Mus musculus

0 known processes

C1s

complement component 1, s subcomponent

(Aliases: AI255193,MGC37773,AA959438,C1sa,AI327365,MGC132830)

C1s biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein activation cascade GO:0072376 19 0.608
Mouse
activation of immune response GO:0002253 138 0.569
Mouse
regulation of peptidase activity GO:0052547 96 0.251
immune effector process GO:0002252 321 0.232
Mouse
complement activation GO:0006956 16 0.219
Mouse
regulation of complement activation GO:0030449 7 0.146
extracellular structure organization GO:0043062 148 0.138
extracellular matrix organization GO:0030198 147 0.127
innate immune response GO:0045087 157 0.123
Mouse
regulation of cytokine production GO:0001817 266 0.111
humoral immune response GO:0006959 57 0.105
Mouse
negative regulation of complement activation GO:0045916 3 0.102
cytokine production GO:0001816 319 0.093
regulation of endopeptidase activity GO:0052548 89 0.091
regulation of proteolysis GO:0030162 164 0.091
protein processing GO:0016485 163 0.087
response to lipopolysaccharide GO:0032496 128 0.086
negative regulation of tooth mineralization GO:0070171 1 0.084
negative regulation of odontogenesis GO:0042483 3 0.079
cell adhesion GO:0007155 329 0.076
oxidation reduction process GO:0055114 342 0.076
negative regulation of proteolysis GO:0045861 74 0.073
negative regulation of protein metabolic process GO:0051248 282 0.072
leukocyte mediated immunity GO:0002443 174 0.071
protein maturation GO:0051604 176 0.071
angiogenesis GO:0001525 201 0.066
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.066
positive regulation of cytokine production GO:0001819 174 0.065
regulation of hydrolase activity GO:0051336 246 0.062
regulation of innate immune response GO:0045088 91 0.061
negative regulation of molecular function GO:0044092 258 0.057
lymphocyte mediated immunity GO:0002449 139 0.054
complement activation lectin pathway GO:0001867 5 0.054
Mouse
positive regulation of defense response GO:0031349 124 0.053
negative regulation of cell proliferation GO:0008285 296 0.053
negative regulation of protein activation cascade GO:2000258 3 0.052
response to molecule of bacterial origin GO:0002237 143 0.052
cell substrate adhesion GO:0031589 130 0.049
wound healing GO:0042060 157 0.046
biomineral tissue development GO:0031214 64 0.045
production of molecular mediator of immune response GO:0002440 103 0.044
glycoprotein metabolic process GO:0009100 116 0.044
chondroitin sulfate proteoglycan metabolic process GO:0050654 20 0.044
urogenital system development GO:0001655 261 0.043
cellular response to cytokine stimulus GO:0071345 189 0.042
cellular amine metabolic process GO:0044106 44 0.041
regulation of inflammatory response GO:0050727 147 0.040
small gtpase mediated signal transduction GO:0007264 97 0.040
positive regulation of protein modification process GO:0031401 299 0.040
sulfur compound metabolic process GO:0006790 100 0.038
cytokine mediated signaling pathway GO:0019221 115 0.037
cellular response to molecule of bacterial origin GO:0071219 83 0.037
proteoglycan metabolic process GO:0006029 38 0.036
cation transport GO:0006812 399 0.035
collagen fibril organization GO:0030199 32 0.035
defense response to other organism GO:0098542 197 0.034
regulation of vasculature development GO:1901342 88 0.032
regulation of cell adhesion GO:0030155 154 0.032
negative regulation of endopeptidase activity GO:0010951 44 0.032
kidney development GO:0001822 213 0.032
transmembrane transport GO:0055085 412 0.031
defense response to bacterium GO:0042742 119 0.031
negative regulation of hydrolase activity GO:0051346 71 0.031
negative regulation of cellular protein metabolic process GO:0032269 247 0.031
cellular response to growth factor stimulus GO:0071363 197 0.031
regulation of cell migration GO:0030334 219 0.031
cellular lipid metabolic process GO:0044255 323 0.030
activation of membrane attack complex GO:0001905 4 0.030
sterol metabolic process GO:0016125 58 0.029
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.029
mucopolysaccharide metabolic process GO:1903510 25 0.028
blood vessel morphogenesis GO:0048514 285 0.028
protein import into nucleus GO:0006606 95 0.028
regulation of protein processing GO:0070613 96 0.028
tissue remodeling GO:0048771 102 0.027
cellular ketone metabolic process GO:0042180 84 0.027
anatomical structure homeostasis GO:0060249 145 0.027
positive regulation of activation of membrane attack complex GO:0001970 2 0.027
regulation of acute inflammatory response GO:0002673 27 0.027
regulation of response to wounding GO:1903034 189 0.027
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.027
regulation of angiogenesis GO:0045765 81 0.027
regulation of cellular ketone metabolic process GO:0010565 66 0.027
mapk cascade GO:0000165 281 0.027
regulation of ras protein signal transduction GO:0046578 114 0.026
cytoplasmic transport GO:0016482 234 0.026
regulation of cellular amine metabolic process GO:0033238 20 0.026
positive regulation of peptidase activity GO:0010952 49 0.026
positive regulation of cellular amine metabolic process GO:0033240 5 0.026
chondroitin sulfate metabolic process GO:0030204 17 0.026
amine metabolic process GO:0009308 45 0.025
regulation of adaptive immune response GO:0002819 90 0.025
peptidyl amino acid modification GO:0018193 336 0.025
nucleoside phosphate metabolic process GO:0006753 338 0.025
response to growth factor GO:0070848 198 0.025
gland development GO:0048732 330 0.024
epithelial cell proliferation GO:0050673 174 0.024
macromolecule catabolic process GO:0009057 281 0.024
carbohydrate homeostasis GO:0033500 128 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
regulation of defense response GO:0031347 233 0.023
carbohydrate metabolic process GO:0005975 230 0.023
circulatory system process GO:0003013 197 0.023
fat cell differentiation GO:0045444 160 0.023
regulation of tooth mineralization GO:0070170 2 0.023
regulation of lymphocyte mediated immunity GO:0002706 84 0.022
regulation of kinase activity GO:0043549 249 0.022
rho protein signal transduction GO:0007266 32 0.022
regulation of cell activation GO:0050865 289 0.022
antibacterial peptide biosynthetic process GO:0002780 2 0.022
response to acid chemical GO:0001101 111 0.022
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.022
positive regulation of immune effector process GO:0002699 107 0.022
blood circulation GO:0008015 195 0.021
response to interferon gamma GO:0034341 34 0.021
cellular response to organonitrogen compound GO:0071417 145 0.021
nucleotide metabolic process GO:0009117 332 0.021
ras protein signal transduction GO:0007265 77 0.021
reactive oxygen species biosynthetic process GO:1903409 8 0.021
negative regulation of phosphorus metabolic process GO:0010563 184 0.020
regulation of protein activation cascade GO:2000257 7 0.020
negative regulation of epithelial cell proliferation GO:0050680 64 0.020
reactive oxygen species metabolic process GO:0072593 84 0.020
cartilage development GO:0051216 140 0.020
response to steroid hormone GO:0048545 56 0.020
aromatic compound catabolic process GO:0019439 286 0.020
respiratory system development GO:0060541 190 0.019
peptide metabolic process GO:0006518 46 0.019
nucleoside phosphate catabolic process GO:1901292 222 0.019
negative regulation of protein maturation GO:1903318 79 0.019
lipid biosynthetic process GO:0008610 179 0.019
connective tissue development GO:0061448 179 0.019
regulation of glucose metabolic process GO:0010906 60 0.019
positive regulation of protein phosphorylation GO:0001934 242 0.019
negative regulation of peptidase activity GO:0010466 46 0.019
organic cyclic compound catabolic process GO:1901361 295 0.019
camera type eye development GO:0043010 266 0.019
regulation of blood pressure GO:0008217 93 0.019
inorganic ion transmembrane transport GO:0098660 234 0.019
t cell activation GO:0042110 289 0.019
positive regulation of protein kinase activity GO:0045860 144 0.018
regulation of system process GO:0044057 200 0.018
phagocytosis GO:0006909 66 0.018
regulation of apoptotic signaling pathway GO:2001233 197 0.018
fatty acid metabolic process GO:0006631 121 0.018
regulation of epithelial cell proliferation GO:0050678 141 0.018
physiological muscle hypertrophy GO:0003298 3 0.018
negative regulation of protein processing GO:0010955 79 0.018
cellular response to biotic stimulus GO:0071216 92 0.018
positive regulation of cell substrate adhesion GO:0010811 47 0.018
negative regulation of immune system process GO:0002683 209 0.018
nitrogen compound transport GO:0071705 271 0.018
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.018
iron ion import into cell GO:0097459 4 0.017
positive regulation of apoptotic cell clearance GO:2000427 3 0.017
transition metal ion transport GO:0000041 38 0.017
cellular response to lipopolysaccharide GO:0071222 77 0.017
cellular response to lipid GO:0071396 145 0.017
heterocycle catabolic process GO:0046700 280 0.017
cellular amino acid metabolic process GO:0006520 103 0.017
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.017
triglyceride metabolic process GO:0006641 51 0.017
monocarboxylic acid metabolic process GO:0032787 191 0.017
regulation of hormone levels GO:0010817 211 0.017
regulation of secretion by cell GO:1903530 249 0.017
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.017
response to oxidative stress GO:0006979 123 0.016
response to organic cyclic compound GO:0014070 198 0.016
Rat
inflammatory response GO:0006954 244 0.016
regulation of mapk cascade GO:0043408 248 0.016
positive regulation of endocytosis GO:0045807 42 0.016
regulation of blood vessel size GO:0050880 56 0.016
ion transmembrane transport GO:0034220 361 0.016
homeostasis of number of cells GO:0048872 210 0.016
positive regulation of protein kinase b signaling GO:0051897 32 0.016
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.016
monosaccharide metabolic process GO:0005996 106 0.016
regulation of reactive oxygen species metabolic process GO:2000377 40 0.016
apoptotic signaling pathway GO:0097190 306 0.016
sensory system development GO:0048880 3 0.016
cytokine production involved in immune response GO:0002367 34 0.016
cellular macromolecule catabolic process GO:0044265 206 0.015
muscle tissue development GO:0060537 308 0.015
organonitrogen compound biosynthetic process GO:1901566 192 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.015
regulation of cellular catabolic process GO:0031329 242 0.015
negative regulation of phosphorylation GO:0042326 166 0.015
regulation of cellular response to stress GO:0080135 159 0.015
protein modification by small protein conjugation or removal GO:0070647 207 0.015
multicellular organismal homeostasis GO:0048871 164 0.015
regulation of secretion GO:0051046 274 0.015
negative regulation of immune effector process GO:0002698 55 0.015
muscle cell differentiation GO:0042692 261 0.015
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.015
respiratory tube development GO:0030323 167 0.015
peptide cross linking GO:0018149 10 0.015
regulation of fatty acid biosynthetic process GO:0042304 12 0.015
positive regulation of kinase activity GO:0033674 155 0.014
nucleoside triphosphate metabolic process GO:0009141 230 0.014
cation transmembrane transport GO:0098655 266 0.014
positive regulation of innate immune response GO:0045089 80 0.014
renal system development GO:0072001 225 0.014
organ growth GO:0035265 117 0.014
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.014
negative regulation of cellular component organization GO:0051129 194 0.014
cellular response to hormone stimulus GO:0032870 150 0.014
regulation of systemic arterial blood pressure GO:0003073 61 0.014
spermatogenesis GO:0007283 284 0.014
cellular nitrogen compound catabolic process GO:0044270 280 0.014
purine nucleoside triphosphate catabolic process GO:0009146 203 0.014
lymphocyte proliferation GO:0046651 164 0.014
positive regulation of cell activation GO:0050867 158 0.014
cell type specific apoptotic process GO:0097285 268 0.014
morphogenesis of a branching epithelium GO:0061138 193 0.014
glucose transport GO:0015758 56 0.014
nucleobase containing small molecule metabolic process GO:0055086 352 0.014
ribose phosphate metabolic process GO:0019693 291 0.014
regulation of fat cell differentiation GO:0045598 81 0.014
positive regulation of glucose transport GO:0010828 16 0.014
regulation of glucose transport GO:0010827 32 0.014
glucose homeostasis GO:0042593 128 0.014
response to decreased oxygen levels GO:0036293 59 0.013
activation of innate immune response GO:0002218 56 0.013
prostate gland development GO:0030850 48 0.013
positive regulation of cell adhesion GO:0045785 80 0.013
monocarboxylic acid biosynthetic process GO:0072330 61 0.013
response to radiation GO:0009314 165 0.013
multicellular organismal macromolecule metabolic process GO:0044259 19 0.013
regulation of neuron differentiation GO:0045664 281 0.013
monosaccharide transport GO:0015749 58 0.013
regulation of lymphocyte proliferation GO:0050670 117 0.013
regulation of odontogenesis GO:0042481 18 0.013
regulation of carbohydrate metabolic process GO:0006109 75 0.013
epidermis development GO:0008544 187 0.013
regulation of lipid metabolic process GO:0019216 118 0.013
lateral line system development GO:0048925 1 0.013
positive regulation of hydrolase activity GO:0051345 148 0.013
interleukin 1 production GO:0032612 31 0.013
organic hydroxy compound metabolic process GO:1901615 203 0.013
immunoglobulin mediated immune response GO:0016064 69 0.013
cell matrix adhesion GO:0007160 68 0.013
leukocyte migration GO:0050900 124 0.013
glycosaminoglycan metabolic process GO:0030203 34 0.013
posttranscriptional regulation of gene expression GO:0010608 155 0.013
negative regulation of growth GO:0045926 99 0.013
positive regulation of programmed cell death GO:0043068 218 0.013
peptidyl tyrosine modification GO:0018212 145 0.013
leukocyte chemotaxis GO:0030595 69 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.013
epithelial tube morphogenesis GO:0060562 303 0.013
protein catabolic process GO:0030163 221 0.013
regulation of cellular component biogenesis GO:0044087 181 0.013
positive regulation of apoptotic process GO:0043065 217 0.013
glycerolipid metabolic process GO:0046486 122 0.013
immune response activating signal transduction GO:0002757 116 0.013
positive regulation of nervous system development GO:0051962 221 0.013
female sex differentiation GO:0046660 84 0.013
lung development GO:0030324 164 0.013
positive regulation of proteolysis GO:0045862 85 0.013
endocytosis GO:0006897 168 0.012
regulation of leukocyte mediated immunity GO:0002703 104 0.012
regulation of protein transport GO:0051223 163 0.012
anion transport GO:0006820 177 0.012
positive regulation of cell death GO:0010942 224 0.012
cellularization GO:0007349 1 0.012
chemotaxis GO:0006935 247 0.012
skeletal system development GO:0001501 356 0.012
response to peptide GO:1901652 136 0.012
organic acid biosynthetic process GO:0016053 86 0.012
t cell mediated cytotoxicity GO:0001913 26 0.012
male gamete generation GO:0048232 285 0.012
skeletal system morphogenesis GO:0048705 203 0.012
neuron death GO:0070997 154 0.012
regulation of establishment of protein localization GO:0070201 181 0.012
bone development GO:0060348 120 0.012
regulation of removal of superoxide radicals GO:2000121 4 0.012
positive regulation of inflammatory response GO:0050729 47 0.012
regulation of cellular amino acid metabolic process GO:0006521 5 0.012
cell cell adhesion GO:0098609 41 0.012
nuclear transport GO:0051169 139 0.012
lymphocyte activation involved in immune response GO:0002285 93 0.012
cellular carbohydrate metabolic process GO:0044262 119 0.012
regulation of anatomical structure size GO:0090066 178 0.012
synapse organization GO:0050808 125 0.012
cellular protein catabolic process GO:0044257 155 0.012
peptidyl serine modification GO:0018209 83 0.012
peptide cross linking via chondroitin 4 sulfate glycosaminoglycan GO:0019800 8 0.012
leukocyte mediated cytotoxicity GO:0001909 62 0.012
response to transforming growth factor beta GO:0071559 88 0.012
physiological cardiac muscle hypertrophy GO:0003301 3 0.012
negative regulation of fat cell differentiation GO:0045599 36 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.012
negative regulation of defense response GO:0031348 77 0.012
multicellular organismal signaling GO:0035637 91 0.011
protein localization to organelle GO:0033365 185 0.011
regulation of cell projection organization GO:0031344 206 0.011
inorganic cation transmembrane transport GO:0098662 207 0.011
cellular homeostasis GO:0019725 240 0.011
cofactor metabolic process GO:0051186 80 0.011
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.011
erk1 and erk2 cascade GO:0070371 77 0.011
transmission of nerve impulse GO:0019226 76 0.011
positive regulation of chemotaxis GO:0050921 38 0.011
regulation of protein secretion GO:0050708 82 0.011
type b pancreatic cell proliferation GO:0044342 10 0.011
striated muscle tissue development GO:0014706 293 0.011
hexose transport GO:0008645 56 0.011
cell activation involved in immune response GO:0002263 126 0.011
autophagy GO:0006914 45 0.011
renal system process GO:0003014 48 0.011
divalent inorganic cation transport GO:0072511 178 0.011
carboxylic acid biosynthetic process GO:0046394 86 0.011
regulation of cellular response to growth factor stimulus GO:0090287 82 0.011
cellular response to steroid hormone stimulus GO:0071383 33 0.011
positive regulation of cytokine secretion GO:0050715 41 0.011
negative regulation of protein modification process GO:0031400 163 0.011
cell growth GO:0016049 130 0.011
small molecule biosynthetic process GO:0044283 132 0.011
cellular chemical homeostasis GO:0055082 215 0.011
regulation of blood vessel size by renin angiotensin GO:0002034 5 0.011
protein targeting GO:0006605 143 0.011
protein kinase b signaling GO:0043491 74 0.011
regulation of humoral immune response GO:0002920 22 0.011
regulation of lymphocyte activation GO:0051249 240 0.011
skin development GO:0043588 220 0.010
carboxylic acid transport GO:0046942 100 0.010
macromolecule glycosylation GO:0043413 55 0.010
carbohydrate transport GO:0008643 62 0.010
regulation of body fluid levels GO:0050878 162 0.010
microtubule based process GO:0007017 236 0.010
iron ion homeostasis GO:0055072 36 0.010
metal ion homeostasis GO:0055065 189 0.010
ribonucleotide metabolic process GO:0009259 291 0.010
positive regulation of response to wounding GO:1903036 66 0.010
response to oxygen levels GO:0070482 62 0.010
carbohydrate derivative biosynthetic process GO:1901137 183 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.010
hexose biosynthetic process GO:0019319 39 0.010
lipid catabolic process GO:0016042 69 0.010
positive regulation of lymphocyte activation GO:0051251 140 0.010
purine nucleotide metabolic process GO:0006163 302 0.010
endocrine process GO:0050886 39 0.010
regulation of organelle organization GO:0033043 289 0.010
fatty acid biosynthetic process GO:0006633 41 0.010
positive regulation of protein activation cascade GO:2000259 2 0.010
regulation of cell growth involved in cardiac muscle cell development GO:0061050 3 0.010

C1s disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
hemolytic anemia DOID:583 0 0.091
hemolytic uremic syndrome DOID:12554 0 0.091
immune system disease DOID:2914 0 0.091
normocytic anemia DOID:720 0 0.091
disease of anatomical entity DOID:7 0 0.091
anemia DOID:2355 0 0.091
hematopoietic system disease DOID:74 0 0.091
retinal disease DOID:5679 0 0.040
sensory system disease DOID:0050155 0 0.040
eye and adnexa disease DOID:1492 0 0.040
nervous system disease DOID:863 0 0.040
eye disease DOID:5614 0 0.040
retinal degeneration DOID:8466 0 0.034
disease of metabolism DOID:0014667 0 0.020
inherited metabolic disorder DOID:655 0 0.020
musculoskeletal system disease DOID:17 0 0.018
connective tissue disease DOID:65 0 0.018
integumentary system disease DOID:16 0 0.015
degeneration of macula and posterior pole DOID:2007 0 0.012
macular degeneration DOID:4448 0 0.012
age related macular degeneration DOID:10871 0 0.012