Mus musculus

125 known processes

Cdc73

cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

(Aliases: BC027756,MGC29274,8430414L16Rik,Hrpt2,C130030P16Rik,MGC36559,C81219)

Cdc73 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
covalent chromatin modification GO:0016569 163 0.812
Human
chromatin modification GO:0016568 187 0.754
Human
dna metabolic process GO:0006259 303 0.592
protein modification by small protein conjugation or removal GO:0070647 207 0.563
Human
protein ubiquitination GO:0016567 171 0.493
Human
regulation of cell cycle GO:0051726 281 0.469
Human
mitotic cell cycle GO:0000278 195 0.395
Human
histone modification GO:0016570 159 0.385
Human
protein modification by small protein conjugation GO:0032446 187 0.382
Human
cellular response to dna damage stimulus GO:0006974 207 0.375
blastocyst development GO:0001824 80 0.304
blastocyst growth GO:0001832 23 0.300
intestinal epithelial structure maintenance GO:0060729 4 0.295
modification dependent protein catabolic process GO:0019941 133 0.273
organelle fission GO:0048285 170 0.241
negative regulation of mitotic cell cycle GO:0045930 58 0.229
Human
chromatin organization GO:0006325 206 0.225
Human
negative regulation of protein metabolic process GO:0051248 282 0.210
protein catabolic process GO:0030163 221 0.208
cellular protein catabolic process GO:0044257 155 0.208
nuclear dna replication GO:0033260 3 0.181
negative regulation of protein modification process GO:0031400 163 0.175
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.164
nuclear division GO:0000280 158 0.155
macromolecule catabolic process GO:0009057 281 0.137
ubiquitin dependent protein catabolic process GO:0006511 129 0.137
negative regulation of cellular protein metabolic process GO:0032269 247 0.133
modification dependent macromolecule catabolic process GO:0043632 133 0.132
peptidyl amino acid modification GO:0018193 336 0.128
mitotic nuclear division GO:0007067 48 0.125
dna replication GO:0006260 52 0.122
apoptotic signaling pathway GO:0097190 306 0.118
proteasomal protein catabolic process GO:0010498 98 0.115
regionalization GO:0003002 337 0.108
bmp signaling pathway GO:0030509 93 0.107
macromolecule methylation GO:0043414 120 0.097
regulation of cell cycle process GO:0010564 160 0.094
Human
nucleoside triphosphate metabolic process GO:0009141 230 0.093
cell adhesion GO:0007155 329 0.092
formation of primary germ layer GO:0001704 77 0.092
regulation of chromosome organization GO:0033044 83 0.092
multicellular organism growth GO:0035264 161 0.090
histone h2a ubiquitination GO:0033522 3 0.078
chromosome segregation GO:0007059 48 0.075
myeloid cell differentiation GO:0030099 233 0.075
Human Zebrafish
neuron projection guidance GO:0097485 141 0.071
maintenance of location GO:0051235 89 0.071
dendritic spine development GO:0060996 30 0.070
wnt signaling pathway GO:0016055 188 0.070
Human Fly
intracellular receptor signaling pathway GO:0030522 74 0.066
compound eye development GO:0048749 1 0.064
Fly
cell fate commitment GO:0045165 210 0.062
regulation of cell cycle phase transition GO:1901987 77 0.061
Human
negative regulation of cell cycle phase transition GO:1901988 48 0.061
Human
establishment of mitochondrion localization GO:0051654 4 0.059
development of primary sexual characteristics GO:0045137 143 0.058
protein methylation GO:0006479 81 0.058
regulation of mitotic cell cycle phase transition GO:1901990 73 0.058
Human
response to oxidative stress GO:0006979 123 0.058
neural tube development GO:0021915 160 0.058
germ cell development GO:0007281 185 0.057
organelle localization GO:0051640 179 0.057
cellular amine metabolic process GO:0044106 44 0.056
regulation of histone modification GO:0031056 56 0.055
peptidyl lysine modification GO:0018205 77 0.054
protein alkylation GO:0008213 81 0.053
gonad development GO:0008406 141 0.053
epithelial structure maintenance GO:0010669 9 0.052
regulation of organelle organization GO:0033043 289 0.051
dendrite development GO:0016358 115 0.051
regulation of protein ubiquitination GO:0031396 52 0.050
regulation of apoptotic signaling pathway GO:2001233 197 0.050
amine metabolic process GO:0009308 45 0.050
developmental maturation GO:0021700 193 0.049
regulation of cellular amino acid metabolic process GO:0006521 5 0.048
axonogenesis GO:0007409 274 0.047
pallium development GO:0021543 120 0.047
plus end directed organelle transport along microtubule GO:0072386 2 0.047
regulation of chromatin modification GO:1903308 57 0.045
methylation GO:0032259 134 0.044
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.044
negative regulation of nervous system development GO:0051961 156 0.043
blastocyst formation GO:0001825 33 0.043
histone ubiquitination GO:0016574 10 0.043
Human
ribonucleotide metabolic process GO:0009259 291 0.043
positive regulation of cell activation GO:0050867 158 0.042
regulation of mitotic cell cycle GO:0007346 126 0.041
Human
sequestering of calcium ion GO:0051208 18 0.040
negative regulation of hydrolase activity GO:0051346 71 0.040
rhythmic process GO:0048511 174 0.039
cellular ketone metabolic process GO:0042180 84 0.039
homeostasis of number of cells GO:0048872 210 0.039
Zebrafish
gene silencing GO:0016458 38 0.039
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.039
regulation of cellular component biogenesis GO:0044087 181 0.038
purine nucleotide metabolic process GO:0006163 302 0.038
digestive tract morphogenesis GO:0048546 147 0.038
fertilization GO:0009566 127 0.038
regulation of lymphocyte activation GO:0051249 240 0.038
regulation of neural precursor cell proliferation GO:2000177 70 0.037
ribose phosphate metabolic process GO:0019693 291 0.037
regulation of proteolysis GO:0030162 164 0.036
t cell differentiation GO:0030217 174 0.036
regulation of cellular ketone metabolic process GO:0010565 66 0.036
muscle cell differentiation GO:0042692 261 0.036
gastrulation GO:0007369 116 0.036
mrna processing GO:0006397 63 0.036
Human
cellular macromolecule catabolic process GO:0044265 206 0.036
dna damage checkpoint GO:0000077 26 0.035
digestive tract development GO:0048565 190 0.035
gland development GO:0048732 330 0.035
negative regulation of immune system process GO:0002683 209 0.035
Human
cellular response to growth factor stimulus GO:0071363 197 0.034
regulation of cell activation GO:0050865 289 0.033
anatomical structure homeostasis GO:0060249 145 0.033
striated muscle tissue development GO:0014706 293 0.033
negative regulation of cell cycle GO:0045786 123 0.033
Human
digestion GO:0007586 40 0.033
positive regulation of programmed cell death GO:0043068 218 0.033
positive regulation of cell cycle GO:0045787 92 0.032
female gamete generation GO:0007292 74 0.032
chemotaxis GO:0006935 247 0.032
negative regulation of cellular amine metabolic process GO:0033239 1 0.032
multi multicellular organism process GO:0044706 109 0.032
forebrain development GO:0030900 302 0.032
multicellular organismal homeostasis GO:0048871 164 0.032
protein acylation GO:0043543 64 0.032
positive regulation of cell death GO:0010942 224 0.032
cation transport GO:0006812 399 0.031
protein maturation GO:0051604 176 0.031
synaptic transmission GO:0007268 329 0.031
purine ribonucleotide catabolic process GO:0009154 208 0.031
circadian rhythm GO:0007623 114 0.030
regulation of t cell activation GO:0050863 170 0.030
aromatic compound catabolic process GO:0019439 286 0.029
regulation of cellular catabolic process GO:0031329 242 0.029
negative regulation of molecular function GO:0044092 258 0.029
negative regulation of cell cycle process GO:0010948 69 0.028
Human
purine ribonucleoside catabolic process GO:0046130 205 0.028
stem cell proliferation GO:0072089 117 0.028
cytoplasmic transport GO:0016482 234 0.028
organic cyclic compound catabolic process GO:1901361 295 0.028
canonical wnt signaling pathway GO:0060070 130 0.028
regulation of transcription by chromatin organization GO:0034401 0 0.028
transcription initiation from rna polymerase ii promoter GO:0006367 8 0.027
purine nucleoside catabolic process GO:0006152 205 0.027
macromolecule deacylation GO:0098732 37 0.027
regulation of ion transport GO:0043269 215 0.027
cell cycle checkpoint GO:0000075 47 0.027
protein processing GO:0016485 163 0.027
histone monoubiquitination GO:0010390 3 0.027
Human
locomotory behavior GO:0007626 195 0.027
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.027
hindbrain development GO:0030902 128 0.027
signal transduction by p53 class mediator GO:0072331 51 0.027
oocyte axis specification GO:0007309 2 0.027
oocyte construction GO:0007308 2 0.027
purine containing compound catabolic process GO:0072523 213 0.027
negative regulation of cell proliferation GO:0008285 296 0.026
Human
dna integrity checkpoint GO:0031570 28 0.026
spermatogenesis GO:0007283 284 0.026
t cell activation GO:0042110 289 0.026
regulation of stem cell proliferation GO:0072091 78 0.026
cell division GO:0051301 120 0.026
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.026
skeletal muscle organ development GO:0060538 163 0.026
cell cycle switching mitotic to meiotic cell cycle GO:0051728 1 0.025
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.025
rna processing GO:0006396 105 0.025
Human
lymphocyte proliferation GO:0046651 164 0.025
purine ribonucleotide metabolic process GO:0009150 290 0.025
rna 3 end processing GO:0031123 20 0.025
Human
regulation of leukocyte proliferation GO:0070663 121 0.025
microtubule based process GO:0007017 236 0.025
ossification GO:0001503 216 0.024
posttranscriptional regulation of gene expression GO:0010608 155 0.024
Human
cellular amino acid metabolic process GO:0006520 103 0.024
muscle tissue development GO:0060537 308 0.024
respiratory tube development GO:0030323 167 0.024
hematopoietic progenitor cell differentiation GO:0002244 143 0.024
dna templated transcription initiation GO:0006352 13 0.024
neural precursor cell proliferation GO:0061351 121 0.024
response to organic cyclic compound GO:0014070 198 0.024
response to inorganic substance GO:0010035 96 0.023
positive regulation of growth GO:0045927 104 0.023
stem cell differentiation GO:0048863 268 0.023
establishment of organelle localization GO:0051656 122 0.023
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.023
regulation of cellular amine metabolic process GO:0033238 20 0.022
leukocyte differentiation GO:0002521 342 0.022
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.022
regulation of protein maturation GO:1903317 96 0.022
b cell activation GO:0042113 161 0.022
cell growth GO:0016049 130 0.022
intracellular protein transport GO:0006886 204 0.022
sensory perception GO:0007600 245 0.022
small gtpase mediated signal transduction GO:0007264 97 0.021
negative regulation of proteolysis GO:0045861 74 0.021
male meiosis i GO:0007141 16 0.021
regulation of mesenchymal cell proliferation GO:0010464 37 0.021
microtubule based movement GO:0007018 84 0.021
cell type specific apoptotic process GO:0097285 268 0.020
ribonucleoside triphosphate metabolic process GO:0009199 220 0.020
visceral motor neuron differentiation GO:0021524 3 0.020
regulation of protein complex assembly GO:0043254 83 0.020
response to growth factor GO:0070848 198 0.020
negative regulation of dna replication GO:0008156 4 0.020
positive regulation of immature t cell proliferation GO:0033091 4 0.020
regulation of leukocyte differentiation GO:1902105 159 0.020
negative regulation of cellular component organization GO:0051129 194 0.020
negative regulation of protein processing GO:0010955 79 0.020
inorganic ion transmembrane transport GO:0098660 234 0.019
purine containing compound metabolic process GO:0072521 311 0.019
carbohydrate derivative catabolic process GO:1901136 231 0.019
cellular nitrogen compound catabolic process GO:0044270 280 0.019
lymphocyte differentiation GO:0030098 242 0.019
positive regulation of cellular amine metabolic process GO:0033240 5 0.019
negative regulation of apoptotic signaling pathway GO:2001234 104 0.019
metal ion homeostasis GO:0055065 189 0.019
divalent inorganic cation homeostasis GO:0072507 138 0.019
circulatory system process GO:0003013 197 0.019
nucleoside metabolic process GO:0009116 246 0.019
cellular lipid metabolic process GO:0044255 323 0.019
cellular response to cytokine stimulus GO:0071345 189 0.019
negative regulation of phosphate metabolic process GO:0045936 184 0.019
membrane organization GO:0061024 245 0.019
mitochondrion transport along microtubule GO:0047497 3 0.019
digestive system development GO:0055123 200 0.019
carbohydrate metabolic process GO:0005975 230 0.018
endodermal cell fate specification GO:0001714 4 0.018
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.018
tissue homeostasis GO:0001894 115 0.018
regulation of protein processing GO:0070613 96 0.018
single organismal cell cell adhesion GO:0016337 131 0.018
cellular calcium ion homeostasis GO:0006874 119 0.018
regulation of t cell differentiation GO:0045580 83 0.018
axon guidance GO:0007411 141 0.018
trophectodermal cell differentiation GO:0001829 21 0.018
skeletal system morphogenesis GO:0048705 203 0.018
cellularization GO:0007349 1 0.018
nucleotide metabolic process GO:0009117 332 0.017
histone acetylation GO:0016573 41 0.017
chromatin silencing GO:0006342 15 0.017
regulation of canonical wnt signaling pathway GO:0060828 82 0.017
jak stat cascade GO:0007259 42 0.017
cellular response to oxidative stress GO:0034599 76 0.017
cellular chemical homeostasis GO:0055082 215 0.017
camera type eye development GO:0043010 266 0.017
transcription from rna polymerase i promoter GO:0006360 13 0.017
organonitrogen compound catabolic process GO:1901565 264 0.017
glucose homeostasis GO:0042593 128 0.017
ribonucleoside monophosphate metabolic process GO:0009161 80 0.017
cellular response to organonitrogen compound GO:0071417 145 0.017
respiratory system development GO:0060541 190 0.016
positive regulation of organelle organization GO:0010638 128 0.016
cellular response to acid chemical GO:0071229 68 0.016
developmental growth involved in morphogenesis GO:0060560 138 0.016
tube formation GO:0035148 140 0.016
cellular homeostasis GO:0019725 240 0.016
calcium ion homeostasis GO:0055074 127 0.016
positive regulation of nervous system development GO:0051962 221 0.016
defecation GO:0030421 1 0.016
regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0000083 3 0.016
nucleoside phosphate metabolic process GO:0006753 338 0.016
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.016
meiotic cell cycle GO:0051321 122 0.015
regulation of ossification GO:0030278 112 0.015
regulation of b cell activation GO:0050864 81 0.015
negative regulation of phosphorus metabolic process GO:0010563 184 0.015
positive regulation of apoptotic process GO:0043065 217 0.015
leukocyte proliferation GO:0070661 172 0.015
regulation of cellular protein catabolic process GO:1903362 61 0.015
response to radiation GO:0009314 165 0.015
multi organism behavior GO:0051705 62 0.015
regulation of lymphocyte proliferation GO:0050670 117 0.015
neuron migration GO:0001764 122 0.015
atp catabolic process GO:0006200 55 0.015
glycerolipid metabolic process GO:0046486 122 0.015
negative regulation of phosphorylation GO:0042326 166 0.015
ribonucleotide catabolic process GO:0009261 208 0.015
plasma membrane organization GO:0007009 90 0.015
nucleoside phosphate catabolic process GO:1901292 222 0.015
leukocyte homeostasis GO:0001776 79 0.014
glycosyl compound metabolic process GO:1901657 246 0.014
appendage development GO:0048736 166 0.014
Fly
defense response to other organism GO:0098542 197 0.014
adaptive immune response GO:0002250 155 0.014
positive regulation of b cell activation GO:0050871 49 0.014
positive regulation of stem cell proliferation GO:2000648 59 0.014
cell maturation GO:0048469 127 0.014
epithelial cell development GO:0002064 159 0.014
embryonic epithelial tube formation GO:0001838 130 0.014
lipid localization GO:0010876 126 0.014
lateral inhibition GO:0046331 1 0.014
response to organonitrogen compound GO:0010243 246 0.014
cellular response to lipid GO:0071396 145 0.014
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.014
histone lysine methylation GO:0034968 50 0.014
embryonic placenta development GO:0001892 98 0.013
nucleotide catabolic process GO:0009166 217 0.013
positive regulation of t cell differentiation GO:0045582 52 0.013
female gonad development GO:0008585 71 0.013
striated muscle cell development GO:0055002 125 0.013
negative regulation of peptidase activity GO:0010466 46 0.013
cation homeostasis GO:0055080 212 0.013
mesenchymal cell proliferation GO:0010463 44 0.013
oogenesis GO:0048477 56 0.013
negative regulation of protein maturation GO:1903318 79 0.013
mitotic cell cycle checkpoint GO:0007093 31 0.013
negative regulation of gene expression epigenetic GO:0045814 15 0.013
inorganic cation transmembrane transport GO:0098662 207 0.013
protein localization to plasma membrane GO:0072659 57 0.013
tissue migration GO:0090130 68 0.013
skeletal system development GO:0001501 356 0.013
regulation of secretion GO:0051046 274 0.013
smoothened signaling pathway GO:0007224 105 0.013
Fly
fat cell differentiation GO:0045444 160 0.013
protein deacetylation GO:0006476 32 0.013
regulation of lymphocyte differentiation GO:0045619 107 0.013
negative regulation of mesenchymal cell proliferation GO:0072201 3 0.013
negative regulation of synapse assembly GO:0051964 3 0.013
detection of stimulus GO:0051606 84 0.013
single organism cell adhesion GO:0098602 156 0.013
histone methylation GO:0016571 71 0.013
regulation of chromatin organization GO:1902275 57 0.013
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.013
rna interference GO:0016246 2 0.013
cytoskeleton dependent intracellular transport GO:0030705 50 0.013
endodermal cell differentiation GO:0035987 14 0.012
calcium ion transport GO:0006816 159 0.012
dna alkylation GO:0006305 43 0.012
telencephalon development GO:0021537 186 0.012
purine ribonucleoside metabolic process GO:0046128 241 0.012
segmentation GO:0035282 93 0.012
regulation of establishment of protein localization GO:0070201 181 0.012
hexose metabolic process GO:0019318 98 0.012
regulation of cell migration GO:0030334 219 0.012
positive regulation of cell development GO:0010720 237 0.012
adipose tissue development GO:0060612 25 0.012
defense response to bacterium GO:0042742 119 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.012
microtubule polymerization or depolymerization GO:0031109 26 0.012
regulation of t cell proliferation GO:0042129 92 0.012
positive regulation of histone modification GO:0031058 28 0.012
nucleoside catabolic process GO:0009164 206 0.012
wound healing GO:0042060 157 0.012
response to hydrogen peroxide GO:0042542 32 0.012
internal protein amino acid acetylation GO:0006475 42 0.012
regulation of peptidase activity GO:0052547 96 0.012
nucleoside monophosphate metabolic process GO:0009123 85 0.012
glycosyl compound catabolic process GO:1901658 206 0.012
protein localization to membrane GO:0072657 108 0.011
purine nucleotide catabolic process GO:0006195 211 0.011
organophosphate catabolic process GO:0046434 232 0.011
divalent inorganic cation transport GO:0072511 178 0.011
b cell proliferation GO:0042100 53 0.011
chromatin remodeling GO:0006338 32 0.011
negative regulation of endopeptidase activity GO:0010951 44 0.011
stem cell maintenance GO:0019827 130 0.011
protein autophosphorylation GO:0046777 61 0.011
organelle assembly GO:0070925 177 0.011
purine nucleoside triphosphate catabolic process GO:0009146 203 0.011
regulation of genetic imprinting GO:2000653 5 0.011
endocytosis GO:0006897 168 0.011
central nervous system neuron differentiation GO:0021953 162 0.011
mitotic cell cycle process GO:1903047 159 0.011
Human
somitogenesis GO:0001756 69 0.011
cation transmembrane transport GO:0098655 266 0.011
glycoprotein metabolic process GO:0009100 116 0.011
organic anion transport GO:0015711 137 0.011
morphogenesis of a branching epithelium GO:0061138 193 0.011
regulation of cell projection organization GO:0031344 206 0.011
positive regulation of t cell activation GO:0050870 101 0.011
purine nucleoside monophosphate metabolic process GO:0009126 81 0.011
ncrna processing GO:0034470 26 0.011
intrinsic apoptotic signaling pathway GO:0097193 132 0.011
positive regulation of macroautophagy GO:0016239 3 0.011
positive regulation of mitotic metaphase anaphase transition GO:0045842 2 0.011
positive regulation of t cell proliferation GO:0042102 52 0.011
endocrine system development GO:0035270 98 0.011
regulation of neuron projection development GO:0010975 169 0.011
negative regulation of translation GO:0017148 22 0.011
cellular response to fibroblast growth factor stimulus GO:0044344 47 0.011
regulation of protein transport GO:0051223 163 0.011
response to acid chemical GO:0001101 111 0.010
transcription elongation from rna polymerase ii promoter GO:0006368 9 0.010
Human Zebrafish
regulation of protein kinase b signaling GO:0051896 56 0.010
regulation of cellular response to stress GO:0080135 159 0.010
regulation of cell division GO:0051302 76 0.010
lens fiber cell apoptotic process GO:1990086 4 0.010
positive regulation of lymphocyte differentiation GO:0045621 61 0.010
limbic system development GO:0021761 72 0.010
reproductive behavior GO:0019098 32 0.010
cell cycle switching GO:0060184 1 0.010
regulation of voltage gated calcium channel activity GO:1901385 4 0.010
response to lipopolysaccharide GO:0032496 128 0.010
cell aging GO:0007569 35 0.010
atp metabolic process GO:0046034 75 0.010
dna modification GO:0006304 50 0.010
ribonucleoside catabolic process GO:0042454 206 0.010
golgi vesicle transport GO:0048193 30 0.010
regulation of wnt signaling pathway GO:0030111 123 0.010
Human
regulation of b cell proliferation GO:0030888 39 0.010

Cdc73 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.112
Human
disease of cellular proliferation DOID:14566 0 0.112
Human
organ system cancer DOID:0050686 0 0.112
Human
disease of anatomical entity DOID:7 0 0.038
Human
nervous system disease DOID:863 0 0.038
central nervous system disease DOID:331 0 0.022
neurodegenerative disease DOID:1289 0 0.022