Mus musculus

0 known processes

Adam5

a disintegrin and metallopeptidase domain 5

(Aliases: tMDC II,tMDCII)

Adam5 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
spermatid differentiation GO:0048515 115 0.130
male gamete generation GO:0048232 285 0.111
spermatid development GO:0007286 108 0.085
spermatogenesis GO:0007283 284 0.079
cilium assembly GO:0042384 81 0.065
cilium morphogenesis GO:0060271 102 0.062
germ cell development GO:0007281 185 0.061
reactive oxygen species metabolic process GO:0072593 84 0.051
organelle assembly GO:0070925 177 0.044
cellular homeostasis GO:0019725 240 0.044
cell cell recognition GO:0009988 44 0.043
cation transport GO:0006812 399 0.041
oxidation reduction process GO:0055114 342 0.040
cation transmembrane transport GO:0098655 266 0.037
fertilization GO:0009566 127 0.037
organic anion transport GO:0015711 137 0.035
immune response activating signal transduction GO:0002757 116 0.034
cellular chemical homeostasis GO:0055082 215 0.033
skeletal system morphogenesis GO:0048705 203 0.032
regulation of cell migration GO:0030334 219 0.030
regulation of organelle organization GO:0033043 289 0.028
blood circulation GO:0008015 195 0.028
myeloid cell differentiation GO:0030099 233 0.027
binding of sperm to zona pellucida GO:0007339 34 0.027
inorganic ion transmembrane transport GO:0098660 234 0.027
anion transport GO:0006820 177 0.027
cellular component assembly involved in morphogenesis GO:0010927 139 0.026
membrane organization GO:0061024 245 0.026
leukocyte differentiation GO:0002521 342 0.026
nitrogen compound transport GO:0071705 271 0.026
circulatory system process GO:0003013 197 0.026
homeostasis of number of cells GO:0048872 210 0.025
myeloid cell homeostasis GO:0002262 114 0.025
protein modification by small protein conjugation GO:0032446 187 0.024
negative regulation of cellular component organization GO:0051129 194 0.024
cellular ion homeostasis GO:0006873 165 0.024
cellular response to lipid GO:0071396 145 0.024
single fertilization GO:0007338 82 0.023
activation of immune response GO:0002253 138 0.023
response to organonitrogen compound GO:0010243 246 0.023
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.022
organonitrogen compound biosynthetic process GO:1901566 192 0.022
response to peptide GO:1901652 136 0.022
ion transmembrane transport GO:0034220 361 0.022
immune response regulating signaling pathway GO:0002764 125 0.022
peptide metabolic process GO:0006518 46 0.021
chemotaxis GO:0006935 247 0.021
cellular ketone metabolic process GO:0042180 84 0.021
response to inorganic substance GO:0010035 96 0.020
determination of left right symmetry GO:0007368 80 0.020
regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling GO:0003027 1 0.020
reactive oxygen species biosynthetic process GO:1903409 8 0.020
metal ion homeostasis GO:0055065 189 0.020
striated muscle tissue development GO:0014706 293 0.020
cell adhesion GO:0007155 329 0.020
cellular response to growth factor stimulus GO:0071363 197 0.020
activation of innate immune response GO:0002218 56 0.020
innate immune response GO:0045087 157 0.019
sequestering of metal ion GO:0051238 19 0.019
renal system development GO:0072001 225 0.019
macromolecule catabolic process GO:0009057 281 0.019
cardiocyte differentiation GO:0035051 87 0.019
skeletal muscle organ development GO:0060538 163 0.019
regulation of reactive oxygen species metabolic process GO:2000377 40 0.019
regulation of retina development in camera type eye GO:1902866 3 0.018
cellular response to hormone stimulus GO:0032870 150 0.018
cellular response to acid chemical GO:0071229 68 0.018
regulation of transmembrane transport GO:0034762 128 0.018
hematopoietic progenitor cell differentiation GO:0002244 143 0.018
cellular amino acid metabolic process GO:0006520 103 0.018
microtubule based movement GO:0007018 84 0.018
transmembrane transport GO:0055085 412 0.018
inorganic cation transmembrane transport GO:0098662 207 0.017
carboxylic acid transport GO:0046942 100 0.017
microtubule based process GO:0007017 236 0.017
reactive nitrogen species metabolic process GO:2001057 0 0.017
cell maturation GO:0048469 127 0.017
regulation of homeostatic process GO:0032844 182 0.017
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.017
regulation of angiotensin metabolic process GO:0060177 4 0.016
endocytosis GO:0006897 168 0.016
leukocyte migration GO:0050900 124 0.016
eosinophil migration GO:0072677 3 0.016
cytoplasmic transport GO:0016482 234 0.016
positive regulation of keratinocyte proliferation GO:0010838 4 0.016
amino acid transport GO:0006865 61 0.016
negative regulation of multi organism process GO:0043901 68 0.016
regulation of cell motility GO:2000145 236 0.016
negative regulation of immune system process GO:0002683 209 0.016
response to lipopolysaccharide GO:0032496 128 0.016
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.016
cellular protein catabolic process GO:0044257 155 0.016
response to acid chemical GO:0001101 111 0.016
protein maturation GO:0051604 176 0.016
myeloid leukocyte migration GO:0097529 57 0.016
glucose homeostasis GO:0042593 128 0.016
cell type specific apoptotic process GO:0097285 268 0.015
muscle cell differentiation GO:0042692 261 0.015
response to growth factor GO:0070848 198 0.015
regulation of ion transport GO:0043269 215 0.015
wound healing GO:0042060 157 0.015
camera type eye development GO:0043010 266 0.015
single organismal cell cell adhesion GO:0016337 131 0.014
negative regulation of growth GO:0045926 99 0.014
nuclear transport GO:0051169 139 0.014
carbohydrate homeostasis GO:0033500 128 0.014
nucleocytoplasmic transport GO:0006913 139 0.014
multicellular organism growth GO:0035264 161 0.014
positive regulation of cell death GO:0010942 224 0.014
cellular amide metabolic process GO:0043603 58 0.014
apoptotic signaling pathway GO:0097190 306 0.014
skeletal system development GO:0001501 356 0.014
exocytosis GO:0006887 121 0.014
response to organic cyclic compound GO:0014070 198 0.014
lipid biosynthetic process GO:0008610 179 0.014
neutrophil mediated killing of gram positive bacterium GO:0070946 2 0.014
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 4 0.014
regulation of cell cycle GO:0051726 281 0.014
protein catabolic process GO:0030163 221 0.014
intracellular protein transport GO:0006886 204 0.014
mechanoreceptor differentiation GO:0042490 67 0.014
protein targeting GO:0006605 143 0.014
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.014
defense response to bacterium GO:0042742 119 0.013
establishment or maintenance of neuroblast polarity GO:0045196 1 0.013
sequestering of calcium ion GO:0051208 18 0.013
response to peptide hormone GO:0043434 127 0.013
extracellular matrix dependent thymocyte migration GO:0072680 1 0.013
developmental maturation GO:0021700 193 0.013
multicellular organismal homeostasis GO:0048871 164 0.013
regulation of neural retina development GO:0061074 3 0.013
ear development GO:0043583 200 0.013
cellular protein complex assembly GO:0043623 116 0.013
response to molecule of bacterial origin GO:0002237 143 0.013
cardiac muscle cell differentiation GO:0055007 69 0.013
covalent chromatin modification GO:0016569 163 0.013
cellular response to organonitrogen compound GO:0071417 145 0.013
cognition GO:0050890 149 0.013
cofactor transport GO:0051181 4 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.013
regulation of cellular ketone metabolic process GO:0010565 66 0.013
anatomical structure homeostasis GO:0060249 145 0.013
interspecies interaction between organisms GO:0044419 83 0.013
cellular response to carbohydrate stimulus GO:0071322 50 0.013
transepithelial chloride transport GO:0030321 4 0.013
ossification GO:0001503 216 0.013
male sex differentiation GO:0046661 109 0.013
immune effector process GO:0002252 321 0.013
single organism cell adhesion GO:0098602 156 0.013
regulation of eosinophil migration GO:2000416 2 0.012
tissue homeostasis GO:0001894 115 0.012
meiotic nuclear division GO:0007126 115 0.012
negative regulation of cell development GO:0010721 169 0.012
mitral valve development GO:0003174 4 0.012
positive regulation of programmed cell death GO:0043068 218 0.012
positive regulation of membrane protein ectodomain proteolysis GO:0051044 3 0.012
chromatin modification GO:0016568 187 0.012
protein processing GO:0016485 163 0.012
cytokine production GO:0001816 319 0.012
regulation of monocyte chemotaxis GO:0090025 3 0.012
regulation of cell adhesion GO:0030155 154 0.012
positive regulation of apoptotic process GO:0043065 217 0.012
response to nutrient levels GO:0031667 109 0.012
stimulatory c type lectin receptor signaling pathway GO:0002223 2 0.012
response to monosaccharide GO:0034284 67 0.012
multi multicellular organism process GO:0044706 109 0.012
sperm egg recognition GO:0035036 37 0.012
chromatin organization GO:0006325 206 0.012
cellular amine metabolic process GO:0044106 44 0.012
divalent inorganic cation transport GO:0072511 178 0.011
negative regulation of homeostatic process GO:0032845 71 0.011
coagulation GO:0050817 78 0.011
regulation of complement activation classical pathway GO:0030450 1 0.011
regulation of cellular catabolic process GO:0031329 242 0.011
response to oxidative stress GO:0006979 123 0.011
regulation of protein transport GO:0051223 163 0.011
cellular response to gonadotropin stimulus GO:0071371 4 0.011
skeletal muscle cell differentiation GO:0035914 66 0.011
respiratory tube development GO:0030323 167 0.011
sclerotome development GO:0061056 4 0.011
positive regulation of homeostatic process GO:0032846 64 0.011
negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 2 0.011
ameboidal type cell migration GO:0001667 128 0.011
positive regulation of response to wounding GO:1903036 66 0.011
nuclear division GO:0000280 158 0.011
transmission of nerve impulse GO:0019226 76 0.011
regulation of binding GO:0051098 111 0.011
regulation of hormone levels GO:0010817 211 0.011
positive regulation of protein kinase b signaling GO:0051897 32 0.011
cellular response to external stimulus GO:0071496 88 0.011
regulation of mapk cascade GO:0043408 248 0.011
regulation of organ morphogenesis GO:2000027 144 0.011
negative regulation of intracellular signal transduction GO:1902532 167 0.011
compound eye development GO:0048749 1 0.011
limb development GO:0060173 166 0.011
negative regulation of nervous system development GO:0051961 156 0.011
regulation of secretion by cell GO:1903530 249 0.011
mitochondrion organization GO:0007005 134 0.011
regulation of auditory receptor cell differentiation GO:0045607 4 0.011
epithelial cell proliferation GO:0050673 174 0.010
asymmetric stem cell division GO:0098722 3 0.010
trachea cartilage morphogenesis GO:0060535 4 0.010
dephosphorylation GO:0016311 129 0.010
hepaticobiliary system development GO:0061008 67 0.010
hemostasis GO:0007599 78 0.010
cellular response to peptide hormone stimulus GO:0071375 92 0.010
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.010
pallium development GO:0021543 120 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.010
regulation of body fluid levels GO:0050878 162 0.010
calcium ion transport GO:0006816 159 0.010
lymphocyte mediated immunity GO:0002449 139 0.010
maintenance of location GO:0051235 89 0.010
regulation of cytoskeleton organization GO:0051493 122 0.010

Adam5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.034
musculoskeletal system disease DOID:17 0 0.034
nervous system disease DOID:863 0 0.031
bone disease DOID:0080001 0 0.017
connective tissue disease DOID:65 0 0.017