Mus musculus

0 known processes

Cdk12

cyclin-dependent kinase 12

(Aliases: AI646528,Crkrs,Pksc,MGC141525,1810022J16Rik,Crk7,D11Ertd752e)

Cdk12 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
spermatogenesis GO:0007283 284 0.071
regulation of cellular ketone metabolic process GO:0010565 66 0.065
regulation of cell cycle process GO:0010564 160 0.059
male gamete generation GO:0048232 285 0.059
cellular macromolecule catabolic process GO:0044265 206 0.057
chromatin organization GO:0006325 206 0.055
modification dependent macromolecule catabolic process GO:0043632 133 0.050
regulation of cell cycle GO:0051726 281 0.049
regulation of cellular amino acid metabolic process GO:0006521 5 0.047
germ cell development GO:0007281 185 0.046
amine metabolic process GO:0009308 45 0.045
covalent chromatin modification GO:0016569 163 0.045
macromolecule catabolic process GO:0009057 281 0.044
regulation of organelle organization GO:0033043 289 0.044
cellular amino acid metabolic process GO:0006520 103 0.042
protein modification by small protein conjugation or removal GO:0070647 207 0.041
protein ubiquitination GO:0016567 171 0.041
cellular ketone metabolic process GO:0042180 84 0.041
regulation of transferase activity GO:0051338 263 0.041
Human
nuclear division GO:0000280 158 0.035
multicellular organism growth GO:0035264 161 0.035
gland development GO:0048732 330 0.034
cellular nitrogen compound catabolic process GO:0044270 280 0.033
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.033
heterocycle catabolic process GO:0046700 280 0.032
regulation of kinase activity GO:0043549 249 0.032
Human
negative regulation of cellular protein metabolic process GO:0032269 247 0.031
mrna metabolic process GO:0016071 84 0.031
Mouse
rna catabolic process GO:0006401 29 0.031
histone modification GO:0016570 159 0.030
dna metabolic process GO:0006259 303 0.030
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.030
appendage morphogenesis GO:0035107 149 0.029
chromatin modification GO:0016568 187 0.029
protein modification by small protein conjugation GO:0032446 187 0.029
aromatic compound catabolic process GO:0019439 286 0.029
regulation of neuron differentiation GO:0045664 281 0.029
myeloid cell differentiation GO:0030099 233 0.028
negative regulation of cellular component organization GO:0051129 194 0.028
positive regulation of protein modification process GO:0031401 299 0.028
organelle fission GO:0048285 170 0.028
positive regulation of transferase activity GO:0051347 167 0.028
positive regulation of cellular amine metabolic process GO:0033240 5 0.028
cytokine production GO:0001816 319 0.028
posttranscriptional regulation of gene expression GO:0010608 155 0.027
modification dependent protein catabolic process GO:0019941 133 0.026
hematopoietic progenitor cell differentiation GO:0002244 143 0.026
cellular response to dna damage stimulus GO:0006974 207 0.026
positive regulation of protein phosphorylation GO:0001934 242 0.025
negative regulation of molecular function GO:0044092 258 0.025
cellular amine metabolic process GO:0044106 44 0.024
spermatid differentiation GO:0048515 115 0.024
regulation of cellular amine metabolic process GO:0033238 20 0.024
embryonic placenta development GO:0001892 98 0.024
ubiquitin dependent protein catabolic process GO:0006511 129 0.024
limb morphogenesis GO:0035108 149 0.024
regulation of cellular component biogenesis GO:0044087 181 0.024
peptidyl amino acid modification GO:0018193 336 0.024
rna processing GO:0006396 105 0.023
Mouse Rat
negative regulation of immune system process GO:0002683 209 0.023
cellular protein catabolic process GO:0044257 155 0.022
respiratory system development GO:0060541 190 0.022
regulation of protein kinase activity GO:0045859 232 0.022
Human
endocytosis GO:0006897 168 0.022
Worm Fly
protein catabolic process GO:0030163 221 0.022
positive regulation of organelle organization GO:0010638 128 0.022
rhythmic process GO:0048511 174 0.022
methylation GO:0032259 134 0.022
organelle assembly GO:0070925 177 0.021
positive regulation of mapk cascade GO:0043410 170 0.021
Fly
protein maturation GO:0051604 176 0.021
negative regulation of protein metabolic process GO:0051248 282 0.021
positive regulation of cell death GO:0010942 224 0.020
interspecies interaction between organisms GO:0044419 83 0.020
histone methylation GO:0016571 71 0.020
protein methylation GO:0006479 81 0.020
cytoplasmic transport GO:0016482 234 0.019
digestive system development GO:0055123 200 0.019
blastocyst development GO:0001824 80 0.019
stem cell differentiation GO:0048863 268 0.019
apoptotic signaling pathway GO:0097190 306 0.019
positive regulation of kinase activity GO:0033674 155 0.019
histone lysine methylation GO:0034968 50 0.018
meiotic cell cycle GO:0051321 122 0.018
nucleobase containing small molecule metabolic process GO:0055086 352 0.018
leukocyte differentiation GO:0002521 342 0.018
respiratory tube development GO:0030323 167 0.018
limb development GO:0060173 166 0.018
female gamete generation GO:0007292 74 0.018
stem cell development GO:0048864 219 0.018
lateral inhibition GO:0046331 1 0.018
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.018
immune effector process GO:0002252 321 0.017
intracellular protein transport GO:0006886 204 0.017
cell type specific apoptotic process GO:0097285 268 0.017
fertilization GO:0009566 127 0.017
lymphocyte mediated immunity GO:0002449 139 0.017
regulation of protein serine threonine kinase activity GO:0071900 157 0.017
Human
regulation of protein complex assembly GO:0043254 83 0.017
positive regulation of nervous system development GO:0051962 221 0.017
positive regulation of protein kinase activity GO:0045860 144 0.017
multicellular organismal homeostasis GO:0048871 164 0.017
regulation of apoptotic signaling pathway GO:2001233 197 0.017
regulation of protein localization GO:0032880 231 0.017
meiotic nuclear division GO:0007126 115 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.016
nucleoside triphosphate metabolic process GO:0009141 230 0.016
heart morphogenesis GO:0003007 178 0.016
proteasomal protein catabolic process GO:0010498 98 0.016
chromosome segregation GO:0007059 48 0.016
mitotic cell cycle GO:0000278 195 0.016
regulation of chromosome organization GO:0033044 83 0.016
mapk cascade GO:0000165 281 0.016
Human Fly
appendage development GO:0048736 166 0.016
negative regulation of nervous system development GO:0051961 156 0.016
pharynx development GO:0060465 1 0.015
extracellular structure organization GO:0043062 148 0.015
hindbrain development GO:0030902 128 0.015
urogenital system development GO:0001655 261 0.015
meiotic cell cycle process GO:1903046 77 0.015
mrna processing GO:0006397 63 0.015
Mouse
nucleoside phosphate metabolic process GO:0006753 338 0.015
placenta development GO:0001890 140 0.015
organic cyclic compound catabolic process GO:1901361 295 0.015
phospholipid metabolic process GO:0006644 87 0.015
actin filament organization GO:0007015 113 0.015
male meiosis i GO:0007141 16 0.015
sensory perception GO:0007600 245 0.015
nuclear transport GO:0051169 139 0.015
ribose phosphate metabolic process GO:0019693 291 0.015
purine ribonucleotide catabolic process GO:0009154 208 0.015
ossification GO:0001503 216 0.015
mitotic cell cycle process GO:1903047 159 0.015
regulation of multi organism process GO:0043900 111 0.015
protein processing GO:0016485 163 0.014
positive regulation of growth GO:0045927 104 0.014
multi organism behavior GO:0051705 62 0.014
t cell activation GO:0042110 289 0.014
regulation of epithelial cell proliferation GO:0050678 141 0.014
epithelial cell development GO:0002064 159 0.014
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.014
regulation of protein processing GO:0070613 96 0.014
viral life cycle GO:0019058 36 0.014
morphogenesis of a branching epithelium GO:0061138 193 0.014
nucleocytoplasmic transport GO:0006913 139 0.014
regulation of membrane potential GO:0042391 192 0.014
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.014
neural tube development GO:0021915 160 0.014
renal system development GO:0072001 225 0.014
regulation of cell division GO:0051302 76 0.014
cellular response to gamma radiation GO:0071480 4 0.014
camera type eye development GO:0043010 266 0.014
regulation of lymphocyte activation GO:0051249 240 0.014
adaptive immune response GO:0002250 155 0.014
regulation of protein maturation GO:1903317 96 0.014
muscle tissue development GO:0060537 308 0.014
regulation of proteolysis GO:0030162 164 0.013
cellular response to cytokine stimulus GO:0071345 189 0.013
membrane organization GO:0061024 245 0.013
regulation of mapk cascade GO:0043408 248 0.013
Human Fly
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.013
innate immune response GO:0045087 157 0.013
sensory perception of mechanical stimulus GO:0050954 107 0.013
protein alkylation GO:0008213 81 0.013
cellular lipid metabolic process GO:0044255 323 0.013
sensory system development GO:0048880 3 0.013
cell division GO:0051301 120 0.013
organonitrogen compound catabolic process GO:1901565 264 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.013
digestive tract morphogenesis GO:0048546 147 0.013
regulation of cell projection organization GO:0031344 206 0.013
embryonic appendage morphogenesis GO:0035113 126 0.013
regulation of defense response GO:0031347 233 0.013
negative regulation of multi organism process GO:0043901 68 0.013
regulation of cellular response to stress GO:0080135 159 0.013
negative regulation of cellular amine metabolic process GO:0033239 1 0.013
carbohydrate derivative catabolic process GO:1901136 231 0.013
regulation of cell activation GO:0050865 289 0.012
negative regulation of apoptotic signaling pathway GO:2001234 104 0.012
regulation of neuron death GO:1901214 134 0.012
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.012
Mouse
maintenance of location GO:0051235 89 0.012
alpha beta t cell activation GO:0046631 91 0.012
oogenesis GO:0048477 56 0.012
nucleotide metabolic process GO:0009117 332 0.012
protein localization to organelle GO:0033365 185 0.012
synapse organization GO:0050808 125 0.012
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.012
cation transmembrane transport GO:0098655 266 0.012
regulation of stem cell proliferation GO:0072091 78 0.012
regulation of cytokine production GO:0001817 266 0.012
small gtpase mediated signal transduction GO:0007264 97 0.012
Fly
skeletal system development GO:0001501 356 0.012
habituation GO:0046959 3 0.012
glycosyl compound metabolic process GO:1901657 246 0.012
microtubule cytoskeleton organization GO:0000226 157 0.012
negative regulation of defense response GO:0031348 77 0.012
cellularization GO:0007349 1 0.012
cellular protein complex assembly GO:0043623 116 0.012
negative regulation of mesenchymal cell proliferation GO:0072201 3 0.012
nucleoside phosphate catabolic process GO:1901292 222 0.012
spermatid development GO:0007286 108 0.012
translation GO:0006412 93 0.012
locomotory behavior GO:0007626 195 0.012
cell maturation GO:0048469 127 0.012
trophectodermal cell differentiation GO:0001829 21 0.012
cellular response to organonitrogen compound GO:0071417 145 0.012
b cell activation GO:0042113 161 0.012
leukocyte mediated immunity GO:0002443 174 0.012
glycerolipid metabolic process GO:0046486 122 0.012
hepaticobiliary system development GO:0061008 67 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.012
cytokine mediated signaling pathway GO:0019221 115 0.012
regulation of translation GO:0006417 71 0.011
epithelial tube formation GO:0072175 130 0.011
lung development GO:0030324 164 0.011
negative regulation of protein maturation GO:1903318 79 0.011
homeostasis of number of cells GO:0048872 210 0.011
negative regulation of cellular catabolic process GO:0031330 47 0.011
meiosis i GO:0007127 60 0.011
positive regulation of apoptotic process GO:0043065 217 0.011
action potential GO:0001508 78 0.011
regulation of hydrolase activity GO:0051336 246 0.011
response to growth factor GO:0070848 198 0.011
transmembrane transport GO:0055085 412 0.011
regulation of vesicle mediated transport GO:0060627 139 0.011
regulation of chromatin organization GO:1902275 57 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.011
cardiac muscle tissue development GO:0048738 130 0.011
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.011
sensory perception of sound GO:0007605 97 0.011
jak stat cascade GO:0007259 42 0.011
endodermal cell fate specification GO:0001714 4 0.011
nucleotide catabolic process GO:0009166 217 0.011
viral gene expression GO:0019080 3 0.011
ear development GO:0043583 200 0.011
mesenchymal cell proliferation involved in ureter development GO:0072198 4 0.011
negative regulation of protein processing GO:0010955 79 0.011
purine nucleoside catabolic process GO:0006152 205 0.011
regulation of viral transcription GO:0046782 3 0.011
multi multicellular organism process GO:0044706 109 0.011
regulation of cellular catabolic process GO:0031329 242 0.011
embryonic limb morphogenesis GO:0030326 126 0.011
skeletal system morphogenesis GO:0048705 203 0.011
stem cell maintenance GO:0019827 130 0.010
rna interference GO:0016246 2 0.010
gastrulation GO:0007369 116 0.010
lymphocyte differentiation GO:0030098 242 0.010
extrinsic apoptotic signaling pathway GO:0097191 126 0.010
regionalization GO:0003002 337 0.010
cell fate commitment GO:0045165 210 0.010
neuron death GO:0070997 154 0.010
muscle tissue morphogenesis GO:0060415 53 0.010
morphogenesis of a branching structure GO:0001763 203 0.010
mrna catabolic process GO:0006402 22 0.010
negative regulation of cell proliferation GO:0008285 296 0.010
purine nucleotide catabolic process GO:0006195 211 0.010
cell activation involved in immune response GO:0002263 126 0.010
positive regulation of cell development GO:0010720 237 0.010
ribonucleoside metabolic process GO:0009119 245 0.010
vagus nerve development GO:0021564 3 0.010
primary neural tube formation GO:0014020 95 0.010

Cdk12 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.021
nervous system disease DOID:863 0 0.021
disease of cellular proliferation DOID:14566 0 0.021
cancer DOID:162 0 0.019
organ system cancer DOID:0050686 0 0.019
immune system disease DOID:2914 0 0.016