Mus musculus

33 known processes

Map2k5

mitogen-activated protein kinase kinase 5

(Aliases: AI428457,AI324775,Prkmk5,MEK5,Mapkk5)

Map2k5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
p38mapk cascade GO:0038066 4 0.376
vesicle localization GO:0051648 86 0.199
neuronal action potential GO:0019228 54 0.110
regulation of p38mapk cascade GO:1900744 3 0.104
ensheathment of neurons GO:0007272 76 0.098
mapk cascade GO:0000165 281 0.090
synaptic transmission GO:0007268 329 0.082
myelination GO:0042552 74 0.075
ras protein signal transduction GO:0007265 77 0.074
transmission of nerve impulse GO:0019226 76 0.074
cytoplasmic transport GO:0016482 234 0.072
nuclear division GO:0000280 158 0.072
cellular amino acid metabolic process GO:0006520 103 0.071
regulation of cellular amino acid metabolic process GO:0006521 5 0.067
small gtpase mediated signal transduction GO:0007264 97 0.066
regulation of mapk cascade GO:0043408 248 0.066
Rat
negative regulation of cellular amine metabolic process GO:0033239 1 0.065
multicellular organismal signaling GO:0035637 91 0.064
meiotic cell cycle process GO:1903046 77 0.063
action potential GO:0001508 78 0.062
regulation of neuron differentiation GO:0045664 281 0.062
dna metabolic process GO:0006259 303 0.059
regulation of cellular amine metabolic process GO:0033238 20 0.054
organelle fission GO:0048285 170 0.052
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.052
endomembrane system organization GO:0010256 147 0.050
intracellular protein transport GO:0006886 204 0.049
regulation of protein transport GO:0051223 163 0.049
amine metabolic process GO:0009308 45 0.048
carbohydrate derivative catabolic process GO:1901136 231 0.048
establishment of vesicle localization GO:0051650 81 0.047
nucleotide metabolic process GO:0009117 332 0.046
regulation of cell projection organization GO:0031344 206 0.045
organophosphate catabolic process GO:0046434 232 0.044
gtp metabolic process GO:0046039 144 0.044
cytoskeleton dependent intracellular transport GO:0030705 50 0.043
positive regulation of protein modification process GO:0031401 299 0.043
Rat
regulation of engulfment of apoptotic cell GO:1901074 2 0.041
cellular lipid metabolic process GO:0044255 323 0.040
engulfment of apoptotic cell GO:0043652 3 0.040
regulation of membrane potential GO:0042391 192 0.040
meiotic nuclear division GO:0007126 115 0.039
digestive tract development GO:0048565 190 0.039
Rat
regulation of cellular catabolic process GO:0031329 242 0.038
oxidation reduction process GO:0055114 342 0.038
histone modification GO:0016570 159 0.038
purine nucleotide metabolic process GO:0006163 302 0.038
sensory organ morphogenesis GO:0090596 242 0.038
ribonucleotide metabolic process GO:0009259 291 0.037
camera type eye development GO:0043010 266 0.037
regulation of cell cycle GO:0051726 281 0.037
cellular ketone metabolic process GO:0042180 84 0.037
microtubule based movement GO:0007018 84 0.036
axon ensheathment GO:0008366 76 0.035
male gamete generation GO:0048232 285 0.035
regulation of cellular ketone metabolic process GO:0010565 66 0.035
negative regulation of intracellular signal transduction GO:1902532 167 0.035
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.035
axon cargo transport GO:0008088 33 0.034
negative regulation of cellular component organization GO:0051129 194 0.034
wnt signaling pathway GO:0016055 188 0.033
positive regulation of protein phosphorylation GO:0001934 242 0.033
Rat
establishment of synaptic vesicle localization GO:0097480 57 0.032
negative regulation of synapse assembly GO:0051964 3 0.032
response to growth factor GO:0070848 198 0.032
Rat
regulation of organelle organization GO:0033043 289 0.032
spermatogenesis GO:0007283 284 0.032
purine ribonucleoside metabolic process GO:0046128 241 0.031
regulation of ras protein signal transduction GO:0046578 114 0.031
purine nucleoside metabolic process GO:0042278 241 0.031
smoothened signaling pathway GO:0007224 105 0.031
skeletal system development GO:0001501 356 0.031
positive regulation of cellular catabolic process GO:0031331 148 0.031
cell division GO:0051301 120 0.030
mitochondrion organization GO:0007005 134 0.030
aromatic compound catabolic process GO:0019439 286 0.030
cellular amine metabolic process GO:0044106 44 0.029
positive regulation of p38mapk cascade GO:1900745 1 0.029
cytoplasmic mrna processing body assembly GO:0033962 6 0.029
purine containing compound metabolic process GO:0072521 311 0.029
regulation of mitotic cell cycle GO:0007346 126 0.029
cellular carbohydrate metabolic process GO:0044262 119 0.028
carbohydrate metabolic process GO:0005975 230 0.028
gastrulation GO:0007369 116 0.028
Rat
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.028
modification dependent protein catabolic process GO:0019941 133 0.028
dephosphorylation GO:0016311 129 0.028
synaptic vesicle localization GO:0097479 59 0.028
organelle assembly GO:0070925 177 0.027
protein modification by small protein conjugation or removal GO:0070647 207 0.026
cellular homeostasis GO:0019725 240 0.026
central nervous system neuron differentiation GO:0021953 162 0.026
regulation of secretion GO:0051046 274 0.026
protein autophosphorylation GO:0046777 61 0.026
membrane organization GO:0061024 245 0.026
glycerolipid metabolic process GO:0046486 122 0.026
mesoderm development GO:0007498 100 0.025
anatomical structure homeostasis GO:0060249 145 0.025
stress activated mapk cascade GO:0051403 80 0.025
positive regulation of stress activated mapk cascade GO:0032874 48 0.025
i kappab kinase nf kappab signaling GO:0007249 85 0.024
nucleoside phosphate catabolic process GO:1901292 222 0.024
protein catabolic process GO:0030163 221 0.024
organophosphate biosynthetic process GO:0090407 122 0.024
stress activated protein kinase signaling cascade GO:0031098 81 0.024
peroxisome organization GO:0007031 7 0.024
positive regulation of organelle organization GO:0010638 128 0.024
regulation of vesicle mediated transport GO:0060627 139 0.023
regulation of cellular component size GO:0032535 121 0.023
synaptic vesicle transport GO:0048489 57 0.023
rho protein signal transduction GO:0007266 32 0.023
mitotic cell cycle GO:0000278 195 0.023
regulation of protein localization GO:0032880 231 0.023
regulation of establishment of protein localization GO:0070201 181 0.023
microtubule based process GO:0007017 236 0.022
regulation of cellular protein catabolic process GO:1903362 61 0.022
cell fate commitment GO:0045165 210 0.022
negative regulation of cell development GO:0010721 169 0.022
locomotory behavior GO:0007626 195 0.021
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.021
negative regulation of protein modification process GO:0031400 163 0.021
fertilization GO:0009566 127 0.021
purine containing compound catabolic process GO:0072523 213 0.021
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.021
heterocycle catabolic process GO:0046700 280 0.021
regulation of intracellular protein transport GO:0033157 82 0.021
generation of precursor metabolites and energy GO:0006091 103 0.021
chromatin modification GO:0016568 187 0.021
neuron neuron synaptic transmission GO:0007270 69 0.020
nucleobase containing small molecule metabolic process GO:0055086 352 0.020
transmembrane transport GO:0055085 412 0.020
organonitrogen compound catabolic process GO:1901565 264 0.020
heparin biosynthetic process GO:0030210 2 0.020
microtubule based transport GO:0010970 50 0.020
plasma membrane organization GO:0007009 90 0.020
regulation of stress activated mapk cascade GO:0032872 69 0.020
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.019
developmental growth involved in morphogenesis GO:0060560 138 0.019
cellular chemical homeostasis GO:0055082 215 0.019
positive regulation of phagocytosis engulfment GO:0060100 3 0.019
ribonucleotide catabolic process GO:0009261 208 0.019
spermatid differentiation GO:0048515 115 0.019
regulation of meiotic cell cycle GO:0051445 34 0.019
negative regulation of cellular protein metabolic process GO:0032269 247 0.019
Rat
photoreceptor cell differentiation GO:0046530 52 0.019
telencephalon development GO:0021537 186 0.019
regulation of hydrolase activity GO:0051336 246 0.019
Rat
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.019
positive regulation of intracellular transport GO:0032388 70 0.019
protein oligomerization GO:0051259 67 0.019
meiotic cell cycle GO:0051321 122 0.018
nitrogen compound transport GO:0071705 271 0.018
positive regulation of cellular amine metabolic process GO:0033240 5 0.018
urogenital system development GO:0001655 261 0.018
regulation of anatomical structure size GO:0090066 178 0.018
ribose phosphate metabolic process GO:0019693 291 0.018
protein maturation GO:0051604 176 0.018
Rat
organelle localization GO:0051640 179 0.018
nucleoside phosphate metabolic process GO:0006753 338 0.018
regulation of cell cycle process GO:0010564 160 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.018
negative regulation of protein phosphorylation GO:0001933 126 0.018
ubiquitin dependent protein catabolic process GO:0006511 129 0.018
negative regulation of phosphorylation GO:0042326 166 0.018
establishment of protein localization to organelle GO:0072594 118 0.018
maintenance of location GO:0051235 89 0.018
negative regulation of protein metabolic process GO:0051248 282 0.018
Rat
regulation of chromosome organization GO:0033044 83 0.018
glycerophospholipid metabolic process GO:0006650 71 0.018
protein targeting GO:0006605 143 0.018
regulation of cellular component biogenesis GO:0044087 181 0.018
multicellular organism growth GO:0035264 161 0.017
spermatid development GO:0007286 108 0.017
posttranscriptional regulation of gene expression GO:0010608 155 0.017
purine nucleotide catabolic process GO:0006195 211 0.017
cellular polysaccharide metabolic process GO:0044264 38 0.017
single organism nuclear import GO:1902593 95 0.017
exocytosis GO:0006887 121 0.017
blood vessel morphogenesis GO:0048514 285 0.017
Rat
ribonucleoside metabolic process GO:0009119 245 0.017
organonitrogen compound biosynthetic process GO:1901566 192 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.017
protein ubiquitination GO:0016567 171 0.017
heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process GO:0015014 1 0.017
carbohydrate homeostasis GO:0033500 128 0.017
positive regulation of intracellular protein transport GO:0090316 42 0.017
regulation of neuron projection development GO:0010975 169 0.017
glycosyl compound catabolic process GO:1901658 206 0.016
positive regulation of nucleotide metabolic process GO:0045981 114 0.016
macromolecule catabolic process GO:0009057 281 0.016
sulfur compound biosynthetic process GO:0044272 37 0.016
negative regulation of cell cycle GO:0045786 123 0.016
retina morphogenesis in camera type eye GO:0060042 45 0.016
regulation of transmembrane transport GO:0034762 128 0.016
peptidyl lysine modification GO:0018205 77 0.016
energy derivation by oxidation of organic compounds GO:0015980 77 0.016
protein import GO:0017038 101 0.016
autophagy GO:0006914 45 0.016
blood circulation GO:0008015 195 0.016
peptidyl threonine modification GO:0018210 31 0.016
positive regulation of ras gtpase activity GO:0032320 65 0.016
homeostasis of number of cells GO:0048872 210 0.016
renal system development GO:0072001 225 0.016
positive regulation of macroautophagy GO:0016239 3 0.016
regulation of secretion by cell GO:1903530 249 0.016
small molecule catabolic process GO:0044282 71 0.016
cytokine production GO:0001816 319 0.016
Rat
regulation of kinase activity GO:0043549 249 0.016
Rat
ribonucleoprotein complex subunit organization GO:0071826 28 0.016
lung development GO:0030324 164 0.016
cellular nitrogen compound catabolic process GO:0044270 280 0.016
circulatory system process GO:0003013 197 0.015
gtp catabolic process GO:0006184 143 0.015
germ cell development GO:0007281 185 0.015
epithelial cell proliferation GO:0050673 174 0.015
Rat
establishment of meiotic spindle orientation GO:0051296 1 0.015
respiratory tube development GO:0030323 167 0.015
defense response to other organism GO:0098542 197 0.015
glycerolipid biosynthetic process GO:0045017 50 0.015
dendrite development GO:0016358 115 0.015
regulation of nucleocytoplasmic transport GO:0046822 73 0.015
skin development GO:0043588 220 0.015
cellular macromolecule catabolic process GO:0044265 206 0.015
nucleoside catabolic process GO:0009164 206 0.015
lipid localization GO:0010876 126 0.015
sulfur compound metabolic process GO:0006790 100 0.015
protein acylation GO:0043543 64 0.015
regulation of cell motility GO:2000145 236 0.015
Rat
cation transmembrane transport GO:0098655 266 0.015
positive regulation of cell development GO:0010720 237 0.015
ribonucleoside triphosphate metabolic process GO:0009199 220 0.014
heparan sulfate proteoglycan biosynthetic process GO:0015012 8 0.014
regulation of transferase activity GO:0051338 263 0.014
Rat
positive regulation of triglyceride lipase activity GO:0061365 3 0.014
cellular response to organonitrogen compound GO:0071417 145 0.014
protein localization to membrane GO:0072657 108 0.014
meiosis i GO:0007127 60 0.014
response to monosaccharide GO:0034284 67 0.014
protein polymerization GO:0051258 57 0.014
synapse organization GO:0050808 125 0.014
negative regulation of growth GO:0045926 99 0.014
regulation of purine nucleotide metabolic process GO:1900542 169 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.014
regulation of nucleotide metabolic process GO:0006140 169 0.014
rna processing GO:0006396 105 0.014
glycosyl compound metabolic process GO:1901657 246 0.014
myeloid cell differentiation GO:0030099 233 0.014
striated muscle tissue development GO:0014706 293 0.014
glucose homeostasis GO:0042593 128 0.014
lipid modification GO:0030258 65 0.014
ribonucleoside catabolic process GO:0042454 206 0.014
epithelial tube morphogenesis GO:0060562 303 0.014
cell adhesion GO:0007155 329 0.014
Rat
response to nutrient levels GO:0031667 109 0.013
proteasomal protein catabolic process GO:0010498 98 0.013
muscle tissue development GO:0060537 308 0.013
gliogenesis GO:0042063 141 0.013
regulation of endocytosis GO:0030100 69 0.013
protein localization to organelle GO:0033365 185 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.013
retina development in camera type eye GO:0060041 119 0.013
glycerophospholipid biosynthetic process GO:0046474 32 0.013
positive regulation of mapk cascade GO:0043410 170 0.013
Rat
guanosine containing compound metabolic process GO:1901068 144 0.013
digestive tract morphogenesis GO:0048546 147 0.013
Rat
regulation of intracellular transport GO:0032386 159 0.013
microtubule cytoskeleton organization GO:0000226 157 0.013
negative regulation of neuron differentiation GO:0045665 101 0.013
axonogenesis GO:0007409 274 0.013
regulation of asymmetric cell division GO:0009786 4 0.013
histone deubiquitination GO:0016578 2 0.013
proteoglycan biosynthetic process GO:0030166 20 0.013
mitochondrion distribution GO:0048311 4 0.013
polysaccharide metabolic process GO:0005976 39 0.013
pharynx development GO:0060465 1 0.013
establishment or maintenance of cell polarity GO:0007163 86 0.013
adult behavior GO:0030534 135 0.013
angiogenesis GO:0001525 201 0.013
Rat
response to organonitrogen compound GO:0010243 246 0.013
immune effector process GO:0002252 321 0.013
negative regulation of wnt signaling pathway GO:0030178 73 0.013
developmental cell growth GO:0048588 84 0.013
nucleocytoplasmic transport GO:0006913 139 0.013
regulation of cell division GO:0051302 76 0.012
stem cell development GO:0048864 219 0.012
adult locomotory behavior GO:0008344 91 0.012
hormone secretion GO:0046879 128 0.012
innate immune response GO:0045087 157 0.012
male genitalia morphogenesis GO:0048808 4 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.012
female gamete generation GO:0007292 74 0.012
regulation of lymphocyte proliferation GO:0050670 117 0.012
positive regulation of engulfment of apoptotic cell GO:1901076 1 0.012
establishment of protein localization to membrane GO:0090150 54 0.012
hindbrain development GO:0030902 128 0.012
regulation of autophagy GO:0010506 30 0.012
nuclear transport GO:0051169 139 0.012
peptidyl amino acid modification GO:0018193 336 0.012
nucleoside phosphate biosynthetic process GO:1901293 79 0.012
lateral inhibition GO:0046331 1 0.012
response to organic cyclic compound GO:0014070 198 0.012
regulation of t cell activation GO:0050863 170 0.012
glial cell differentiation GO:0010001 131 0.012
ribonucleoside triphosphate catabolic process GO:0009203 199 0.012
methylation GO:0032259 134 0.012
localization within membrane GO:0051668 4 0.012
oocyte anterior posterior axis specification GO:0007314 2 0.012
camera type eye photoreceptor cell differentiation GO:0060219 15 0.012
regulation of homeostatic process GO:0032844 182 0.012
ion transmembrane transport GO:0034220 361 0.012
purine ribonucleotide catabolic process GO:0009154 208 0.012
central nervous system neuron development GO:0021954 67 0.012
protein import into nucleus GO:0006606 95 0.012
regulation of hormone levels GO:0010817 211 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
Rat
learning or memory GO:0007611 148 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.011
regulation of purine nucleotide catabolic process GO:0033121 122 0.011
cytokine mediated signaling pathway GO:0019221 115 0.011
organic hydroxy compound metabolic process GO:1901615 203 0.011
regionalization GO:0003002 337 0.011
nucleoside triphosphate metabolic process GO:0009141 230 0.011
habituation GO:0046959 3 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.011
cerebellum development GO:0021549 77 0.011
synapse assembly GO:0007416 56 0.011
regulation of myeloid cell differentiation GO:0045637 96 0.011
molting cycle GO:0042303 90 0.011
Worm
single fertilization GO:0007338 82 0.011
cellular response to dna damage stimulus GO:0006974 207 0.011
dna alkylation GO:0006305 43 0.011
phospholipid metabolic process GO:0006644 87 0.011
positive regulation of cell motility GO:2000147 116 0.011
phagosome maturation GO:0090382 4 0.011
nucleoside monophosphate metabolic process GO:0009123 85 0.011
regulation of cell size GO:0008361 72 0.011
alpha amino acid metabolic process GO:1901605 59 0.011
multicellular organismal homeostasis GO:0048871 164 0.011
regulation of cytoskeleton organization GO:0051493 122 0.011
regulation of protein processing GO:0070613 96 0.011
Rat
ossification GO:0001503 216 0.011
cellular response to external stimulus GO:0071496 88 0.011
chemotaxis GO:0006935 247 0.011
protein localization to plasma membrane GO:0072659 57 0.011
peptide secretion GO:0002790 114 0.011
guanosine containing compound catabolic process GO:1901069 144 0.011
regulation of system process GO:0044057 200 0.011
response to extracellular stimulus GO:0009991 127 0.011
glycoprotein metabolic process GO:0009100 116 0.011
monocarboxylic acid metabolic process GO:0032787 191 0.011
development of primary sexual characteristics GO:0045137 143 0.011
Worm
cognition GO:0050890 149 0.011
cardiac chamber morphogenesis GO:0003206 93 0.011
positive regulation of t cell activation GO:0050870 101 0.010
embryonic appendage morphogenesis GO:0035113 126 0.010
peptidyl serine modification GO:0018209 83 0.010
macroautophagy GO:0016236 21 0.010
morphogenesis of a branching epithelium GO:0061138 193 0.010
positive regulation of kinase activity GO:0033674 155 0.010
Rat
peptide hormone secretion GO:0030072 109 0.010
energy reserve metabolic process GO:0006112 39 0.010
cellular protein catabolic process GO:0044257 155 0.010
positive regulation of hydrolase activity GO:0051345 148 0.010
nuclear import GO:0051170 95 0.010
negative regulation of molecular function GO:0044092 258 0.010
Rat
cell type specific apoptotic process GO:0097285 268 0.010
early endosome to late endosome transport GO:0045022 2 0.010
oogenesis GO:0048477 56 0.010
purine ribonucleotide metabolic process GO:0009150 290 0.010
positive regulation of nucleotide catabolic process GO:0030813 88 0.010
oocyte construction GO:0007308 2 0.010
kidney development GO:0001822 213 0.010
positive regulation of apoptotic cell clearance GO:2000427 3 0.010
synaptic transmission gabaergic GO:0051932 19 0.010
positive regulation of nucleoside metabolic process GO:0045979 91 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.010
regulation of leukocyte differentiation GO:1902105 159 0.010

Map2k5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.074
nervous system disease DOID:863 0 0.074
neuropathy DOID:870 0 0.043
neuromuscular disease DOID:440 0 0.042
disease of metabolism DOID:0014667 0 0.024
charcot marie tooth disease DOID:10595 0 0.024
central nervous system disease DOID:331 0 0.017
inherited metabolic disorder DOID:655 0 0.011
musculoskeletal system disease DOID:17 0 0.011
connective tissue disease DOID:65 0 0.011
brain disease DOID:936 0 0.011