesis GO:0035162 23 0.200
frontal suture morphogenesis GO:0060364 2 0.200
negative regulation of cell cycle phase transition GO:1901988 48 0.200
embryonic appendage morphogenesis GO:0035113 126 0.200
regulation of transcription from rna polymerase ii promoter involved in definitive endodermal cell fate specification GO:0060807 1 0.199

Ptch1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.958
cancer DOID:162 0 0.957
organ system cancer DOID:0050686 0 0.957
disease of anatomical entity DOID:7 0 0.862
musculoskeletal system disease DOID:17 0 0.862
connective tissue disease DOID:65 0 0.862
bone disease DOID:0080001 0 0.238
bone development disease DOID:0080006 0 0.237
dysostosis DOID:1934 0 0.237
gastrointestinal system cancer DOID:3119 0 0.203