Mus musculus

0 known processes

Nkx2-4

NK2 transcription factor related, locus 4 (Drosophila)

(Aliases: tinman,Nkx-2.4,1700001P03Rik)

Nkx2-4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cell fate commitment GO:0045165 210 0.707
Mouse
regulation of neuron differentiation GO:0045664 281 0.645
Mouse
regionalization GO:0003002 337 0.562
Mouse
heart morphogenesis GO:0003007 178 0.518
Mouse
telencephalon development GO:0021537 186 0.479
Mouse
skeletal system development GO:0001501 356 0.431
Mouse
connective tissue development GO:0061448 179 0.404
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.390
Mouse
determination of left right symmetry GO:0007368 80 0.388
Mouse
striated muscle tissue development GO:0014706 293 0.370
Mouse
muscle tissue development GO:0060537 308 0.359
Mouse
renal system development GO:0072001 225 0.355
neuron fate specification GO:0048665 30 0.353
Mouse
camera type eye development GO:0043010 266 0.334
embryonic organ morphogenesis GO:0048562 276 0.323
Mouse
mesoderm morphogenesis GO:0048332 64 0.307
epithelial cell development GO:0002064 159 0.299
Mouse
bmp signaling pathway GO:0030509 93 0.290
Mouse
cell fate specification GO:0001708 72 0.276
Mouse
mesoderm development GO:0007498 100 0.273
pancreatic pp cell differentiation GO:0003312 2 0.273
Mouse
cartilage development GO:0051216 140 0.270
Mouse
mesoderm formation GO:0001707 62 0.267
stem cell differentiation GO:0048863 268 0.261
Mouse
digestive system development GO:0055123 200 0.259
Mouse
digestive tract development GO:0048565 190 0.251
Mouse
outflow tract morphogenesis GO:0003151 53 0.248
Mouse
regulation of organ morphogenesis GO:2000027 144 0.242
paraxial mesodermal cell differentiation GO:0048342 2 0.242
forebrain development GO:0030900 302 0.241
Mouse
digestive tract morphogenesis GO:0048546 147 0.240
Mouse
embryonic heart tube development GO:0035050 65 0.231
Mouse
stem cell proliferation GO:0072089 117 0.221
negative regulation of cell proliferation GO:0008285 296 0.218
Mouse
kidney development GO:0001822 213 0.217
regulation of kinase activity GO:0043549 249 0.207
cardiac ventricle development GO:0003231 83 0.200
Mouse
endocrine system development GO:0035270 98 0.198
Zebrafish Mouse
cardiac muscle tissue development GO:0048738 130 0.195
Mouse
sensory organ morphogenesis GO:0090596 242 0.189
Mouse
cardiac chamber morphogenesis GO:0003206 93 0.189
Mouse
pallium development GO:0021543 120 0.188
Mouse
skeletal system morphogenesis GO:0048705 203 0.188
Mouse
myeloid leukocyte differentiation GO:0002573 119 0.182
Mouse
morphogenesis of embryonic epithelium GO:0016331 159 0.180
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.180
formation of primary germ layer GO:0001704 77 0.177
embryonic heart tube morphogenesis GO:0003143 51 0.177
Mouse
negative regulation of neuron differentiation GO:0045665 101 0.173
Mouse
positive regulation of voltage gated calcium channel activity GO:1901387 2 0.172
Mouse
ear development GO:0043583 200 0.171
Mouse
negative regulation of nervous system development GO:0051961 156 0.171
Mouse
limbic system development GO:0021761 72 0.165
Mouse
striated muscle cell proliferation GO:0014855 39 0.160
Mouse
appendage morphogenesis GO:0035107 149 0.159
globus pallidus development GO:0021759 2 0.158
Mouse
spleen development GO:0048536 39 0.156
Mouse
cell type specific apoptotic process GO:0097285 268 0.153
Mouse
lateral inhibition GO:0046331 1 0.152
cell recognition GO:0008037 83 0.149
axonogenesis GO:0007409 274 0.148
Mouse
leukocyte differentiation GO:0002521 342 0.146
Mouse
inorganic cation transmembrane transport GO:0098662 207 0.141
Mouse
epidermis development GO:0008544 187 0.140
astrocyte fate commitment GO:0060018 4 0.138
epithelial tube morphogenesis GO:0060562 303 0.138
Mouse
embryonic skeletal system development GO:0048706 120 0.137
Mouse
ossification GO:0001503 216 0.134
microtubule based process GO:0007017 236 0.133
muscle tissue morphogenesis GO:0060415 53 0.132
Mouse
positive regulation of protein modification process GO:0031401 299 0.129
pancreatic a cell fate commitment GO:0003326 2 0.129
Mouse
ion transmembrane transport GO:0034220 361 0.129
Mouse
positive regulation of neuron differentiation GO:0045666 141 0.128
Mouse
respiratory system development GO:0060541 190 0.128
Mouse
mesenchyme development GO:0060485 152 0.127
Mouse
blood vessel morphogenesis GO:0048514 285 0.125
Mouse
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.125
cardiac ventricle morphogenesis GO:0003208 50 0.125
Mouse
tissue remodeling GO:0048771 102 0.124
cardiocyte differentiation GO:0035051 87 0.123
Mouse
smoothened signaling pathway GO:0007224 105 0.122
Mouse
angiogenesis GO:0001525 201 0.119
negative regulation of cell development GO:0010721 169 0.119
Mouse
skeletal muscle cell differentiation GO:0035914 66 0.118
gland development GO:0048732 330 0.116
Zebrafish Mouse
regulation of organ formation GO:0003156 34 0.116
metanephros development GO:0001656 79 0.116
ventral spinal cord interneuron fate commitment GO:0060579 14 0.115
Mouse
regulation of transferase activity GO:0051338 263 0.114
ear morphogenesis GO:0042471 118 0.113
Mouse
cell adhesion GO:0007155 329 0.111
pulmonary myocardium development GO:0003350 3 0.111
Mouse
left right pattern formation GO:0060972 23 0.110
Mouse
response to growth factor GO:0070848 198 0.109
spinal cord oligodendrocyte cell differentiation GO:0021529 3 0.109
Mouse
spinal cord oligodendrocyte cell fate specification GO:0021530 3 0.108
Mouse
cation transport GO:0006812 399 0.107
Mouse
respiratory tube development GO:0030323 167 0.106
Mouse
positive regulation of transferase activity GO:0051347 167 0.104
stem cell development GO:0048864 219 0.103
specification of organ identity GO:0010092 30 0.102
cation transmembrane transport GO:0098655 266 0.101
Mouse
positive regulation of kinase activity GO:0033674 155 0.101
cellular amino acid metabolic process GO:0006520 103 0.100
neural tube development GO:0021915 160 0.099
primary neural tube formation GO:0014020 95 0.099
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.098
regulation of bmp signaling pathway GO:0030510 60 0.098
regulation of neuron projection development GO:0010975 169 0.096
morphogenesis of a branching structure GO:0001763 203 0.096
positive regulation of transcription via serum response element binding GO:0010735 1 0.096
Mouse
mesenchymal cell development GO:0014031 93 0.095
cardiac muscle tissue morphogenesis GO:0055008 44 0.094
Mouse
male sex differentiation GO:0046661 109 0.094
Mouse
limb development GO:0060173 166 0.092
microtubule cytoskeleton organization GO:0000226 157 0.091
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.091
sensory perception GO:0007600 245 0.091
positive regulation of cell cycle GO:0045787 92 0.090
developmental maturation GO:0021700 193 0.090
branching morphogenesis of an epithelial tube GO:0048754 159 0.089
regulation of cell adhesion GO:0030155 154 0.089
regulation of testosterone biosynthetic process GO:2000224 2 0.088
notch signaling pathway GO:0007219 71 0.086
cardiac pacemaker cell fate commitment GO:0060927 1 0.086
Mouse
regulation of cell projection organization GO:0031344 206 0.085
cerebral cortex development GO:0021987 86 0.085
Mouse
carbohydrate metabolic process GO:0005975 230 0.084
regulation of ion transmembrane transport GO:0034765 119 0.083
Mouse
organ growth GO:0035265 117 0.083
Mouse
pancreatic pp cell fate commitment GO:0003329 2 0.083
Mouse
pancreas development GO:0031016 57 0.082
Mouse
determination of heart left right asymmetry GO:0061371 48 0.081
Mouse
regulation of cell motility GO:2000145 236 0.081
paraxial mesodermal cell fate commitment GO:0048343 2 0.081
regulation of microtubule based process GO:0032886 52 0.080
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.080
hormone metabolic process GO:0042445 86 0.080
embryonic epithelial tube formation GO:0001838 130 0.080
regulation of protein kinase activity GO:0045859 232 0.080
hippocampus development GO:0021766 52 0.079
Mouse
response to transforming growth factor beta GO:0071559 88 0.079
inner ear morphogenesis GO:0042472 101 0.079
cardiac chamber development GO:0003205 108 0.078
Mouse
neural precursor cell proliferation GO:0061351 121 0.076
atrioventricular node cell development GO:0060928 2 0.075
Mouse
septum transversum development GO:0003343 2 0.072
Mouse
action potential GO:0001508 78 0.072
mesenchymal cell differentiation GO:0048762 107 0.072
positive regulation of mapk cascade GO:0043410 170 0.072
negative regulation of cellular component organization GO:0051129 194 0.072
epithelial tube formation GO:0072175 130 0.071
regulation of cell activation GO:0050865 289 0.071
phagocytosis GO:0006909 66 0.071
neuron migration GO:0001764 122 0.070
Mouse
regulation of muscle tissue development GO:1901861 97 0.070
Mouse
his purkinje system cell differentiation GO:0060932 2 0.070
Mouse
regulation of cell migration GO:0030334 219 0.068
artery development GO:0060840 53 0.068
spermatogenesis GO:0007283 284 0.067
appendage development GO:0048736 166 0.067
odontogenesis of dentin containing tooth GO:0042475 66 0.067
Mouse
regulation of stem cell proliferation GO:0072091 78 0.067
regulation of cell cycle process GO:0010564 160 0.067
regulation of cardiac muscle tissue growth GO:0055021 26 0.067
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.066
ureteric bud development GO:0001657 94 0.066
negative regulation of molecular function GO:0044092 258 0.065
regulation of organelle organization GO:0033043 289 0.065
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.065
Mouse
negative regulation of wnt signaling pathway GO:0030178 73 0.064
Mouse
positive regulation of nervous system development GO:0051962 221 0.063
Mouse
negative regulation of phosphate metabolic process GO:0045936 184 0.063
skin development GO:0043588 220 0.063
regulation of ossification GO:0030278 112 0.063
regulation of epithelial cell proliferation GO:0050678 141 0.063
Mouse
regulation of reproductive process GO:2000241 66 0.062
mitotic cell cycle GO:0000278 195 0.062
cell fate determination GO:0001709 32 0.062
Mouse
regulation of transmembrane transport GO:0034762 128 0.062
Mouse
negative regulation of neuron projection development GO:0010977 50 0.061
neural crest cell differentiation GO:0014033 54 0.061
forebrain neuron differentiation GO:0021879 52 0.061
Mouse
visceral serous pericardium development GO:0061032 2 0.061
regulation of hormone levels GO:0010817 211 0.061
ventral spinal cord interneuron fate determination GO:0060580 1 0.060
Mouse
segmentation GO:0035282 93 0.060
chromatin organization GO:0006325 206 0.060
regulation of voltage gated calcium channel activity GO:1901385 4 0.060
Mouse
renal tubule morphogenesis GO:0061333 72 0.060
b cell activation GO:0042113 161 0.059
Mouse
skeletal muscle organ development GO:0060538 163 0.059
proteoglycan metabolic process GO:0006029 38 0.059
negative regulation of organelle organization GO:0010639 90 0.059
heart growth GO:0060419 45 0.059
Mouse
regulation of cell cycle GO:0051726 281 0.058
hair follicle development GO:0001942 85 0.057
positive regulation of cell development GO:0010720 237 0.057
Mouse
spinal cord motor neuron differentiation GO:0021522 35 0.057
Mouse
negative regulation of apoptotic signaling pathway GO:2001234 104 0.057
cellular response to growth factor stimulus GO:0071363 197 0.057
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 4 0.057
tissue migration GO:0090130 68 0.056
t cell activation GO:0042110 289 0.056
Mouse
intracellular protein transport GO:0006886 204 0.056
single organism cell adhesion GO:0098602 156 0.056
cellular ketone metabolic process GO:0042180 84 0.056
placenta development GO:0001890 140 0.056
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.055
cellular amine metabolic process GO:0044106 44 0.055
synaptic transmission GO:0007268 329 0.055
epithelial cell migration GO:0010631 63 0.055
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.055
Mouse
calcium ion transmembrane transport GO:0070588 85 0.055
Mouse
atrial cardiac muscle cell development GO:0055014 2 0.054
Mouse
t cell differentiation GO:0030217 174 0.054
Mouse
endothelial cell differentiation GO:0045446 41 0.054
mechanoreceptor differentiation GO:0042490 67 0.053
keratinocyte proliferation GO:0043616 21 0.053
divalent metal ion transport GO:0070838 172 0.053
Mouse
menarche GO:0042696 1 0.053
Mouse
synapse organization GO:0050808 125 0.053
embryonic placenta development GO:0001892 98 0.052
cell differentiation in spinal cord GO:0021515 53 0.052
Mouse
locomotory behavior GO:0007626 195 0.052
Mouse
gastrulation GO:0007369 116 0.051
central nervous system vasculogenesis GO:0022009 3 0.051
negative regulation of intracellular signal transduction GO:1902532 167 0.051
positive regulation of cell adhesion GO:0045785 80 0.051
mesenchyme morphogenesis GO:0072132 32 0.050
forebrain regionalization GO:0021871 25 0.050
Mouse
lymphocyte differentiation GO:0030098 242 0.050
Mouse
homeostasis of number of cells GO:0048872 210 0.050
Mouse
male gamete generation GO:0048232 285 0.049
neural crest cell development GO:0014032 48 0.049
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.049
Mouse
regulation of organ growth GO:0046620 61 0.049
Mouse
mesonephric epithelium development GO:0072163 94 0.049
purkinje myocyte differentiation GO:0003168 1 0.049
Mouse
inorganic ion transmembrane transport GO:0098660 234 0.048
Mouse
negative regulation of cell cycle GO:0045786 123 0.048
proepicardium development GO:0003342 2 0.048
Mouse
atrioventricular node cell fate commitment GO:0060929 1 0.048
Mouse
renal outer medulla development GO:0072054 2 0.048
tube closure GO:0060606 91 0.047
somatotropin secreting cell differentiation GO:0060126 4 0.047
dna metabolic process GO:0006259 303 0.046
regulation of neural precursor cell proliferation GO:2000177 70 0.046
urogenital system development GO:0001655 261 0.046
wnt signaling pathway GO:0016055 188 0.046
Mouse
auditory receptor cell fate specification GO:0042667 1 0.045
regulation of wnt signaling pathway GO:0030111 123 0.045
Mouse
fat cell differentiation GO:0045444 160 0.045
forebrain cell migration GO:0021885 58 0.045
Mouse
spinal cord development GO:0021510 81 0.044
Mouse
plasma cell differentiation GO:0002317 3 0.044
Mouse
endocardial cushion development GO:0003197 26 0.044
g protein coupled receptor signaling pathway GO:0007186 243 0.044
cardiac muscle tissue growth GO:0055017 37 0.044
Mouse
limb morphogenesis GO:0035108 149 0.044
epithelium migration GO:0090132 63 0.044
diencephalon development GO:0021536 63 0.043
Mouse
glandular epithelial cell differentiation GO:0002067 38 0.043
Mouse
cell maturation GO:0048469 127 0.043
mitotic cell cycle process GO:1903047 159 0.043
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.042
carbon catabolite activation of transcription GO:0045991 4 0.042
neural tube closure GO:0001843 90 0.042
chromatin modification GO:0016568 187 0.042
extracellular structure organization GO:0043062 148 0.041
ameboidal type cell migration GO:0001667 128 0.041
response to radiation GO:0009314 165 0.041
negative regulation of cell projection organization GO:0031345 56 0.041
positive regulation of cellular amine metabolic process GO:0033240 5 0.041
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.041
atrioventricular node cell differentiation GO:0060922 2 0.041
Mouse
mesodermal cell differentiation GO:0048333 22 0.041
aminoglycan metabolic process GO:0006022 34 0.041
post anal tail morphogenesis GO:0036342 23 0.040
nephron tubule morphogenesis GO:0072078 68 0.040
lung development GO:0030324 164 0.040
Mouse
dendrite development GO:0016358 115 0.040
Fly
regulation of retina development in camera type eye GO:1902866 3 0.040
neuromuscular process GO:0050905 99 0.040
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.040
central nervous system neuron differentiation GO:0021953 162 0.040
Mouse
neuroepithelial cell differentiation GO:0060563 37 0.040
endocytosis GO:0006897 168 0.040
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.039
regulation of osteoblast differentiation GO:0045667 67 0.039
cytoplasmic transport GO:0016482 234 0.039
nucleoside phosphate metabolic process GO:0006753 338 0.039
myeloid cell differentiation GO:0030099 233 0.039
Mouse
regulation of neural retina development GO:0061074 3 0.039
blood circulation GO:0008015 195 0.039
Mouse
mesonephric tubule development GO:0072164 94 0.038
axis elongation involved in somitogenesis GO:0090245 4 0.038
heart formation GO:0060914 16 0.038
endocrine pancreas development GO:0031018 29 0.038
Mouse
tissue homeostasis GO:0001894 115 0.038
kidney morphogenesis GO:0060993 83 0.038
uterus morphogenesis GO:0061038 2 0.038
oviduct development GO:0060066 3 0.038
forebrain generation of neurons GO:0021872 63 0.038
Mouse
regulation of anagen GO:0051884 1 0.038
regulation of cellular component size GO:0032535 121 0.038
regulation of heart growth GO:0060420 31 0.038
Mouse
palate development GO:0060021 76 0.037
regulation of auditory receptor cell differentiation GO:0045607 4 0.037
sclerotome development GO:0061056 4 0.037
regulation of cellular response to growth factor stimulus GO:0090287 82 0.037
hair cycle GO:0042633 90 0.037
inner medullary collecting duct development GO:0072061 2 0.037
mesodermal cell fate commitment GO:0001710 17 0.037
hindbrain development GO:0030902 128 0.037
cardiac muscle cell proliferation GO:0060038 31 0.036
Mouse
muscle cell differentiation GO:0042692 261 0.036
Mouse
tube formation GO:0035148 140 0.036
positive regulation of bmp signaling pathway GO:0030513 23 0.036
germ cell development GO:0007281 185 0.036
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.036
positive regulation of epithelial cell proliferation GO:0050679 68 0.036
axon guidance GO:0007411 141 0.036
Mouse
regulation of myeloid cell differentiation GO:0045637 96 0.036
fertilization GO:0009566 127 0.036
regulation of mitotic cell cycle GO:0007346 126 0.036
organic hydroxy compound metabolic process GO:1901615 203 0.036
paramesonephric duct development GO:0061205 3 0.035
endothelium development GO:0003158 45 0.035
regulation of membrane potential GO:0042391 192 0.035
neural tube formation GO:0001841 108 0.035
canonical wnt signaling pathway GO:0060070 130 0.035
Mouse
semicircular canal fusion GO:0060879 1 0.035
midbrain hindbrain boundary maturation GO:0021732 1 0.035
somitogenesis GO:0001756 69 0.035
protein polymerization GO:0051258 57 0.035
nucleocytoplasmic transport GO:0006913 139 0.034
protein depolymerization GO:0051261 34 0.034
nephron development GO:0072006 109 0.034
regulation of lymphocyte activation GO:0051249 240 0.034
regulation of embryonic development GO:0045995 71 0.034
glial cell development GO:0021782 54 0.034
Mouse
positive regulation of protein kinase activity GO:0045860 144 0.034
neuronal action potential GO:0019228 54 0.034
bone morphogenesis GO:0060349 78 0.034
embryonic appendage morphogenesis GO:0035113 126 0.033
endodermal cell fate specification GO:0001714 4 0.033
pyramidal neuron migration GO:0021852 1 0.033
positive regulation of anagen GO:0051885 1 0.033
carbon catabolite regulation of transcription GO:0045990 4 0.033
regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation GO:2000079 1 0.033
ectoderm formation GO:0001705 3 0.033
b cell differentiation GO:0030183 78 0.032
Mouse
ventricular cardiac muscle tissue development GO:0003229 38 0.032
Mouse
nuclear transport GO:0051169 139 0.032
developmental growth involved in morphogenesis GO:0060560 138 0.032
neural tube patterning GO:0021532 43 0.032
organelle fission GO:0048285 170 0.032
cell matrix adhesion GO:0007160 68 0.032
protein modification by small protein conjugation or removal GO:0070647 207 0.032
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.032
transmembrane transport GO:0055085 412 0.032
Mouse
cellular protein complex assembly GO:0043623 116 0.032
positive regulation of cardioblast differentiation GO:0051891 3 0.032
Mouse
thymus development GO:0048538 41 0.031
hexose metabolic process GO:0019318 98 0.031
positive regulation of fat cell proliferation GO:0070346 1 0.031
cardiac epithelial to mesenchymal transition GO:0060317 18 0.031
regulation of cellular amine metabolic process GO:0033238 20 0.031
mammary gland duct morphogenesis GO:0060603 38 0.031
auditory receptor cell fate determination GO:0042668 3 0.031
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.031
Mouse
nuclear import GO:0051170 95 0.031
central nervous system morphogenesis GO:0021551 2 0.031
negative regulation of apoptotic process involved in outflow tract morphogenesis GO:1902257 2 0.031
membrane organization GO:0061024 245 0.031
blood vessel remodeling GO:0001974 33 0.031
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.031
nephrogenic mesenchyme development GO:0072076 3 0.031
mesangial cell differentiation GO:0072007 4 0.031
cell fate determination involved in pattern specification GO:0060582 1 0.031
Mouse
cerebellum formation GO:0021588 1 0.030
positive regulation of transcription by glucose GO:0046016 3 0.030
regulation of leukocyte differentiation GO:1902105 159 0.030
multi multicellular organism process GO:0044706 109 0.030
single organismal cell cell adhesion GO:0016337 131 0.030
cardiac septum development GO:0003279 59 0.030
mapk cascade GO:0000165 281 0.030
muscle cell proliferation GO:0033002 52 0.030
Mouse
trabecula morphogenesis GO:0061383 40 0.030
Mouse
mesonephros development GO:0001823 97 0.030
stem cell maintenance GO:0019827 130 0.030
morphogenesis of an epithelial fold GO:0060571 28 0.030
negative regulation of gastrulation GO:2000542 3 0.030
somatic stem cell maintenance GO:0035019 47 0.030
development of primary sexual characteristics GO:0045137 143 0.030
Mouse
regulation of cardiac muscle cell proliferation GO:0060043 23 0.030
Mouse
protein import GO:0017038 101 0.030
small gtpase mediated signal transduction GO:0007264 97 0.030
asymmetric neuroblast division GO:0055059 1 0.030
mesodermal cell fate specification GO:0007501 11 0.029
biological phase GO:0044848 20 0.029
Mouse
negative regulation of kinase activity GO:0033673 81 0.029
spemann organizer formation at the anterior end of the primitive streak GO:0060064 1 0.029
regulation of ketone biosynthetic process GO:0010566 2 0.029
cardiac cell fate determination GO:0060913 2 0.029
kidney epithelium development GO:0072073 121 0.029
actin cytoskeleton organization GO:0030036 220 0.029
Mouse
oligodendrocyte development GO:0014003 20 0.029
Mouse
forebrain neuron development GO:0021884 30 0.029
cellular lipid metabolic process GO:0044255 323 0.029
Mouse
sensory perception of sound GO:0007605 97 0.029
apoptotic process involved in morphogenesis GO:0060561 25 0.029
Mouse
cervix development GO:0060067 2 0.029
spinal cord dorsal ventral patterning GO:0021513 23 0.029
Mouse
rho protein signal transduction GO:0007266 32 0.029
zygotic determination of anterior posterior axis embryo GO:0007354 3 0.028
positive regulation of transcription from rna polymerase ii promoter by glucose GO:0000432 3 0.028
lung pattern specification process GO:0060432 1 0.028
closure of optic fissure GO:0061386 2 0.028
regulation of cell division GO:0051302 76 0.028
regulation of apoptotic signaling pathway GO:2001233 197 0.028
glucose metabolic process GO:0006006 92 0.028
nephron morphogenesis GO:0072028 69 0.028
regulation of ion transmembrane transporter activity GO:0032412 54 0.028
Mouse
amine metabolic process GO:0009308 45 0.027
monosaccharide metabolic process GO:0005996 106 0.027
positive regulation of high voltage gated calcium channel activity GO:1901843 1 0.027
muscle contraction GO:0006936 101 0.027
Mouse
ensheathment of neurons GO:0007272 76 0.027
response to parathyroid hormone GO:0071107 3 0.027
protein processing GO:0016485 163 0.027
organelle localization GO:0051640 179 0.027
regulation of mapk cascade GO:0043408 248 0.027
salivary gland development GO:0007431 37 0.027
regulation of anatomical structure size GO:0090066 178 0.027
regulation of morphogenesis of a branching structure GO:0060688 53 0.027
type b pancreatic cell fate commitment GO:0003327 1 0.027
Mouse
embryonic camera type eye development GO:0031076 36 0.027
transcription from rna polymerase iii promoter GO:0006383 3 0.027
metanephric loop of henle development GO:0072236 4 0.027
renal capsule specification GO:0072130 1 0.027
cell substrate adhesion GO:0031589 130 0.027
pattern specification involved in metanephros development GO:0072268 4 0.027
learning or memory GO:0007611 148 0.027
hair cell differentiation GO:0035315 40 0.026
corticotropin hormone secreting cell differentiation GO:0060128 3 0.026
somite development GO:0061053 81 0.026
adult behavior GO:0030534 135 0.026
positive regulation of secretion by cell GO:1903532 114 0.026
cellular carbohydrate metabolic process GO:0044262 119 0.026
mammary gland bud formation GO:0060615 2 0.026
development of primary male sexual characteristics GO:0046546 88 0.026
Mouse
establishment of organ orientation GO:0048561 1 0.026
developmental induction GO:0031128 34 0.026
Mouse
negative regulation of phosphorus metabolic process GO:0010563 184 0.026
positive regulation of peptide secretion GO:0002793 33 0.026
calcium ion transport GO:0006816 159 0.026
Mouse
gonad development GO:0008406 141 0.026
Mouse
hypophysis morphogenesis GO:0048850 3 0.026
pericardium development GO:0060039 16 0.026
Mouse
nucleotide metabolic process GO:0009117 332 0.026
negative regulation of growth GO:0045926 99 0.026
cellular response to lipid GO:0071396 145 0.026
submandibular salivary gland formation GO:0060661 1 0.026
ras protein signal transduction GO:0007265 77 0.026
regulation of hormone secretion GO:0046883 88 0.026
circulatory system process GO:0003013 197 0.026
Mouse
morphogenesis of a branching epithelium GO:0061138 193 0.026
regulation of apoptotic process involved in outflow tract morphogenesis GO:1902256 2 0.026
single organism nuclear import GO:1902593 95 0.026
muscle system process GO:0003012 141 0.026
Mouse
cell surface receptor signaling pathway involved in heart development GO:0061311 15 0.025
nucleobase containing small molecule metabolic process GO:0055086 352 0.025
regulation of map kinase activity GO:0043405 120 0.025
ventricular cardiac myofibril assembly GO:0055005 3 0.025
Mouse
epithelial cell proliferation GO:0050673 174 0.025
Mouse
metanephric nephron development GO:0072210 34 0.025
endocardial cushion morphogenesis GO:0003203 18 0.025
autonomic nervous system development GO:0048483 43 0.025
inner ear receptor cell differentiation GO:0060113 61 0.025
type b pancreatic cell differentiation GO:0003309 13 0.025
Mouse
regulation of microtubule polymerization or depolymerization GO:0031110 20 0.025
multicellular organismal homeostasis GO:0048871 164 0.025
regulation of cell size GO:0008361 72 0.025
macromolecule catabolic process GO:0009057 281 0.025
prostate gland epithelium morphogenesis GO:0060740 31 0.025
granulocyte colony stimulating factor production GO:0071611 1 0.025
protein catabolic process GO:0030163 221 0.025
proteoglycan biosynthetic process GO:0030166 20 0.025

Nkx2-4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
bone development disease DOID:0080006 0 0.123
bone disease DOID:0080001 0 0.123
disease of anatomical entity DOID:7 0 0.123
musculoskeletal system disease DOID:17 0 0.123
connective tissue disease DOID:65 0 0.123