Mus musculus

0 known processes

Letm1

leucine zipper-EF-hand containing transmembrane protein 1

Letm1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 103 0.067
nucleoside phosphate metabolic process GO:0006753 338 0.065
regulation of cellular ketone metabolic process GO:0010565 66 0.064
transmembrane transport GO:0055085 412 0.060
Fly
cellular amine metabolic process GO:0044106 44 0.057
nucleotide metabolic process GO:0009117 332 0.056
ribose phosphate metabolic process GO:0019693 291 0.054
cation transport GO:0006812 399 0.053
Yeast Fly
nucleobase containing small molecule metabolic process GO:0055086 352 0.053
synaptic transmission GO:0007268 329 0.052
Fly
regulation of cellular amino acid metabolic process GO:0006521 5 0.051
purine ribonucleotide metabolic process GO:0009150 290 0.049
cellular homeostasis GO:0019725 240 0.048
Yeast
ribonucleoside metabolic process GO:0009119 245 0.048
response to organonitrogen compound GO:0010243 246 0.048
cellular nitrogen compound catabolic process GO:0044270 280 0.047
oxidation reduction process GO:0055114 342 0.046
purine containing compound metabolic process GO:0072521 311 0.045
heterocycle catabolic process GO:0046700 280 0.045
membrane organization GO:0061024 245 0.045
Human Yeast
positive regulation of cellular amine metabolic process GO:0033240 5 0.044
amine metabolic process GO:0009308 45 0.043
cation homeostasis GO:0055080 212 0.043
Yeast
organonitrogen compound catabolic process GO:1901565 264 0.043
endomembrane system organization GO:0010256 147 0.042
lipid biosynthetic process GO:0008610 179 0.041
cellular ketone metabolic process GO:0042180 84 0.041
regulation of cellular amine metabolic process GO:0033238 20 0.040
organic cyclic compound catabolic process GO:1901361 295 0.040
protein localization to organelle GO:0033365 185 0.040
Yeast
intracellular protein transport GO:0006886 204 0.039
purine nucleotide metabolic process GO:0006163 302 0.039
glycosyl compound metabolic process GO:1901657 246 0.038
regulation of neuron differentiation GO:0045664 281 0.036
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.036
purine ribonucleoside metabolic process GO:0046128 241 0.035
aromatic compound catabolic process GO:0019439 286 0.034
organonitrogen compound biosynthetic process GO:1901566 192 0.034
ribonucleotide metabolic process GO:0009259 291 0.034
cellular lipid metabolic process GO:0044255 323 0.034
cellular chemical homeostasis GO:0055082 215 0.034
Yeast
organophosphate catabolic process GO:0046434 232 0.033
peptidyl amino acid modification GO:0018193 336 0.032
protein localization to membrane GO:0072657 108 0.032
Yeast
regulation of cell motility GO:2000145 236 0.032
ion transmembrane transport GO:0034220 361 0.032
Fly
nucleoside triphosphate catabolic process GO:0009143 205 0.032
ribonucleoside triphosphate metabolic process GO:0009199 220 0.032
nucleotide catabolic process GO:0009166 217 0.031
nucleoside phosphate catabolic process GO:1901292 222 0.031
purine nucleoside metabolic process GO:0042278 241 0.030
purine nucleotide catabolic process GO:0006195 211 0.030
monocarboxylic acid metabolic process GO:0032787 191 0.030
cellular metal ion homeostasis GO:0006875 151 0.029
Yeast
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.029
nucleoside catabolic process GO:0009164 206 0.028
carbohydrate derivative catabolic process GO:1901136 231 0.027
regulation of organelle organization GO:0033043 289 0.027
Yeast
dephosphorylation GO:0016311 129 0.027
ribonucleoside catabolic process GO:0042454 206 0.027
nucleoside metabolic process GO:0009116 246 0.027
mitochondrion organization GO:0007005 134 0.027
Human Yeast Fly
nitrogen compound transport GO:0071705 271 0.027
muscle cell differentiation GO:0042692 261 0.027
macromolecule catabolic process GO:0009057 281 0.027
regulation of homeostatic process GO:0032844 182 0.027
divalent inorganic cation transport GO:0072511 178 0.027
Fly
fatty acid metabolic process GO:0006631 121 0.026
ras protein signal transduction GO:0007265 77 0.026
purine ribonucleoside catabolic process GO:0046130 205 0.026
nucleoside triphosphate metabolic process GO:0009141 230 0.026
positive regulation of protein phosphorylation GO:0001934 242 0.025
mapk cascade GO:0000165 281 0.025
small gtpase mediated signal transduction GO:0007264 97 0.025
endocytosis GO:0006897 168 0.024
regulation of anatomical structure size GO:0090066 178 0.024
cellular ion homeostasis GO:0006873 165 0.024
Yeast
ribonucleotide catabolic process GO:0009261 208 0.024
protein modification by small protein conjugation GO:0032446 187 0.024
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.024
cytoplasmic transport GO:0016482 234 0.023
positive regulation of cell development GO:0010720 237 0.023
regulation of ion transport GO:0043269 215 0.023
purine containing compound catabolic process GO:0072523 213 0.023
regulation of ion transmembrane transport GO:0034765 119 0.023
purine ribonucleotide catabolic process GO:0009154 208 0.023
positive regulation of transferase activity GO:0051347 167 0.023
carbohydrate metabolic process GO:0005975 230 0.023
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.023
skin development GO:0043588 220 0.022
blood vessel morphogenesis GO:0048514 285 0.022
anion transport GO:0006820 177 0.022
positive regulation of nervous system development GO:0051962 221 0.022
purine nucleoside triphosphate metabolic process GO:0009144 226 0.022
glycosyl compound catabolic process GO:1901658 206 0.022
ribonucleoside triphosphate catabolic process GO:0009203 199 0.022
positive regulation of protein modification process GO:0031401 299 0.022
response to organic cyclic compound GO:0014070 198 0.022
microtubule based process GO:0007017 236 0.022
inorganic ion transmembrane transport GO:0098660 234 0.022
Fly
regulation of transferase activity GO:0051338 263 0.022
muscle tissue development GO:0060537 308 0.022
regulation of cytoskeleton organization GO:0051493 122 0.022
sensory perception GO:0007600 245 0.021
regulation of membrane potential GO:0042391 192 0.021
cation transmembrane transport GO:0098655 266 0.021
Fly
regulation of cell projection organization GO:0031344 206 0.021
forebrain development GO:0030900 302 0.021
divalent inorganic cation homeostasis GO:0072507 138 0.021
nucleocytoplasmic transport GO:0006913 139 0.021
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.021
regulation of cellular component biogenesis GO:0044087 181 0.021
inorganic cation transmembrane transport GO:0098662 207 0.020
Fly
regulation of protein kinase activity GO:0045859 232 0.020
cellular calcium ion homeostasis GO:0006874 119 0.020
amide transport GO:0042886 138 0.020
male gamete generation GO:0048232 285 0.020
cognition GO:0050890 149 0.020
carbohydrate derivative biosynthetic process GO:1901137 183 0.020
regulation of protein localization GO:0032880 231 0.019
cell substrate adhesion GO:0031589 130 0.019
striated muscle tissue development GO:0014706 293 0.019
synapse organization GO:0050808 125 0.019
skeletal system development GO:0001501 356 0.019
cellular response to growth factor stimulus GO:0071363 197 0.019
small molecule biosynthetic process GO:0044283 132 0.019
compound eye development GO:0048749 1 0.019
response to growth factor GO:0070848 198 0.019
regulation of purine nucleotide metabolic process GO:1900542 169 0.019
regulation of establishment of protein localization GO:0070201 181 0.019
negative regulation of cellular protein metabolic process GO:0032269 247 0.019
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.019
regulation of cell migration GO:0030334 219 0.019
calcium ion homeostasis GO:0055074 127 0.019
axonogenesis GO:0007409 274 0.019
maintenance of location GO:0051235 89 0.018
metal ion homeostasis GO:0055065 189 0.018
Yeast
rho protein signal transduction GO:0007266 32 0.018
cofactor metabolic process GO:0051186 80 0.018
regulation of cellular catabolic process GO:0031329 242 0.018
regulation of cellular component size GO:0032535 121 0.018
regulation of intracellular transport GO:0032386 159 0.018
developmental maturation GO:0021700 193 0.018
negative regulation of protein modification process GO:0031400 163 0.018
neuron apoptotic process GO:0051402 142 0.018
response to extracellular stimulus GO:0009991 127 0.018
carboxylic acid biosynthetic process GO:0046394 86 0.018
regulation of kinase activity GO:0043549 249 0.018
neural tube development GO:0021915 160 0.018
regulation of cell adhesion GO:0030155 154 0.018
cellular response to hormone stimulus GO:0032870 150 0.018
action potential GO:0001508 78 0.017
plasma membrane organization GO:0007009 90 0.017
multicellular organismal homeostasis GO:0048871 164 0.017
purine nucleoside catabolic process GO:0006152 205 0.017
purine nucleoside triphosphate catabolic process GO:0009146 203 0.017
placenta development GO:0001890 140 0.017
translation GO:0006412 93 0.017
Yeast
response to radiation GO:0009314 165 0.017
response to light stimulus GO:0009416 135 0.017
regulation of nucleotide metabolic process GO:0006140 169 0.017
negative regulation of molecular function GO:0044092 258 0.017
negative regulation of cellular component organization GO:0051129 194 0.017
cellular response to organonitrogen compound GO:0071417 145 0.017
spermatid differentiation GO:0048515 115 0.017
cell growth GO:0016049 130 0.017
glycerolipid metabolic process GO:0046486 122 0.017
cellular protein complex assembly GO:0043623 116 0.017
regulation of secretion GO:0051046 274 0.017
positive regulation of neuron differentiation GO:0045666 141 0.017
organic acid transport GO:0015849 101 0.017
microtubule cytoskeleton organization GO:0000226 157 0.017
organelle localization GO:0051640 179 0.017
regulation of cell cycle GO:0051726 281 0.017
cell adhesion GO:0007155 329 0.017
positive regulation of protein kinase activity GO:0045860 144 0.017
protein modification by small protein conjugation or removal GO:0070647 207 0.017
positive regulation of mapk cascade GO:0043410 170 0.017
regulation of cell activation GO:0050865 289 0.016
negative regulation of protein metabolic process GO:0051248 282 0.016
inflammatory response GO:0006954 244 0.016
regulation of hormone levels GO:0010817 211 0.016
organelle fission GO:0048285 170 0.016
spermatogenesis GO:0007283 284 0.016
digestive tract morphogenesis GO:0048546 147 0.016
protein targeting GO:0006605 143 0.016
organic hydroxy compound metabolic process GO:1901615 203 0.016
organic anion transport GO:0015711 137 0.016
cellular response to cytokine stimulus GO:0071345 189 0.016
regulation of protein transport GO:0051223 163 0.016
cellular divalent inorganic cation homeostasis GO:0072503 127 0.016
organic acid biosynthetic process GO:0016053 86 0.016
sequestering of calcium ion GO:0051208 18 0.016
gtp catabolic process GO:0006184 143 0.016
mitotic cell cycle GO:0000278 195 0.016
carboxylic acid transport GO:0046942 100 0.016
positive regulation of cell motility GO:2000147 116 0.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.015
regulation of transmembrane transport GO:0034762 128 0.015
reactive oxygen species metabolic process GO:0072593 84 0.015
transmission of nerve impulse GO:0019226 76 0.015
alcohol metabolic process GO:0006066 116 0.015
embryonic organ morphogenesis GO:0048562 276 0.015
oocyte axis specification GO:0007309 2 0.015
digestive system development GO:0055123 200 0.015
adult behavior GO:0030534 135 0.015
g protein coupled receptor signaling pathway GO:0007186 243 0.015
response to inorganic substance GO:0010035 96 0.015
divalent metal ion transport GO:0070838 172 0.015
Fly
neuron death GO:0070997 154 0.015
posttranscriptional regulation of gene expression GO:0010608 155 0.015
Yeast
positive regulation of hydrolase activity GO:0051345 148 0.015
positive regulation of nucleotide metabolic process GO:0045981 114 0.015
negative regulation of cellular amine metabolic process GO:0033239 1 0.015
ear development GO:0043583 200 0.015
fat cell differentiation GO:0045444 160 0.015
regulation of actin cytoskeleton organization GO:0032956 84 0.015
regulation of muscle tissue development GO:1901861 97 0.015
gland development GO:0048732 330 0.015
protein ubiquitination GO:0016567 171 0.014
cellular component assembly involved in morphogenesis GO:0010927 139 0.014
peptidyl tyrosine modification GO:0018212 145 0.014
protein localization to plasma membrane GO:0072659 57 0.014
chromatin organization GO:0006325 206 0.014
camera type eye development GO:0043010 266 0.014
dna metabolic process GO:0006259 303 0.014
nucleoside monophosphate metabolic process GO:0009123 85 0.014
cell type specific apoptotic process GO:0097285 268 0.014
angiogenesis GO:0001525 201 0.014
sensory organ morphogenesis GO:0090596 242 0.014
regulation of secretion by cell GO:1903530 249 0.014
alpha amino acid metabolic process GO:1901605 59 0.014
steroid metabolic process GO:0008202 119 0.014
monosaccharide metabolic process GO:0005996 106 0.014
nuclear transport GO:0051169 139 0.014
regulation of reactive oxygen species metabolic process GO:2000377 40 0.014
regulation of vesicle mediated transport GO:0060627 139 0.014
negative regulation of cell proliferation GO:0008285 296 0.014
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.014
developmental growth involved in morphogenesis GO:0060560 138 0.014
immune effector process GO:0002252 321 0.014
nucleotide biosynthetic process GO:0009165 78 0.014
epithelial tube morphogenesis GO:0060562 303 0.014
energy derivation by oxidation of organic compounds GO:0015980 77 0.014
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.014
regulation of mapk cascade GO:0043408 248 0.014
tube formation GO:0035148 140 0.013
actin cytoskeleton organization GO:0030036 220 0.013
regulation of cytokine production GO:0001817 266 0.013
kidney development GO:0001822 213 0.013
ameboidal type cell migration GO:0001667 128 0.013
skeletal muscle organ development GO:0060538 163 0.013
positive regulation of cell adhesion GO:0045785 80 0.013
calcium ion transport GO:0006816 159 0.013
Fly
urogenital system development GO:0001655 261 0.013
peptide transport GO:0015833 133 0.013
epithelial cell development GO:0002064 159 0.013
ossification GO:0001503 216 0.013
regulation of inflammatory response GO:0050727 147 0.013
homeostasis of number of cells GO:0048872 210 0.013
positive regulation of programmed cell death GO:0043068 218 0.013
positive regulation of cell migration GO:0030335 109 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.013
regulation of system process GO:0044057 200 0.013
apoptotic signaling pathway GO:0097190 306 0.013
response to nutrient levels GO:0031667 109 0.013
glycoprotein metabolic process GO:0009100 116 0.013
microtubule based movement GO:0007018 84 0.013
neutral lipid metabolic process GO:0006638 57 0.013
positive regulation of organelle organization GO:0010638 128 0.013
Yeast
pallium development GO:0021543 120 0.013
locomotory behavior GO:0007626 195 0.013
regulation of metal ion transport GO:0010959 106 0.013
peptidyl tyrosine phosphorylation GO:0018108 143 0.013
morphogenesis of a branching epithelium GO:0061138 193 0.013
microtubule based transport GO:0010970 50 0.013
epidermis development GO:0008544 187 0.013
regulation of ion transmembrane transporter activity GO:0032412 54 0.013
gtp metabolic process GO:0046039 144 0.012
regulation of leukocyte differentiation GO:1902105 159 0.012
lateral inhibition GO:0046331 1 0.012
anatomical structure homeostasis GO:0060249 145 0.012
positive regulation of kinase activity GO:0033674 155 0.012
cellular carbohydrate metabolic process GO:0044262 119 0.012
negative regulation of phosphorus metabolic process GO:0010563 184 0.012
regulation of intracellular protein transport GO:0033157 82 0.012
positive regulation of cellular catabolic process GO:0031331 148 0.012
regulation of hydrolase activity GO:0051336 246 0.012
regulation of defense response GO:0031347 233 0.012
positive regulation of cell activation GO:0050867 158 0.012
t cell activation GO:0042110 289 0.012
neuron migration GO:0001764 122 0.012
multicellular organismal signaling GO:0035637 91 0.012
hexose metabolic process GO:0019318 98 0.012
asymmetric neuroblast division GO:0055059 1 0.012
nuclear division GO:0000280 158 0.012
regulation of feeding behavior GO:0060259 3 0.012
extracellular matrix organization GO:0030198 147 0.012
regulation of neuron apoptotic process GO:0043523 122 0.012
regulation of lipid metabolic process GO:0019216 118 0.012
modification dependent protein catabolic process GO:0019941 133 0.012
regulation of neuron death GO:1901214 134 0.012
negative regulation of neuron death GO:1901215 98 0.012
reactive nitrogen species metabolic process GO:2001057 0 0.012
exocytosis GO:0006887 121 0.012
response to peptide GO:1901652 136 0.012
regulation of transporter activity GO:0032409 57 0.012
chemotaxis GO:0006935 247 0.012
regulation of circadian sleep wake cycle GO:0042749 3 0.012
response to oxidative stress GO:0006979 123 0.012
glycosylation GO:0070085 62 0.012
regulation of actin filament based process GO:0032970 99 0.012
epithelial cell proliferation GO:0050673 174 0.012
cellularization GO:0007349 1 0.012
protein catabolic process GO:0030163 221 0.012
response to peptide hormone GO:0043434 127 0.012
leukocyte differentiation GO:0002521 342 0.012
cytokine mediated signaling pathway GO:0019221 115 0.012
regulation of apoptotic signaling pathway GO:2001233 197 0.012
lymphocyte proliferation GO:0046651 164 0.012
cytokine production GO:0001816 319 0.012
developmental cell growth GO:0048588 84 0.012
rhythmic process GO:0048511 174 0.012
negative regulation of nervous system development GO:0051961 156 0.011
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.011
establishment of organelle localization GO:0051656 122 0.011
wound healing GO:0042060 157 0.011
lymphocyte differentiation GO:0030098 242 0.011
guanosine containing compound catabolic process GO:1901069 144 0.011
regulation of protein serine threonine kinase activity GO:0071900 157 0.011
monocarboxylic acid biosynthetic process GO:0072330 61 0.011
hematopoietic progenitor cell differentiation GO:0002244 143 0.011
organophosphate biosynthetic process GO:0090407 122 0.011
digestive tract development GO:0048565 190 0.011
extracellular structure organization GO:0043062 148 0.011
response to acid chemical GO:0001101 111 0.011
establishment of protein localization to membrane GO:0090150 54 0.011
Yeast
regulation of cellular response to stress GO:0080135 159 0.011
germ cell development GO:0007281 185 0.011
stem cell development GO:0048864 219 0.011
nuclear import GO:0051170 95 0.011
generation of precursor metabolites and energy GO:0006091 103 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
cell maturation GO:0048469 127 0.011
fatty acid biosynthetic process GO:0006633 41 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
establishment of protein localization to organelle GO:0072594 118 0.011
Yeast
regulation of response to wounding GO:1903034 189 0.011
establishment or maintenance of cell polarity GO:0007163 86 0.011
nucleoside phosphate biosynthetic process GO:1901293 79 0.011
protein import GO:0017038 101 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.011
regulation of neuron projection development GO:0010975 169 0.011
connective tissue development GO:0061448 179 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
adult locomotory behavior GO:0008344 91 0.011
regulation of ras protein signal transduction GO:0046578 114 0.011
central nervous system neuron differentiation GO:0021953 162 0.011
guanosine containing compound metabolic process GO:1901068 144 0.011
cytokinetic process GO:0032506 2 0.011
regulation of translation GO:0006417 71 0.011
Yeast
innate immune response GO:0045087 157 0.011
morphogenesis of a branching structure GO:0001763 203 0.011
ribonucleotide biosynthetic process GO:0009260 59 0.011
renal system development GO:0072001 225 0.011
oocyte construction GO:0007308 2 0.011
telencephalon development GO:0021537 186 0.011
female sex differentiation GO:0046660 84 0.010
sulfur compound metabolic process GO:0006790 100 0.010
smoothened signaling pathway GO:0007224 105 0.010
neuron neuron synaptic transmission GO:0007270 69 0.010
protein glycosylation GO:0006486 55 0.010
neuron projection extension GO:1990138 64 0.010
retina development in camera type eye GO:0060041 119 0.010
learning or memory GO:0007611 148 0.010
neural precursor cell proliferation GO:0061351 121 0.010
muscle contraction GO:0006936 101 0.010
meiotic nuclear division GO:0007126 115 0.010
cell junction organization GO:0034330 77 0.010
cell activation involved in immune response GO:0002263 126 0.010
protein polymerization GO:0051258 57 0.010
multi multicellular organism process GO:0044706 109 0.010
regulation of lymphocyte activation GO:0051249 240 0.010
ubiquitin dependent protein catabolic process GO:0006511 129 0.010
positive regulation of cell death GO:0010942 224 0.010
axon cargo transport GO:0008088 33 0.010
regulation of epithelial cell proliferation GO:0050678 141 0.010
regulation of endocytosis GO:0030100 69 0.010
protein localization to nucleus GO:0034504 121 0.010
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.010
sequestering of metal ion GO:0051238 19 0.010
response to oxygen levels GO:0070482 62 0.010
Fly
inter male aggressive behavior GO:0002121 3 0.010
positive regulation of nucleoside metabolic process GO:0045979 91 0.010
positive regulation of neuron projection development GO:0010976 79 0.010
sodium ion transport GO:0006814 73 0.010
Fly
asymmetric stem cell division GO:0098722 3 0.010
hormone metabolic process GO:0042445 86 0.010
detection of external stimulus GO:0009581 61 0.010
positive regulation of homeostatic process GO:0032846 64 0.010
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.010
myosin filament organization GO:0031033 3 0.010
cellular response to peptide hormone stimulus GO:0071375 92 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.010

Letm1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.048
disease of anatomical entity DOID:7 0 0.023
nervous system disease DOID:863 0 0.023
inherited metabolic disorder DOID:655 0 0.021
central nervous system disease DOID:331 0 0.016
musculoskeletal system disease DOID:17 0 0.016
immune system disease DOID:2914 0 0.015
brain disease DOID:936 0 0.015
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.010
muscular disease DOID:0080000 0 0.010