Mus musculus

20 known processes

Prnd

prion protein dublet

(Aliases: Dpl,AI450264,doppel,PrPLP)

Prnd biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
extracellular structure organization GO:0043062 148 0.172
male gamete generation GO:0048232 285 0.108
regulation of defense response GO:0031347 233 0.098
cell adhesion GO:0007155 329 0.098
extracellular matrix organization GO:0030198 147 0.095
renal system development GO:0072001 225 0.085
inorganic cation transmembrane transport GO:0098662 207 0.080
spermatogenesis GO:0007283 284 0.079
protein catabolic process GO:0030163 221 0.078
cellular amine metabolic process GO:0044106 44 0.074
regulation of cellular amino acid metabolic process GO:0006521 5 0.072
cellular amino acid metabolic process GO:0006520 103 0.072
transmembrane transport GO:0055085 412 0.071
small gtpase mediated signal transduction GO:0007264 97 0.071
regulation of cell activation GO:0050865 289 0.070
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.063
ion transmembrane transport GO:0034220 361 0.063
regulation of cellular ketone metabolic process GO:0010565 66 0.061
regulation of cellular amine metabolic process GO:0033238 20 0.061
negative regulation of nervous system development GO:0051961 156 0.061
kidney development GO:0001822 213 0.061
protein maturation GO:0051604 176 0.061
regulation of neuron differentiation GO:0045664 281 0.060
macromolecule catabolic process GO:0009057 281 0.057
cytokine production GO:0001816 319 0.055
regulation of inflammatory response GO:0050727 147 0.052
positive regulation of cell projection organization GO:0031346 95 0.048
cellular ketone metabolic process GO:0042180 84 0.048
inflammatory response GO:0006954 244 0.046
rho protein signal transduction GO:0007266 32 0.046
regulation of response to wounding GO:1903034 189 0.045
inorganic ion transmembrane transport GO:0098660 234 0.045
apoptotic signaling pathway GO:0097190 306 0.045
cation transmembrane transport GO:0098655 266 0.044
ribonucleoside triphosphate metabolic process GO:0009199 220 0.044
ras protein signal transduction GO:0007265 77 0.044
cation transport GO:0006812 399 0.043
negative regulation of cell development GO:0010721 169 0.042
mapk cascade GO:0000165 281 0.040
binding of sperm to zona pellucida GO:0007339 34 0.040
positive regulation of nervous system development GO:0051962 221 0.039
nephron development GO:0072006 109 0.039
protein processing GO:0016485 163 0.039
negative regulation of molecular function GO:0044092 258 0.039
ureteric bud development GO:0001657 94 0.038
cell cell recognition GO:0009988 44 0.038
positive regulation of cell development GO:0010720 237 0.038
ribose phosphate metabolic process GO:0019693 291 0.038
nucleobase containing small molecule metabolic process GO:0055086 352 0.038
positive regulation of neuron differentiation GO:0045666 141 0.037
cell substrate adhesion GO:0031589 130 0.037
negative regulation of immune system process GO:0002683 209 0.037
purine ribonucleotide metabolic process GO:0009150 290 0.036
urogenital system development GO:0001655 261 0.036
regulation of cell migration GO:0030334 219 0.036
cellular homeostasis GO:0019725 240 0.036
spermatid development GO:0007286 108 0.035
regulation of neuron projection development GO:0010975 169 0.035
negative regulation of protein metabolic process GO:0051248 282 0.034
developmental maturation GO:0021700 193 0.034
homeostasis of number of cells GO:0048872 210 0.034
regulation of apoptotic signaling pathway GO:2001233 197 0.034
amine metabolic process GO:0009308 45 0.033
regulation of mapk cascade GO:0043408 248 0.033
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.033
positive regulation of programmed cell death GO:0043068 218 0.032
skin development GO:0043588 220 0.032
epithelial cell proliferation GO:0050673 174 0.031
regulation of ion transmembrane transport GO:0034765 119 0.031
purine nucleotide metabolic process GO:0006163 302 0.031
sensory perception GO:0007600 245 0.031
regulation of neuron death GO:1901214 134 0.031
cell type specific apoptotic process GO:0097285 268 0.031
positive regulation of neuron projection development GO:0010976 79 0.030
epithelial tube morphogenesis GO:0060562 303 0.030
cellular response to growth factor stimulus GO:0071363 197 0.030
spermatid differentiation GO:0048515 115 0.030
negative regulation of apoptotic signaling pathway GO:2001234 104 0.029
leukocyte differentiation GO:0002521 342 0.029
negative regulation of neuron death GO:1901215 98 0.029
neuron death GO:0070997 154 0.029
positive regulation of cell death GO:0010942 224 0.028
membrane organization GO:0061024 245 0.028
neuronal action potential GO:0019228 54 0.028
organ growth GO:0035265 117 0.028
single organismal cell cell adhesion GO:0016337 131 0.028
regulation of cytokine production GO:0001817 266 0.028
blood vessel morphogenesis GO:0048514 285 0.027
potassium ion transport GO:0006813 52 0.027
positive regulation of apoptotic process GO:0043065 217 0.027
negative regulation of cell proliferation GO:0008285 296 0.027
synapse organization GO:0050808 125 0.027
single fertilization GO:0007338 82 0.027
nucleoside phosphate metabolic process GO:0006753 338 0.027
regulation of cell projection organization GO:0031344 206 0.026
ribonucleotide metabolic process GO:0009259 291 0.026
regionalization GO:0003002 337 0.026
fertilization GO:0009566 127 0.026
positive regulation of cellular amine metabolic process GO:0033240 5 0.026
regulation of t cell activation GO:0050863 170 0.026
regulation of transferase activity GO:0051338 263 0.025
sperm egg recognition GO:0035036 37 0.025
synaptic transmission GO:0007268 329 0.025
branching morphogenesis of an epithelial tube GO:0048754 159 0.025
circulatory system process GO:0003013 197 0.024
positive regulation of cell activation GO:0050867 158 0.024
purine containing compound metabolic process GO:0072521 311 0.024
heterocycle catabolic process GO:0046700 280 0.024
negative regulation of cellular component organization GO:0051129 194 0.024
gliogenesis GO:0042063 141 0.024
regulation of proteolysis GO:0030162 164 0.023
cellular protein catabolic process GO:0044257 155 0.023
cellular calcium ion homeostasis GO:0006874 119 0.023
single organism cell adhesion GO:0098602 156 0.023
blood circulation GO:0008015 195 0.023
negative regulation of cellular protein metabolic process GO:0032269 247 0.023
nucleoside phosphate catabolic process GO:1901292 222 0.023
gland development GO:0048732 330 0.023
regulation of membrane potential GO:0042391 192 0.023
muscle tissue development GO:0060537 308 0.023
regulation of kinase activity GO:0043549 249 0.022
endomembrane system organization GO:0010256 147 0.022
regulation of protein maturation GO:1903317 96 0.022
cellular divalent inorganic cation homeostasis GO:0072503 127 0.022
calcium ion homeostasis GO:0055074 127 0.022
organonitrogen compound biosynthetic process GO:1901566 192 0.022
organic cyclic compound catabolic process GO:1901361 295 0.022
carbohydrate derivative catabolic process GO:1901136 231 0.022
sensory organ morphogenesis GO:0090596 242 0.021
protein modification by small protein conjugation or removal GO:0070647 207 0.021
immune effector process GO:0002252 321 0.021
regulation of eosinophil migration GO:2000416 2 0.021
skeletal system development GO:0001501 356 0.021
oxidation reduction process GO:0055114 342 0.021
dna recombination GO:0006310 92 0.021
regulation of cellular component biogenesis GO:0044087 181 0.021
cellular response to biotic stimulus GO:0071216 92 0.021
regulation of leukocyte differentiation GO:1902105 159 0.021
multicellular organismal signaling GO:0035637 91 0.021
cell recognition GO:0008037 83 0.021
sequestering of metal ion GO:0051238 19 0.020
regulation of cell motility GO:2000145 236 0.020
regulation of transmembrane transport GO:0034762 128 0.020
sequestering of calcium ion GO:0051208 18 0.020
cellular ion homeostasis GO:0006873 165 0.020
purine containing compound catabolic process GO:0072523 213 0.020
transmission of nerve impulse GO:0019226 76 0.020
regulation of system process GO:0044057 200 0.020
nephron epithelium morphogenesis GO:0072088 68 0.020
striated muscle tissue development GO:0014706 293 0.020
ear development GO:0043583 200 0.020
regulation of protein localization GO:0032880 231 0.020
regulation of cellular catabolic process GO:0031329 242 0.019
action potential GO:0001508 78 0.019
regulation of neuron apoptotic process GO:0043523 122 0.019
divalent inorganic cation homeostasis GO:0072507 138 0.019
developmental growth involved in morphogenesis GO:0060560 138 0.019
negative regulation of phosphorus metabolic process GO:0010563 184 0.019
regulation of striated muscle cell differentiation GO:0051153 81 0.019
regulation of cell cycle GO:0051726 281 0.019
response to molecule of bacterial origin GO:0002237 143 0.019
regulation of anatomical structure size GO:0090066 178 0.019
positive regulation of mapk cascade GO:0043410 170 0.018
mesodermal cell migration GO:0008078 4 0.018
chondrocyte differentiation GO:0002062 72 0.018
nucleotide metabolic process GO:0009117 332 0.018
negative regulation of cell activation GO:0050866 111 0.018
regulation of organelle organization GO:0033043 289 0.018
negative regulation of neuron apoptotic process GO:0043524 92 0.018
regulation of ion transport GO:0043269 215 0.018
positive regulation of response to wounding GO:1903036 66 0.018
extrinsic apoptotic signaling pathway GO:0097191 126 0.018
ossification GO:0001503 216 0.018
locomotory behavior GO:0007626 195 0.018
regulation of protein catabolic process GO:0042176 108 0.018
cellular response to lipopolysaccharide GO:0071222 77 0.018
skeletal muscle organ development GO:0060538 163 0.018
regulation of cell substrate adhesion GO:0010810 73 0.018
regulation of nucleotide metabolic process GO:0006140 169 0.018
cellular chemical homeostasis GO:0055082 215 0.018
developmental cell growth GO:0048588 84 0.018
potassium ion transmembrane transport GO:0071805 43 0.018
regulation of cell adhesion GO:0030155 154 0.018
camera type eye development GO:0043010 266 0.018
wnt signaling pathway GO:0016055 188 0.018
cellular macromolecule catabolic process GO:0044265 206 0.018
positive regulation of thymocyte migration GO:2000412 2 0.017
fat cell differentiation GO:0045444 160 0.017
regulation of muscle tissue development GO:1901861 97 0.017
development of primary sexual characteristics GO:0045137 143 0.017
chromatin organization GO:0006325 206 0.017
regulation of cell cycle process GO:0010564 160 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.017
positive regulation of growth GO:0045927 104 0.017
response to lipopolysaccharide GO:0032496 128 0.017
positive regulation of protein modification process GO:0031401 299 0.017
neuron apoptotic process GO:0051402 142 0.017
hematopoietic progenitor cell differentiation GO:0002244 143 0.017
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.017
purine nucleoside metabolic process GO:0042278 241 0.017
regulation of peptidase activity GO:0052547 96 0.017
negative regulation of phosphate metabolic process GO:0045936 184 0.017
mesenchyme development GO:0060485 152 0.017
muscle fiber development GO:0048747 76 0.017
positive regulation of transferase activity GO:0051347 167 0.017
renal tubule morphogenesis GO:0061333 72 0.017
organophosphate catabolic process GO:0046434 232 0.017
anion transport GO:0006820 177 0.017
glial cell differentiation GO:0010001 131 0.017
tube formation GO:0035148 140 0.017
bone development GO:0060348 120 0.017
glycosyl compound metabolic process GO:1901657 246 0.016
histone modification GO:0016570 159 0.016
positive regulation of defense response GO:0031349 124 0.016
nitrogen compound transport GO:0071705 271 0.016
cognition GO:0050890 149 0.016
purine nucleotide catabolic process GO:0006195 211 0.016
connective tissue development GO:0061448 179 0.016
heart contraction GO:0060047 93 0.016
striated muscle cell development GO:0055002 125 0.016
sensory perception of mechanical stimulus GO:0050954 107 0.016
forebrain development GO:0030900 302 0.016
regulation of hydrolase activity GO:0051336 246 0.016
regulation of protein processing GO:0070613 96 0.016
covalent chromatin modification GO:0016569 163 0.016
physiological cardiac muscle hypertrophy GO:0003301 3 0.016
cation homeostasis GO:0055080 212 0.015
cell growth involved in cardiac muscle cell development GO:0061049 3 0.015
gonad development GO:0008406 141 0.015
nucleoside triphosphate catabolic process GO:0009143 205 0.015
organelle assembly GO:0070925 177 0.015
mesonephric epithelium development GO:0072163 94 0.015
nucleoside metabolic process GO:0009116 246 0.015
cardiac muscle tissue development GO:0048738 130 0.015
muscle adaptation GO:0043500 39 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.015
positive regulation of cell migration GO:0030335 109 0.015
inositol phosphate mediated signaling GO:0048016 13 0.015
response to transforming growth factor beta GO:0071559 88 0.015
nephron epithelium development GO:0072009 92 0.015
axonogenesis GO:0007409 274 0.015
protein modification by small protein conjugation GO:0032446 187 0.015
cell growth GO:0016049 130 0.015
dna metabolic process GO:0006259 303 0.015
cellular potassium ion transport GO:0071804 43 0.015
regulation of rho protein signal transduction GO:0035023 71 0.015
regulation of binding GO:0051098 111 0.015
cellular response to lipid GO:0071396 145 0.015
ribonucleotide catabolic process GO:0009261 208 0.015
regulation of ras protein signal transduction GO:0046578 114 0.015
peptidyl amino acid modification GO:0018193 336 0.015
anatomical structure homeostasis GO:0060249 145 0.015
response to radiation GO:0009314 165 0.015
cell maturation GO:0048469 127 0.014
morphogenesis of a branching epithelium GO:0061138 193 0.014
retina morphogenesis in camera type eye GO:0060042 45 0.014
morphogenesis of a branching structure GO:0001763 203 0.014
response to organonitrogen compound GO:0010243 246 0.014
neuron migration GO:0001764 122 0.014
wound healing GO:0042060 157 0.014
cellular response to abiotic stimulus GO:0071214 56 0.014
compound eye development GO:0048749 1 0.014
adult behavior GO:0030534 135 0.014
negative regulation of synapse assembly GO:0051964 3 0.014
cellular response to dna damage stimulus GO:0006974 207 0.014
negative regulation of cellular amine metabolic process GO:0033239 1 0.014
mesonephros development GO:0001823 97 0.014
reactive oxygen species metabolic process GO:0072593 84 0.014
calcium ion transmembrane transport GO:0070588 85 0.014
chromatin modification GO:0016568 187 0.014
positive regulation of proteolysis GO:0045862 85 0.014
positive regulation of cytokine production GO:0001819 174 0.014
negative regulation of neuron differentiation GO:0045665 101 0.014
purine ribonucleotide catabolic process GO:0009154 208 0.014
muscle cell differentiation GO:0042692 261 0.014
regulation of cellular component size GO:0032535 121 0.014
metal ion homeostasis GO:0055065 189 0.013
cellular nitrogen compound catabolic process GO:0044270 280 0.013
nephron morphogenesis GO:0072028 69 0.013
negative regulation of protein modification process GO:0031400 163 0.013
lung development GO:0030324 164 0.013
kidney epithelium development GO:0072073 121 0.013
modification dependent macromolecule catabolic process GO:0043632 133 0.013
response to light stimulus GO:0009416 135 0.013
maintenance of location GO:0051235 89 0.013
oocyte construction GO:0007308 2 0.013
retina development in camera type eye GO:0060041 119 0.013
visual perception GO:0007601 52 0.013
anion transmembrane transport GO:0098656 71 0.013
cell matrix adhesion GO:0007160 68 0.013
photoreceptor cell differentiation GO:0046530 52 0.013
myeloid cell differentiation GO:0030099 233 0.013
rna processing GO:0006396 105 0.013
positive regulation of inflammatory response GO:0050729 47 0.013
negative regulation of protein processing GO:0010955 79 0.013
response to growth factor GO:0070848 198 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.013
intrinsic apoptotic signaling pathway GO:0097193 132 0.013
metanephros development GO:0001656 79 0.012
peripheral nervous system development GO:0007422 53 0.012
regulation of chromosome organization GO:0033044 83 0.012
oocyte axis specification GO:0007309 2 0.012
posttranscriptional regulation of gene expression GO:0010608 155 0.012
mitotic cell cycle GO:0000278 195 0.012
reactive nitrogen species metabolic process GO:2001057 0 0.012
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 40 0.012
divalent metal ion transport GO:0070838 172 0.012
negative regulation of cell adhesion GO:0007162 45 0.012
regulation of cell size GO:0008361 72 0.012
lymphocyte differentiation GO:0030098 242 0.012
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.012
engulfment of apoptotic cell GO:0043652 3 0.012
organelle fission GO:0048285 170 0.012
positive regulation of hydrolase activity GO:0051345 148 0.012
positive regulation of neuron projection regeneration GO:0070572 2 0.012
protein ubiquitination GO:0016567 171 0.012
ubiquitin dependent protein catabolic process GO:0006511 129 0.012
negative regulation of response to wounding GO:1903035 77 0.012
t cell activation GO:0042110 289 0.012
carbohydrate derivative biosynthetic process GO:1901137 183 0.012
telencephalon development GO:0021537 186 0.012
nucleoside catabolic process GO:0009164 206 0.012
cellular response to external stimulus GO:0071496 88 0.012
cellular response to acid chemical GO:0071229 68 0.012
cellular protein complex assembly GO:0043623 116 0.012
regulation of endopeptidase activity GO:0052548 89 0.012
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.012
thymocyte migration GO:0072679 2 0.012
gastrulation GO:0007369 116 0.012
leukocyte migration GO:0050900 124 0.012
inner ear receptor cell differentiation GO:0060113 61 0.012
myotube differentiation GO:0014902 105 0.012
purine ribonucleoside catabolic process GO:0046130 205 0.012
regulation of cell growth involved in cardiac muscle cell development GO:0061050 3 0.012
cellular metal ion homeostasis GO:0006875 151 0.012
regulation of t cell proliferation GO:0042129 92 0.011
rna interference GO:0016246 2 0.011
mitotic cell cycle process GO:1903047 159 0.011
negative regulation of protein maturation GO:1903318 79 0.011
germ cell development GO:0007281 185 0.011
skeletal system morphogenesis GO:0048705 203 0.011
negative regulation of protein phosphorylation GO:0001933 126 0.011
myeloid cell homeostasis GO:0002262 114 0.011
positive regulation of lymphocyte activation GO:0051251 140 0.011
lateral line system development GO:0048925 1 0.011
negative regulation of hydrolase activity GO:0051346 71 0.011
endocytosis GO:0006897 168 0.011
asymmetric stem cell division GO:0098722 3 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
cdc42 protein signal transduction GO:0032488 0 0.011
actin cytoskeleton organization GO:0030036 220 0.011
regulation of secretion GO:0051046 274 0.011
feeding behavior GO:0007631 62 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
epithelial cell development GO:0002064 159 0.011
glycosyl compound catabolic process GO:1901658 206 0.011
ureteric bud morphogenesis GO:0060675 62 0.011
regulation of skeletal muscle fiber development GO:0048742 36 0.011
embryonic organ morphogenesis GO:0048562 276 0.011
regulation of chromatin organization GO:1902275 57 0.011
organophosphate biosynthetic process GO:0090407 122 0.011
purine nucleoside triphosphate metabolic process GO:0009144 226 0.011
cytoplasmic transport GO:0016482 234 0.011
cellular response to oxidative stress GO:0034599 76 0.011
lymphocyte mediated immunity GO:0002449 139 0.011
digestive system development GO:0055123 200 0.011
organonitrogen compound catabolic process GO:1901565 264 0.011
epidermis development GO:0008544 187 0.011
physiological muscle hypertrophy GO:0003298 3 0.011
sensory system development GO:0048880 3 0.011
regulation of establishment of protein localization GO:0070201 181 0.011
regulation of cellular response to growth factor stimulus GO:0090287 82 0.011
regulation of purine nucleotide metabolic process GO:1900542 169 0.011
regulation of heart contraction GO:0008016 77 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.011
response to oxidative stress GO:0006979 123 0.011
purine ribonucleoside metabolic process GO:0046128 241 0.011
signal transduction in absence of ligand GO:0038034 55 0.011
positive regulation of organelle organization GO:0010638 128 0.011
cellular response to cytokine stimulus GO:0071345 189 0.011
activation of mapk activity GO:0000187 59 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.011
organic hydroxy compound metabolic process GO:1901615 203 0.011
pharynx development GO:0060465 1 0.011
negative regulation of growth GO:0045926 99 0.011
t cell differentiation GO:0030217 174 0.011
learning or memory GO:0007611 148 0.010
nucleoside monophosphate metabolic process GO:0009123 85 0.010
eosinophil migration GO:0072677 3 0.010
nucleotide catabolic process GO:0009166 217 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.010
negative regulation of immune effector process GO:0002698 55 0.010
negative regulation of proteolysis GO:0045861 74 0.010
sensory perception of sound GO:0007605 97 0.010
purine nucleoside triphosphate catabolic process GO:0009146 203 0.010
small molecule biosynthetic process GO:0044283 132 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.010
negative regulation of t cell activation GO:0050868 65 0.010
purine nucleoside monophosphate metabolic process GO:0009126 81 0.010
stem cell differentiation GO:0048863 268 0.010
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.010
negative regulation of cytokine production GO:0001818 84 0.010
regulation of secretion by cell GO:1903530 249 0.010
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.010
regulation of ossification GO:0030278 112 0.010
exocytosis GO:0006887 121 0.010
intestinal epithelial structure maintenance GO:0060729 4 0.010
leukocyte mediated immunity GO:0002443 174 0.010
protein acylation GO:0043543 64 0.010
regulation of homeostatic process GO:0032844 182 0.010
atp metabolic process GO:0046034 75 0.010
somatic diversification of immune receptors GO:0002200 53 0.010

Prnd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.020
nervous system disease DOID:863 0 0.020
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
organ system cancer DOID:0050686 0 0.018
physical disorder DOID:0080015 0 0.010
sensory system disease DOID:0050155 0 0.010
myopathy DOID:423 0 0.010
musculoskeletal system disease DOID:17 0 0.010
muscle tissue disease DOID:66 0 0.010
muscular disease DOID:0080000 0 0.010