Mus musculus

0 known processes

Top3a

topoisomerase (DNA) III alpha

(Aliases: MGC106383)

Top3a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 0.170
Human Worm
regulation of cell cycle GO:0051726 281 0.055
nuclear division GO:0000280 158 0.055
Worm
apoptotic signaling pathway GO:0097190 306 0.044
transmembrane transport GO:0055085 412 0.041
cellular response to dna damage stimulus GO:0006974 207 0.039
lymphocyte differentiation GO:0030098 242 0.039
purine ribonucleotide metabolic process GO:0009150 290 0.037
leukocyte differentiation GO:0002521 342 0.037
purine nucleotide metabolic process GO:0006163 302 0.034
glycosyl compound catabolic process GO:1901658 206 0.034
male gamete generation GO:0048232 285 0.033
rna processing GO:0006396 105 0.033
meiotic cell cycle GO:0051321 122 0.032
Worm
immune effector process GO:0002252 321 0.031
dna repair GO:0006281 107 0.030
positive regulation of cell death GO:0010942 224 0.030
regulation of mapk cascade GO:0043408 248 0.029
cellular amino acid metabolic process GO:0006520 103 0.029
dna recombination GO:0006310 92 0.028
nucleobase containing small molecule metabolic process GO:0055086 352 0.028
cellular macromolecule catabolic process GO:0044265 206 0.028
protein modification by small protein conjugation or removal GO:0070647 207 0.027
purine containing compound metabolic process GO:0072521 311 0.027
organophosphate catabolic process GO:0046434 232 0.027
chromatin organization GO:0006325 206 0.027
heterocycle catabolic process GO:0046700 280 0.027
cytoplasmic transport GO:0016482 234 0.027
protein processing GO:0016485 163 0.027
double strand break repair GO:0006302 48 0.027
meiotic nuclear division GO:0007126 115 0.027
Worm
negative regulation of protein metabolic process GO:0051248 282 0.026
ribonucleoside metabolic process GO:0009119 245 0.026
aromatic compound catabolic process GO:0019439 286 0.026
ribonucleotide metabolic process GO:0009259 291 0.026
organelle fission GO:0048285 170 0.025
Worm
purine ribonucleotide catabolic process GO:0009154 208 0.025
protein localization to organelle GO:0033365 185 0.025
positive regulation of apoptotic process GO:0043065 217 0.025
nucleoside triphosphate catabolic process GO:0009143 205 0.025
purine nucleoside catabolic process GO:0006152 205 0.025
purine containing compound catabolic process GO:0072523 213 0.025
digestive tract morphogenesis GO:0048546 147 0.024
b cell activation GO:0042113 161 0.024
regulation of organelle organization GO:0033043 289 0.024
negative regulation of cellular protein metabolic process GO:0032269 247 0.024
regulation of cell activation GO:0050865 289 0.023
positive regulation of programmed cell death GO:0043068 218 0.023
t cell activation GO:0042110 289 0.023
cellular ketone metabolic process GO:0042180 84 0.023
fucosylation GO:0036065 9 0.023
maintenance of location GO:0051235 89 0.023
purine nucleoside metabolic process GO:0042278 241 0.023
nucleoside phosphate catabolic process GO:1901292 222 0.022
male meiosis GO:0007140 37 0.022
regulation of proteolysis GO:0030162 164 0.022
organic cyclic compound catabolic process GO:1901361 295 0.022
mitotic cell cycle GO:0000278 195 0.022
nucleoside metabolic process GO:0009116 246 0.022
reactive oxygen species metabolic process GO:0072593 84 0.022
cytokine production GO:0001816 319 0.022
glycosyl compound metabolic process GO:1901657 246 0.022
posttranscriptional regulation of gene expression GO:0010608 155 0.022
intracellular protein transport GO:0006886 204 0.022
mitotic cell cycle process GO:1903047 159 0.022
regulation of cellular ketone metabolic process GO:0010565 66 0.022
nucleoside catabolic process GO:0009164 206 0.022
cellularization GO:0007349 1 0.022
nucleotide metabolic process GO:0009117 332 0.021
purine nucleotide catabolic process GO:0006195 211 0.021
cellular nitrogen compound catabolic process GO:0044270 280 0.021
nucleoside triphosphate metabolic process GO:0009141 230 0.021
germ cell development GO:0007281 185 0.021
Worm
anatomical structure homeostasis GO:0060249 145 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.021
rna splicing GO:0008380 54 0.021
macromolecule catabolic process GO:0009057 281 0.021
mapk cascade GO:0000165 281 0.020
nucleoside phosphate metabolic process GO:0006753 338 0.020
spermatid development GO:0007286 108 0.020
regulation of apoptotic signaling pathway GO:2001233 197 0.020
positive regulation of cellular amine metabolic process GO:0033240 5 0.020
chromatin modification GO:0016568 187 0.020
leukocyte mediated immunity GO:0002443 174 0.020
mrna metabolic process GO:0016071 84 0.020
mrna processing GO:0006397 63 0.020
regulation of cytokine production GO:0001817 266 0.020
ribonucleoside triphosphate catabolic process GO:0009203 199 0.020
ribose phosphate metabolic process GO:0019693 291 0.020
regulation of hydrolase activity GO:0051336 246 0.020
meiotic cell cycle process GO:1903046 77 0.020
regulation of cysteine type endopeptidase activity GO:2000116 65 0.020
meiosis i GO:0007127 60 0.020
carbohydrate derivative catabolic process GO:1901136 231 0.019
regulation of lymphocyte activation GO:0051249 240 0.019
nucleocytoplasmic transport GO:0006913 139 0.019
methylation GO:0032259 134 0.019
oocyte construction GO:0007308 2 0.018
digestive system development GO:0055123 200 0.018
microtubule based process GO:0007017 236 0.018
protein maturation GO:0051604 176 0.018
purine ribonucleoside metabolic process GO:0046128 241 0.018
macromolecule methylation GO:0043414 120 0.018
development of primary sexual characteristics GO:0045137 143 0.017
positive regulation of protein phosphorylation GO:0001934 242 0.017
ribonucleoside triphosphate metabolic process GO:0009199 220 0.017
dephosphorylation GO:0016311 129 0.017
response to molecule of bacterial origin GO:0002237 143 0.017
regulation of kinase activity GO:0043549 249 0.017
organelle localization GO:0051640 179 0.017
compound eye development GO:0048749 1 0.017
sensory organ morphogenesis GO:0090596 242 0.016
innate immune response GO:0045087 157 0.016
response to lipopolysaccharide GO:0032496 128 0.016
nuclear transport GO:0051169 139 0.016
regulation of transferase activity GO:0051338 263 0.016
positive regulation of endopeptidase activity GO:0010950 43 0.016
nuclear import GO:0051170 95 0.016
ribonucleoside catabolic process GO:0042454 206 0.016
purine nucleoside triphosphate metabolic process GO:0009144 226 0.016
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.016
bone development GO:0060348 120 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.016
purine nucleoside triphosphate catabolic process GO:0009146 203 0.016
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.016
regulation of cellular response to stress GO:0080135 159 0.016
oocyte axis specification GO:0007309 2 0.015
positive regulation of protein modification process GO:0031401 299 0.015
intrinsic apoptotic signaling pathway GO:0097193 132 0.015
blastocyst development GO:0001824 80 0.015
positive regulation of protein kinase activity GO:0045860 144 0.015
regulation of binding GO:0051098 111 0.015
progesterone metabolic process GO:0042448 4 0.015
negative regulation of proteolysis GO:0045861 74 0.015
regulation of cell cycle process GO:0010564 160 0.015
negative regulation of molecular function GO:0044092 258 0.015
retina development in camera type eye GO:0060041 119 0.015
rna splicing via transesterification reactions GO:0000375 43 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.015
cation transmembrane transport GO:0098655 266 0.015
ribonucleotide catabolic process GO:0009261 208 0.015
regulation of protein processing GO:0070613 96 0.015
small molecule biosynthetic process GO:0044283 132 0.015
gonad development GO:0008406 141 0.015
nitrogen compound transport GO:0071705 271 0.015
regulation of cell cycle phase transition GO:1901987 77 0.015
regulation of endopeptidase activity GO:0052548 89 0.014
ion transmembrane transport GO:0034220 361 0.014
regulation of mitotic cell cycle phase transition GO:1901990 73 0.014
rhythmic process GO:0048511 174 0.014
microtubule cytoskeleton organization GO:0000226 157 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.014
respiratory tube development GO:0030323 167 0.014
cation transport GO:0006812 399 0.014
small gtpase mediated signal transduction GO:0007264 97 0.014
regulation of lymphocyte proliferation GO:0050670 117 0.014
modification dependent protein catabolic process GO:0019941 133 0.014
negative regulation of cellular component organization GO:0051129 194 0.014
spermatogenesis GO:0007283 284 0.014
purine ribonucleoside catabolic process GO:0046130 205 0.014
single organism nuclear import GO:1902593 95 0.014
camera type eye development GO:0043010 266 0.014
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.014
regulation of multi organism process GO:0043900 111 0.014
inorganic ion transmembrane transport GO:0098660 234 0.014
carboxylic acid biosynthetic process GO:0046394 86 0.013
negative regulation of organelle organization GO:0010639 90 0.013
membrane organization GO:0061024 245 0.013
skeletal system development GO:0001501 356 0.013
cilium morphogenesis GO:0060271 102 0.013
rna interference GO:0016246 2 0.013
negative regulation of immune system process GO:0002683 209 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.013
cellular amine metabolic process GO:0044106 44 0.013
interleukin 8 production GO:0032637 4 0.013
mesodermal cell migration GO:0008078 4 0.013
organonitrogen compound catabolic process GO:1901565 264 0.013
regulation of lymphocyte mediated immunity GO:0002706 84 0.013
positive regulation of lymphocyte activation GO:0051251 140 0.013
fertilization GO:0009566 127 0.013
ribonucleoside monophosphate metabolic process GO:0009161 80 0.013
homeostasis of number of cells GO:0048872 210 0.013
regulation of reactive oxygen species metabolic process GO:2000377 40 0.013
ribonucleoprotein complex subunit organization GO:0071826 28 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.012
respiratory system development GO:0060541 190 0.012
intracellular mrna localization GO:0008298 4 0.012
atp catabolic process GO:0006200 55 0.012
mrna splicing via spliceosome GO:0000398 43 0.012
endocytosis GO:0006897 168 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.012
regulation of protein kinase activity GO:0045859 232 0.012
positive regulation of transferase activity GO:0051347 167 0.012
cellular protein complex assembly GO:0043623 116 0.012
lipid localization GO:0010876 126 0.012
stem cell differentiation GO:0048863 268 0.012
regulation of protein maturation GO:1903317 96 0.012
chromosome segregation GO:0007059 48 0.012
spermatid differentiation GO:0048515 115 0.012
cellular response to lipid GO:0071396 145 0.012
response to organic cyclic compound GO:0014070 198 0.012
regulation of mitotic cell cycle GO:0007346 126 0.012
response to organonitrogen compound GO:0010243 246 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.012
nucleotide catabolic process GO:0009166 217 0.012
protein localization to nucleus GO:0034504 121 0.012
regulation of cellular catabolic process GO:0031329 242 0.012
regulation of purine nucleotide metabolic process GO:1900542 169 0.012
positive regulation of cell activation GO:0050867 158 0.012
regulation of protein transport GO:0051223 163 0.012
establishment of protein localization to organelle GO:0072594 118 0.012
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.012
cilium assembly GO:0042384 81 0.012
cellular response to lipopolysaccharide GO:0071222 77 0.011
organelle assembly GO:0070925 177 0.011
nucleoside monophosphate catabolic process GO:0009125 59 0.011
protein ubiquitination GO:0016567 171 0.011
regulation of membrane potential GO:0042391 192 0.011
negative regulation of apoptotic signaling pathway GO:2001234 104 0.011
regulation of cellular amine metabolic process GO:0033238 20 0.011
multicellular organismal homeostasis GO:0048871 164 0.011
organonitrogen compound biosynthetic process GO:1901566 192 0.011
cellular response to biotic stimulus GO:0071216 92 0.011
regulation of cell cell adhesion mediated by cadherin GO:2000047 2 0.011
protein import GO:0017038 101 0.011
glucose metabolic process GO:0006006 92 0.011
protein modification by small protein conjugation GO:0032446 187 0.011
developmental maturation GO:0021700 193 0.011
signal transduction involved in dna damage checkpoint GO:0072422 3 0.011
lipid biosynthetic process GO:0008610 179 0.011
positive regulation of hydrolase activity GO:0051345 148 0.011
myeloid cell differentiation GO:0030099 233 0.011
regulation of b cell activation GO:0050864 81 0.011
ribonucleoprotein complex disassembly GO:0032988 3 0.011
negative regulation of phosphorylation GO:0042326 166 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.011
positive regulation of mapk cascade GO:0043410 170 0.011
b cell differentiation GO:0030183 78 0.011
oocyte anterior posterior axis specification GO:0007314 2 0.011
oxidation reduction process GO:0055114 342 0.010
immunoglobulin production GO:0002377 73 0.010
response to inorganic substance GO:0010035 96 0.010
ossification GO:0001503 216 0.010
regionalization GO:0003002 337 0.010
activation of immune response GO:0002253 138 0.010
regulation of leukocyte differentiation GO:1902105 159 0.010
positive regulation of nervous system development GO:0051962 221 0.010
response to radiation GO:0009314 165 0.010
myeloid cell homeostasis GO:0002262 114 0.010
regulation of neuron differentiation GO:0045664 281 0.010
lymphocyte mediated immunity GO:0002449 139 0.010
maternal determination of anterior posterior axis embryo GO:0008358 2 0.010
ribonucleoside monophosphate catabolic process GO:0009158 57 0.010
blood circulation GO:0008015 195 0.010
organic hydroxy compound metabolic process GO:1901615 203 0.010
purine nucleoside monophosphate metabolic process GO:0009126 81 0.010
positive regulation of proteolysis GO:0045862 85 0.010
purine nucleoside monophosphate catabolic process GO:0009128 58 0.010
molting cycle GO:0042303 90 0.010
male meiosis i GO:0007141 16 0.010
sensory perception GO:0007600 245 0.010
negative regulation of cell size GO:0045792 3 0.010
monocarboxylic acid metabolic process GO:0032787 191 0.010
leukocyte proliferation GO:0070661 172 0.010

Top3a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.026
cancer DOID:162 0 0.025
disease of cellular proliferation DOID:14566 0 0.025
organ system cancer DOID:0050686 0 0.024
musculoskeletal system disease DOID:17 0 0.019
disease of metabolism DOID:0014667 0 0.018
inherited metabolic disorder DOID:655 0 0.018
immune system disease DOID:2914 0 0.018
hematopoietic system disease DOID:74 0 0.018
retinal disease DOID:5679 0 0.015
sensory system disease DOID:0050155 0 0.015
eye and adnexa disease DOID:1492 0 0.015
eye disease DOID:5614 0 0.015
kidney cancer DOID:263 0 0.014
urinary system cancer DOID:3996 0 0.014
renal cell carcinoma DOID:4450 0 0.014
renal carcinoma DOID:4451 0 0.014
retinal degeneration DOID:8466 0 0.013
central nervous system disease DOID:331 0 0.010