Mus musculus

141 known processes

Fech

ferrochelatase

(Aliases: fch,Fcl,AI894116)

Fech biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cofactor biosynthetic process GO:0051188 41 0.571
myeloid cell differentiation GO:0030099 233 0.340
porphyrin containing compound biosynthetic process GO:0006779 16 0.305
membrane organization GO:0061024 245 0.291
organonitrogen compound biosynthetic process GO:1901566 192 0.282
tetrapyrrole metabolic process GO:0033013 22 0.263
plasma membrane organization GO:0007009 90 0.224
axonogenesis GO:0007409 274 0.212
porphyrin containing compound metabolic process GO:0006778 22 0.196
erythrocyte differentiation GO:0030218 88 0.193
endomembrane system organization GO:0010256 147 0.178
neuron projection guidance GO:0097485 141 0.157
protein localization to membrane GO:0072657 108 0.129
cellular amino acid metabolic process GO:0006520 103 0.126
protein localization to plasma membrane GO:0072659 57 0.117
chemotaxis GO:0006935 247 0.112
axon guidance GO:0007411 141 0.105
homeostasis of number of cells GO:0048872 210 0.100
regulation of transferase activity GO:0051338 263 0.100
sulfur compound biosynthetic process GO:0044272 37 0.099
cellular ketone metabolic process GO:0042180 84 0.081
hindbrain development GO:0030902 128 0.069
intracellular protein transport GO:0006886 204 0.069
tetrapyrrole biosynthetic process GO:0033014 16 0.068
response to radiation GO:0009314 165 0.067
iron ion homeostasis GO:0055072 36 0.067
amp metabolic process GO:0046033 4 0.065
single organism nuclear import GO:1902593 95 0.062
glycerolipid metabolic process GO:0046486 122 0.061
myeloid cell homeostasis GO:0002262 114 0.060
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.055
negative regulation of protein metabolic process GO:0051248 282 0.055
regulation of membrane potential GO:0042391 192 0.054
protein catabolic process GO:0030163 221 0.053
cellular component assembly involved in morphogenesis GO:0010927 139 0.053
cellular macromolecule catabolic process GO:0044265 206 0.053
regulation of apoptotic signaling pathway GO:2001233 197 0.053
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 12 0.051
protein targeting to plasma membrane GO:0072661 7 0.051
multicellular organism growth GO:0035264 161 0.050
protein ubiquitination GO:0016567 171 0.050
dephosphorylation GO:0016311 129 0.049
protein modification by small protein conjugation or removal GO:0070647 207 0.049
nuclear division GO:0000280 158 0.049
monocarboxylic acid metabolic process GO:0032787 191 0.046
metencephalon development GO:0022037 89 0.046
response to oxidative stress GO:0006979 123 0.046
regulation of protein serine threonine kinase activity GO:0071900 157 0.045
regulation of cellular amino acid metabolic process GO:0006521 5 0.045
transmembrane transport GO:0055085 412 0.045
cellular ion homeostasis GO:0006873 165 0.044
organic acid biosynthetic process GO:0016053 86 0.043
alcohol metabolic process GO:0006066 116 0.042
positive regulation of potassium ion transport GO:0043268 3 0.042
regulation of cellular ketone metabolic process GO:0010565 66 0.042
defecation GO:0030421 1 0.040
cellular lipid metabolic process GO:0044255 323 0.040
transition metal ion homeostasis GO:0055076 54 0.039
ras protein signal transduction GO:0007265 77 0.039
positive regulation of growth GO:0045927 104 0.038
negative regulation of phosphorus metabolic process GO:0010563 184 0.038
regulation of cellular response to stress GO:0080135 159 0.038
negative regulation of molecular function GO:0044092 258 0.038
adiponectin activated signaling pathway GO:0033211 4 0.038
cerebellum development GO:0021549 77 0.036
response to nutrient levels GO:0031667 109 0.036
developmental maturation GO:0021700 193 0.036
Zebrafish
regulation of system process GO:0044057 200 0.034
cellular response to oxidative stress GO:0034599 76 0.033
anion transport GO:0006820 177 0.033
negative regulation of heart rate GO:0010459 4 0.033
apoptotic signaling pathway GO:0097190 306 0.032
sensory perception GO:0007600 245 0.032
organic anion transport GO:0015711 137 0.032
regulation of kinase activity GO:0043549 249 0.032
mitotic cell cycle process GO:1903047 159 0.032
cellular amine metabolic process GO:0044106 44 0.030
intrinsic apoptotic signaling pathway GO:0097193 132 0.030
amine metabolic process GO:0009308 45 0.030
transmission of nerve impulse GO:0019226 76 0.030
positive regulation of potassium ion transmembrane transporter activity GO:1901018 1 0.030
sulfur compound metabolic process GO:0006790 100 0.030
heme biosynthetic process GO:0006783 12 0.029
nuclear transport GO:0051169 139 0.029
negative regulation of cellular protein metabolic process GO:0032269 247 0.029
regulation of cellular amine metabolic process GO:0033238 20 0.028
response to iron ion GO:0010039 4 0.028
sequestering of metal ion GO:0051238 19 0.028
regulation of intracellular transport GO:0032386 159 0.028
mitochondrion transport along microtubule GO:0047497 3 0.028
oxidation reduction process GO:0055114 342 0.027
protein import into nucleus GO:0006606 95 0.026
negative regulation of phosphorylation GO:0042326 166 0.026
peptidyl amino acid modification GO:0018193 336 0.026
regulation of cytolysis GO:0042268 1 0.025
response to light stimulus GO:0009416 135 0.025
regulation of ion transport GO:0043269 215 0.025
modification dependent macromolecule catabolic process GO:0043632 133 0.025
response to inorganic substance GO:0010035 96 0.025
hydrogen peroxide catabolic process GO:0042744 5 0.024
positive regulation of leukocyte proliferation GO:0070665 73 0.024
carboxylic acid biosynthetic process GO:0046394 86 0.024
protein processing GO:0016485 163 0.024
ribose phosphate metabolic process GO:0019693 291 0.024
cellular metal ion homeostasis GO:0006875 151 0.024
fertilization GO:0009566 127 0.023
ubiquitin dependent protein catabolic process GO:0006511 129 0.023
cellular response to hormone stimulus GO:0032870 150 0.023
negative regulation of protein modification process GO:0031400 163 0.023
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.023
positive regulation of cellular amine metabolic process GO:0033240 5 0.023
response to growth factor GO:0070848 198 0.023
blood circulation GO:0008015 195 0.023
small molecule biosynthetic process GO:0044283 132 0.023
modification dependent protein catabolic process GO:0019941 133 0.023
purine nucleotide metabolic process GO:0006163 302 0.023
ribonucleotide metabolic process GO:0009259 291 0.022
cation transmembrane transport GO:0098655 266 0.022
metal ion homeostasis GO:0055065 189 0.022
nuclear import GO:0051170 95 0.022
acylglycerol metabolic process GO:0006639 55 0.022
nucleobase containing small molecule metabolic process GO:0055086 352 0.022
protein modification by small protein conjugation GO:0032446 187 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.022
inorganic ion transmembrane transport GO:0098660 234 0.022
sa node cell to atrial cardiac muscle cell signalling GO:0086018 4 0.021
protein oligomerization GO:0051259 67 0.021
generation of precursor metabolites and energy GO:0006091 103 0.021
carbohydrate derivative biosynthetic process GO:1901137 183 0.021
response to extracellular stimulus GO:0009991 127 0.021
phospholipid metabolic process GO:0006644 87 0.021
cell maturation GO:0048469 127 0.021
Zebrafish
regulation of cell activation GO:0050865 289 0.021
regulation of cellular catabolic process GO:0031329 242 0.020
cellular response to growth factor stimulus GO:0071363 197 0.020
macromolecule catabolic process GO:0009057 281 0.020
organelle assembly GO:0070925 177 0.020
response to starvation GO:0042594 65 0.020
purine ribonucleotide metabolic process GO:0009150 290 0.020
atp metabolic process GO:0046034 75 0.020
cellular protein catabolic process GO:0044257 155 0.020
divalent inorganic cation homeostasis GO:0072507 138 0.020
negative regulation of intracellular signal transduction GO:1902532 167 0.020
nucleoside metabolic process GO:0009116 246 0.020
locomotory behavior GO:0007626 195 0.019
nucleocytoplasmic transport GO:0006913 139 0.019
negative regulation of phosphate metabolic process GO:0045936 184 0.019
cerebellar cortex morphogenesis GO:0021696 32 0.019
cerebellum morphogenesis GO:0021587 42 0.019
neutral lipid metabolic process GO:0006638 57 0.019
triglyceride metabolic process GO:0006641 51 0.019
carbohydrate metabolic process GO:0005975 230 0.019
regulation of protein processing GO:0070613 96 0.019
reactive oxygen species metabolic process GO:0072593 84 0.019
organelle fission GO:0048285 170 0.019
regulation of heart contraction GO:0008016 77 0.019
central nervous system neuron differentiation GO:0021953 162 0.018
hormone mediated signaling pathway GO:0009755 23 0.018
cellular chemical homeostasis GO:0055082 215 0.018
negative regulation of transferase activity GO:0051348 85 0.018
spermatogenesis GO:0007283 284 0.018
purine containing compound metabolic process GO:0072521 311 0.018
cytoplasmic transport GO:0016482 234 0.018
action potential GO:0001508 78 0.018
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.018
glycerophospholipid metabolic process GO:0006650 71 0.018
t cell proliferation GO:0042098 120 0.018
microtubule based process GO:0007017 236 0.017
mitotic cell cycle GO:0000278 195 0.017
monocarboxylic acid transport GO:0015718 44 0.017
cell type specific apoptotic process GO:0097285 268 0.017
ribonucleoside triphosphate metabolic process GO:0009199 220 0.017
regulation of leukocyte proliferation GO:0070663 121 0.017
regulation of cytokine production GO:0001817 266 0.017
negative regulation of homeostatic process GO:0032845 71 0.017
adult behavior GO:0030534 135 0.017
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 10 0.017
neuronal action potential GO:0019228 54 0.017
multicellular organismal homeostasis GO:0048871 164 0.017
cerebellar purkinje cell layer development GO:0021680 26 0.017
protein targeting GO:0006605 143 0.017
cation homeostasis GO:0055080 212 0.016
purine nucleoside triphosphate metabolic process GO:0009144 226 0.016
regulation of cellular response to growth factor stimulus GO:0090287 82 0.016
regulation of nucleotide catabolic process GO:0030811 122 0.016
regulation of lymphocyte proliferation GO:0050670 117 0.016
establishment of protein localization to membrane GO:0090150 54 0.016
protein homooligomerization GO:0051260 43 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.016
purine nucleotide catabolic process GO:0006195 211 0.016
negative regulation of protein activation cascade GO:2000258 3 0.016
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.016
negative regulation of complement activation GO:0045916 3 0.016
lipid biosynthetic process GO:0008610 179 0.016
sensory perception of mechanical stimulus GO:0050954 107 0.016
response to reactive oxygen species GO:0000302 56 0.016
pyruvate transport GO:0006848 2 0.016
organic hydroxy compound metabolic process GO:1901615 203 0.015
regulation of reactive oxygen species metabolic process GO:2000377 40 0.015
establishment of protein localization to organelle GO:0072594 118 0.015
nucleoside phosphate metabolic process GO:0006753 338 0.015
signal transduction in absence of ligand GO:0038034 55 0.015
regulation of organelle organization GO:0033043 289 0.015
cerebellar cortex development GO:0021695 48 0.015
purine nucleoside metabolic process GO:0042278 241 0.015
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.015
carboxylic acid transport GO:0046942 100 0.015
response to metal ion GO:0010038 47 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.015
nucleoside monophosphate metabolic process GO:0009123 85 0.015
cellular amino acid biosynthetic process GO:0008652 22 0.015
regulation of binding GO:0051098 111 0.015
forebrain development GO:0030900 302 0.015
multicellular organismal signaling GO:0035637 91 0.015
myeloid leukocyte differentiation GO:0002573 119 0.015
ribonucleoside metabolic process GO:0009119 245 0.015
heart contraction GO:0060047 93 0.014
regulation of transmembrane transport GO:0034762 128 0.014
purine ribonucleoside metabolic process GO:0046128 241 0.014
activation of membrane attack complex GO:0001905 4 0.014
divalent inorganic cation transport GO:0072511 178 0.014
muscle cell differentiation GO:0042692 261 0.014
adult locomotory behavior GO:0008344 91 0.014
positive regulation of programmed cell death GO:0043068 218 0.014
regulation of protein binding GO:0043393 60 0.014
fatty acid metabolic process GO:0006631 121 0.014
hindbrain morphogenesis GO:0021575 46 0.014
multi organism behavior GO:0051705 62 0.014
regulation of t cell activation GO:0050863 170 0.014
nonribosomal peptide biosynthetic process GO:0019184 5 0.014
dna endoreduplication GO:0042023 4 0.014
regulation of protein localization GO:0032880 231 0.014
striated muscle tissue development GO:0014706 293 0.013
regulation of protein kinase activity GO:0045859 232 0.013
regulation of protein maturation GO:1903317 96 0.013
regulation of mapk cascade GO:0043408 248 0.013
protein import GO:0017038 101 0.013
muscle tissue development GO:0060537 308 0.013
regulation of leukocyte differentiation GO:1902105 159 0.013
negative regulation of cellular amine metabolic process GO:0033239 1 0.013
response to organonitrogen compound GO:0010243 246 0.013
divalent metal ion transport GO:0070838 172 0.013
digestive tract development GO:0048565 190 0.013
multicellular organismal aging GO:0010259 24 0.013
calcium ion homeostasis GO:0055074 127 0.013
cellular modified amino acid metabolic process GO:0006575 63 0.013
cellular response to cytokine stimulus GO:0071345 189 0.013
organophosphate biosynthetic process GO:0090407 122 0.012
cell cycle g1 s phase transition GO:0044843 57 0.012
negative regulation of organelle organization GO:0010639 90 0.012
organic cyclic compound catabolic process GO:1901361 295 0.012
calcium ion transport GO:0006816 159 0.012
sequestering of calcium ion GO:0051208 18 0.012
guanosine containing compound metabolic process GO:1901068 144 0.012
endocytic recycling GO:0032456 7 0.012
nucleoside phosphate biosynthetic process GO:1901293 79 0.012
negative regulation of cell cycle GO:0045786 123 0.012
ossification GO:0001503 216 0.012
mapk cascade GO:0000165 281 0.012
response to molecule of bacterial origin GO:0002237 143 0.012
nucleotide biosynthetic process GO:0009165 78 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.012
negative regulation of protein processing GO:0010955 79 0.012
negative regulation of apoptotic signaling pathway GO:2001234 104 0.012
neuron death GO:0070997 154 0.012
organic acid transport GO:0015849 101 0.012
immune effector process GO:0002252 321 0.012
thioester biosynthetic process GO:0035384 7 0.012
lymphocyte proliferation GO:0046651 164 0.012
extrinsic apoptotic signaling pathway GO:0097191 126 0.012
synapse organization GO:0050808 125 0.012
purine nucleotide biosynthetic process GO:0006164 65 0.012
regulation of cell cycle GO:0051726 281 0.012
paracrine signaling GO:0038001 1 0.012
liver development GO:0001889 66 0.011
protein acylation GO:0043543 64 0.011
small gtpase mediated signal transduction GO:0007264 97 0.011
multi multicellular organism process GO:0044706 109 0.011
heart morphogenesis GO:0003007 178 0.011
negative regulation of kinase activity GO:0033673 81 0.011
negative regulation of protein phosphorylation GO:0001933 126 0.011
cation transport GO:0006812 399 0.011
protein localization to nucleus GO:0034504 121 0.011
regulation of t cell proliferation GO:0042129 92 0.011
glycosyl compound metabolic process GO:1901657 246 0.011
xenobiotic catabolic process GO:0042178 1 0.011
positive regulation of lymphocyte proliferation GO:0050671 70 0.011
positive regulation of gtpase activity GO:0043547 85 0.011
anatomical structure homeostasis GO:0060249 145 0.011
protein targeting to membrane GO:0006612 20 0.011
lipoprotein metabolic process GO:0042157 43 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
meiotic cell cycle GO:0051321 122 0.011
neural tube closure GO:0001843 90 0.011
water soluble vitamin metabolic process GO:0006767 10 0.011
positive regulation of protein modification process GO:0031401 299 0.011
cellular response to arsenic containing substance GO:0071243 4 0.011
regulation of cardiac muscle cell membrane potential GO:0086036 3 0.011
wnt signaling pathway GO:0016055 188 0.011
negative regulation of dna replication GO:0008156 4 0.011
stem cell maintenance GO:0019827 130 0.011
fibroblast growth factor production GO:0090269 4 0.011
male gamete generation GO:0048232 285 0.011
long chain fatty acid import GO:0044539 2 0.011
myelination GO:0042552 74 0.011
negative regulation of immune system process GO:0002683 209 0.011
heart process GO:0003015 94 0.011
ion transmembrane transport GO:0034220 361 0.011
reactive nitrogen species metabolic process GO:2001057 0 0.011
nucleoside phosphate catabolic process GO:1901292 222 0.011
nitrogen compound transport GO:0071705 271 0.010
response to organic cyclic compound GO:0014070 198 0.010
ribonucleotide biosynthetic process GO:0009260 59 0.010
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.010
regulation of defense response GO:0031347 233 0.010
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.010
purine nucleoside monophosphate metabolic process GO:0009126 81 0.010
activation of immune response GO:0002253 138 0.010
regulation of ras protein signal transduction GO:0046578 114 0.010
circulatory system process GO:0003013 197 0.010
glycoprotein biosynthetic process GO:0009101 89 0.010
striated muscle cell development GO:0055002 125 0.010
retrograde vesicle mediated transport golgi to er GO:0006890 1 0.010
actin mediated cell contraction GO:0070252 15 0.010
heterocycle catabolic process GO:0046700 280 0.010
organophosphate catabolic process GO:0046434 232 0.010
purine ribonucleoside catabolic process GO:0046130 205 0.010
purine containing compound biosynthetic process GO:0072522 70 0.010
rho protein signal transduction GO:0007266 32 0.010
organic hydroxy compound catabolic process GO:1901616 25 0.010

Fech disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.513
disease of anatomical entity DOID:7 0 0.513
anemia DOID:2355 0 0.513
hematopoietic system disease DOID:74 0 0.513
disease of metabolism DOID:0014667 0 0.169
inherited metabolic disorder DOID:655 0 0.080
nervous system disease DOID:863 0 0.048
central nervous system disease DOID:331 0 0.041
hemolytic anemia DOID:583 0 0.025
normocytic anemia DOID:720 0 0.025
neurodegenerative disease DOID:1289 0 0.023
sensory system disease DOID:0050155 0 0.014
eye and adnexa disease DOID:1492 0 0.014
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010
eye disease DOID:5614 0 0.010