Mus musculus

29 known processes

Pcsk1

proprotein convertase subtilisin/kexin type 1

(Aliases: Nec-1,PC3,PC1,MGC124320,MGC124321,Phpp-1,SPC3,Nec1)

Pcsk1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
fertilization GO:0009566 127 0.618
Mouse
cellular response to organonitrogen compound GO:0071417 145 0.277
membrane organization GO:0061024 245 0.258
synaptic transmission GO:0007268 329 0.255
single fertilization GO:0007338 82 0.230
Mouse
positive regulation of programmed cell death GO:0043068 218 0.227
exocytosis GO:0006887 121 0.225
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.205
cellular lipid metabolic process GO:0044255 323 0.198
male gamete generation GO:0048232 285 0.192
Mouse
action potential GO:0001508 78 0.189
regulation of apoptotic signaling pathway GO:2001233 197 0.188
glycerolipid metabolic process GO:0046486 122 0.185
cellular ketone metabolic process GO:0042180 84 0.180
protein processing GO:0016485 163 0.166
positive regulation of apoptotic process GO:0043065 217 0.165
neuronal action potential GO:0019228 54 0.165
regulation of cellular amine metabolic process GO:0033238 20 0.154
regulation of secretion by cell GO:1903530 249 0.153
Rat
positive regulation of cellular amine metabolic process GO:0033240 5 0.150
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.149
cellular amino acid metabolic process GO:0006520 103 0.148
carboxylic acid transport GO:0046942 100 0.144
positive regulation of cell death GO:0010942 224 0.144
nitrogen compound transport GO:0071705 271 0.143
cytoplasmic transport GO:0016482 234 0.137
glucose metabolic process GO:0006006 92 0.136
neuron death GO:0070997 154 0.136
establishment of vesicle localization GO:0051650 81 0.135
protein maturation GO:0051604 176 0.132
calcium ion dependent exocytosis GO:0017156 35 0.130
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.130
cellular amine metabolic process GO:0044106 44 0.128
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.118
vesicle localization GO:0051648 86 0.118
phospholipid metabolic process GO:0006644 87 0.116
regulation of erk1 and erk2 cascade GO:0070372 71 0.116
regulation of hydrolase activity GO:0051336 246 0.112
binding of sperm to zona pellucida GO:0007339 34 0.110
Mouse
cellular response to lipid GO:0071396 145 0.110
positive regulation of mapk cascade GO:0043410 170 0.109
endomembrane system organization GO:0010256 147 0.109
vascular process in circulatory system GO:0003018 62 0.104
sensory perception GO:0007600 245 0.104
mapk cascade GO:0000165 281 0.103
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.100
negative regulation of neuron death GO:1901215 98 0.100
leukocyte differentiation GO:0002521 342 0.099
regulation of protein transport GO:0051223 163 0.098
Rat
germ cell development GO:0007281 185 0.098
Mouse
positive regulation of secretion by cell GO:1903532 114 0.094
Rat
zymogen activation GO:0031638 41 0.094
wound healing GO:0042060 157 0.093
myelination GO:0042552 74 0.091
glucose transport GO:0015758 56 0.089
positive regulation of apoptotic signaling pathway GO:2001235 95 0.088
regulation of intracellular transport GO:0032386 159 0.086
engulfment of apoptotic cell GO:0043652 3 0.085
synaptic vesicle transport GO:0048489 57 0.084
monosaccharide metabolic process GO:0005996 106 0.084
multicellular organism growth GO:0035264 161 0.083
peptidyl tyrosine modification GO:0018212 145 0.083
neuron apoptotic process GO:0051402 142 0.080
glycerophospholipid metabolic process GO:0006650 71 0.080
glycerolipid biosynthetic process GO:0045017 50 0.079
regulation of hormone levels GO:0010817 211 0.078
regulation of protein localization GO:0032880 231 0.078
Rat
organonitrogen compound catabolic process GO:1901565 264 0.078
amide transport GO:0042886 138 0.077
regulation of mapk cascade GO:0043408 248 0.076
regulation of anatomical structure size GO:0090066 178 0.076
ensheathment of neurons GO:0007272 76 0.075
regulation of cell motility GO:2000145 236 0.075
intracellular protein transport GO:0006886 204 0.075
regulation of neuron death GO:1901214 134 0.073
cation transport GO:0006812 399 0.073
membrane fusion GO:0061025 38 0.072
adaptive immune response GO:0002250 155 0.070
regulation of ion transport GO:0043269 215 0.070
cell type specific apoptotic process GO:0097285 268 0.067
erk1 and erk2 cascade GO:0070371 77 0.066
response to organonitrogen compound GO:0010243 246 0.066
Rat
regulation of neuron projection development GO:0010975 169 0.065
regulation of cellular catabolic process GO:0031329 242 0.065
divalent inorganic cation transport GO:0072511 178 0.064
intrinsic apoptotic signaling pathway GO:0097193 132 0.064
innate immune response GO:0045087 157 0.064
peptidyl tyrosine phosphorylation GO:0018108 143 0.063
regulation of exocytosis GO:0017157 61 0.063
phospholipid biosynthetic process GO:0008654 36 0.063
organonitrogen compound biosynthetic process GO:1901566 192 0.063
cell adhesion GO:0007155 329 0.062
positive regulation of protein kinase b signaling GO:0051897 32 0.062
negative regulation of phosphorus metabolic process GO:0010563 184 0.061
response to inorganic substance GO:0010035 96 0.061
Rat
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.060
negative regulation of cell development GO:0010721 169 0.059
glycerophospholipid biosynthetic process GO:0046474 32 0.059
peptidyl serine modification GO:0018209 83 0.058
negative regulation of phosphate metabolic process GO:0045936 184 0.058
negative regulation of cell activation GO:0050866 111 0.057
regulation of cell migration GO:0030334 219 0.057
apoptotic signaling pathway GO:0097190 306 0.057
protein localization to nucleus GO:0034504 121 0.057
inorganic ion transmembrane transport GO:0098660 234 0.054
regulation of cellular response to stress GO:0080135 159 0.054
positive regulation of leukocyte differentiation GO:1902107 86 0.054
monocarboxylic acid metabolic process GO:0032787 191 0.054
synaptic vesicle localization GO:0097479 59 0.054
cell recognition GO:0008037 83 0.053
Mouse
positive regulation of nervous system development GO:0051962 221 0.053
peptidyl amino acid modification GO:0018193 336 0.053
digestive system development GO:0055123 200 0.053
Mouse
positive regulation of organelle organization GO:0010638 128 0.052
nuclear transport GO:0051169 139 0.052
axon ensheathment GO:0008366 76 0.052
g protein coupled receptor signaling pathway GO:0007186 243 0.051
amine metabolic process GO:0009308 45 0.051
regulation of proteolysis GO:0030162 164 0.048
epidermis development GO:0008544 187 0.048
peptide transport GO:0015833 133 0.048
microtubule based process GO:0007017 236 0.048
regulation of lipid metabolic process GO:0019216 118 0.047
organelle localization GO:0051640 179 0.046
regulation of neuron differentiation GO:0045664 281 0.046
plasma membrane organization GO:0007009 90 0.046
endocytosis GO:0006897 168 0.045
response to organic cyclic compound GO:0014070 198 0.045
Rat
maintenance of location GO:0051235 89 0.045
regulation of homeostatic process GO:0032844 182 0.045
regulation of transferase activity GO:0051338 263 0.045
regulation of cell activation GO:0050865 289 0.045
regulation of innate immune response GO:0045088 91 0.045
negative regulation of molecular function GO:0044092 258 0.044
olfactory learning GO:0008355 2 0.044
membrane lipid biosynthetic process GO:0046467 32 0.044
oxidation reduction process GO:0055114 342 0.044
sperm egg recognition GO:0035036 37 0.044
Mouse
regulation of kinase activity GO:0043549 249 0.044
positive regulation of necrotic cell death GO:0010940 1 0.044
extrinsic apoptotic signaling pathway GO:0097191 126 0.043
protein kinase b signaling GO:0043491 74 0.043
regulation of lymphocyte activation GO:0051249 240 0.043
regulation of cellular amino acid metabolic process GO:0006521 5 0.042
cellular nitrogen compound catabolic process GO:0044270 280 0.042
nucleocytoplasmic transport GO:0006913 139 0.042
spermatid differentiation GO:0048515 115 0.042
Mouse
chemotaxis GO:0006935 247 0.041
establishment of organelle localization GO:0051656 122 0.041
negative regulation of homeostatic process GO:0032845 71 0.041
asymmetric stem cell division GO:0098722 3 0.041
transmembrane transport GO:0055085 412 0.041
cation homeostasis GO:0055080 212 0.041
regulation of membrane potential GO:0042391 192 0.041
cellular response to peptide hormone stimulus GO:0071375 92 0.041
positive regulation of intracellular transport GO:0032388 70 0.041
cell cell recognition GO:0009988 44 0.040
Mouse
carbohydrate metabolic process GO:0005975 230 0.040
myeloid cell differentiation GO:0030099 233 0.039
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.039
negative regulation of apoptotic signaling pathway GO:2001234 104 0.039
leukocyte apoptotic process GO:0071887 71 0.039
positive regulation of lipid metabolic process GO:0045834 40 0.039
cellular response to peptide GO:1901653 92 0.039
hormone secretion GO:0046879 128 0.039
response to lipopolysaccharide GO:0032496 128 0.038
Rat
regulation of cytokine production GO:0001817 266 0.038
regulation of protein kinase b signaling GO:0051896 56 0.038
negative regulation of intracellular signal transduction GO:1902532 167 0.038
multicellular organismal signaling GO:0035637 91 0.038
peptide secretion GO:0002790 114 0.038
negative regulation of phosphorylation GO:0042326 166 0.037
cation transmembrane transport GO:0098655 266 0.037
regulation of cytoplasmic transport GO:1903649 112 0.037
positive regulation of transferase activity GO:0051347 167 0.037
cellular response to insulin stimulus GO:0032869 78 0.037
response to acid chemical GO:0001101 111 0.036
Rat
regulation of t cell activation GO:0050863 170 0.036
adult behavior GO:0030534 135 0.036
glial cell development GO:0021782 54 0.035
response to oxidative stress GO:0006979 123 0.035
transmission of nerve impulse GO:0019226 76 0.035
regulation of nucleocytoplasmic transport GO:0046822 73 0.034
response to insulin GO:0032868 100 0.034
macromolecule catabolic process GO:0009057 281 0.034
gonad development GO:0008406 141 0.034
cellular response to fibroblast growth factor stimulus GO:0044344 47 0.034
ion transmembrane transport GO:0034220 361 0.034
positive regulation of hydrolase activity GO:0051345 148 0.033
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.033
microtubule cytoskeleton organization GO:0000226 157 0.033
t helper 2 cell cytokine production GO:0035745 4 0.033
cellular response to oxidative stress GO:0034599 76 0.033
positive regulation of secretion GO:0051047 130 0.033
Rat
cellular chemical homeostasis GO:0055082 215 0.033
stem cell differentiation GO:0048863 268 0.033
learning GO:0007612 98 0.033
regulation of vesicle mediated transport GO:0060627 139 0.033
gliogenesis GO:0042063 141 0.033
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.033
leukocyte mediated immunity GO:0002443 174 0.033
sequestering of metal ion GO:0051238 19 0.032
cellular response to biotic stimulus GO:0071216 92 0.032
response to nutrient levels GO:0031667 109 0.032
Rat
regulation of establishment of protein localization GO:0070201 181 0.032
Rat
purine ribonucleoside catabolic process GO:0046130 205 0.031
cellular response to growth factor stimulus GO:0071363 197 0.031
response to peptide hormone GO:0043434 127 0.031
Rat
activation of immune response GO:0002253 138 0.031
negative regulation of nervous system development GO:0051961 156 0.031
striated muscle tissue development GO:0014706 293 0.031
ameboidal type cell migration GO:0001667 128 0.031
regulation of secretion GO:0051046 274 0.031
Rat
regulation of lymphocyte mediated immunity GO:0002706 84 0.030
hexose metabolic process GO:0019318 98 0.030
regulation of neuron apoptotic process GO:0043523 122 0.030
response to molecule of bacterial origin GO:0002237 143 0.030
Rat
small gtpase mediated signal transduction GO:0007264 97 0.030
divalent metal ion transport GO:0070838 172 0.029
positive regulation of immune effector process GO:0002699 107 0.029
regulation of response to drug GO:2001023 2 0.029
negative regulation of cell proliferation GO:0008285 296 0.029
intracellular receptor signaling pathway GO:0030522 74 0.029
blood vessel morphogenesis GO:0048514 285 0.029
blood circulation GO:0008015 195 0.029
angiogenesis GO:0001525 201 0.029
cellular response to osmotic stress GO:0071470 7 0.029
regulation of endopeptidase activity GO:0052548 89 0.029
regulation of hormone secretion GO:0046883 88 0.029
production of molecular mediator of immune response GO:0002440 103 0.029
response to peptide GO:1901652 136 0.029
Rat
positive regulation of cell motility GO:2000147 116 0.029
purine containing compound metabolic process GO:0072521 311 0.028
response to amino acid GO:0043200 37 0.028
digestive tract morphogenesis GO:0048546 147 0.028
morphogenesis of a branching structure GO:0001763 203 0.028
lipid biosynthetic process GO:0008610 179 0.028
cellular response to dna damage stimulus GO:0006974 207 0.028
regulation of protein maturation GO:1903317 96 0.028
regulation of lymphocyte differentiation GO:0045619 107 0.028
positive regulation of proteolysis GO:0045862 85 0.028
regulation of leukocyte mediated immunity GO:0002703 104 0.028
peptidyl serine phosphorylation GO:0018105 74 0.028
regulation of response to wounding GO:1903034 189 0.028
axonogenesis GO:0007409 274 0.027
secondary metabolic process GO:0019748 18 0.027
regulation of cellular component size GO:0032535 121 0.027
positive regulation of vasoconstriction GO:0045907 4 0.027
inflammatory response GO:0006954 244 0.027
spermatogenesis GO:0007283 284 0.027
Mouse
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.027
regulation of peptide transport GO:0090087 91 0.026
cellular response to amino acid stimulus GO:0071230 29 0.026
regulation of t cell differentiation GO:0045580 83 0.026
cellular response to lipopolysaccharide GO:0071222 77 0.026
negative regulation of lymphocyte activation GO:0051250 91 0.026
cellular response to hormone stimulus GO:0032870 150 0.026
acrosome reaction GO:0007340 19 0.026
Mouse
lymphocyte homeostasis GO:0002260 64 0.026
regulation of protein processing GO:0070613 96 0.026
reactive oxygen species metabolic process GO:0072593 84 0.026
chloride transmembrane transport GO:1902476 24 0.025
positive regulation of cell migration GO:0030335 109 0.025
humoral immune response GO:0006959 57 0.025
divalent inorganic cation homeostasis GO:0072507 138 0.025
cellular component assembly involved in morphogenesis GO:0010927 139 0.025
organic hydroxy compound metabolic process GO:1901615 203 0.025
negative regulation of neuron apoptotic process GO:0043524 92 0.025
glycoprotein metabolic process GO:0009100 116 0.025
leukocyte homeostasis GO:0001776 79 0.025
response to growth factor GO:0070848 198 0.025
regulation of leukocyte differentiation GO:1902105 159 0.025
positive regulation of intracellular protein transport GO:0090316 42 0.025
purine ribonucleoside metabolic process GO:0046128 241 0.025
regulation of organelle organization GO:0033043 289 0.025
positive regulation of cell development GO:0010720 237 0.025
neural precursor cell proliferation GO:0061351 121 0.025
ear development GO:0043583 200 0.024
regulation of peptidase activity GO:0052547 96 0.024
single organismal cell cell adhesion GO:0016337 131 0.024
regulation of gtp catabolic process GO:0033124 113 0.024
branching morphogenesis of an epithelial tube GO:0048754 159 0.024
regulation of cell cycle GO:0051726 281 0.024
regulation of blood vessel size GO:0050880 56 0.024
cellular response to inorganic substance GO:0071241 37 0.024
calcium ion transport GO:0006816 159 0.024
dephosphorylation GO:0016311 129 0.024
circulatory system process GO:0003013 197 0.023
positive regulation of lipid kinase activity GO:0090218 11 0.023
alpha amino acid metabolic process GO:1901605 59 0.023
positive regulation of protein phosphorylation GO:0001934 242 0.023
prevention of polyspermy GO:0060468 4 0.023
regulation of calcium ion transport GO:0051924 69 0.023
nuclear import GO:0051170 95 0.023
skin development GO:0043588 220 0.023
membrane invagination GO:0010324 17 0.023
negative regulation of growth GO:0045926 99 0.023
negative regulation of multi organism process GO:0043901 68 0.023
positive regulation of fat cell proliferation GO:0070346 1 0.023
regulation of protein catabolic process GO:0042176 108 0.022
locomotory behavior GO:0007626 195 0.022
sensory perception of pain GO:0019233 47 0.022
carbohydrate transport GO:0008643 62 0.022
regulation of tube size GO:0035150 57 0.022
rhythmic process GO:0048511 174 0.022
alcohol metabolic process GO:0006066 116 0.022
monosaccharide transport GO:0015749 58 0.022
homeostasis of number of cells GO:0048872 210 0.022
defense response to other organism GO:0098542 197 0.022
metal ion homeostasis GO:0055065 189 0.022
negative regulation of cellular component organization GO:0051129 194 0.022
protein catabolic process GO:0030163 221 0.022
protein targeting GO:0006605 143 0.022
carbohydrate derivative catabolic process GO:1901136 231 0.021
cellular carbohydrate metabolic process GO:0044262 119 0.021
development of primary sexual characteristics GO:0045137 143 0.021
negative regulation of protein processing GO:0010955 79 0.021
single organism nuclear import GO:1902593 95 0.021
negative regulation of cellular protein metabolic process GO:0032269 247 0.021
cytokine mediated signaling pathway GO:0019221 115 0.021
cellular homeostasis GO:0019725 240 0.021
myeloid leukocyte differentiation GO:0002573 119 0.021
regulation of peptide secretion GO:0002791 77 0.021
establishment of glial blood brain barrier GO:0060857 2 0.020
necrotic cell death GO:0070265 30 0.020
positive regulation of membrane protein ectodomain proteolysis GO:0051044 3 0.020
sequestering of calcium ion GO:0051208 18 0.020
purine nucleoside triphosphate metabolic process GO:0009144 226 0.020
cytosolic calcium ion homeostasis GO:0051480 70 0.020
negative regulation of neuron differentiation GO:0045665 101 0.020
protein import into nucleus GO:0006606 95 0.020
gtp catabolic process GO:0006184 143 0.020
insulin receptor signaling pathway GO:0008286 49 0.020
cellular response to cytokine stimulus GO:0071345 189 0.020
regulation of cell projection organization GO:0031344 206 0.020
generation of precursor metabolites and energy GO:0006091 103 0.020
positive regulation of kinase activity GO:0033674 155 0.020
posttranscriptional regulation of gene expression GO:0010608 155 0.020
positive regulation of map kinase activity GO:0043406 84 0.020
ribonucleoside triphosphate metabolic process GO:0009199 220 0.019
heterocycle catabolic process GO:0046700 280 0.019
organic cyclic compound catabolic process GO:1901361 295 0.019
purine containing compound catabolic process GO:0072523 213 0.019
inorganic anion transport GO:0015698 43 0.019
asymmetric neuroblast division GO:0055059 1 0.019
purine nucleoside catabolic process GO:0006152 205 0.019
fat cell differentiation GO:0045444 160 0.019
leukocyte migration GO:0050900 124 0.019
regulation of purine nucleotide catabolic process GO:0033121 122 0.019
regulation of adaptive immune response GO:0002819 90 0.019
blastocyst growth GO:0001832 23 0.019
regulation of ion homeostasis GO:2000021 64 0.019
regulation of protein kinase activity GO:0045859 232 0.019
molting cycle GO:0042303 90 0.019
morphogenesis of a branching epithelium GO:0061138 193 0.019
regulation of multi organism process GO:0043900 111 0.019
negative regulation of protein maturation GO:1903318 79 0.019
regulation of smoothened signaling pathway GO:0008589 58 0.019
negative regulation of mapk cascade GO:0043409 65 0.018
response to histamine GO:0034776 1 0.018
establishment of synaptic vesicle localization GO:0097480 57 0.018
chloride transport GO:0006821 32 0.018
positive regulation of cellular catabolic process GO:0031331 148 0.018
stem cell development GO:0048864 219 0.018
response to extracellular stimulus GO:0009991 127 0.018
Rat
gtp metabolic process GO:0046039 144 0.018
spermatid development GO:0007286 108 0.018
Mouse
anion transport GO:0006820 177 0.018
coagulation GO:0050817 78 0.018
autophagy GO:0006914 45 0.018
negative regulation of hydrolase activity GO:0051346 71 0.018
regulation of lymphocyte migration GO:2000401 14 0.018
negative regulation of immune system process GO:0002683 209 0.018
lymphocyte mediated immunity GO:0002449 139 0.018
activation of mapk activity involved in innate immune response GO:0035419 2 0.017
regulation of chemotaxis GO:0050920 53 0.017
positive regulation of growth GO:0045927 104 0.017
regulation of carbohydrate biosynthetic process GO:0043255 40 0.017
dna metabolic process GO:0006259 303 0.017
circadian rhythm GO:0007623 114 0.017
response to metal ion GO:0010038 47 0.017
Rat
inflammatory response to antigenic stimulus GO:0002437 30 0.017
detection of stimulus GO:0051606 84 0.017
regulation of peptide hormone secretion GO:0090276 75 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.017
positive regulation of protein localization to nucleus GO:1900182 30 0.017
cellular amino acid catabolic process GO:0009063 25 0.017
regulation of membrane protein ectodomain proteolysis GO:0051043 3 0.017
protein autophosphorylation GO:0046777 61 0.017
cell maturation GO:0048469 127 0.017
Mouse
embryonic genitalia morphogenesis GO:0030538 4 0.017
positive regulation of glial cell proliferation GO:0060252 4 0.017
regulation of protein import into nucleus GO:0042306 52 0.017
aromatic compound catabolic process GO:0019439 286 0.016
positive regulation of peptidase activity GO:0010952 49 0.016
reactive nitrogen species metabolic process GO:2001057 0 0.016
nucleotide metabolic process GO:0009117 332 0.016
positive regulation of protein kinase activity GO:0045860 144 0.016
regulation of metal ion transport GO:0010959 106 0.016
regulation of intracellular protein transport GO:0033157 82 0.016
protein localization to organelle GO:0033365 185 0.016
purine nucleoside metabolic process GO:0042278 241 0.016
membrane lipid metabolic process GO:0006643 53 0.016
organophosphate catabolic process GO:0046434 232 0.016
acute inflammatory response GO:0002526 41 0.016
regulation of phospholipid biosynthetic process GO:0071071 3 0.016
regulation of protein targeting GO:1903533 61 0.016
phosphatidylinositol metabolic process GO:0046488 45 0.016
protein complex disassembly GO:0043241 40 0.016
phagocytosis GO:0006909 66 0.016
regulation of inflammatory response GO:0050727 147 0.016
positive regulation of t cell activation GO:0050870 101 0.016
regulation of necrotic cell death GO:0010939 13 0.015
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.015
carbohydrate derivative biosynthetic process GO:1901137 183 0.015
synaptic transmission glycinergic GO:0060012 2 0.015
nucleotide catabolic process GO:0009166 217 0.015
immunoglobulin mediated immune response GO:0016064 69 0.015
response to radiation GO:0009314 165 0.015
lymphocyte differentiation GO:0030098 242 0.015
response to reactive oxygen species GO:0000302 56 0.015
purine nucleotide metabolic process GO:0006163 302 0.015
organelle fission GO:0048285 170 0.015
sodium ion transport GO:0006814 73 0.015
regulation of leukocyte apoptotic process GO:2000106 56 0.015
nucleoside phosphate metabolic process GO:0006753 338 0.015
purine ribonucleotide catabolic process GO:0009154 208 0.015
oogenesis GO:0048477 56 0.015
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.015
fast calcium ion dependent exocytosis of neurotransmitter GO:0098746 1 0.015
regulation of lymphocyte proliferation GO:0050670 117 0.015
somatostatin receptor signaling pathway GO:0038169 2 0.015
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.015
cytokine production GO:0001816 319 0.015
Mouse
single organism cell adhesion GO:0098602 156 0.015
regulation of leukocyte proliferation GO:0070663 121 0.015
actin polymerization or depolymerization GO:0008154 54 0.015
cellular response to cadmium ion GO:0071276 3 0.015
regulation of glucose transport GO:0010827 32 0.015
phosphatidylethanolamine biosynthetic process GO:0006646 2 0.015
negative regulation of protein phosphorylation GO:0001933 126 0.014
positive regulation of thymocyte migration GO:2000412 2 0.014
positive regulation of hormone secretion GO:0046887 38 0.014
positive regulation of lymphocyte activation GO:0051251 140 0.014
cell chemotaxis GO:0060326 81 0.014
oocyte axis specification GO:0007309 2 0.014
positive regulation of ion transport GO:0043270 65 0.014
regulation of cytokine production involved in immune response GO:0002718 26 0.014
regulation of cysteine type endopeptidase activity GO:2000116 65 0.014
protein localization to membrane GO:0072657 108 0.014
nucleoside triphosphate catabolic process GO:0009143 205 0.014
cofactor metabolic process GO:0051186 80 0.014
cell division GO:0051301 120 0.014
female gamete generation GO:0007292 74 0.014
leukocyte activation involved in immune response GO:0002366 126 0.014
fat cell proliferation GO:0070341 4 0.014
ribose phosphate metabolic process GO:0019693 291 0.014
regulation of lipid biosynthetic process GO:0046890 54 0.014
jnk cascade GO:0007254 72 0.014
leukocyte proliferation GO:0070661 172 0.014
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 26 0.014
regulation of myeloid cell differentiation GO:0045637 96 0.014
establishment of neuroblast polarity GO:0045200 1 0.014
nucleobase containing small molecule metabolic process GO:0055086 352 0.014
tissue homeostasis GO:0001894 115 0.014
hatching GO:0035188 4 0.014
epithelial tube morphogenesis GO:0060562 303 0.014
carboxylic acid catabolic process GO:0046395 51 0.014
ribonucleotide metabolic process GO:0009259 291 0.014
mesoderm development GO:0007498 100 0.014
positive regulation of nucleotide metabolic process GO:0045981 114 0.014
positive regulation of vesicle fusion GO:0031340 2 0.014
regulation of canonical wnt signaling pathway GO:0060828 82 0.014
interleukin 13 secretion GO:0072611 2 0.014
cellular response to acid chemical GO:0071229 68 0.014
regulation of purine nucleotide metabolic process GO:1900542 169 0.014
intracellular mrna localization GO:0008298 4 0.014
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.014
ceramide biosynthetic process GO:0046513 20 0.014
establishment of protein localization to organelle GO:0072594 118 0.013
lipid modification GO:0030258 65 0.013
substantia nigra development GO:0021762 2 0.013
thymocyte migration GO:0072679 2 0.013
osteoclast differentiation GO:0030316 62 0.013
regulation of thymocyte migration GO:2000410 2 0.013
negative regulation of adaptive immune response GO:0002820 25 0.013
insulin secretion GO:0030073 89 0.013
regulation of cell adhesion GO:0030155 154 0.013
innervation GO:0060384 22 0.013
positive regulation of interleukin 12 production GO:0032735 21 0.013
regulation of jak stat cascade GO:0046425 34 0.013
ribonucleoside metabolic process GO:0009119 245 0.013

Pcsk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 0 0.037
disease of anatomical entity DOID:7 0 0.037
nervous system disease DOID:863 0 0.037
cancer DOID:162 0 0.021
disease of cellular proliferation DOID:14566 0 0.021
organ system cancer DOID:0050686 0 0.021
neurodegenerative disease DOID:1289 0 0.019