Mus musculus

5 known processes

Top3b

topoisomerase (DNA) III beta

Top3b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 207 0.085
regulation of cellular ketone metabolic process GO:0010565 66 0.082
dna repair GO:0006281 107 0.073
cilium morphogenesis GO:0060271 102 0.066
protein processing GO:0016485 163 0.063
dna metabolic process GO:0006259 303 0.060
cytoplasmic transport GO:0016482 234 0.058
cilium assembly GO:0042384 81 0.052
cellular ketone metabolic process GO:0042180 84 0.052
cellular amine metabolic process GO:0044106 44 0.048
amine metabolic process GO:0009308 45 0.048
regulation of cellular amino acid metabolic process GO:0006521 5 0.047
purine nucleoside triphosphate catabolic process GO:0009146 203 0.043
regulation of cell cycle GO:0051726 281 0.041
positive regulation of cellular amine metabolic process GO:0033240 5 0.039
regulation of mitotic cell cycle GO:0007346 126 0.038
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.038
cellular amino acid metabolic process GO:0006520 103 0.038
heterocycle catabolic process GO:0046700 280 0.035
cellular macromolecule catabolic process GO:0044265 206 0.034
positive regulation of apoptotic process GO:0043065 217 0.034
regulation of organelle organization GO:0033043 289 0.034
protein maturation GO:0051604 176 0.032
intracellular protein transport GO:0006886 204 0.031
macromolecule catabolic process GO:0009057 281 0.030
microtubule based process GO:0007017 236 0.029
regulation of proteolysis GO:0030162 164 0.029
cellular nitrogen compound catabolic process GO:0044270 280 0.029
aromatic compound catabolic process GO:0019439 286 0.028
appendage development GO:0048736 166 0.028
regulation of cellular amine metabolic process GO:0033238 20 0.028
viral gene expression GO:0019080 3 0.027
oocyte construction GO:0007308 2 0.026
ribonucleotide metabolic process GO:0009259 291 0.026
positive regulation of protein phosphorylation GO:0001934 242 0.026
nucleoside phosphate metabolic process GO:0006753 338 0.025
organic cyclic compound catabolic process GO:1901361 295 0.025
chromatin organization GO:0006325 206 0.024
cellular component assembly involved in morphogenesis GO:0010927 139 0.024
skeletal system development GO:0001501 356 0.024
positive regulation of cell death GO:0010942 224 0.024
nitrogen compound transport GO:0071705 271 0.024
peptidyl amino acid modification GO:0018193 336 0.024
positive regulation of viral entry into host cell GO:0046598 3 0.023
immune effector process GO:0002252 321 0.023
nuclear division GO:0000280 158 0.023
carbohydrate derivative biosynthetic process GO:1901137 183 0.023
negative regulation of cell development GO:0010721 169 0.022
ras protein signal transduction GO:0007265 77 0.022
small gtpase mediated signal transduction GO:0007264 97 0.021
negative regulation of cellular component organization GO:0051129 194 0.021
regulation of apoptotic signaling pathway GO:2001233 197 0.021
apoptotic signaling pathway GO:0097190 306 0.020
mitotic cell cycle GO:0000278 195 0.020
innate immune response GO:0045087 157 0.020
transmembrane transport GO:0055085 412 0.020
protein localization to organelle GO:0033365 185 0.020
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.020
organelle assembly GO:0070925 177 0.020
purine nucleoside triphosphate metabolic process GO:0009144 226 0.020
regulation of cell cycle process GO:0010564 160 0.019
negative regulation of protein metabolic process GO:0051248 282 0.019
glycerolipid metabolic process GO:0046486 122 0.019
positive regulation of programmed cell death GO:0043068 218 0.019
asymmetric neuroblast division GO:0055059 1 0.019
regulation of cellular component biogenesis GO:0044087 181 0.018
nucleotide catabolic process GO:0009166 217 0.018
positive regulation of protein modification process GO:0031401 299 0.018
regulation of actin nucleation GO:0051125 4 0.018
regulation of hydrolase activity GO:0051336 246 0.017
purine nucleotide catabolic process GO:0006195 211 0.017
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.017
response to radiation GO:0009314 165 0.017
synaptic transmission GO:0007268 329 0.017
purine ribonucleotide catabolic process GO:0009154 208 0.017
smoothened signaling pathway GO:0007224 105 0.017
cell type specific apoptotic process GO:0097285 268 0.017
mitotic cell cycle process GO:1903047 159 0.017
chromatin modification GO:0016568 187 0.017
glycosyl compound metabolic process GO:1901657 246 0.017
microtubule cytoskeleton organization GO:0000226 157 0.017
germ cell development GO:0007281 185 0.016
asymmetric stem cell division GO:0098722 3 0.016
cytokine production GO:0001816 319 0.016
inorganic cation transmembrane transport GO:0098662 207 0.016
purine ribonucleotide metabolic process GO:0009150 290 0.016
spermatogenesis GO:0007283 284 0.016
carbohydrate derivative catabolic process GO:1901136 231 0.016
striated muscle tissue development GO:0014706 293 0.016
regionalization GO:0003002 337 0.016
establishment of organelle localization GO:0051656 122 0.016
organonitrogen compound biosynthetic process GO:1901566 192 0.016
negative regulation of dna templated transcription elongation GO:0032785 6 0.016
nucleoside triphosphate metabolic process GO:0009141 230 0.016
organelle localization GO:0051640 179 0.016
response to growth factor GO:0070848 198 0.016
regulation of protein complex assembly GO:0043254 83 0.016
cation transmembrane transport GO:0098655 266 0.016
glycosyl compound catabolic process GO:1901658 206 0.015
regulation of secretion GO:0051046 274 0.015
organelle fission GO:0048285 170 0.015
spermatid development GO:0007286 108 0.015
protein targeting GO:0006605 143 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.015
maternal determination of anterior posterior axis embryo GO:0008358 2 0.015
cellular homeostasis GO:0019725 240 0.015
appendage morphogenesis GO:0035107 149 0.015
anatomical structure homeostasis GO:0060249 145 0.015
ribonucleotide catabolic process GO:0009261 208 0.015
oocyte axis specification GO:0007309 2 0.015
muscle tissue development GO:0060537 308 0.015
cation transport GO:0006812 399 0.015
ribonucleoside triphosphate metabolic process GO:0009199 220 0.015
organonitrogen compound catabolic process GO:1901565 264 0.015
posttranscriptional regulation of gene expression GO:0010608 155 0.015
digestive system development GO:0055123 200 0.015
response to molecule of bacterial origin GO:0002237 143 0.015
establishment of protein localization to organelle GO:0072594 118 0.015
mrna metabolic process GO:0016071 84 0.015
purine nucleoside metabolic process GO:0042278 241 0.015
multicellular organism growth GO:0035264 161 0.015
exocytosis GO:0006887 121 0.015
purine nucleotide metabolic process GO:0006163 302 0.014
negative regulation of cell proliferation GO:0008285 296 0.014
sensory perception GO:0007600 245 0.014
compound eye development GO:0048749 1 0.014
carbohydrate metabolic process GO:0005975 230 0.014
telomere maintenance GO:0000723 19 0.014
purine ribonucleoside metabolic process GO:0046128 241 0.014
nuclear transport GO:0051169 139 0.014
cellular protein catabolic process GO:0044257 155 0.014
ribonucleoside catabolic process GO:0042454 206 0.014
purine containing compound metabolic process GO:0072521 311 0.014
macromolecule methylation GO:0043414 120 0.014
nucleobase containing small molecule metabolic process GO:0055086 352 0.014
regulation of cytoskeleton organization GO:0051493 122 0.014
negative regulation of nlrp3 inflammasome complex assembly GO:1900226 2 0.014
dna replication GO:0006260 52 0.014
cellular protein complex assembly GO:0043623 116 0.014
positive regulation of viral genome replication GO:0045070 2 0.013
protein modification by small protein conjugation or removal GO:0070647 207 0.013
nucleotide excision repair GO:0006289 13 0.013
muscle cell differentiation GO:0042692 261 0.013
purine containing compound catabolic process GO:0072523 213 0.013
nucleotide metabolic process GO:0009117 332 0.013
atp metabolic process GO:0046034 75 0.013
inorganic ion transmembrane transport GO:0098660 234 0.013
wnt signaling pathway GO:0016055 188 0.013
regulation of secretion by cell GO:1903530 249 0.013
oocyte anterior posterior axis specification GO:0007314 2 0.013
morphogenesis of embryonic epithelium GO:0016331 159 0.013
organophosphate catabolic process GO:0046434 232 0.013
mitochondrion organization GO:0007005 134 0.013
regulation of cytokine production GO:0001817 266 0.013
positive regulation of tor signaling GO:0032008 3 0.013
positive regulation of organelle organization GO:0010638 128 0.013
actin filament polymerization GO:0030041 44 0.013
protein ubiquitination GO:0016567 171 0.013
glycerophospholipid metabolic process GO:0006650 71 0.013
purine nucleoside catabolic process GO:0006152 205 0.013
reactive oxygen species metabolic process GO:0072593 84 0.013
modification dependent macromolecule catabolic process GO:0043632 133 0.012
purine ribonucleoside catabolic process GO:0046130 205 0.012
carbohydrate homeostasis GO:0033500 128 0.012
response to organonitrogen compound GO:0010243 246 0.012
nucleoside monophosphate catabolic process GO:0009125 59 0.012
acetylcholine transport GO:0015870 2 0.012
response to acid chemical GO:0001101 111 0.012
nucleoside triphosphate catabolic process GO:0009143 205 0.012
skin development GO:0043588 220 0.012
cellular response to biotic stimulus GO:0071216 92 0.012
positive regulation of transferase activity GO:0051347 167 0.012
viral transcription GO:0019083 3 0.012
nucleoside phosphate catabolic process GO:1901292 222 0.012
regulation of peptide transport GO:0090087 91 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.012
regulation of vesicle mediated transport GO:0060627 139 0.012
defecation GO:0030421 1 0.012
negative regulation of organelle organization GO:0010639 90 0.012
positive regulation of hydrolase activity GO:0051345 148 0.012
regulation of chromosome organization GO:0033044 83 0.012
localization within membrane GO:0051668 4 0.012
regulation of membrane potential GO:0042391 192 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
sequestering of calcium ion GO:0051208 18 0.012
cellular response to organonitrogen compound GO:0071417 145 0.012
regulation of cellular response to stress GO:0080135 159 0.012
developmental maturation GO:0021700 193 0.012
modification dependent protein catabolic process GO:0019941 133 0.012
gland development GO:0048732 330 0.012
nucleoside catabolic process GO:0009164 206 0.012
methylation GO:0032259 134 0.012
ribonucleoside triphosphate catabolic process GO:0009203 199 0.011
extrinsic apoptotic signaling pathway GO:0097191 126 0.011
divalent inorganic cation transport GO:0072511 178 0.011
positive regulation of proteolysis GO:0045862 85 0.011
protein modification by small protein conjugation GO:0032446 187 0.011
action potential GO:0001508 78 0.011
stem cell differentiation GO:0048863 268 0.011
regulation of protein maturation GO:1903317 96 0.011
regulation of smoothened signaling pathway GO:0008589 58 0.011
regulation of exocytosis GO:0017157 61 0.011
regulation of protein processing GO:0070613 96 0.011
negative regulation of viral transcription GO:0032897 3 0.011
regulation of mapk cascade GO:0043408 248 0.011
homeostasis of number of cells GO:0048872 210 0.011
neuron death GO:0070997 154 0.011
limb development GO:0060173 166 0.011
cell maturation GO:0048469 127 0.011
regulation of cell projection organization GO:0031344 206 0.011
lipid biosynthetic process GO:0008610 179 0.011
ion transmembrane transport GO:0034220 361 0.011
protein polymerization GO:0051258 57 0.011
response to oxygen levels GO:0070482 62 0.011
peptide transport GO:0015833 133 0.011
nucleoside metabolic process GO:0009116 246 0.011
b cell activation GO:0042113 161 0.011
negative regulation of nervous system development GO:0051961 156 0.011
purine nucleoside monophosphate metabolic process GO:0009126 81 0.011
nucleoside monophosphate metabolic process GO:0009123 85 0.011
interleukin 8 production GO:0032637 4 0.011
sensory system development GO:0048880 3 0.010
digestive tract development GO:0048565 190 0.010
forebrain development GO:0030900 302 0.010
regulation of transferase activity GO:0051338 263 0.010
embryonic organ morphogenesis GO:0048562 276 0.010
response to lipopolysaccharide GO:0032496 128 0.010
negative regulation of intracellular signal transduction GO:1902532 167 0.010
cellular response to peptide GO:1901653 92 0.010
negative regulation of cytokine production GO:0001818 84 0.010
rna processing GO:0006396 105 0.010
amide transport GO:0042886 138 0.010
stem cell maintenance GO:0019827 130 0.010
negative regulation of cellular protein metabolic process GO:0032269 247 0.010
protein catabolic process GO:0030163 221 0.010
fat cell differentiation GO:0045444 160 0.010
double strand break repair via homologous recombination GO:0000724 21 0.010
sequestering of metal ion GO:0051238 19 0.010
regulation of binding GO:0051098 111 0.010
leukocyte differentiation GO:0002521 342 0.010
regulation of protein transport GO:0051223 163 0.010
establishment or maintenance of cell polarity GO:0007163 86 0.010
regulation of homeostatic process GO:0032844 182 0.010
organophosphate biosynthetic process GO:0090407 122 0.010
locomotory behavior GO:0007626 195 0.010
atp catabolic process GO:0006200 55 0.010
synapsis GO:0007129 34 0.010
actin cytoskeleton organization GO:0030036 220 0.010

Top3b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.029
nervous system disease DOID:863 0 0.029
immune system disease DOID:2914 0 0.024
hematopoietic system disease DOID:74 0 0.024
central nervous system disease DOID:331 0 0.022
disease of metabolism DOID:0014667 0 0.013
inherited metabolic disorder DOID:655 0 0.013
sensory system disease DOID:0050155 0 0.011
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011
retinal disease DOID:5679 0 0.011
retinal degeneration DOID:8466 0 0.011
carbohydrate metabolic disorder DOID:2978 0 0.011
brain disease DOID:936 0 0.010